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All Journal Natural Science: Journal of Science and Technology Media Eksakta Jurnal Veteriner Indonesian Journal of Pharmaceutical Science and Technology Biocelebes Jurnal Farmasi Sains dan Komunitas Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Indonesian Journal of Chemistry JPSCR : Journal of Pharmaceutical Science and Clinical Research JFIOnline Jurnal Ilmiah Medicamento Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal DiMas (Jurnal Pengabdian Kepada Masyarakat) Medical Sains : Jurnal Ilmiah Kefarmasian Dedication : Jurnal Pengabdian Masyarakat Journal of Public Health and Pharmacy Jurnal Medika: Medika Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Pengabdian Farmasi dan Sains Poltekita: Jurnal Pengabdian Masyarakat

Khildah Khaerati

Program Studi Farmasi, Fakultas MIPA, Universitas Tadulako, Palu-Sulawesi Tengah

Author-ID : 297762

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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EFEKTIVITAS ANTIINFLAMASI EKSTRAK ETANOL DAUN SUMAMBU (Hyptis capitata Jacq.) PADA TIKUS PUTIH JANTAN (Rattus norvegicus L.) YANG DIINDUKSI DENGAN KARAGENAN Mia Audina; Yuliet Yuliet; Khildah Khaerati
Biocelebes Vol. 12 No. 2 (2018)
Publisher : Biology Department, Mathematics and natural science, Tadulako University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (166.646 KB)

One of the medical plants that can be used as an anti-inflamation treatment is sumambu leaf (Hyptis capitata Jacq.). Most of people in binangga village, Subdistric of central Parigi, Regency of Parigi Moutong, have been used this sumambu leaf for deducting inflammation, swelling, and painful. The aimed of this research is to know the effectiveness of the anti-inflamation of Sumambu leaf (Hyptis capitata Jacq.) towards white male mouse (Rattus novergicus L.) which has been given carrageenan induction. The extract was made by using a maseration method using 96% ethanol liquid. The test of the effectiveness of anti-inflamation was divided into your treatments which each treatment was consist of five mice which have been given negative control 0.5% CMC-Na suspension ;100 mg/KgBW, 200 mg/KgBW, 300 mg/KgBW of sumambu leaf extract. After 60 minutes, 0.1 ml carregeenan has been injected using subplantar method at the paw of the mice. The inflamation volume measured using pletysmometer for 6 hours. The data collection was statistically analyzed by ANOVA (Analysis of variance) one direction and continued to Duncan test. The results of this research showed that the three doses of sumambu extract which are ES 100 mg/KgBW, 200 mg/KgBW, 300 mg/KgBWhave the effect of anti-inflamation. Moreover, it can be said that the result of this research showed that the dose that has a lower inflamation percent was ES 300 mg/KgBW. Keywords: Anti-inflammation, Hyptis capitata Jacq., Carrageenan, Inflamed Paw Volume.

PENGARUH PEMBERIAN TOPIKAL EKSTRAK ETANOL DAUN PECUT KUDA (Stachytarpheta jamaicensis (L.) Vahl) TERHADAP PENYEMBUHAN LUKA BAKAR DERAJAT II PADA PUNGGUNG KELINCI (Oryctolagus cuniculus) Muhammad Anggriawan; Yuliet Yuliet; Khildah Khaerati
Biocelebes Vol. 12 No. 2 (2018)
Publisher : Biology Department, Mathematics and natural science, Tadulako University

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Pecut kuda (Stachytarpheta jamaicensis (L.) Vahl) is one of plant that has the potentials to heal various diseases, one of them as an alternative in the cure of burns. Pecut kuda leaf has been used hereditary by some people at Layana Wintu, Mantikulore subdistrict, Donggala regency for cure of burns. This research is conducted to find out the effect of topical administration of ethanol extract of pecut kuda leaf towards healing burns second degree on the rabbit’s back (Oryctolagus cuniculus) by using many extract concentration variation which are 1%, 3% and 5% with gel basic as the carrier. Testing was conducted on 5 rabbits, each rabbit was induced on his back by 5 burns for five treatments with burns diameter is 2 cm . Burns that has been induced was given each treatments which are negative control (gel basic without extract), ethanol extract of pecut kuda leaf in basic gel with each concentration 1%, 3% and 5%. Positive control used bioplacenton gel. Later, the burns diameter was measured on certain day during 28 days. Data that are achieved was statistically analyzed with one way anova method and is continued by testing post hoc duncan with 95% confidance level. The reasult of this research shows every extract ethanol concentration variation of pecut kuda leaf have activity to heal burns. Extract ethanol concentration of pecut kuda leaf which is efective in healing burns is 3% concentration.Keywords: Gel, (Stachytarpheta jamaicensis (L.) Vahl), Burns, Oryctolagus cuniculus

AKTIVITAS EKSTRAK KULIT BATANG LANGSAT (Lansium parasiticum (Osbeck) Sahni & Bennet) TERHADAP KELARUTAN KALSIUM BATU GINJAL SECARA in vitro Nur Ramadhani; Yuliet Yuliet; Khildah Khaerati
Biocelebes Vol. 12 No. 2 (2018)
Publisher : Biology Department, Mathematics and natural science, Tadulako University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (242.094 KB)

The kidney stone is a stone which is found in the kidney or other parts of urinary tract. The most frequently type of stone encountered are composed of calcium crystals. As much as 60% content of kidney stones consist of calcium oxalate, phosphate, carbonate, uric acid, magnesium, and ammonium. Langsat (Lansium parasiticum (Osbeck) Sahni & Bennet) is a plant that may dissolve kidney stones and smooth urination, particularly its bark. This study aims to determine the activity as well as the greatest concentration of Langsat bark ethanol extract in dissolving dissolves calcium of kidney stones conducted in vitro. The ethanol extract was obtained by maceration method using 96% ethanol followed by phytochemical screening test and thin layer chromatograpy (TLC) profiling of the extract. Chromatogram result shows that the extract contains flavonoids. The research methodology conducted was the kidney stone powder dissolution in the ethanol extract of Langsat bark after being destructed with concentrations of respectively 0.5%, 1% and 1.5% then incubated in 37ºC temperature for 3 hours. The solubility of calcium was assayedby measuring the calcium (Ca) levelsat the beginning and at after being incubated with the kidney stone.The positive control used was Calcusol® and the negative onewas aquadest. The dissolved calcium levels were measured by using Atomic Absorption Spectrophotometer at λ = 422.7 nm. The research results show that Langsat Bark ethanol extract has the activity in dissolving the calcium of kidney stones in vitro of which concentration with greatestactivity of calcium dissolution is 1.5% w/v. Keywords: Kidney Stone, Langsat, Lansium parasiticum, Calcium.

EFEK ANTIPIRETIK EKSTRAK DAUN CABE RAWIT (Capsicum annum L) TERHADAP TIKUS PUTIH JANTAN (Rattus norvegicus) YANG DIINDUKSI VAKSIN Difteri Pertusis Tetanus Inggrid Yuliana; Yuliet Yuliet; Khildah Khaerati
Biocelebes Vol. 12 No. 3 (2018)
Publisher : Biology Department, Mathematics and natural science, Tadulako University

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Leaves cayenne pepper (Capsicum annuum L) is a plant that empirically has been used as a fever-lowering. This study aims to determine the effect of the antipyretic effect of leaf extract of cayenne pepper and determine the effective dose as an antipyretic. Tests carried out using fever inducers ie vaccine DPT (Diphtheria Tetanus Pertussis) 0.2 ml. Tests the antipyretic effect is divided into six treatment groups. The first group was given Na-CMC 1% as the normal control group were given a 2nd Na-CMC and DPT vaccine induced a 0.2 ml as a negative control group all 3 were given paracetamol as a positive control, a group of 4th, 5th and all six were given the leaf extract of cayenne pepper with a dose of 100 mg/kg BW, 200 mg/kg BW, and 300 mg/kg BW. Rectal temperature measurement is carried out for 6 hours with intervals of 30 minutes. Temperature measurement data were statistically analyzed using oneway ANOVA test. Antipyretic activity test results showed that the leaf extract of cayenne pepper has antipyretic activity in male rats and the dose that effectively lower rectal temperature of rat is 300 mg/kg BW.

TERATOGENIK EKSTRAK ETANOL UWI BANGGAI UNGU (Dioscorea alata L.) PADA MENCIT BETINA (Mus musculus) Ihwan Ihwan; Rahmatia Rahmatia; Khildah Khaerati
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 5 No 2 (2020): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Teratogenic is an abnormal development on embryo and is the cause of congenital defect or birth defect. This study aims to determine the effect of the addition of Dioscorea alata L. ethanol extracts to the embryo development on pregnant mice whose given orally to 24 mice which divided to 4 treatment groups, they are the normal group (NG) with NaCMC 0.5%; 28 mg/KgBB treatment group; 35 mg/KgBB; 42 mg/Kg BB. The addition of Dioscorea alata L ethanol extracts was done on the sixth day until the 15th day of pregnancy. On the 18th day of pregnancy, Laparaktomi was done to the pregnant mice and the embryo was taken out of the uterus. The observation was done to the fetus numbers, weight weighing of the fetus's body, dan length measurement of the fetus's body. Another observation is the observation of the external organ defect of the embryo. The study results that the addition of Dioscorea alata L ethanol extracts with various doses have no significant effect (P>0.5) to the mice external fetus development. On the examination of the fetus, we can conclude that Dioscorea alata L ethanol extracts donÃƒÂ¢Ã¢â€šÂ¬Ã¢â€žÂ¢t give any effect that may cause the defect of the fetusÃƒÂ¢Ã¢â€šÂ¬Ã¢â€žÂ¢ external organ.

PENGARUH PEMBERIAN EKSTRAK DAUN SALAM (Syzygium polyanthum Wight.) TERHADAP GLIBENKLAMID DALAM MENURUNKAN KADAR GLUKOSA DARAH MENCIT (Mus musculus) YANG DIINDUKSI ALOKSAN Nur Hikmah; Yuliet Yuliet; Khildah Khaerati
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 2 No. 1 (2016): (March 2016)
Publisher : Universitas Tadulako

The use of herbal medicines and synthetic drugs simultaneously carried out by diabetics for the maintenance of blood glucose levels, such as the use of glibenclamide and bay leaf. This research was carried out to know the impact of administration bay leaf extract on glibenclamide in lowering blood glucose levels on mices that induced by alloxan. This research used 40 male mices which were divided into 8 groups. Before the experiment, the mices were first induced by alloxan (70 mg/kg BW) intravenously. The negative control was the group that given Na CMC 0,5%, KG was the control of glibenclamide 0,65 mg/kg BW, group DS1, DS2, DS3 were the control of single bay leaf extract with each dose 250 mg/kg BW, 500 mg/kg BW, and 750 mg/kg BW, group KD1, KD2, KD3 were the combination group of glibenclamide and bay leaf extract with each dose glibenclamide combined bay leaf extract 250 mg/kg BW, glibenclamide combined bay leaf extract 500 mg/kg BW, and glibenclamide combined bay leaf extract 750 mg/kg BW, with an hour interval. The data were statistically analyzed using ANOVA (Analysis of Variance) at 95% confidence interval with parameter of blood glucose levels difference between before and after treatment. The results showed that the administration of bay leaf extract gave significant impact on glibenclamide in lowering blood glucose levels and the effective dose was the combination of glibenclamide 0,65 mg/kg BW and bay leaf extract 250 mg/kg BW

AKTIVITAS PENGHAMBATAN PEMBENTUKAN BATU GINJAL (Antinefrolithiasis) EKSTRAK ETANOL DAUN GEDI MERAH (Abelmoschus moschtus Medik) PADA TIKUS PUTIH JANTAN Triana Riandani Djamhuri; Yuliet Yuliet; Khildah Khaerati
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 2 No. 1 (2016): (March 2016)
Publisher : Universitas Tadulako

Red Gedi (Abelmoschus moschatus Medik) is a plant found only in tropical climate areas such as Africa and Asia. Some people’s experience in Manado stated that red gedi plants can be used to treat various types of disease, one of them was kidney stones. Therefore, this study aimed to determine the activity and the effective dose of red gedi leaf extract as an inhibitor of kidney stone formation. The extract was prepared by maceration using ethanol 96%. Inhibitory activity test of kidney stone formation was done by firstly dividing the labrats into 6 groups. Each group consisted of 3 male rats. Both the first group (Normal control) and the second group (Negative control) weregiven Na.CMC 0.5%; the third group (Positive control) was given Batugin Elixir at a dose of 2.7 ml/kgBW; while the fourth, fifth, and sixth were respectively given red gedileaf extract at doses of 50, 100, and 150 mg/kgBW. After 2 hours, all treatment groups were induced with0.75% of ethylene glycol and 2% of ammonium chloride except for the normal control. Ratio of kidney weight and the level of calcium were then measured and calculated. Data obtained were statistically analyzed using ANOVA (Analysis Of variance) and continued with LSD (Least Significantly Difference). It can be concluded that ethanol extract of red gedileaves had inhibitory activity of kidney stones formation in all dose variation and the most effective one was at a dose of 150 mg/kgBW

UJI AKTIVITAS SERBUK JAMUR TIRAM PUTIH (Pleurotus ostreatus (Jacq.) P.Kumm) TERHADAP KADAR GLUKOSA DARAH PADA MODEL HEWAN HIPERKOLESTEROLEMIA-DIABETES Dwinthasari Meilinda Azhari; Yuliet Yuliet; Khildah Khaerati
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 2 No. 2 (2016): (October 2016)
Publisher : Universitas Tadulako

Research on the activity of white oyster mushroom powder (Pleurotus ostreatus (Jacq.) P.Kumm) against blood glucose levels in animal model of hypercholesterolemia-diabeties has been conducted. This research aimed to determine its activity as well as its effective dose in lowering blood glucose levels. A number of laboratory rats were divided into five groups and each group consisted of four rats. The 1st group (negative control) was given 0.5% suspension of Na-CMC; the 2nd and 3rd group (positive controls) were respectively given 0.45 mg/kgBW of Glibenclamide and 45 mg/KgBW of Metformin; while each of the 4th, 5th, and 6th groups was given the powder as much as of 250, 500 and 750 mg/kgBW. On day 1 to day 14, they were fed with high cholesterol food then induced with 30 mg/kgBW of streptozotocin, and on day 17 were treated with suspension of white oyster mushroom powder. On day 24 and day 31, the blood glucose levels were checked. Data of blood glucose levels difference between before and after treatment were calculated and statistically processed of which normality had been previously tested using Shapiro Wilk and homogeneity using Levene Test. Data that had normal distribution were statistically analyzed using ANOVA (analysis of variance) with 95% confidence interval and continued with Post hoc Duncan to see the differences among the groups which were significantly different. While, data that did not have normal distribution were analyzed using non-parametric statistics, Kruskal Wallis Test, and then further using Mann Whitney Test. The results showed that powder of white oyster mushroom had antidiabetic activity at effective dose of 250 mg/KgBW

PENGARUH GEL EKSTRAK DAUN SIRIH MERAH (Piper crocatum Ruiz & Pav) TERHADAP PENYEMBUHAN LUKA BAKAR PADA KELINCI (Oryctolagus cuniculus) Fina Ulviani; Yusriadi Yusriadi; Khildah Khaerati
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 2 No. 2 (2016): (October 2016)
Publisher : Universitas Tadulako

Research on Gel Formulation of red betel leaf extract (Piper crocatum Ruiz & Pav) for the treatment of burn wounds in rabbits (Oryctolagus cuniculus) has been conducted. This study aimed to determine variation’s effect of concentration in gel of red betel leaf extract for the treatment of burn wounds in rabbits which had been wounded using hot metal. In this study, the viscous extract was formulated into gel with concentrations of 1%, 2% and 3%. The Gel’s Physical quality evaluation included organoleptic, pH, homogeneity and dispersive ability tests on day 0 until day 28. The gel activity test was performed on 5 rabbits divided into five treatment groups. Each rabbit was burn-wounded using hot metal plate at diameter of 20 mm. Each group was given five wounds consisting of a negative control, 1%, 2%, 3% of extract formula and a positive control. The diameter measurement of the wounds was done on the 1st, 3rd, 5th, 7th, 9th and the 21st day. Data of wound healing percentage was statistically analyzed with Two-Way ANOVA. The results showed that the gel with 3% of red betel leaf extract of which percentage of healing as much as 85.81% compared to gel extract 1% and 2% with percentage 65,32% dan 76,58%.

EFEKTIVITAS ANTIDIABETES EKSTRAK DAUN RAMBUSA (Passiflora foetida L.) PADA MENCIT (Mus musculus) DENGAN INDUKSI GLUKOSA Khildah Khaerati; Ihwan Ihwan; Musdalifah S Maya
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 1 No. 2 (2015): (October 2015)
Publisher : Universitas Tadulako

Passiflora foetida leaves used by the society for generations as a natural antidiabetic drug research aims to test the effectiveness of the leaf extract of Passiflora foetida with variations of a dose of 250 mg / kg, 500 mg / kg, and 750 mg / kg in lowering blood sugar levels in mice. Passiflora foetida leaves were extracted by sokhletasi method with 70% ethanol, the extract was tested on 15 mice, the test animals were randomized into 5 groups consist of negative control group given 0.5% Na-CMC, positive control group was given glibenclamide 0, 65 mg / kg, and the treatment group were given the leaf extract of Passiflorafoetida with variations of each dose of 250 mg / kg, 500 mg / kg, 750 mg / kg. To increase blood sugar levels in mice induced glucose 50%. Measurement of blood sugar levels in mice were performed using an easy touch glucometer and blood is taken via the lateral tail vein. The results showed that the percentage of blood sugar levels drop to a negative control is 13.1%, for a dose of 250 mg / kg body weight of 29.52%, for a dose of 500 mg / kg was 38.79%, to dosis750 mg / kg was 49, 21%, and 48.1% for the positive control. The results showed that the leaf extract of Passiflorafoetida at a dose of 750 mg / kg is most effective as an antidiabetic

Co-Authors A.A. Ketut Agung Cahyawan W Agustinus Widodo Akhmad Khumaidi Ali Djamhuri Amelia Rumi Amini, Delina Andi Alfianto Andi Athira Masyta Andi Fadya Andi Mustika Andi Ratihsekarningrum Siradje Apriyana Soputra Armini Syamsidi Atirah Atirah Calsum, Umi Cornelia Ayu Putri Corry Stephanie Sulastra Dwinthasari Meilinda Azhari Fina Ulviani Finta Amalinda Fitri Anggun Solehah Hardani, Muhammad Fakhrul Heni Pujiastuti Ihwam Ihwan Ihwan Ihwan Ihwan Inggrid Yuliana Ismail, Ihwan Jamaluddin Jamaluddin Jamaluddin Jamaluddin Janes Krisly Joni Tandi Khairiah Kartini Khusnul Diana Klerensia Defneir Titing Lokong, Gladies Melinda Masyita, Andi Atirah Mia Audina Moh. Rifki Muhammad Anggriawan Muhammad Fahrul Hardani Muhammad Fahrul Hardani Musdalifah S Maya Ni Wayan Swintari Novianti Batti Novita Christiana Ponganan Nur Hikmah Nur Ramadhani Nurlaila Ramadhani Primadia, Rizki Putri, Ayu Dinawati Rahmatia Rahmatia Ramadhani, Nurlaila Recky Patala Rini Saputri Ririen Hardani Ririen Ririen Ririn Hardani Rivani Rivani Rivani, Rivani Siti Anisa Sugeng, Santoso Sulastra, Corry Stephanie Triana Riandani Djamhuri Yonelian Yuyun Yuliet Yuliet Yusriadi Yusriadi

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