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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Dentino: Jurnal Kedokteran Gigi Berkala Kedokteran Acta Biochimica Indonesiana Homeostasis: Jurnal Mahasiswa Pendidikan Dokter Jurnal Abdimas Mahakam
Dona Marisa, Dona
Departemen Biomedik Divisi Fisiologi Fakultas Kedokteran Universitas Lambung Mangkurat, Banjarmasin
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Other

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PHYTOCHEMICAL PROFILING AND ANTIBACTERIAL ACTIVITY OF SUNGKAI (PERONEMA CANESCENS) LEAF EXTRACT AGAINST STAPHYLOCOCCUS AUREUS Muthmainah, Noor; Suhartono, Eko; Perdana Putera, Gusti Muhammad; Marisa, Dona; Mashuri, Mashuri; Hayatie, Lisda; Iskandar, Iskandar; Pradito, Syaifullah Akbar
Dentino: Jurnal Kedokteran Gigi Vol 11, No 1 (2026)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v11i1.26090

Abstract

Background: Staphylococcus aureus is an opportunistic Gram-positive bacterium that can colonize the oral cavity and cause various infections such as oral abscesses, stomatitis, and post-dental procedure infections. The increasing problem of antibiotic resistance has encouraged the exploration of medicinal plants as alternative antibacterial agents. Sungkai (Peronema canescens) leaves are traditionally used by the Dayak Meratus community as herbal medicine and are known to contain bioactive compounds with potential antibacterial activity. Purpose: This study aimed to analyse the phytochemical content and antibacterial activity of sungkai leaf extract against Staphylococcus aureus. Methods: This research used a true experimental design with a post-test-only control group design. Methanol extract of sungkai leaves was prepared using the maceration method. Phytochemical analysis included determination of flavonoid, alkaloid, and steroid contents using spectrophotometric and gravimetric methods. Antibacterial activity was tested using the disc diffusion method on Mueller Hinton Agar against S. aureus at concentrations of 25%, 50%, 75%, and 100%. Clindamycin was used as a positive control and sterile distilled water as a negative control. Results: Phytochemical analysis showed that sungkai leaf extract contained flavonoids (85.47 mg/mL QE), steroids (26.797%), and alkaloids (18.436%). The antibacterial test showed inhibition zones that increased with extract concentration, namely 10.19 ± 0.23 mm (25%), 12.89 ± 0.43 mm (50%), 14.80 ± 0.41 mm (75%), and 17.72 ± 0.57 mm (100%). Conclusion Sungkai leaf extract contains several bioactive compounds and demonstrates antibacterial activity against Staphylococcus aureus, indicating its potential as a natural antibacterial agent.Keywords: Antibacterial Activity, Phytochemical Analysis, Staphylococcus aureus, Sungkai Leaf Extract.
Co-Authors Abdian Purnapita Pambudi Achmad Rofii Ahmad Husairi Ahmad Husairi Ahmad Husairi Ajeng Dwi Novitasari Alfi Yasmina Anggia Ayunanda Arrafieka Annisa Susilo Anwari Delmi Ariewardana, Angger Asnawati Asnawati Asnawati Asnawati Asnawati Asnawati Athiya Nadifa Azzahra, Wikha Bagus Maulana Akbar Cibro, Impana Dewi Indah Noviana Pratiwi, Dewi Indah Noviana Diah Mutia Rahmawati Didik Dwi Sanyoto Diva Aurellia Rosa Dohamid, Firdinia Gafuri Dwi Laksono Adiputro Dwi Laksono Adiputro Dwi Laksono Adiputro Dwi Laksono Adiputro Edi Hartoyo Edyson Edyson Effiyana, Arika Eka Dewi Yanti Eko Suhartono Fakhrurrazy Fakhrurrazy Farisa Shauma Fachir Farisa Shauma Fachir, Farisa Shauma Farizka Erianti Farizka Erianti, Farizka Fauzan Muttaqien Fauzan Muttaqien Fauzan Muttaqien Febryan, Marcellino Finna Rahmiati Firdaus, Muhammad Reyhan Firdinia Gafuri Dohamid Firman Raudana Gusti Muhamma Edy Muttaqin Gusti Muhamma Edy Muttaqin, Gusti Muhamma Edy Handono Kalim Haryati Haryati Hasna, Usratul Hayati, Azka Huldani Huldani Irham Taufiqurrahman Iskandar Iskandar Islami, Shafira Aulia Istiana Istiana Ivana Ellenora Ellenora June Astri Nijka Khan, Muhammad Fawwaz Kusworini Handono Lisda Hayatie, Lisda M Naufal Firdaus M. Iqbal Hisyam Qiroth Mashuri Mashuri Mohammad Bakhriansyah Mohammad Bakhriansyah Mohammad Rudiansyah Muhammad Farid Adlirrahman Muhammad Hasan Ridhoni Muhammad Marwan Muhammad Muzain Azhar Muhammad Welly Dafif Muhammad Welly Dafif Munirah, Nida Muthaminah, Noor Muthmainah, Noor Nanang Miftah Fajari Nasywa Maharani Yudiantara Noer Komari Noor Muthaminah Nur Qamariah Oski Illiandri Oski Illiandri Pagan Pambudi Panghiyangani, Roselina Perdana Putera, Gusti Muhammad Pradito, Syaifullah Akbar Prenggono, Muhamad Darwin Putri Nur Aini Rafida Ikhsania Camalis Ramadan, Yoga Aditya Noor Rizki Amalia Sari Rizky Frida Monica Santrino, Syifa Nurafifah Sanyoto, Didik Dwi Septiyan Dimas Putra Akbar Sherly Limantara Sherly Limantara Siddik, Muhammad Siti Juliati Siti Kaidah Theresa Tyra Sertani Vini Yulia Anhar Vivin Nurul Islami Widi Aurelia Mirmaningtyas Wiwit Agung Sri Nur Cahyawati Yusril Gunawan Zairin Noor Zulfikar, Muhammad Rakha