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All Journal ODONTO Dental Journal Majalah Obat Tradisional Dentino: Jurnal Kedokteran Gigi Berkala Kedokteran Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) JCPS (Journal of Current Pharmaceutical Sciences) Dentin Borneo Journal Of Pharmascientech Jurnal Insan Farmasi Indonesia Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Odonto dental journal Jurnal Pengabdian Masyarakat Panacea Jurnal Sains dan Kesehatan Jurnal Bioteknologi & Biosains Indonesia (JBBI) Jurnal Bioteknologi & Biosains Indonesia
Yusrinie Wasiaturrahmah
Universitas Lambung Mangkurat
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary

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QUANTITATIVE PHYTOCHEMICAL ANALYSIS OF MAULI BANANA STEM AND BASIL LEAVES EXTRACT MIXTURE A.M. Della Namira Aghnina; Dewi Puspitasari; Yusrinie Wasiaturrahmah
Dentino: Jurnal Kedokteran Gigi Vol 9, No 1 (2024)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v9i1.18853

Abstract

Background: Mauli banana stem extract and basil leaves extract are ingredients that has been involved in in vitro and in vivo researches for their pharmacognosy and therapeutic applications. Preliminary phytochemical test of both individual extract revealed the presence of triterpenoid, tannin, phenolic, saponin, steroid, alkaloid, and flavonoid compound. A combination of mauli banana stem and basil leaves extract is believed to work synergistically and may have a more beneficial effect than in single herbal extract. Purpose: To analyze the results of quantitative phytochemical of mauli banana stem and basil leaves extract mixture. Method: Non-experimental research with quantitative laboratory examination to determine sample content. Results: The result showed that mauli banana stem and basil leaves extract mixture contain triterpenoid (30%), saponin (24,75%), flavonoid (15%), alkaloid (22%), phenolic (8%), steroid (4,62%), and tannin (0,03%). Conclusion: Mauli banana stem and basil leaves extract mixture correlated with an increase in majority of the bioactive compound compared to the single extract and would serve as a promising source for phytomedicine. The bioactive compound with the highest content was triterpenoid with 30%, while the lowest was tannin with 0,03%. Keywords: Basil leave extract, Mauli banana stem extract, Quantitative phytochemical test
EFFECT OF GALAM LEAF EXTRACT AND TRI-CALCIUM SILICATE CEMENT ON NEUTROPHIL CELLS IN WISTAR RAT PULP Fedriko Gamaliel Putra; Sherli Diana; Nurdiana Dewi; Yusrinie Wasiaturrahmah; Amy Nindia Carabelly
Dentino: Jurnal Kedokteran Gigi Vol 9, No 2 (2024)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v9i2.20409

Abstract

Background: Pulp capping is a method of sealing the pulp chamber in teeth with cavities that extend to the pulp. Direct pulp capping involves applying a material directly onto the exposed pulp tissue. Tri-calcium silicate cement (Ca3SiO5) is commonly used due to its nanoparticle mineral composition, but it can cause continued inflammation. Galam leaf (Melaleuca cajuputi) is known for its anti-inflammatory properties, owing to secondary metabolites like alkaloids, flavonoids, polyphenols, and saponins, potentially compensating for the drawbacks of tri-calcium silicate cement. Purpose: To determine the effect of combining Galam leaf extract (Melaleuca cajuputi subsp. Cumingiana (Turz) Barlow) with tri-calcium silicate cement as a direct pulp capping material on neutrophil cell count in the pulp of Wistar rats (Rattus norvegicus). Methods: This pure experimental study used a posttest-only control design. Thirty-six Wistar rats were divided into nine groups: one received a combination of 100% Galam leaf extract and tri-calcium silicate cement; one positive control group received tri-calcium silicate cement alone; and one negative control group received direct placement with glass ionomer cement (GIC). The neutrophil cell count was assessed on days 1, 2, and 3. Results: Two-way ANOVA results indicated a significant effect based on treatment and time (p < 0.05). Further analysis with the Post Hoc Bonferroni test (p < 0.05) revealed differences in neutrophil cell counts across nearly all groups on days 1, 2, and 3. Conclusion: The combination of 100% Galam leaf extract and tri-calcium silicate cement significantly reduced neutrophil cell counts compared to both positive and negative control groups on days 1, 2, and 3, indicating anti-inflammatory effect.
TOXICITY TEST OF KELAKAI LEAF EXTRACT (Stenochlaena palustris) TOWARD WISTAR RATS LIVER (Rattus norvegicus) Krisna Erlangga Putra Ramadhani; I Wayan Arya Krishnawan Firdaus; Yusrinie Wasiaturrahmah; Didit Aspriyanto; Erida Wydiamala
Dentino: Jurnal Kedokteran Gigi Vol 10, No 1 (2025)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v10i1.22200

Abstract

Background: Kelakai leaf extract can be used as an alternative wound healing medicine because it contains flavonoid and phenolic compounds that act as antioxidants. Before use, herbal plants must ensure the level of safety that can be obtained from toxicity tests, one of which is in vivo which can be seen from their effect on the liver of Wistar rats based on SGOT and SGPT levels. Purpose: Proving there is no toxic effect from the administration of kelakai leaf extract doses of 2,000, 2,500, and 3,000 mg/kgBW on the liver of Wistar rats based on SGOT and SGPT levels. Method: Pure laboratory experimental research with posttest-only design with control group design, consisting of 16 wistar rats divided into 4 groups with 1 negative control group given distilled water and 3 treatment groups given doses of kelakai leaf extract 2,000, 2,500 and 3,000 mg/kgBW twice a day every morning and evening for 28 days. Results: SGOT and SGPT levels after 28 days were still in the normal range. SGOT levels in treatment groups 1, 2, and 3 were 61.244 U/L, 58.953 U/L, and 53.536 U/L. SGPT levels in treatment groups 1, 2 and 3 were 25.137 U/L, 23.331 U/L, and 21.179 U/L. Based on statistical tests, there were significant differences in all treatment groups. Conclusion: There is no toxic effect from the administration of kelakai leaf extract doses of 2,000, 2,500, 3,000 mg/kgBW orally for 28 days on the liver of Wistar rats based on SGOT and SGPT levels.
Co-Authors A.M. Della Namira Aghnina Adhimas Rilo Pambudi Adhiya, Geyanina Melda Agung Satria Wardhana Alexander Sitepu Almadina Latanza Amy Nindia Carabelly Anna Khumaira Sari Arifin, Rahmad Asphia Rahmah Aspriyanto, Didit Ayulia Dwi Sandi, Dita Bambang Setiawan Bayu Indra Sukmana Beta Widya Oktiani Cita Nursyaina Tasya Dewi Nurdiana Dewi Puspitasari Diana Wibowo Difa Intannia Dini Maulani Erida Wydiamala Fedriko Gamaliel Putra Firdaus, I Wayan Arya Krishnawan Fitri Syahrina Fransiska Uli Arta Puspitasari I Wayan Arya Krishnawan Firdaus I Wayan Arya Krisnawan Firdaus Ichrom Nahzi, Muhammad Yanuar Isnaini, Nazhifah Jatmiko, Habibi Naufal Khoirunnisa Muslimawati Kholish Atikah Azzam Krisna Erlangga Putra Ramadhani Laili Nurul Islami Luthfi Ridhwana Maharani Laillyza Apriasari Maharani Laylliza Apriasari Maman Diki Wahyudi Mega Sari Mia Fitriana MUHAMMAD RAYHAN Nahdha Nahdha Nahdha Nahdiya Rahmah Nahdiya Rahmah Nahdiya Rahmah Nahzi, Yanuar Ichrom Namira Fathya Salsabila Nida Amalia Nor Kamalia Nor Rahman Sugiarto Noval Ihza Maulana Nugraha, Tyas Setia Nurrahman, Tri Okta Muthia Sari Pambudi, Adhimas Rilo Pramitha, Selviana Rizky Putra, Aditya Maulana Perdana Rahmatullah, Satrio Wibowo Ramadhaniyah, Nur Raudhatul Jannah Reski Nurafia Rosihan Adhani, Rosihan Sherli Diana Tri Putri, Deby Kania Utami, Juliyatin Putri