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Dia Rofinda, Zelly Dia
Bagian Patologi Klinik Fakultas Kedokteran Universitas Andalas
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Journal : JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia

 1 
PENGUJIAN EFEKTIVITAS EKSTRAK CAPSICUM ANNUUM SEBAGAI ANTI INFLAMASI PADA TIKUS WISTAR YANG DIINDUKSI CCL4 Aldian Mulyanto Lokaria; Berliana Islamiyarti Hydra; Zelly Dia Rofinda
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 6 No 1 (2018): JIMKI : Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 6.1 Edisi April - Sep
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

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Abstract

Background: Inflammation has a major role in the pathogenesis of various diseases. Non steroidal anti inflammatory drugs (NSAIDs) being the most often used drug in community, but prolonged use NSAIDs can cause digestive problems and other side effects. Capsaicin from red chilli (Capsicum annuum) extract have anti-inflammatory effects and as a replacement candidate of NSAIDs. Methods: This research is an experimental research with pre and post test design for differential count and post test only design to leukocytes count and erythrocyte sedimentation rate (ESR). The four positive control groups and treatment group contains 5 samples of wistar rat for each group induced by CCl4 2% 0,5 ml/day for 30 days. After induction, the samples were given treatment for 14 days with ad libitum standard diet (negative control); aspirin; acetaminophen; ibuprofen; mefenamic acid (positive control), and extracts of C. annuum 2% (treatment group). Results: The differential count from extracts of C. annuum 2% group showed a decrease in lymphocytes (p <0,001) than before treatment. While the results of leukocytes count and ESR from C. annuum extract 2% group showed smaller results, ie 5.020 ± 2.071 (p = 0,209) and 2,00 ± 1,26 (p = 0,174) compared to the NSAIDs groups. Conclusion: Extract of C. annuum 2% were able to decrease the proportion of lymphocytes significantly, but the reduced of leukocytes count and ESR unsignificantly.
Co-Authors Adelin, Prima Afriwardi Afriwardi Aisah Aisah Aisyah Elliyanti Aisyah Ellyanti Aldian Mulyanto Lokaria Aldian Mulyanto Lokaria Alles Firmansyah Almurdi Almurdi Alqadri Alqadri Alvarino Amanda Rizki Andry Kurniawan Andry Kurniawan Antonius, Puja Agung Arina Widya Murni Ashal, Taufik Asterina Asterina Aswiyanti Asri Berliana Islamiyarti Hydra Berliana Islamiyarti Hydra Bobby Indra Utama Daan Khambri Daulat Azhari Dessy Arisanti Desta Purwati Desywar Desywar Desywar Desywar Dian Jenova Dian Pertiwi Dian Pertiwi Dinda Aprillia Dinda Aprillia Dwi Yulia Edison Edison Efrida Efrida Efrida Elizabeth Bahar Ellyza Nasrul Elmatris Sy Elvinawaty Elvinawaty Endrinaldi Endrinaldi Endrinaldi Erkadius Erkadius Eti Yerizel Etriyel Myh Fadil Oenzil Fauzan Arisyi Koto Fauzar Fauzar Fauzar Fauzar Febby Genta Wahyuni Febrita Joniarti Feby Febriatama Fiona Septi Mulya Firdawati Firdawati Gusti Revilla Hanifah Maani Hanifah Maani Hasmiwati Hendriati, Hendriati Hevrina Yufani Hevrina Yufani Husna Yetti Husni Husni Husni Husni Husni Husni Husnil Kadri Husnil Wardiyah Ira Ferawati Julizar Julizar Julizar Julizar M. Ikhlasul Amal Eel Taslim Masrul Masrul Syafri Mohamad Reza Najirman Najirman Nanda Oktavia Nur Izzah Atirah Hardinur Putri Auliya Putri, Biomechy Oktomalio Rahmat Syawqi Rahmat Syawqi Rama Dhanivita Djamin Rani Novelty Rauza Sukma Rita Ricca Fitria Rika Susanti Rikarni Rikarni Rina Gustia Risma Isti Rismawati Yaswir Rizanda Machmud Rizki Rahmadian Rosfita Rasyid Rulli Firmansyah Salsabila Dhiyaa Syifa Saptino Miro Sharon Serafim Bosawer Siti Nurhajjah Sri Widyaningsih Suswita, Rini Tuti Asryani Verbrini Rifnayeni Willy Valerian Wirsma Arif Yulistini, Yulistini Yusrawati Yusrawati Yustini Alioes