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All Journal ODONTO Dental Journal Majalah Obat Tradisional Dentino: Jurnal Kedokteran Gigi Berkala Kedokteran Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) JCPS (Journal of Current Pharmaceutical Sciences) Dentin Borneo Journal Of Pharmascientech Jurnal Insan Farmasi Indonesia Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Odonto dental journal Jurnal Pengabdian Masyarakat Panacea Jurnal Sains dan Kesehatan Jurnal Bioteknologi & Biosains Indonesia (JBBI) Jurnal Bioteknologi & Biosains Indonesia
Yusrinie Wasiaturrahmah
Universitas Lambung Mangkurat
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary

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ANTIBACTERIAL EFFECTIVENESS OF KECAPI SENTUL EXTRACT (SANDORICUM KOETJAPE MERR.) AGAINST STREPTOCOCCUS MUTANS Pambudi, Adhimas Rilo; Wasiaturrahmah, Yusrinie; Aspriyanto, Didit
Odonto : Dental Journal Vol 8, No 2 (2021): December 2021
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (278.864 KB) | DOI: 10.30659/odj.8.2.1-10

Abstract

ABSTRACTBackground: One of the causing dental caries is a microorganism, namely Streptococcus mutans. Kecapi sentul leaves extract (Sandoricum koetjape Merr.) contain alkaloid, flavonoid, saponin, steroid, phenol, and triterpenoid which have antibacterial properties on the inhibition Streptococcus mutans which has the potential to prevent dental caries.Method: This research uses a laboratory experimental design with a post-test control group only design, using seven treatment groups, namely kecapi sentul leaves extract with the concentration of group 30%, 40%, 50%, 60%, 70%, Chlorhexidine gluconate 0.2% as positive control and aquadest as negative control were repeated 4 times. Result: Non parametric test Kruskal Wallis and Post Hoc Mann Whitney methods showed that each treatment group was significantly different in the diameter of the formed inhibition zone. The mean diameter of the inhibition zone with a concentration of 30% was 9.1 mm, 40% was 13.3 mm, 50% was 17.13 mm, 60% was 18.65 mm and 70% was 21.05 mm.Conclusion: Kecapi sentul leaves extract (Sandoricum koetjape Merr.) with the concentration of group 30%, 40%, 50%, 60% and 70% have antibacterial potential against the growth of Streptococcus mutans.
TOXICITY TEST OF KELAKAI LEAF EXTRACT (Stenochlaena palustris) TOWARD WISTAR RATS LIVER (Rattus norvegicus) Putra Ramadhani, Krisna Erlangga; Krishnawan Firdaus, I Wayan Arya; Wasiaturrahmah, Yusrinie; Aspriyanto, Didit; Wydiamala, Erida
Dentino: Jurnal Kedokteran Gigi Vol 10, No 1 (2025)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v10i1.22200

Abstract

Background: Kelakai leaf extract can be used as an alternative wound healing medicine because it contains flavonoid and phenolic compounds that act as antioxidants. Before use, herbal plants must ensure the level of safety that can be obtained from toxicity tests, one of which is in vivo which can be seen from their effect on the liver of Wistar rats based on SGOT and SGPT levels. Purpose: Proving there is no toxic effect from the administration of kelakai leaf extract doses of 2,000, 2,500, and 3,000 mg/kgBW on the liver of Wistar rats based on SGOT and SGPT levels. Method: Pure laboratory experimental research with posttest-only design with control group design, consisting of 16 wistar rats divided into 4 groups with 1 negative control group given distilled water and 3 treatment groups given doses of kelakai leaf extract 2,000, 2,500 and 3,000 mg/kgBW twice a day every morning and evening for 28 days. Results: SGOT and SGPT levels after 28 days were still in the normal range. SGOT levels in treatment groups 1, 2, and 3 were 61.244 U/L, 58.953 U/L, and 53.536 U/L. SGPT levels in treatment groups 1, 2 and 3 were 25.137 U/L, 23.331 U/L, and 21.179 U/L. Based on statistical tests, there were significant differences in all treatment groups. Conclusion: There is no toxic effect from the administration of kelakai leaf extract doses of 2,000, 2,500, 3,000 mg/kgBW orally for 28 days on the liver of Wistar rats based on SGOT and SGPT levels.
TOXICITY TEST OF Eusideroxylon zwageri BARK EXTRACT BASED ON KIDNEY HISTOPATHOLOGY OF BLEEDING AND NECROSIS Salsabila, Namira Fathya; Krishnawan Firdaus, I Wayan Arya; Wasiaturrahmah, Yusrinie; Putri Utami, Juliyatin; Setiawan, Bambang
Dentino: Jurnal Kedokteran Gigi Vol 10, No 1 (2025)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v10i1.22201

Abstract

Background: Ironwood plant (Eusideroxylon zwageri) can potentially be an herbal medicine that accelerates wound healing because of the antioxidant compounds contained in it. The dominant compounds contained in ironwood bark are flavonoids 30.48 mgCE/g, phenolics 31.28 mgCE/g, and proanthocyanidins 183.3 mgCE/g. Before used as an herbal medicine, it is necessary to do an acute toxicity test on ironwood bark at doses of 1.250 mg/kgBW, 2.750 mg/kgBW, and 4.750 mg/kgBW to consider the right dose. Acute toxicity tests can be seen using histopathological appearance in the kidney based on bleeding and necrosis. Purpose: Determine the toxic effects of giving Eusideroxylon zwageri doses of 1.250 mg/kgBW, 2.750 mg/kgBW, and 4.750 mg/kgBW on the kidneys of Wistar rats (Rattus norvegicus) based on bleeding and necrosis in histopathological appearance. Method: Research is true experimental and  posttest-only with control design. The study was divided into a control group given aquades and a treatment group given ironbark extract dose of 1.250 mg/kgBW, 2.750 mg/kgBW, and 4.750 mg/kgBW as much as 1 ml given 2 times a day orally for 14 days. Results: The percentage of histopathological appearances of bleeding and necrosis score is 1 or mild. Analysis of bleeding and necrosis did not show significant differences of ironwood bark extract doses of 1.250 mg/kgBW, 2.750 mg/kgBW, and 4.750 mg/kgBW. Conclusion: There were no toxic effects of ironwood bark extract doses  of 1.250 mg/kgBW, 2.750 mg/kgBW, and 4.750 mg/kgBW on the kidney organs of wistar rats based on bleeding and necrosis in histopathological appearances.
Co-Authors Adhimas Rilo Pambudi Adhiya, Geyanina Melda Agung Satria Wardhana Alexander Sitepu Almadina Latanza Amy Nindia Carabelly Anna Khumaira Sari Arifin, Rahmad Asphia Rahmah Aspriyanto, Didit Bambang Setiawan Bayu Indra Sukmana Beta Widya Oktiani Cita Nursyaina Tasya Dewi Nurdiana Dewi Puspitasari Dewi Puspitasari Diana Wibowo Difa Intannia Dini Maulani Firdaus, I Wayan Arya Krishnawan Fitri Syahrina Fransiska Uli Arta Puspitasari I Wayan Arya Krishnawan Firdaus I Wayan Arya Krisnawan Firdaus Ichrom Nahzi, Muhammad Yanuar Isnaini, Nazhifah Jatmiko, Habibi Naufal Khoirunnisa Muslimawati Kholish Atikah Azzam Krishnawan Firdaus, I Wayan Arya Laili Nurul Islami Luthfi Ridhwana Maharani Laillyza Apriasari Maharani Laylliza Apriasari Maman Diki Wahyudi Mega Sari Mia Fitriana MUHAMMAD RAYHAN Nahdha Nahdha Nahdha Nahdiya Rahmah Nahdiya Rahmah Nahdiya Rahmah Nahzi, Yanuar Ichrom Namira Aghnina, A.M. Della Nida Amalia Nor Kamalia Nor Rahman Sugiarto Noval Ihza Maulana Nugraha, Tyas Setia Nurrahman, Tri Okta Muthia Sari Okta Muthia Sari Pambudi, Adhimas Rilo Pramitha, Selviana Rizky Putra Ramadhani, Krisna Erlangga Putra, Aditya Maulana Perdana Putra, Fedriko Gamaliel Rahmatullah, Satrio Wibowo Ramadhaniyah, Nur Raudhatul Jannah Reski Nurafia Rosihan Adhani, Rosihan Salsabila, Namira Fathya Sandi, Dita Ayulia Dwi Sherli Diana Tri Putri, Deby Kania Utami, Juliyatin Putri Wydiamala, Erida