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All Journal journal of internal medicine Indonesian Journal of Tropical and Infectious Disease The Indonesian Biomedical Journal Syntax Literate: Jurnal Ilmiah Indonesia Biomolecular and Health Science Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Majalah Biomorfologi (Biomorphology Journal) JOURNAL OF COMMUNITY MEDICINE AND PUBLIC HEALTH RESEARCH CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Indian Journal of Forensic Medicine & Toxicology Narra J Journal of Scientech Research and Development The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Health & Medical Sciences Folia Medica Indonesiana
Ummi Maimunah
Division Of Gastroentero-Hepatology, Departement Of Internal Medicine, Faculty Of Medicine, Universitas Airlangga/Dr. Soetomo General Hospital, Surabaya
Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Spleen Stiffness Measurement as a Predictor of Advanced Liver Fibrosis in Chronic Hepatitis B Patients Carisa Irene Hertanto; Ummi Maimunah; Aryati -; Muhammad Miftahussurur
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 3 (2025): VOLUME 26, NUMBER 3, December, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2632025237-244

Abstract

Background: Chronic hepatitis B is a viral infection that may progress to liver fibrosis. Progressive fibrosis increases portal pressure, leading to elevated spleen stiffness. Although inflammatory reactions and mechanical cholestasis affect liver stiffness, the effect is comparatively limited. Therefore, this study aims to analyze spleen stiffness as a noninvasive marker of liver fibrosis and evaluate the correlation between spleen and liver stiffness.Methods: A retrospective cross-sectional study was performed on chronic hepatitis B patients. Fibroscan was used to measure liver and spleen stiffness. Liver fibrosis was categorized as nonsignificant (F0–F1), significant (F2–F3), and advanced (F4). Correlations between spleen stiffness and liver fibrosis stages were assessed using Spearman’s test, with p 0.05 considered statistically significant. Results: The results showed that 127 patients were eligible for analysis, predominantly male (71.7%), with a mean age of 46.4 ± 9.8 years. The median spleen and liver stiffness were 25.5 kPa (range 5.6–100) and 9.4 kPa (range 2.4–75), respectively. Moreover, spleen stiffness had a positive correlation with liver stiffness (Spearman r = 0.503; p 0.001) and liver fibrosis stages (Spearman r = 0.479; p 0.001). The optimal cutoff for spleen stiffness in predicting advanced fibrosis was 28 kPa, with an area under the receiver operating characteristic curve(AUROC) of 0.816, sensitivity of 0.739, and specificity of 0.753.Conclusion: Spleen stiffness is significantly correlated with liver fibrosis severity. A cutoff of 28 kPa was identified for advanced fibrosis, suggesting spleen stiffness measurement serves as a promising alternative to biopsy.
Co-Authors , Sulistiawati Adaninggar PN Alphania Rahniayu Alshawsh, Mohammed A. Amie Vidyani Anang Endaryanto Anggoro, Adhitri Annisa Zahra Mufida Ariani, Grace Arin Nurtya Artaria Tjempakasari, Artaria Aryati Aryati - Aswin, R Haryanto atika Bernadetta Jonan Bramantono Bramantono, Bramantono Brimantyo, Dio Budi W Budi Widodo Budi Widodo Budi Yuwono Carisa Auralia Ramadhani Carisa Irene Hertanto Chatarina Umbul Wahyuni Denny Vianto Diah Rizki Rahma Dini Djuanda, Stephanie N. DYAH FAUZIAH, DYAH Edi Suyanto Eko Budi Koendhori, Eko Budi Endang Retnowati Erik Hasudungan Esti Rohani Fauziah Diayu Retnaningtyas Gatot Soegiarto Gilda Hartecia Gunawan, Vania A. Hadisuwarno, Wiharjo Hartecia, Gilda Hernomo Ontoseno Kusumobroto HERNOMO ONTOSENO KUSUMOBROTO Herry Purbayu I Made Subhawa Harsa Imelda Maria Loho, Imelda Maria Imro'ati, Tri Asih Inne Tria Ramafita Isna Mahmudah Iswan A Nusi Iswan A Nusi Iswan A Nusi Iswan Abbas Nusi Izzatul Fithriyah Jonan, Bernadetta Khairu Zein Kusumastuti, Etty H. KUSUMASTUTI, ETTY HARY Lefi, Achmad Lilihata, Jilientasia G. Maharani, Andi RK. Marhana, Isnin A. Maria Inge Lusida MOCHAMAD AMIN Muhammad Aafi Baharuddin Attamimi Muhammad Miftahussurur Muhammad Miftahussurur Munawaroh Fitriyah Nadya Wulandari Alshanti Namira Amelia Septiarini Natasya Ariesta Selyardi Putri Nenci Siagian Nila Kurniasari Nugraha, Ricardo A. Nugroho, Gilang MS. Nurtya, Arin Pangestu Adi PN, Adaninggar Poernomo B Setiawan Poernomo Boedi Setiawan Poernomo Budi Setiawan Priyo Budi Purwono Puspa Wardhani Puspa Wardhani Puspa Wardhani Puspitasari, Yessy Putra, Rheza Rahmadika Putri, Dyeneka Rustanti Indreswara Rahaju, Anny S. Retno Handajani Rinjani, Lalu GP. Rosyid, Alfian N. Rudyanto Rudyanto Ruslan, S. Eriaty N. Savita, Lady Semedi, Bambang P. Setiawan, Poernomo B Setiawati, Rosy Shahnaz Azzahra Soelistijo, Soebagijo Adi SOETJIPTO . Sulistiawati Suprapto Ma’at Supriadi Supriadi Tanaya, Willa M. Thamrin, Husin Titong Sugiharto Titong Sugihartono Tjahjadi, Angela Kimberly Tri Asih Imro'ati Ulfa Kholili Wahyu, Dwi Wessels, Firda I. Widodo, Budi Willy Sandhika Wirantara, Hendy Wiratama, Priangga A. Wiwin Retnowati Wungu, Citrawati Dyah Kencono Yandi, I KR. Yetti Hernaningsih Yoshio Yamaoka Yoshio Yamaoka, Yoshio Yudith Annisa Ayu Rezkitha, Yudith Annisa Ayu Yulia Nadar Indrasari Zein, Khairu