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All Journal Natural Science: Journal of Science and Technology Media Eksakta Jurnal Veteriner Indonesian Journal of Pharmaceutical Science and Technology Biocelebes Jurnal Farmasi Sains dan Komunitas Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Indonesian Journal of Chemistry JPSCR : Journal of Pharmaceutical Science and Clinical Research JFIOnline Jurnal Ilmiah Medicamento Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal DiMas (Jurnal Pengabdian Kepada Masyarakat) Medical Sains : Jurnal Ilmiah Kefarmasian Dedication : Jurnal Pengabdian Masyarakat Journal of Public Health and Pharmacy Jurnal Medika: Medika Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Pengabdian Farmasi dan Sains Poltekita: Jurnal Pengabdian Masyarakat
Khildah Khaerati
Program Studi Farmasi, Fakultas MIPA, Universitas Tadulako, Palu-Sulawesi Tengah
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Standardization of Ethanol Extract of Dioscorea alata L. Variety of Paoateno from Banggai Islands District, Central Sulawesi: Standarisasi Ekstrak Etanol Dioscorea alata L. Varietas Paoateno Asal Kabupaten Banggai Kepulauan Sulawesi Tengah Ismail, Ihwan; Khumaidi, Akhmad; Putri, Ayu Dinawati; Primadia, Rizki; Syamsidi, Armini; Khaerati, Khildah
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 9 No. 2 (2023): (October 2023)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2023.v9.i2.16065

Abstract

Background: Standardizing herbal medicines is crucial for assessing their quality and effectiveness. Objectives: This study aims to determine non-specific and specific standardization parameters for medicinal plants. Non-specific parameters include drying shrinkage, water content, total ash content, acid insoluble ash content, total bacteria, total mold, and metal limits (Pb, Hg, and Cd). Specific parameters involve organoleptic examination, identification of chemical content in extracts, dissolved compounds in specific solvents, total flavonoid content, and qualitative testing of anthocyanin content in the extract. Materials and Methods: An experimental laboratory approach was employed to extract Dioscorea alata L using 96% ethanol, which was later concentrated through a rotary evaporator to obtain a viscous extract. Specific and non-specific parameters were determined using standardized techniques. Results: The extract yielded 3.32% of the initial substance. Drying shrinkage was 19.7769±1.2682%, and specific gravity was 0.6192±0.1476 gram/ml for 5% m/v and 0.5101±3.9591 gram/ml for 10% m/v. Ash content was 0.6793%, with acid insoluble ash content at 0.1895%. Heavy metal contamination for Hg was 0.47 ppm, but undetected for Pb & Cd). The total plate number was 27 x 103 colonies/g, and negative Escherichia coli contamination. The mold count was 39 x 101 colonies/g. Additional specific parameters included the organoleptic properties of the viscous extract (purple color, characteristic odor, and sweet taste), water-soluble compound content (15.63%), ethanol-soluble compound content (14.73%), and a flavonoid content of 76.669 mg EQ/100 mg. Conclusions: The ethanol extract of Dioscorea alata complies with the standard requirements established by the Food and Drug Supervisory Agency. It presents as a viscous extract with a distinct odor, purple-black color, and sweet taste. The extract contains alkaloids, flavonoids, saponins, tannins, steroids, and phenolic compounds, with a total flavonoid content of 76.669 mg. Furthermore, it tested positive for anthocyanins.
UPAYA EDUKASI PENCEGAHAN PENYAKIT DISLIPIDEMIA MELALUI INFORMASI BROSUR PADA LANSIA DI KELURAHAN PANAU, KOTA PALU Ismail, Ihwan; Khildah Khaerati; Muhammad Fahrul Hardani; Andi Athira Masyta; Ririn Hardani; Yuliet
JURNAL PENGABDIAN FARMASI DAN SAINS Vol. 3 No. 1 (2024): Oktober 2024
Publisher : Jurusan Farmasi FMIPA Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/jpsf.2024.v3.i1.17469

Abstract

Dyslipidemia is a medical condition caused by a lipid metabolism disorder in the body. In the early stages, dyslipidemia often shows no symptoms or complaints, so many sufferers are unaware of their condition. However, examinations of total cholesterol, low-density lipoprotein (LDL), and triglyceride levels often show elevated results in people with dyslipidemia. Public awareness of the dangers of dyslipidemia remains low, particularly among the elderly. To increase understanding and awareness of dyslipidemia, a community service activity was conducted in Pana Village. This activity began with cholesterol level checks. Following this, a presentation was given on the dangers of dyslipidemia, especially among the elderly, and the importance of maintaining a healthy lifestyle to prevent risks of heart disease, stroke, and even death. This counseling session focused on lifestyle changes that can help control cholesterol levels, such as regulating diet, exercising regularly, and avoiding unhealthy habits like smoking. Out of 95 participants who underwent cholesterol testing, the results showed that 46 elderly individuals (43%) had cholesterol levels below 200 mg/dl, which is still considered within normal limits. However, 54 elderly individuals (57.3%) had cholesterol levels above 200 mg/dl, indicating a high prevalence of dyslipidemia in this age group. These findings emphasize the importance of health education for the elderly, so they become more aware of the risks of dyslipidemia and are motivated to adopt a healthier lifestyle to prevent serious complications.
Gastroprotective Potential of Hantap Leaves (Sterculia coccinea Jack) Extract in Stress-Induced Gastric Ulcers of Male White Rats Yuliet, Yuliet -; Khaerati, Khildah; Lokong, Gladies Melinda
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 2 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.006398

Abstract

Stomach ulcer is a prevalent digestive problem that can lead to serious complications such as bleeding in the digestive tract, perforation, recurrence, cancer, and even death. One of its potential remedies lies in the antioxidant compounds contained in hantap leaves. Accordingly, this study aimed to investigate the anti-gastric ulcer effects of hantap leaf extract in white male rats induced by water immersion and cold-resistant stress methods. Hantap leaf extract (EEDH) was obtained by maceration using 96% ethanol, resulting in a yield of 7.8%. The results of gastric macroscopic observations based on percentage of ulcer inhibition showed that EEDH doses of 50, 100, and 200 mg/kg BW did not have a significant difference (p0.05) with ranitidine, exhibiting the same gastroprotective effects. An increase in the dose does not lead to a corresponding rise in the gastroprotective effect. Therefore, 50 mg/kg BW of EEDH was considered to be the optimum dose.
Aktivitas Ekstrak Etanol Kulit Batang Kayu Jawa (Lannea coromandelica) terhadap Penyembuhan Luka Sayat pada Tikus Putih (Rattus Norvegicus L.): Activity of Ethanolic Extract of Jawa Bark (Lannea coromandelica) on Healing Wound at White Rat (Rattus Norvegicus L.) Calsum, Umi; Khumaidi, Akhmad; Khaerati, Khildah
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 4 No. 2 (2018): (October 2018)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (138.494 KB) | DOI: 10.22487/j24428744.2018.v4.i2.11078

Abstract

Jawa bark (Lannea coromandelica) is a part of the plant that can be used empirically for handling wounds. This study aims to determine the activity of ethanol extract of Jawa bark on healing wound and determine the effective dose compared with povidone iodine. The test animals used were white rats (Rattus norvegicus L.) consisting of 5 groups, namely negative control (vaseline without extract), positive control (povidone iodine), dose of 250 mg/kg BW, dose of 500 mg/kg BW, dose of 750 mg/kg BW. Each rat made an incision in the area parallel to the spine with 2 cm long and 2 mm deep. Measuring the length of the wound was done every day for 14 days. The data obtained were analyzed statistically using One Way Anova and followed by Post Hoc Duncan test. Statistical results showed that the ethanol extract of Jawa bark has an activity in curing slice where the effective dose is a dose of 500 mg/kg BW with a wound healing time of 12 days.
Aktivitas Antidiabetes Ekstrak Air-Etanol, n-Heksan, dan Etil Asetat Uwi Banggai (Dioscorea alata L.) Dengan Metode Induksi Aloksan Pada Mencit Jantan (Mus musculus): Antidiabetic Activity of Water-Ethanol, N-Hexane, and Ethyl Acetate Extracts of Dioscorea Alata L. Using Alloxan Induction Method on White Rats (Mus musculus) Khaerati, Khildah; Amini, Delina; Ihwan
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 6 No. 2 (2020): (October 2020)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2020.v6.i2.15154

Abstract

Hyperglycemia is a condition of increased blood glucose levels caused by insufficient insulin enzymes produced to control blood sugar levels in the body. This study aimed to determine the activity of ethanol-water, nhexane, and ethyl acetate extracts of Dioscorea alata L. in reducing blood glucose levels in hyperglycemia modeled mice that were given intraperitoneal alloxan induction. 25 white rats were divided into 5 groups of test animals. Each group consists of 5 mice. The first group was given 0.5% sodium carboxymethylcellulose solution as a placebo, the second group was given 0.65 mg/kg BW glibenclamide as a positive comparison group, the third group was given the suspension of ethanol-water extract, the fourth group was given n-hexane extract, and the fifth group was given ethyl acetate extract at a dose of 140 mg/kg BW. The test preparation was orally given within 14 days of testing. The test was measured as the initial blood glucose levels of mice after alloxan induction and after giving the test preparation suspension. The results of the qualitative analysis illustrate that the water-ethanol extract can reduce blood glucose levels by 31.39%, n-hexane extract by 51.11%, and ethyl acetate extract by 50.77%. The results of quantitative analysis using One Way ANOVA method showed that the water-ethanol, n-hexane, and ethyl acetate extracts significantly decreased the blood glucose levels of mice. The best antidiabetic activity was ethyl acetate extract with a decrease in rat blood glucose levels by 169 mg/kg BW.
Edukasi Pengelolaan Obat Tidak Terpakai dan Pemahaman Batas Kedaluwarsa Yuliet, Yuliet; Khaerati, Khildah; Ihwan, Ihwan; Hardani, Ririen; Hardani, Muhammad Fakhrul; Patala, Recky; Masyita, Andi Atirah
Jurnal Medika: Medika Vol. 4 No. 4 (2025)
Publisher : LPPM Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/rk5wmh65

Abstract

Obat yang disimpan atau dibuang secara tidak tepat di rumah tangga berpotensi menurunkan efektivitas terapi, menimbulkan risiko kesehatan dan mencemari lingkungan. Rendahnya pemahaman masyarakat mengenai beyond use date (BUD) dan tata kelola limbah obat memerlukan intervensi edukatif. Kegiatan Pengabdian masyarakat ini bertujuan meningkatkan pengetahuan dan sikap masyarakat rumah tangga terkait pengelolaan obat tidak terpakai dan BUD serta melakukan deteksi dini kadar gula darah sebagai upaya promotif dan preventif di tingkat keluarga. Sasaran kegiatan adalah anggota Dasawisma Sinar Mawar Roviga, Kelurahan Tondo, Palu, yang mayoritas merupakan ibu rumah tangga. Metode pelaksanaan menggunakan pendekatan Participatory Action Research (PAR) melalui edukasi dengan pembagian booklet, diskusi interaktif, dan demonstrasi pemusnahan obat yang aman, dilanjutkan dengan skrining kadar gula darah menggunakan glukometer.  Evaluasi melalui kuisioner pasca edukasi menunjukkan peningkatan pengetahuan, dengan 90% peserta menjawab benar terkait BUD dan pengelolaan limbah obat, serta rata-rata skor sikap positif 8.7 (skala 1-10). Skrining kesehatan menemukan 85,2% peserta kadar gula darah normal, 7,4% prediabetes dan 7,4% diabetes. Intervensi edukatif terintegrasi skrining ini efektif membangun literasi kesehatan, mendorong perilaku penggunaan obat yang aman, dan mengidentifikasi risiko penyakit tidak menular
Edukasi dan Skrining Anemia Melalui Program Wish and Care di Desa Tosale Susanto, Yuliet; Khaerati, Khildah; Widodo, Agustinus; Jamaluddin, Jamaluddin
Poltekita: Jurnal Pengabdian Masyarakat Vol. 6 No. 1 (2025)
Publisher : Pusat Penelitian & Pengabdian Masyarakat Poltekkes Kemenkes Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33860/pjpm.v6i1.2461

Abstract

Anemia is a global problem, especially for adolescent girls and pregnant women. The high prevalence of anemia among adolescents increases susceptibility to disease in adulthood. Likewise, in pregnant women, anemia has the potential to cause complications in pregnancy and childbirth as well as maternal and child mortality. Increasing the knowledge of adolescent girls and pregnant women in efforts to recognize signs and symptoms of anemia, prevent and overcome anemia and motivation to undergo examinations related to anemia needs to be done. Therefore, community service activities are carried out to participate in educational efforts through the wish and care program in order to increase awareness and understanding of adolescent girls and pregnant women around the PKM area, namely Tosale village. The wish and care program is provided in the form of education, counseling, and practice, namely physical examination and Hb levels in 42 community service participants. Evaluation is carried out through pre-test and post-test. The results of the education showed an increase in knowledge in the good category of 71.43% and the sufficient category of 11.90%. The results obtained indicate that the wish and care method can increase public knowledge and awareness of early detection of anemia.
Acute and Lethal Dose Toxicity Test of Pure Eel Fish (Anguilla marmorata [Q.] Gaimard) Oil in Mice (Mus musculus) Jamaluddin, Jamaluddin; Ihwan, Ihwan; Khaerati, Khildah; Hasanuddin, Asriani; Serdiati, Novalina; Nilawati, Jusri; Wijaya, Berniawan; Yuliet, Yuliet; Ahmad, Iftitah
Journal of Public Health and Pharmacy Vol. 5 No. 3: NOVEMBER 2025
Publisher : Pusat Pengembangan Teknologi Informasi dan Jurnal Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/jphp.v5i3.5987

Abstract

Introduction: Eel fish oil (Anguilla marmorata (Q.) Gaimard) highlighted its nutritional advantages, especially vitamin A, EPA (eicosapentaenoic acid), DHA (docosahexaenoic acid), and omega-3. Unsaturated fats in fish oil are known to have positive effects in the treatment of various diseases, although the potential negative impacts also need to be considered. Methods: This research aims to focus on the cytotoxic activity of eel fish oil and carry out extraction using the soxhlation method, Thomson and Weil, and Metode fixed dose. To evaluate the toxicity of the extract, the acute toxicity test was carried out by measuring the middle lethal dose (LD50), which is often used as a benchmark. Apart from that, the research also aims to determine the lethal dose 50 (LD??) value of eel fish oil, namely the dose that can cause the death of 50% of the test animal population. The extraction process uses diethyl ether solvent at 60°C, followed by purification using a 3% bentonite adsorbent. The test was carried out twice with female mice and rats as test animals, divided into groups with oral doses of 5, 50, 300, 2000, and 5000 mg/kg. Result: The results showed no deaths in the test animals, and the LD50 of eel fish oil extract was greater than the dose used. Clinical symptoms in mice include decreased motor activity and increased grooming frequency as the dose increases, as well as increased muscle tone and tension responses. Conclusion: Based on the research results, it can be concluded that eel fish oil extracts up to a dose of 5000 mg/kg are still classified as "safe" for use because they do not cause death in test animals.
Peningkatan Kualitas Hidup Lansia Melalui Pencegahan dan Pengendalian Penyakit Degeneratif Yuliet; Khaerati, Khildah; Jamaluddin; Widodo, Agustinus
Jurnal Dimas Vol 4 No 2 (2022): Jurnal Pengabdian Kepada Masyarakat
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53359/dimas.v4i2.45

Abstract

Indonesia merupakan negara dengan struktur penduduk tua (aging population), dimana populasi lanjut usia (lansia) saat ini diproyeksikan sebesar 27,08 juta jiwa atau 9,99% dari total penduduk Indonesia. Dua permasalahan kesehatan diantara 6 masalah kesehatan terbanyak pada populasi lansia berdasarkan hasil Riskesdas 2018 yaitu 63,5% lansia menderita hipertensi dan 5,7% diabetes mellitus (DM). Pada era pandemi, kelompok lansia merupakan kelompok yang paling berisiko mengalami keparahan/morbiditas dan mortalitas akibat penyakit Covid-19. Hal ini dikarenakan pasien lansia umumnya memiliki berbagai komorbiditas, seperti penyakit DM dan hipertensi. Untuk itu pencegahan melalui upaya promotif dan preventif kepada kelompok lansia sangat penting dilakukan. Oleh karena itu para dosen Prodi S1 Farmasi FMIPA Universitas Tadulako beserta sejumlah mahasiswa Farmasi terpanggil untuk ikut berpartisipasi dalam upaya edukasi dalam rangka peningkatan kesadaran dan pemahaman masyarakat usia lansia terutama di sekitar daerah PKM tentang pencegahan dan penanganan hipertensi dan DM untuk meningkatkan kualitas hidup pada usia lanjut/lansia. Edukasi diberikan dalam bentuk penyuluhan; pemeriksaan kondisi fisik: pengukuran berat badan, tekanan darah, dan pemeriksaan kadar gula darah; serta pembagian booklet. Pelaksanaan pengabdian yang telah dilakukan mendapatkan respon yang baik dari warga yang mengikuti karena sebagian besar banyak yang aktif dalam bertanya pada saat konseling diberikan. Berdasarkan hasil pengabdian kepada masyarakat yang dilakukan diperoleh peningkatan pengetahuan terhadap materi tersebut, dan diharapkan peserta dapat menerapkannya dalam kehidupan sehari-hari.
EDUKASI TERAPI KOMPLEMENTER DIABETES DAN HIPERTENSI PADA MASYARAKAT DESA TOSALE KABUPATEN DONGGALA Ismail, Ihwan; Yuliet; Fahrul Hardani, Muhammad; Khaerati, Khildah
JURNAL PENGABDIAN FARMASI DAN SAINS Vol. 1 No. 1 (2022): Oktober 2022
Publisher : Jurusan Farmasi FMIPA Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/jpsf.2022.v1.i1.16110

Abstract

Diabetes melitus dan hipertensi merupakan dua penyakit degeneratif yang mayoritas masyarakat derita diera modern ini. Diabetes melitus merupakan penyakit yang ditandai peningkatan kadar glukosa darah disebabkan retensi insulin, selain bekerja merubah glukosa menjadi glikogen, retensi insulin juga dapat mengakibatkan peningkatan retensi natrium di ginjal dan mengakibatkan aktivitas sistem syaraf simpatik. Retensi natrium dan meningkatnya aktivitas sistem syaraf simpatik merupakan dua hal yang berpengaruh terhadap meningkatnya tekanan darah atau sebut hipertensi. Pengabdian ini bertujuan untuk meningkatkan pengetahuan dan pemahaman masyarakat tentang Diabetes melitus dan hipertensi dan cara penanganannya dengen terapi komplementer berbasis bahan obat tradsional yang ada disekitar masyarakat sehingga dapat meningkatkan kualitas hidup. Metode pelaksanaan pengabdian pada masyarakat ini menggunakan pendekatan pemeriksaan kesehatan meliputi penimbagan berat badan, tekanan darah dengan tensimeter elektrik, kadar gula darah dengan glokotest dan dilanjutkan dengan penyuluhan dengan memberikan edukasi berupa liaflet dan brosur serta booklet terkait terapi komplemeter berbasis bahan alam pada Diabetes melitus dan hipertensi kepada masyarakat Desa Tosale Kecamatan Banawa Selatan Kabupaten Donggala. Hasil pemeriksaan dari 50 warga Desa Tosale diperoleh 2 % (1 warga) memiliki kadar gula darah diatas 200 mg/dl yang dikategorikan dalam diabetes dan 98% (49 warga) memiliki kadar gula darah normal sedangkan pemeriksaan tenanan darah diperoleh 46% warga dengan tekanan dara normal, 28% kategori prehipertensi, 16% hipertensi stage 1 dan 10 % warga mengalami hipertensi stage 2. Kesimpulan pengabdian ini adala terdapat Meningkatnya pengetahuan dan pemahaman masyarakat tentang diabetes melitus dan hipertensi dan cara penanganannya dengen terapi komplementer bahan obat tradsional yang ada disekitar masyarakat sehingga dapat meningkatkan kualitas hidup dan Peningkatan perilaku sehat dengan penggunaan obat berbasis bahan alam
Co-Authors A.A. Ketut Agung Cahyawan W Agustinus Widodo Ahmad, Iftitah Akhmad Khumaidi Ali Djamhuri Amelia Rumi Amini, Delina Andi Alfianto Andi Athira Masyta Andi Fadya Andi Mustika Andi Ratihsekarningrum Siradje Apriyana Soputra Armini Syamsidi Asriani Hasanuddin Atirah Atirah Calsum, Umi Cornelia Ayu Putri Corry Stephanie Sulastra Dwinthasari Meilinda Azhari Fahrul Hardani, Muhammad Fina Ulviani Finta Amalinda Fitri Anggun Solehah Hardani, Muhammad Fakhrul Heni Pujiastuti Ihwam Ihwan Ihwan Ihwan Ihwan Inggrid Yuliana Ismail, Ihwan Jamaluddin Jamaluddin Jamaluddin Janes Krisly Joni Tandi Jusri Nilawati Khairiah Kartini Khusnul Diana Klerensia Defneir Titing Lokong, Gladies Melinda Masyita, Andi Atirah Mia Audina Moh. Rifki Muhammad Anggriawan Muhammad Fahrul Hardani Musdalifah S Maya Ni Wayan Swintari Novalina Serdiati Novianti Batti Novita Christiana Ponganan Nur Hikmah Nur Ramadhani Nurlaila Ramadhani Nurwijayanti Primadia, Rizki Putri, Ayu Dinawati Rahmatia Rahmatia Ramadhani, Nurlaila Recky Patala Rini Saputri Ririen Hardani Ririen Ririen Ririn Hardani Rivani Rivani Rivani, Rivani Siti Anisa Sugeng, Santoso Sulastra, Corry Stephanie Triana Riandani Djamhuri Wijaya, Berniawan Yonelian Yuyun Yuliet Yuliet Yusriadi Yusriadi