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Journal : Techno

PRODUCTION OF LOW METHOXYL PECTIN AS AN ANTI CANCER AGENT FROM CITRUS PEEL PECTIN THROUGH ENZYME DEMETHYLATION BY PAPAYA PECTINESTERASE Indah Hartati; Indah Riwayati; Laeli Kurniasari
Techno (Jurnal Fakultas Teknik, Universitas Muhammadiyah Purwokerto) Vol 12, No 1 (2011): Techno Volume 12 No 1 April 2011
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (221.436 KB) | DOI: 10.30595/techno.v12i1.29

Abstract

Low methoxyl pectin (LMP) is reported posses anti cancer activity. LMP administering could reduce the risk of cancer, halt the progression of cancer, and in a certain percentage of cases caused the cancer cells to start to die. If this can be developed further, LMP administration could be a good co-treatment for chemotherapy or radiation. This would be a positive advancement, due to the high toxicity to the body of both chemotherapy and radiation. LMP can be produced by demethylation of high methoxyl pectin. One of our local resources that is potential for its pectin content is citrus peel. Pectin demethylation can be conducted by acid, alkali, ammonia in alcohol or enzymatic method. LMP produced by enzyme demethylation have been found to be inferior in quality to those produced by other methods. The enzyme took part in the pectin demethylation is pectinesterase. Pectinesterase can be be isolated from various source such as fruit and vegetables. One of our local resources that is potential as source of pectinesterase is papaya. Considering facts above thus it has a great possiblity to produce LMP from citrus peel pectin through enzymatic demethylation by utilize pectinesterase of papaya. Key-word : Low methoxyl pectin pectin (LMP), anti cancer, citrus peel pectin, papaya, pectinesterase
Co-Authors ., Salsabila Ahadta Anindya Rahmah Ajeng Ajeng Ajeng Wijareni Alin, Tanzil Aliyatul Farida Amaranti, Ratna Bernika Andri Cahyo Kumoro Aniq, Nur Aprianto Aprianto Aprilina Purbasari Aqnes Budiarti Ardianto, Sandi Dimas Arif Andrianto Asmanto Asmanto Cahyana, Iga Cahyanto, Yodhi Chandra Pribadi Darmanto Darmanto Darmanto Darmanto Darmanto Darmanto Dien Iffa Hidayatin Dyah Puspa Arum Erma Sulistyaningsih Ernawati Budi Astuti F Widhi Mahatmanti Faizin, Safaah Nur Faria, Rani Aish Farikha Maharani Fatnawati Nur Hidayah Fifi Kurniasari H. Purwanto Hasan, Hasan Hayani, Alfitra I Hartati I. Hartati I. Hartati I. Hartati I. Hartati I. Hartati I. Hartati I. Riwayati Imam Sujarwo Imam Syafaat Indah Hartati Indah Nurdiani Indarwati, Dewi Irma Sulistyo Ismiyatul Kholisoh Ismiyatun Ismiyatun Jati, Isnanto Prasetyo Khornia Dwi Lestari Lailatul Firdaus Kun Ma'adella Nafisawati Laksono, F. W. Lukman Eka Prasaja Luqman Buchori M. Djaeni M. E. Yulianto M. E. Yulianto Maulana, Yafi S. Mauluddin, M. Subchan Mey Sulistiyaningsih Mia Dinnis A Moh Djaeni Muhamad Farid Aminudin Muhammad Dzulfikar Muhammad Farid Aminudin Muhammad Ivan Nurohman Nanik Andar Miningsih Nayyifatus Sa’diyah Ninik Indah Hartati Ninik Indah Hartati Nugroho Widiasmadi Nugroho, Agung Nugroho, Ardi Tio Ageng Nurhayani, Mira Nurrijal, Kolul Nurul Fatkhiyah Prasetyo Jati, Isnanto Prianto, Riska Putri Prihastuti Renan Subantoro Revy Andar Raesta Rita Dwi Ratnani Rita Dwi Ratnani Rohmawati, Alfi Rudi Firyanto Safaah Nurfaizin Saiful Huda Saiful Huda Sari, N. L. S. Setia Budi Sasongko Setia Budi Sasongko Setiyanto Setiyanto Sinta Ariyani Siti Indana Isdiyanti Siti Indana Isdiyanti Siti Iqlima Layudha Siti Sudarmiseh Sri Mulyo Bondan Respati Sumayah Sumayah Suwardiyono Suwardiyono Suwardiyono Suwardiyono Tabah Priangkoso Titin Titin Tristiyanti, Alvia Sefie Tsaniyatul Fitriyah Via Utami Putri Vivi Nurin Shofiyana Wulan Budi Astuti Yance Anas Yuni Susanti, Devi Yuni Wulandari