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All Journal ODONTO Dental Journal Majalah Obat Tradisional Dentino: Jurnal Kedokteran Gigi Berkala Kedokteran Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) JCPS (Journal of Current Pharmaceutical Sciences) Dentin Borneo Journal Of Pharmascientech Jurnal Insan Farmasi Indonesia Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Odonto dental journal Jurnal Pengabdian Masyarakat Panacea Jurnal Sains dan Kesehatan Jurnal Bioteknologi & Biosains Indonesia (JBBI) Jurnal Bioteknologi & Biosains Indonesia
Yusrinie Wasiaturrahmah
Universitas Lambung Mangkurat
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary

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Quantitative Phytochemical Analysis of Ethanol Extract Kelulut Bee Propolis (Trigona laeviceps) Yusrinie Wasiaturrahmah; Maharani Laylliza Apriasari; Cita Nursyaina Tasya
Berkala Kedokteran Vol 18, No 2 (2022)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v18i2.14503

Abstract

Kelulut bees are widely bred in Kalimantan. These bees do not have a stinger and easily adapt to new environments. Another characteristic of the kelulut bee is that it produces more propolis than honey. Kelulut Bee propolis contains tannins, alkaloids, flavonoids, and phenolics bioactive compounds with the potential to heal drugs. Following the concept of 'Back to Nature', namely increasing public interest in using natural ingredients to be used as medicine. Therefore, a test is needed to strengthen the utilization of this potential and quantitative phytochemical analysis is needed to determine the levels of each compound in kelulut bee propolis. The purpose of this research was to analyze the results of the quantitative phytochemical of ethanol extract of kelulut bee propolis (Trigona laeviceps). The research used non- experimental research with quantitative laboratory examination to analyze sample content. The results showed he quantitative phytochemical analysis of ethanol extract of kelulut bee propolis (Trigona laeviceps) showed a content of tannin compound 1.85 mg/ml, alkaloid 154.31 mg/ml, flavonoid 56.83 mg/ml and phenolic 120.37 mg/ml. Ethanol extract of bee propolis (Trigona laeviceps) showed a tannin compound content of 1.85 mg/ml, alkaloids 154.31 mg/ml, flavonoids 56.83 mg/ml and phenolic 120.37 mg/ml. Alkaloid had the highest concentration of 154.31 mg/ml, while tannin had the lowest concentration of 1.85 mg/ml.
PROFIL PENGGUNAAN OBAT PADA PASIEN COVID-19 DI SALAH SATU RUMAH SAKIT DI BANJARMASIN Yusrinie Wasiaturrahmah; Aditya Maulana Perdana Putra; Nahdha Nahdha; Nahdiya Rahmah
Jurnal Insan Farmasi Indonesia Vol 5 No 1 (2022): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v5i1.917

Abstract

Coronavirus 19, Knowing as COVID-19, is a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 treatment is still limited to supportive and oxygen therapy. The use of drugs is on the complaints felt by patients and comorbidities. This study aims to look at drug use profiles in COVID-19 patients. This research was included in descriptive research with a retrospective cross-sectional design. This research data was the entire prescription sheet and medical records of COVID-19 patients for March-August 2020 that meet the inclusion criteria. The result from collecting COVID-19 patient data for March-August 2020 obtained 114 medical records that met the criteria for research inclusion. Research Result: Characteristics of study subjects of the male sex are more infected with COVID-19. The age range with the highest number of COVID-19 patients was 46-55 years. Treatment profiles often used in COVID-19 patients are Supplements and Vitamins for 6538 prescriptions and Antibiotics for 2813 prescriptions. The most prescribed supplements and vitamins are Vitamin C, Lakto B, Zinc, and Vitamin C. The most prescribed antibiotics are Azithromycin, Meropenem, and Levofloxacin. The conclusion obtained in this study is that Supplements and vitamins, and Antibiotics are the most prescribed drug class.
FORMULASI DAN UJI SIFAT FISIK SEDIAAN LOTION DARI EKSTRAK ETANOL DAUN SUKUN (ARTOCARPUS ALTILIS) Tyas Setia Nugraha; Mega Sari; Yusrinie Wasiaturrahmah
JCPS (Journal of Current Pharmaceutical Sciences) Vol 6 No 1 (2022): September
Publisher : LPPM - Universitas Muhammadiyah Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Masyarakat Indonesia telah lama menggunakan tumbuhan sebagai bahan obat. Salah satu tanaman yang dipercaya memiliki khasiat adalah sukun (Artocarpus altilis). Semua bagian dari tanaman ini, dapat dimanfaatkan sebagai obat tradisional terutama daunnya. Salah satu kandungan daun sukun yaitu flavonoid dan fenolik memiliki khasiat sebagai antioksidan alami yang dapat menetralisasi radikal bebas. Salah satu sediaan yang dapat digunakan untuk memberikan perlindungan pada kulit yaitu lotion. Penelitian ini untuk mengetahui formulasi dan uji sifat fisik sedian lotion dari ekstrak etanol daun sukun (Artocarpus altilis). Hasil penelitian menunjukkan bahwa ketiga lotion daun sukun dengan formulasi konsentrasi lanolin 3%, 4% dan 5% memenuhi syarat uji sifat fisik yaitu uji organoleptik, homogenitas, uji daya sebar, uji daya lekat, uji pH, dan uji viskositas. Indonesian people have long used plants as medicinal ingredients. One plant that is believed to have efficacy is sukun (Artocarpus altilis). All parts of this plant can be used as traditional medicine, especially the leaf. One of the content of sukun leaf is flavonoids have properties as antioxidants which can protect free radicals containing ultraviolet light. One preparation that can be used to provide protection to the skin is lotion. This study is to find out the formulation and test for the physical properties of sedian lotion from Sukun leaf ethanol extract (Artocarpus altilis). The results showed that the three breadfruit leaf lotions with the formulation of concentrations of lanolin 3%, 4% and 5% met the test requirements for physical properties, namely organoleptic test, homogeneity, dispersion test, sticky power test, pH test, and viscosity test.
QUANTITATIVE PHYTOCHEMICAL TEST OF METHANOL EXTRACT OF TABAT BARITO LEAVES (Ficus deltoidea Jack.) I Wayan Arya Krishnawan Firdaus; Asphia Rahmah; Maharani Laillyza Apriasari; Yusrinie Wasiaturrahmah
Dentino : Jurnal Kedokteran Gigi Vol 8, No 1 (2023)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v8i1.16085

Abstract

ABSTRACTBackground: Tabat barito is a medicinal plant that has long been used by various ethnic groups in Indonesia, especially on the islands of Sumatra and Kalimantan. The people of Kalimantan use tabat barito as a traditional medicine for women who have just given birth, enhance blood circulation and get energy. Tabat barito leaves contain alkaloids, flavonoids, steroids, and phenolic compounds. Because of its use only based on the results of community trials and passed down orally, scientific research is needed for the chemical content or compounds contained therein. It aims to determine the bioactive profile of plants that play a role in therapy and their use can be accounted for. Purpose: To analyze the quantitative phytochemical test results of the methanol extract of tabat barito leaves (Ficus deltoidea Jack.) 100% concentration. Methods: Non-experimental research with quantitative laboratory examination to determine sample content. Results: The results showed that the total alkaloids content 154.31 mg/ml, flavonoids 62.917 mg/ml, steroids 49.036, and phenolic 99.689 mg/ml. Conclusion: The methanol extract of tabat barito leaves showed the content of alkaloid compounds at 154.31 mg/ml, flavonoids at 62.917 mg/ml, steroids at 49.036 mg/ml, and phenolics at 99.689 mg/ml. The compound with the highest total content was alkaloid at 154.31 mg/ml and the compound with the lowest total content was steroid at 49.036 mg/ml. Keywords: gravimetric, tabat barito leaves, uv-vis spectrophotometry, quantitative phytochemical test
POTENSI ANTIINFLAMASI EKSTRAK DAUN KECAPI SENTUL (Sandoricum koetjape Merr) DENGAN METODE STABILISASI MEMBRAN SEL DARAH MERAH Yusrinie Wasiaturrahmah; Nida Amalia
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 8 No 1 (2023): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v8i1.1277

Abstract

Tissues that experience detrimental disturbances caused by chemical, mechanical or infectious stimuli will respond in the form of inflammation. Inflammatory processes that cannot be controlled and last long can damage cells, causing pathological effects. Kecapi sentul (Sandoricum koetjape Merr) is a plant that can thrive in Indonesia. Kecapi sentul leaves contain saponins, flavonoids, tannins, alkaloids, steroids, phenolics, and triterpenoids. The content of bioactive compounds in kecapi sentul leaves can provide various pharmacological effects, including as an anti-inflammatory. This study aims to determine the anti-inflammatory potential of kecapi sentul leaf extract using the membrane stabilization of the red blood cell method. The results showed that the percentage value of hemolysis inhibition possessed by kecapi sentul leaf extract at concentrations of 50, 100, 200, and 400 ppm were 6.137%, 15.884%, 24.549%, and 40.433%. The percentage of hemolysis inhibition possessed by 100 ppm aspirin as a positive control was 60.650%. The IC50 value of Kecapi sentul leaf extract was 492.305 ppm. Kecapi Sentul leaf extract is known to have the potential as an anti-inflammatory.
ANTIBACTERIAL EFFECTIVENESS OF WATER HYACINTH (Eichhornia crassipes) LEAF EXTRACT ON THE GROWTH OF Porphyromonas gingivalis Laili Nurul Islami; Beta Widya Oktiani; Yusrinie Wasiaturrahmah
Dentin Vol 7, No 2 (2023)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentin.v7i2.9716

Abstract

Background: The most common periodontal disease is periodontitis which is frequently found in the form of chronic periodontitis. Such disease is caused by the accumulation of the bacterium Porphyromonas gingivalis where supporting therapy such as chlorhexidine gluconate mouthwash 0.2% can be given. However, its use in the long term can have a negative effect on the oral cavity. There is a natural plant, namely water hyacinth (Eichhornia crassipes) which contains compounds that can be used as antibacterial, such as: tannins, phenols, flavonoids, alkaloids, saponins, terpenoids, and steroids. As a result of this, the water hyacinth plant can be used as an alternative herbal medicine. Purpose: To analyze the antibacterial effectiveness of water hyacinth leaf extract (Eichhornia crassipes) against the growth of Porphyromonas gingivalis bacteria. Methods: This study used True Experimental with posttest only with control group design. Antibacterial test was performed using liquid dilution method to determine MIC and solid dilution to determine MBC. Results: Based on the results and data analysis, it was found that the water hyacinth leaf extract had MIC at 1,56% and MBC at a concentration of 50%. Conclusion: Leaf extract of water hyacinth (Eichhornia crassipes) can inhibit and have antibacterial properties against the growth of Porphyromonas gingivalis bacteria. Keywords:      Chronic periodontitis, Leaf extract of Water Hyacinth, Porphyromonas gingivalis
ANTIFUNGAL ACTIVITY OF RAMANIA LEAF EXTRACT (Bouea Macrophylla Griff) AGAINST Candida albicans Reski Nurafia; Isyana Erlita; Yusrinie Wasiaturrahmah
Dentino : Jurnal Kedokteran Gigi Vol 8, No 2 (2023)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v8i2.17519

Abstract

Background: Root canal infection is a polymicrobial infection that causes pulpitis or localized pulp inflammation. Root canal infection occurs due to the presence of pathogenic microorganisms in the root canal. One of the most common pathogenic microorganisms found in root canals is the fungus Candida albicans. Treatment that can be done to treat pulp tissue infection is endodontic treatment. Chlorhexidine gluconate 2% is one of the irrigation materials that can be used in root canal treatment. Ramania leaf extract contains compounds such as triterpenoids, phenols, flavonoids, steroids, saponins, alkaloids, and tannins that can function as antifungals. Purpose: Measuring and analyzing the antifungal activity of ramania leaf extract (Bouea Macrophylla Griff) on the growth of Candida albicans. Method: This study is a true experimental study with a post-test-only design with a control group design consisting of 7 treatment groups and repeated 4 times. The antifungal activity was assessed from the inhibition zone formed on Sabouraud Dextrose Agar media by the diffusion method. Results: Based on the Mann-Whitney test showed that there was only 1 pair of groups that did not have a significant difference, namely 100% concentration of ramania leaf extract with 2% chlorhexidine gluconate while the other groups had significant differences from each other. Conclusion: Ramania leaf extract concentrations of 6.25%, 12.5%, 25%, 50%, and 100% had antifungal activity in inhibiting the growth of the fungus Candida albicans. Keywords: Antifungal Activity, Candida albicans, Chlorhexidine gluconate 2%, Ramania Leaf Extract.
EFEKTIVITAS ANTIBAKTERI EKSTRAK DAUN KECAPI (Sandoricum koetjape Merr) TERHADAP PERTUMBUHAN BAKTERI Enterococcus faecalis Yusrinie Wasiaturrahmah; Muhammad Rayhan; Deby Kania Tri Putri; Agung Satria Wardhana; Maharani Laillyza Apriasari
Jurnal Insan Farmasi Indonesia 2023: JIFI: Webinar & call for paper
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v6i3.1699

Abstract

Penyebab terbesar kegagalan perawatan saluran akar sebesar 63% disebabkan oleh bakteri Enterococcus faecalis. Bakteri Enterococcus faecalis dapat dieliminasi dengan melakukan irigasi saluran akar. Kandungan zat aktif seperti saponin yang terdapat di dalam daun kecapi (Sandoricum koetjape Merr) terbukti memiliki efek antibakteri. Tujuan mengukur dan menganalisis efektivitas antibakteri ekstrak daun kecapi (Sandoricum koetjape Merr) terhadap pertumbuhan bakteri Enterococcus faecalis. Metode penelitian ini merupakan eksperimen murni (true experimental) dengan post test only with control group design. Penelitian ini terdiri dari 9 kelompok perlakuan, yaitu ekstrak daun kecapi (Sandoricum koetjape Merr) konsentrasi 10%, 20%, 30%, 40%, 50%, 60%, 70%, sodium hipoklorit (NaOCl), dan aquadest dengan 3 kali pengulangan. Data KHM didapatkan dari pengukuran delta Optical Density (OD) dan data uji KBM didapatkan berdasarkan perhitungan jumlah koloni. Berdasarkan nilai rata-rata dan analisis data diketahui KHM terdapat pada konsentrasi ekstrak daun kecapi 10% dan KBM pada konsentrasi 20%. Ekstrak daun kecapi (Sandoricum koetjape Merr) konsentrasi 10%, 20%, 30%, 40%, 50%, 60%, dan 70% memiliki efektivitas antibakteri terhadap pertumbuhan bakteri Enterococcus faecalis.
EFFECT OF GALAM LEAF EXTRACT AND TRI-CALCIUM SILICATE CEMENT ON NEUTROPHIL CELLS IN WISTAR RAT PULP Putra, Fedriko Gamaliel; Diana, Sherli; Dewi, Nurdiana; Wasiaturrahmah, Yusrinie; Carabelly, Amy Nindia
Dentino: Jurnal Kedokteran Gigi Vol 9, No 2 (2024)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v9i2.20409

Abstract

Background: Pulp capping is a method of sealing the pulp chamber in teeth with cavities that extend to the pulp. Direct pulp capping involves applying a material directly onto the exposed pulp tissue. Tri-calcium silicate cement (Ca3SiO5) is commonly used due to its nanoparticle mineral composition, but it can cause continued inflammation. Galam leaf (Melaleuca cajuputi) is known for its anti-inflammatory properties, owing to secondary metabolites like alkaloids, flavonoids, polyphenols, and saponins, potentially compensating for the drawbacks of tri-calcium silicate cement. Purpose: To determine the effect of combining Galam leaf extract (Melaleuca cajuputi subsp. Cumingiana (Turz) Barlow) with tri-calcium silicate cement as a direct pulp capping material on neutrophil cell count in the pulp of Wistar rats (Rattus norvegicus). Methods: This pure experimental study used a posttest-only control design. Thirty-six Wistar rats were divided into nine groups: one received a combination of 100% Galam leaf extract and tri-calcium silicate cement; one positive control group received tri-calcium silicate cement alone; and one negative control group received direct placement with glass ionomer cement (GIC). The neutrophil cell count was assessed on days 1, 2, and 3. Results: Two-way ANOVA results indicated a significant effect based on treatment and time (p < 0.05). Further analysis with the Post Hoc Bonferroni test (p < 0.05) revealed differences in neutrophil cell counts across nearly all groups on days 1, 2, and 3. Conclusion: The combination of 100% Galam leaf extract and tri-calcium silicate cement significantly reduced neutrophil cell counts compared to both positive and negative control groups on days 1, 2, and 3, indicating anti-inflammatory effect.
QUANTITATIVE PHYTOCHEMICAL ANALYSIS OF MAULI BANANA STEM AND BASIL LEAVES EXTRACT MIXTURE Namira Aghnina, A.M. Della; Puspitasari, Dewi; Wasiaturrahmah, Yusrinie
Dentino: Jurnal Kedokteran Gigi Vol 9, No 1 (2024)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v9i1.18853

Abstract

Background: Mauli banana stem extract and basil leaves extract are ingredients that has been involved in in vitro and in vivo researches for their pharmacognosy and therapeutic applications. Preliminary phytochemical test of both individual extract revealed the presence of triterpenoid, tannin, phenolic, saponin, steroid, alkaloid, and flavonoid compound. A combination of mauli banana stem and basil leaves extract is believed to work synergistically and may have a more beneficial effect than in single herbal extract. Purpose: To analyze the results of quantitative phytochemical of mauli banana stem and basil leaves extract mixture. Method: Non-experimental research with quantitative laboratory examination to determine sample content. Results: The result showed that mauli banana stem and basil leaves extract mixture contain triterpenoid (30%), saponin (24,75%), flavonoid (15%), alkaloid (22%), phenolic (8%), steroid (4,62%), and tannin (0,03%). Conclusion: Mauli banana stem and basil leaves extract mixture correlated with an increase in majority of the bioactive compound compared to the single extract and would serve as a promising source for phytomedicine. The bioactive compound with the highest content was triterpenoid with 30%, while the lowest was tannin with 0,03%. Keywords: Basil leave extract, Mauli banana stem extract, Quantitative phytochemical test
Co-Authors Adhimas Rilo Pambudi Adhiya, Geyanina Melda Agung Satria Wardhana Alexander Sitepu Almadina Latanza Amy Nindia Carabelly Anna Khumaira Sari Arifin, Rahmad Asphia Rahmah Aspriyanto, Didit Bambang Setiawan Bayu Indra Sukmana Beta Widya Oktiani Cita Nursyaina Tasya Dewi Nurdiana Dewi Puspitasari Dewi Puspitasari Diana Wibowo Difa Intannia Dini Maulani Erida Wydiamala Firdaus, I Wayan Arya Krishnawan Fitri Syahrina Fransiska Uli Arta Puspitasari I Wayan Arya Krishnawan Firdaus I Wayan Arya Krisnawan Firdaus Ichrom Nahzi, Muhammad Yanuar Isnaini, Nazhifah Jatmiko, Habibi Naufal Khoirunnisa Muslimawati Kholish Atikah Azzam Krisna Erlangga Putra Ramadhani Laili Nurul Islami Luthfi Ridhwana Maharani Laillyza Apriasari Maharani Laylliza Apriasari Maman Diki Wahyudi Mega Sari Mia Fitriana MUHAMMAD RAYHAN Nahdha Nahdha Nahdha Nahdiya Rahmah Nahdiya Rahmah Nahdiya Rahmah Nahzi, Yanuar Ichrom Namira Aghnina, A.M. Della Namira Fathya Salsabila Nida Amalia Nor Kamalia Nor Rahman Sugiarto Noval Ihza Maulana Nugraha, Tyas Setia Nurrahman, Tri Okta Muthia Sari Okta Muthia Sari Pambudi, Adhimas Rilo Pramitha, Selviana Rizky Putra, Aditya Maulana Perdana Putra, Fedriko Gamaliel Rahmatullah, Satrio Wibowo Ramadhaniyah, Nur Raudhatul Jannah Reski Nurafia Rosihan Adhani, Rosihan Sandi, Dita Ayulia Dwi Sherli Diana Tri Putri, Deby Kania Utami, Juliyatin Putri