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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Folia Medica Indonesiana Jurnal Biosains Pascasarjana Jurnal Antropologi: Isu-Isu Sosial budaya Indonesian Journal of Tropical and Infectious Disease Jurnal Media Gizi Indonesia (MGI) Jurnal Promkes: The Indonesian Journal of Health Promotion and Health Education Kapata Arkeologi Dental Journal (Majalah Kedokteran Gigi) Masyarakat, Kebudayaan dan Politik Berkala Arkeologi SANGKHAKALA JURNAL WALENNAE Berkala Arkeologi Naditira Widya Jurnal SOLMA Jurnal Analisa Sosiologi JOURNAL OF SCIENCE AND SOCIAL RESEARCH Jurnal Penelitian Arkeologi Papua dan Papua Barat Jurnal Ilmu Kepolisian Aspirasi : Jurnal Masalah-masalah Sosial Biokultur Jejaring Administrasi Publik (JAP) Journal of Governance and Administrative Reform Jurnal Medika Nusantara Berkala Arkeologi al-Balagh : Jurnal Dakwah dan Komunikasi Journal of Law and Legal Reform Naditira Widya Jurnal Info Kesehatan indonesian Journal of Administrative Law and Local Government (IJALGOV)
Toetik Koesbardiati
Departemen Antropologi, FISIP, Universitas Airlangga, Surabaya.
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Variation of TTC Repeat Pattern In The Dna of Mycobacterium Leprae Isolates Obtained from Archeological Bones and Leprosy Patients From East Nusa Tenggara Adriaty, Dinar; Wahyuni, Ratna; Iswahyudi, Iswahyudi; Aksono, Bimo; Koesbardiati, Toetik; Agusni, Indropo; Izumi, Shinzo
Journal of Tropical Life Science Vol 2, No 3 (2012)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.2.3.%x

Abstract

The existence of leprosy or kusta or Morbus Hansen or Hansens disease has been known for years, including in Indonesia. Starting from the discovery of Mycobacterium leprae isolates from ancient bone (about 1.000 years B.C), the archaeological excavations results in East Nusa Tenggara, interesting questions arise about how the development of leprosy in eastern Indonesia is. Biology molecular study would become a powerful tool to investigate the presence of leprosy bacillary whether there are similarities between the genomes of M. leprae isolates in the primeval and the present. PCR examinations were performed on mandibular bone fragments from ancient human who lived 1000 years B.C. discovered in archaeological surveys on the island of Lembata and three leprosy patients from East Nusa Tenggara. The DNA extraction was performed using a kit from Qiagen products and its TTC repeating pattern was seen with the method of direct sequencing. It turned out that the TTC profile obtained from samples of archaeological was as many as 13 copies, while the repetition of TTC in three samples of leprosy patients were 15, 17 and 26 copies. The different number of TTC repetition shows the different isolates of M. leprae between in the ancient times and the present. Further studies are needed to verify the differences in the genome that occur, for example from the study of SNPs (single nucleotide polymorphisms).
Variation of TTC Repeat Pattern In The Dna of Mycobacterium Leprae Isolates Obtained from Archeological Bones and Leprosy Patients From East Nusa Tenggara Dinar Adriaty; Ratna Wahyuni; Iswahyudi Iswahyudi; Bimo Aksono; Toetik Koesbardiati; Indropo Agusni; Shinzo Izumi
Journal of Tropical Life Science Vol. 2 No. 3 (2012)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.2.3.%x

Abstract

The existence of leprosy or kusta or Morbus Hansen or Hansens disease has been known for years, including in Indonesia. Starting from the discovery of Mycobacterium leprae isolates from ancient bone (about 1.000 years B.C), the archaeological excavations results in East Nusa Tenggara, interesting questions arise about how the development of leprosy in eastern Indonesia is. Biology molecular study would become a powerful tool to investigate the presence of leprosy bacillary whether there are similarities between the genomes of M. leprae isolates in the primeval and the present. PCR examinations were performed on mandibular bone fragments from ancient human who lived 1000 years B.C. discovered in archaeological surveys on the island of Lembata and three leprosy patients from East Nusa Tenggara. The DNA extraction was performed using a kit from Qiagen products and its TTC repeating pattern was seen with the method of direct sequencing. It turned out that the TTC profile obtained from samples of archaeological was as many as 13 copies, while the repetition of TTC in three samples of leprosy patients were 15, 17 and 26 copies. The different number of TTC repetition shows the different isolates of M. leprae between in the ancient times and the present. Further studies are needed to verify the differences in the genome that occur, for example from the study of SNPs (single nucleotide polymorphisms).
Co-Authors Achmad Yudianto Ahmad Faiz Muhammad Noer Ahmad Yudianto Ali Akbar Maulana Anak Agung Putu Santiasa Putra Azizatul Haq Larasati Bagaskara Adhinugroho Bayoghanta Maulana Mahardika Bayu Praharsena Biandro Wisnuyana Bimo Aksono Bimo Aksono Christrijogo Soemartono Waloejo Daud, Normadiah Delita Bayu Murti Delta Bayu Murti Delta Bayu Murti Desytri Ayu Herina DINAR ADRIATY Eko Herwanto Eko Herwanto Etty Indriati Etty Indriati Evi Susanti Ferry Adhi Dharma Firdaus Dimitra Arsyrahman Gregorius Dwi Kuswanta Gregorius Dwi Kuswanta Gunadi Kasnowihardjo Gunadi Kasnowihardjo Hendrawati, Lucy Dyah Ika Zulkafika Mahmudah Indah Asikin Nurani Indah Asikin Nurani, Indah Asikin INDROPO AGUSNI Irfan Wahyudi Irfan Wahyudi Iswahyudi Iswahyudi ISWAHYUDI ISWAHYUDI Liestianingsih Dwi Dayanti Mareta Bakale Bakoil Mas'udah, Siti Mas'udah, Siti Monika Teguh Mudaim, Syarifah Muhammad Ranau Alejandro Muhammad Wishnu Wibisono Muhammad Wishnu Wibisono Myrtati Dyah Artaria nfn Suhendra Nia Marniati Etie Fajari Nia Marniati Etie Fajari Nuraini Fauziah Oetomo, Dede Olivia Pristiany, Liza Pudjio Santoso Purnama, Anton Roy Qurnia Andayani Rachmah Ida Ramadhiansyah, Dimas Ratih Puspa RATNA WAHYUNI Ratna Wahyuni Rizky Nur Andrian Rizky Sugianto Putri Romadhona, Mochamad Kevin Rusyad Adi Suriyanto Rusyad Adi Suryanto Santoso, Pudjio Sa’diyah, Kamila Sa’diyah, Kamilah Septi Ariadi Setiawati, Rosy Shinzo Izumi SHINZO IZUMI Shrimarti Rukmini Devy Singgih, Doddy S. Sri Endah Kinasih Stefanus Supriyanto Suhanti, Indah Sutinah Sutinah Sutinah Syafarani, Yavrina Tiara Mayang Pratiwi Lio Tiara Mayang Pratiwi Lio Tri Joko Sri Haryono Ulce Oktrivia Ulce Oktrivia W., Christrijogo Sumartono Wibowo, Nimas Wirawan, Hendra Yunita Furinawati, Yunita Yusuf Bilal Abdillah