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Journal : Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan

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UJI EFEKTIVITAS EKSTRAK ETANOL DAUN EKOR NAGA (Rhaphidophora pinnata (L.f) Schott) SEBAGAI ANTIHIPERGLIKEMIA TERHADAP MENCIT PUTIH JANTAN YANG DIINDUKSI SUKROSA Lestari, Dian; Lestari, Intan; Sani K, Fathnur
Jurnal Ilmiah Manuntung Vol 7 No 1 (2021): Jurnal Ilmiah Manuntung
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v7i1.433

Abstract

Hyperglycemia is a condition where blood glucose levels increase above normal. Hyperglycemia is a manifestation of diabetes mellitus (DM). Chronic hyperglycemia in diabetes mellitus has an important role in the damage to various organism, including the heart, gynecological eye, nervous and vascular system, which in turn causes complications of diabetes mellitus. Dragon tail leaf extract (Rhaphidophora pinnata (L.f) Schott) contains several compounds that function to reduce glucose in the blood including flavonoids, alkaloids, saponins, steroids and tanins which can inhibit the action of the enzyme α- glucosidase. The purpose of this study was to determine the effect of giving ethanol extract of dragon tail leaves in blood glucose levels and determine the best dose of ethanol extract of dragon tail leaves in reducing blood glucose levels. The samples used were ethanol extract of dragon tail leaves, acarbose as positive control. The study design used was a completely randomized design (CRD) with 5 treatments in which each treatment consisted of 7 mice. The treatment groups are K + acarbose solution at a dose of 50 mg / kgBB, P1 extract dose 125 mg / kgBB, P2 extract dose 250 mg / kgBB, and P3 extract dose 375 mg / kgBB. The testing method used is the Oral Glucose Tolerance Test (OGTT), which is a standard method in the testing antihiperglycemic effect. Observations were carried out for 120 minutes in the time span of 10; 30; 60; 100 and 120 minutes. The research data were analyzed descriptively and One Way ANOVA test. Based on the analysis of the One Way ANOVA test it was found that there were significant differences for each study treatment (p <0.05). Based on Duncan's further tests it was found that the results of the dragon tail leaf extract had antihiperglycemic effect. The best dose of ethanol extract of dragon tail leaves in percent reduction is dose III 375 mg / KgBB with a percent decrease (38,79%). Then followed by dose II 250 mg/KgBB with a percent decrease (17,01%) anf dose I 125 mg/KgBB with percent decrease (5,325%). So it can be concluded that the ethanol extract of dragon tail leaves has effectiveness as an antihiperglycemia.
Co-Authors -, Rahmi - Abdillah Abdillah Ade Adriadi Adinda, Ladiva Agrina Lisma Agrina, Agrina Agustina, Elsi Alben Ambarita Alfernando, Oki Alkatiri, Jufri Amin, Sahrul Anna Rakhmawati Ariana, Febi Arif, M. Ridwan Asep Rohman Asti Rahayu, Martina Azira, Ayu Azril Damris Muhammad Denny Prabawa, Aditya Desy Kurniawati Dhian Eka Wijaya Diah Riski Gusti DIAN LESTARI Edwin Permana Eko Prasetyo Elisma Elisma Erda, Erda Faizar Farid Febriana - Sabrian Fina Audilla, Yessiska Grasella, Lucintania Gunawan, Anjelli Putri Gusti, Diah Rizki Hery Widijanto Hidayat, Dara Shalsa Billah Hidayat, Vikri Idat Muqodas Indra Lasmana Tarigan Indra Lesmana Indriyani Indriyani Iqbal, Anwar Jalius Jalius Kartiko, Frananda Rizki Kastera, Viven Khatoha, Trisqa Laila Lasmana Tarigan, Indra Lenny Marlinda Mahraja, Mahra Manulang, Ermita Meisa Mastutik, Diah Maulana, Rico Gewana Resdy Maya Lestari, Maya Mia Aina Muhaimin, . Muhammad Damris Munifilia Ekasari Naswir, Muhammad Natadiwijaya, Ismail Fikri Natalia, Desfaur Nelson, Nelson Nilasari, Aprillia Niswah, Coirun Nuralam, Deni Nurjamil, Dimas Setya Nurkholik , Dedeng Nurul, Ramdan Ocktavia, Tyzeka Dwi Oktarise Dwina, Dila Pernadi, Niza Lian Pradina, Armitha Dea Prasetio, Muhamad Reza Prasetyo, Widy Puji Rahayu Putra, Adrisma Juanda Qisthi, Zummul Rahayu, Martina Asti Rahmi Rahmi Rajagukguk, Yuli Evrianti Br Riski, Diah Gusti Rizalzi, Dewa Rustikah, Ika Sani K, Fathnur Sari, Avellyn Shintya Satria, Rinaldi Siti Rachmah Sofiani solihah, Nabilatus Sukor, Mohd Zaki Susanto, Nindita Clourisa A Sutrisno, Sutrisno Syahid, Alwi Syauqi, Rif’at Tarmizi, Fadhilah tekmauk, Jitro valerius Tita Rohita Uce Lestari Wahyudi, Abdi Walidatur Rofiah, Yuliana Wardhana, Alexander Tantra Wawan Setiawan Wibowo, Yudha Gusti Yohana, Agnes Vionita Zahar, Wahyudi