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Journal : Jurnal Medik Veteriner

Evaluation of Acute Dermal Toxicity of Hibiscus Leaves as Simplicial Ointment on Albino Rats Saputra, Made Gede Adi Surya; Sudira, I Wayan; Samsuri, Samsuri; Merdana, I Made; Dharmayudha, Anak Agung Gde Oka; Sudisma, I Gusti Ngurah
Jurnal Medik Veteriner Vol. 6 No. 2 (2023): October
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jmv.vol6.iss2.2023.216-229

Abstract

Hibiscus is a plant that has been shown to contain substances that may be used as sunscreen to protect the skin from UV radiation. In terms of their potential as sunscreens, flavonoids, tannins, and quinone chemicals are crucial because they are antioxidants that can reduce the negative effects of UV radiation and boost photoprotective activity. This study aimed to investigate the acute dermal toxicity potential of hibiscus leaves simplicial ointment 40% on female albino rats. The evaluation method refered to The OECD Guideline for Testing of Chemicals – No. Test: 402, Acute Dermal Toxicity-Fixed Doses Procedure. Based on the Globally Harmonized System compared to this study reported that acute dermal median lethal dose (LD50) was > 2000 mg/kg. It can be concluded that hibiscus leaves simplicial ointment 40% has safe to apply topically and doesn't produce acute skin toxicity.
Sebaceous Adenoma in a Geriatric Poodle Dog: A Case Report Winaya, Ida Bagus Oka; Adi, Anak Agung Ayu Mirah; Sudimartini, Luh Made; Merdana, I Made; Sudipa, Putu Henrywaesa; Pemayun, I Gusti Agung Gde Putra; Sewoyo, Palagan Senopati
Jurnal Medik Veteriner Vol. 7 No. 2 (2024): October
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jmv.vol7.iss2.2024.413-419

Abstract

A 14-year-old black male Poodle was brought to the Animal Teaching Hospital, Udayana University by its owner with clinical signs of frequent licking of its left front paw. Upon examination, red bumps were observed on the left front leg, accompanied by small, round black spots scattered on the dorsal side of the body. Additionally, black nodules were present on the lower eyelids and hind limbs. Surgical intervention was undertaken to excise the tumor mass, with the animal under anesthesia induced by ketamine at 5 mg/kg BW intravenously. The reddish nodule was excised by performing an elliptical incision at the base of tumor. Postoperatively, the animal received an antibacterial injection comprising ceftriaxone and tazobactam at 25 mg/kg BW intramuscularly and antiseptic wound dressing for supportive care. Microscopic examination revealed neoplastic cells arranged into lobules of varying sizes and shapes within the tumor mass. These lobules consisted of differentiated sebocytes and basaloid cells. At the periphery of the neoplastic lobules, the basaloid cells displayed several layers and exhibited invasion with moderate anisocytosis. The mitotic index was no more than ten cells in one field of view. Based on these histopathological features, the tumor was confirmed to be a sebaceous adenoma. After a 10-month follow-up period, there were no signs of tumor recurrence observed.
Co-Authors Adri Yana Rambu Anawenju Afrizal Choirul Umam Agustina, I Putu Sudana Ali, Ahmad Muhammad Alviana Rizqiyah Utami Anak Agung Ayu Mirah Adi Anak Agung Gde Arjana Anak Agung Gde Arjana Anak Agung Gde Oka Dharmayudha Anak Agung Sagung Kendran Anastasia Bhala Arinata, I Ketut Teguh Ayu Prawitasari Citra Pratama Bina Ichsantya Darmawan, I Wayan Eka Dini Hilary Manullang Diyasa, I Gede Susrama Mas Domingas Pereira DWI SURYANTO Elsa Hidayati Elti Febilani Febrina Cicilia Br Ginting, Febrina Cicilia Firdaus, Ihsanul Franky Samuel Milenyano Chandra Fuady Muslih Gde Jasmara Muda Gea, Octo Berkat Gede Iwan Setiabudi Gede Yuda Darmadi Putra Genta Dhamara Adam Putranto Gusti Agung Rama Wiratama Putra Hariyadi, Hariyadi Hartati, Ruth Dwi Hendrawan, I Wayan Dika Wahyu I Dewa Made Nurja Sadhi I Gusti Agung Gede Putra Pemayun I Gusti Ayu Sri Darmayani I Gusti Ketut Suarjana I Gusti Ngurah Sudisma I Gusti Putu Tovan Mahottama I GustiKetut Suarjana I Kadek Ariyuda Prasetya I Kadek Parnayasa I Ketut Berata I Ketut Berata I Ketut Suada I Ketut Suada I Komang Ari Mogi I Komang Ari Mogi I Made Damriyasa I Made Dira Swantara I Made Dodi Gunawan I Made Dwinata I Made Kardena I Made Oka Riawan I Made Robi I NYOMAN ADI SURATMA I Nyoman Sarsana I Nyoman Suartha I Nyoman Sulabda I Nyoman Sulabda I Putu Agus Hendra Wibawa I Putu Agus Santika Putra I Putu Dwi Komala Putra I Putu Mangku Mariasa I Wayan Sudira I Wayan Wirata Ida Ayu Pasti Apsari Ida Bagus Komang Ardana Ida Bagus Made Oka Ida Bagus Oka Winaya Ika Hartini Hutasoit, Ika Hartini Iwan Harjono Utama Jihadulhaq, Jihadulhaq Kadek Febriana Marta Putra Kadek Teguh Wirasastra Ketut Budiasa Kusuma, Putu Winatha Luh Ani Luh Gde Sri Surya Heryani Luh Made Sudimartini Luh Seri Ani Made Gede Adi Surya Saputra Mahardika, I Gusti Bagus Mahmud, Fathmah Monica Lewinsky Ngudiyono Ngudiyono Ni Kadek Eka Widiadnyani Ni Luh Eka Setiasih Ni Luh Watiniasih Ni Nyoman Kencanawati Ni Wayan Arya Utami, Ni Wayan Arya Ningsih, Adriati NYOMAN DITA PAHANG PUTRA, NYOMAN Nyoman Sumiati Pradipta Hendra Setiawan, Pradipta Hendra Putera, I Gusti Ngurah Dwipayana Putra, I Dewa Agung Made Wihanjana Putra, I Made Arya Udyana Putra, Putu Adi Guna Purwaka Putri, Ayu Chitra Adhitya Putu Devi Jayanti Putu Henrywaesa Sudipa Putu Suastika Rama Adi Putra, Rama Adi Sampurno, Ilham Ade Widya Samsuri , Samsuri Samsuri Samsuri Samsuri Samsuri Samsuri Samsuri Samsuri Saputra, I Dewa Ketut Ari Setyawati, Luh Gede Sewoyo, Palagan Senopati Sis wanto Siswanto, Riefqy Tepu ST Kholifah Nor Azizati Suci Nur Qurani Teja, Putu Tessa Hariys Septianda Theresia Ene Ujan, Katarina Kewa Yoga Eka Prasetyo Yoga Pratama Mambela Sarungallo