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Zahratul Idami
Fakultas Hukum, Universitas Syiah Kuala
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Journal : Rumphius Pattimura Biological Journal

 1 
Effect of Moringa oleifera L. Leaf Extract on GPx-3 Gene Expression in the Brain of Induced Ethylene Glycol on Rats (Rattus norvegicus) Nasution, Niska Maulida; Idami, Zahratul; Widiarti, Leni; Ningrum, Nurlian Augustin
RUMPHIUS Vol 8 No 1 (2026): RUMPHIUS Pattimura Biological Journal (in process)
Publisher : Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/rumphiusv8i1p055-060

Abstract

Ethylene glycol is one of the toxic substances commonly used as solvents and is known to induce oxidative stress in neural tissue. GPX-3 is an antioxidant enzyme that works to reduce ROS, maintain redox balance, and protect cells from damage caused by free radicals produced during oxidative stress processes. This study aims to evaluate the effect of administering Moringa oleifera L. leaf extract after ethylene glycol induction on the intensity of GPx-3 gene expression in the brain of white rats (Rattus norvegicus). This research employed a completely randomized design (RAL) using 20 rats divided into five groups: a normal control group, a 0.75% ethylene glycol group, a 150 mg/kgBW Mo group, a 300 mg/kgBW Mo group, and a 450 mg/kgBW Mo group. The research stages included brain RNA extraction, cDNA synthesis, PCR amplification, agarose gel electrophoresis, and band intensity analysis using ImageJ. The results showed that GPx-3 gene expression in rat brain tissue appeared at 300 bp. Administration of Moringa oleifera L. leaf extract increased GPx-3 gene expression intensity in ethylene glycol induced rats, with the most prominent increase observed in treatment 2 (300 mg/kgBW). The increase or decrease in measured expression after normalization to GAPDH indicates that the observed changes reflect a biological response to treatment rather than technical error. This study presents a novelty finding by demonstrating, for the first time, the dose-dependent modulation of GPx-3 gene expression in brain tissue following ethylene glycol induced oxidative stress and identifying 300 mg/kgBW as the most effective dose, thereby revealing a potential molecular mechanism underlying the neuroprotective effect of Moringa oleifera L. leaf extract.
Co-Authors A. Rani, Faisal Abdul Wahab Abdi, Abdul Wahab Abidin Nurdin Aisyah Hutasuhut, Melfa Alfi Rahman Ali Afwanudin Ali Akbar Alkaf, Muhammad Amalia Mukhtar Ashari, Maya Asri Gani Astuti, Astri Widia Azzahra, Fathia Azzahrawi Azzahrawi Balqish, Annisa Br Tarigan, Rindi Atika Cut Khairunnisak Dakiani diana, Rahma Doly, Raja Dur , Sajaratud Dwi Pratiwi, Anggrainy Eddy Purnama Ellianti, Ellianti Erdiwansyah Erdiwansyah Fanisah Labibah Fathiha, Herly Febri Fatiani Manik Fattara, Fajar Putra Febrian, Fadly Ferdy Saputra Fita Nelyza Hadi Iskandar Hafsa, Sri Sholeha Hara, Nina Tiya Harahap, Atika Rahmah Harnita Harnita Hasra, Barratun Nisa Helmi Helmi Husna, Nina Hayatul Husnarika Febriani, Husnarika Husni Djalil Husni Husni Hutasuhut, Melfa Aisyah Ichsan Maulana Ida Muliawati Idham Idham Ihdi Karim Makinara Ihyannisak Zain Israr Hirdayadi Kasmawati Kasmawati Keumala, Meta Khaira MS, Nazlil Kurniasy, Dessy Kusumapradja, Rokiah Leni Widiarti, Leni Lubis, Habib Jailani M Ikhsan M. Hardiansyah M. Idris M. Irham M. Zaki Mahfud Mahfud Mahidin Mahidin Mahriza, Rita Manalu, Kartika Manulu, Kartika Mariana Mariana Masturah, Siti Ghaisani Maulidian, Muhammad Okta Ridha Meutia, Cut Intan Muazzin Muazzin Muhammad Idris muhammad rizky, muhammad Muhammad Tirta Rizky Mukhlis Mukhlis Mukhlis Mukhlis Mumtaz, Raydina Muntiza, Rizka Mursyid Djawas Muslim Zainuddin N. Nazaruddin Nadila, Evi Nasution, Niska Maulida Navisa A, Alya Ningrum, Nurlian Augustin Nova Fahradina Novianti, Mutiara Nugroho, Muhammad Agung Nurisa, Vina Nurul Fadhilah Pocut Navieza Pratama, Yuda Rizky Puspita, Siti Neni Putri, Rahudatul Qudwatin Nisak M. Isa Rahmadhini, Nur Azmi Rahmadina, Rahmadina Rahmadsyah, Rangkuti Rahmah Johar Ramadani, Fitria Ramayati, Ike Rangkuti, Ana Rahmawati Rangkuti, Rahmadsyah Rangkuti, Rahmatsyah Raza, Mohd Hamid Rifa'ah, Sirriyatur Riski Afrial Ritonga, Desi Rohaizati, Ulya Rosifa, Gita Dewi Rossya, Nadila Rizki Rusdianda Rusdianda Sabilla, Bunga Sausan Saifani, Meutia Sajaratud Dur, Sajaratud Salsabila, Nada Sandika , Febri Shafrida Wati, Shafrida Shafridawati Shella Namira Wardia Shinta Seftyana Silalahi, Ali Affan Simbolon, Wira Hariati Siregar, Elsa Manora Suhaimi Suhaimi Suhery, Dedy Syahputra, Akbar Syahreza, Daffa Rizki Syahrizal Abbas Tambunan, Efrida Pima Sari tiara dewi Utami, Mutiara Alya Wahidah Wahidah Wahidah Wahyuni, Rana Wandini, Dwi Febiyanti Wirayudha, Gilang Yanis Rinaldi Yunita Yunita Yusliandi, Rifaldy Yusrizal Hasbi Yusvita, Diana Zaiyana Putri, Zaiyana Zakaria Zakaria Zuhra, Arini Zulyani Mahmud