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Analisis Faktor yang Berhubungan dengan Potensi Interaksi Obat Pasien Covid-19 di Salah Satu Rumah Sakit Kalimantan Selatan: Factors Associated with Potential Drug Interactions in Covid-19 Hospitalized Patients Okta Muthia Sari; Aditya Maulana Perdana Putra; Yusrinie Wasiaturrahmah; Nahdiya Rahmah
Jurnal Sains dan Kesehatan Vol. 5 No. 5 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i5.1811

Patients with COVID-19 are treated with antivirals, supportive therapy, and symptomatic therapy. COVID-19 patients who use multiple drugs may experience drug interactions. The purpose of this study is to investigate factors associated with potential drug interactions in COVID-19 patients who are hospitalized. This cross-sectional retrospective observational study was carried out in a hospital in the Indonesia. The sample consists of medical records from COVID-19 patients who received therapy and were hospitalized between January and March 2021. The IBM Micromedex website, DrugBank Interaction Checker, and Stockley Drug Interactions 9th Edition are research tools used to assess the potential and mechanism of drug interactions. The results were 82 medical records that were analyzed for potential drug interactions. The proportion of patients who have potential drug interactions is 69.5%. in hospitalized COVID-19 patients. The drug interaction mechanism in COVID-19 patients is potentially in the pharmacokinetics phase. Age (p=0.034; OR 0.327, CI 0.11-0.94), number of drugs used during treatment (p=0.002; OR 14.00, CI 1.76-111.11), and length of stay (p=0.000; OR 0.009, CI 0.001-0.07) were factors associated to potential drug interactions. Subsequently, factors associated with potential drug interactions in COVID-19 hospitalized patients include age, number of drugs used during treatment, and length of stay. Keywords: COVID-19, drug interactions, factors associated, potential Abstrak Tatalaksana pengobatan pada pasien COVID-19 diberikan antivirus, terapi suportif dan terapi simptomatik. Penggunaan beberapa jenis obat tersebut membuat pasien COVID-19 berpotensi mengalami interaksi obat. Penelitian ini bertujuan menganalisis faktor yang berhubungan dengan potensi interaksi obat pada pasien COVID-19 rawat inap di rumah sakit. Penelitian obeservasional retrospektif cross sectional ini dilaksanakan di salah satu rumah sakit Kalimantan Selatan. Sampel yakni rekam medis pasien COVID-19 yang mendapat terapi dan rawat inap di rumah sakit periode Januari-Maret 2021 Instrumen penelitian mengkaji potensi dan mekanisme interaksi obat meliputi situs IBM Micromedex , DrugBank Interaction Checker dan Stockley Drug Interactions 9th Edition. Hasil diperoleh sebanyak 82 rekam medis dianalisis potensi interaksi obat. Persentase pasien mengalami potensi interaksi obat sebesar 69,5%. pada pasien COVID-19 rawat inap di rumah sakit. Mekanisme interaksi obat pada pada pasien COVID-19 pada berpotensi pada fase farmakokinetika. Faktor berhubungan potensi interaksi obat pasien COVID-19 yakni usia (p=0.034; OR 0.327, CI 0.11-0.94), jumlah obat yang digunakan selama dirawat (p=0.002; OR 14.00, CI 1.76-111.11) dan lama dirawat (p=0.000; OR 0.009 , CI 0.001-0.07). Kesimpulan, faktor berhubungan potensi interaksi obat pada pasien COVID-19 rawat inap di rumah sakit meliputi usia, jumlah obat yang digunakan selama dirawat dan lama dirawat. Kata Kunci: COVID-19, faktor berhubungan, interaksi obat, potensi

Pemberdayaan Kader dalam Upaya Deteksi Dini Penyakit Tidak Menular (PTM) sebagai Upaya Preventif dan Optimalisasi Kegiatan Posyandu di Puskesmas Landasan Ulin Fitriana, Mia; Sari, Anna Khumaira; Intannia, Difa; Rahmatullah, Satrio Wibowo; Sandi, Dita Ayulia Dwi; Wasiaturrahmah, Yusrinie; Muslimawati, Khoirunnisa; Isnaini, Nazhifah
Jurnal Pengabdian Masyarakat Panacea Vol 2, No 4 (2024): Jurnal Pengabdian Masyarakat Panacea
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jpmp.v2i4.14140

Penyakit Tidak menular (PTM) menjadi permasalahan global yang membutuhkan perhatian serius, karena menyebabkan kasus kematian terbanyak di dunia (74%). Pelayanan kesehatan dasar pada Penyakit Tidak Menular (PTM) di Puskesmas Landasan Ulin masih ada yang belum mencapai target yang diharapkan, Kegiatan pengabdian masyarakat ini bertujuan untuk melakukan pemberdayaan kader posyandu di wilayah Puskesmas Landasan Ulin melalui pembuatan paket edukasi dan sosialisasi tentang PTM, melakukan deteksi dini dan upaya promosi kesehatan terkait PTM kepada masyarakat. Kegiatan meliputi sosialisasi kepada kader dan peserta posyandu, pelatihan dan penerapan teknologi dilakukan kepada kader posyandu tentang penggunaan alat cek kadar glukosa, kolesterol dan asam urat yang digunakan untuk deteksi dini PTM serta interpretasi dari hasil tes yang diperoleh kemudian dievaluasi dengan hasil pretest dan postest. Berdasarkan hasil evaluasi, terjadi peningkatan skor rata-rata dari kader dan peserta. Hasil skor rata-rata kader posyandu saat pretest sebesar 7,88 meningkat menjadi 8,6 pada skor rata-rata postest, sedangkan hasil skor rata-rata peserta posyandu saat pretest sebesar 7,2 meningkat menjadi 7,9 pada skor rata-rata postest. Peningkatan yang terjadi tidak terlalu signifikan (8 % untuk kader dan 7 % untuk peserta), hal ini mungkin dikarenakan pengetahuan dasar baik kader maupun peserta sudah cukup baik sebelum diberikan sosialisasi. Kata Kunci: Hipertensi, Diabetes Miletus, Faktor Resiko, Pelatihan Non-communicable diseases (NCDs) are a global problem that requires serious attention. This NCDs has become the cause of most deaths in the world, namely 74%. Landasan Ulin Community Health Center has a population of 77,982 people. In basic health services for Non-Communicable Diseases (NCDs), there are still some that have not reached the expected target. This community service activity aims to empower posyandu cadres in the Landasan Ulin Community Health Center area through creating educational packages and outreach about NCDs, carrying out early detection and efforts health promotion related to NCDs to the community. Activities include outreach to posyandu cadres and participants, training and application of technology to posyandu cadres regarding the use of tools to check glucose, cholesterol and uric acid levels which are used for early detection of NCDs as well as interpretation of the test results obtained which are then evaluated with pretest and posttest results. Based on the evaluation results, there was an increase in the average score of cadres and participants. The average score of posyandu cadres during the pretest was 7.88, increasing to 8.6 in the average score of the posttest, while the average score of posyandu participants during the pretest was 7.2, increasing to 7.9 in the average score of the posttest. The increase that occurred was not very significant (8% for cadres and 7% for participants), this may be because the basic knowledge of both cadres and participants was quite good before being given socialization and education.

PHARMACOLOGICAL INVESTIGATION OF THE ORAL WOUND HEALING ACTIVITY OF Stachytarpheta jamaicensis ROOT EXTRACT GEL IN WISTAR RATS Utami, Juliyatin Putri; Wasiaturrahmah, Yusrinie; Carabelly, Amy Nindia; Aspriyanto, Didit; Nahzi, Yanuar Ichrom; Arifin, Rahmad; Ramadhaniyah, Nur; Jatmiko, Habibi Naufal
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 12 No. 1 (2025)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2025.9390

The Stachytarpheta jamaicensis (L) Vahl root contains bioactive compounds like saponins, alkaloids, flavonoids, tannins, phenols, and terpenoids, which have antibacterial and anti-inflammatory properties. This study investigates the wound healing effects of Stachytarpheta jamaicensis (L) Vahl root extract gel in oral mucosa. The experiment involved 28 male Wistar rats, divided into four groups: a positive control treated with povidone iodine 10%, a negative control treated with gel base, and two experimental groups treated with 6% and 10% S. jamaicensis root extract gels. The gel was applied twice daily, and wound healing was assessed by epithelial thickness, inflammation cell and hydroxyproline content. Both concentrations of S. jamaicensis root extract gel significantly enhanced wound healing, as shown by increased epithelial thickness, inflammation cell and hydroxyproline content levels compared to the negative control. These findings suggest that S. jamaicensis root extract gel effectively promotes wound healing in the excision wound model.

Antibacterial, Antifungal And Subchronic Toxicity Test Of Ficus Deltoidea Jack Leaves Extract Apriasari, Maharani Laillyza; Adhiya, Geyanina Melda; Wasiaturrahmah, Yusrinie; Utami, Juliyatin Putri; Firdaus, I Wayan Arya Krishnawan; Pramitha, Selviana Rizky
Odonto : Dental Journal Vol 12, No 1 (2025): April 2025
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.12.1.19-28

Background: Ficus deltoidea Jack is a plant that is often used as herbs medicine because of secondary metabolites such as alkaloids, phenolics, flavonoids, and steroids. This study aims to determine the activity of antibacterial, antifungal and toxicity effect of Ficus deltoidea Jack leaves (FDLE) extract. Method: Pure experimental study with a posttest-only design with a control group design. The in vitro test by dilution methods using Staphylococcus aureus and Candida albicans. The toxicity test used 16 male Rattus novergicus divided into four group consist a control group and three treatment group given FDLE doses with 1,250, 2,500, and 3,750 mg/kgBW. The treatment applied 2x1 ml FDLE every 24 hours orally for 28 days. Result: The MIC value and the MBC value of FDLE againts S. aureus were 8% and 10%, respectively. While, MIC and MBC value on C. albicans has similar value about 25%. The mean results of kidney toxicity test were still in the normal range. There was a significant difference in the results of the Kruskall Wallis test for urea (p<0.05), while there was no significant difference in the results of urea and creatinine level (p>0.05). Conclusion: There was antibacterial and antifungal efficacy of FDLE. Also, there was no toxic effect of giving FDLE at doses of 1,250, 2,500, and 3,750 mg/kgBW was showed on urea and creatinine normal level.

Antibacterial, Antifungal And Subchronic Toxicity Test Of Ficus Deltoidea Jack Leaves Extract Apriasari, Maharani Laillyza; Adhiya, Geyanina Melda; Wasiaturrahmah, Yusrinie; Utami, Juliyatin Putri; Firdaus, I Wayan Arya Krishnawan; Pramitha, Selviana Rizky
Odonto : Dental Journal Vol 12, No 1 (2025): April 2025
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.12.1.19-28

Background: Ficus deltoidea Jack is a plant that is often used as herbs medicine because of secondary metabolites such as alkaloids, phenolics, flavonoids, and steroids. This study aims to determine the activity of antibacterial, antifungal and toxicity effect of Ficus deltoidea Jack leaves (FDLE) extract. Method: Pure experimental study with a posttest-only design with a control group design. The in vitro test by dilution methods using Staphylococcus aureus and Candida albicans. The toxicity test used 16 male Rattus novergicus divided into four group consist a control group and three treatment group given FDLE doses with 1,250, 2,500, and 3,750 mg/kgBW. The treatment applied 2x1 ml FDLE every 24 hours orally for 28 days. Result: The MIC value and the MBC value of FDLE againts S. aureus were 8% and 10%, respectively. While, MIC and MBC value on C. albicans has similar value about 25%. The mean results of kidney toxicity test were still in the normal range. There was a significant difference in the results of the Kruskall Wallis test for urea (p<0.05), while there was no significant difference in the results of urea and creatinine level (p>0.05). Conclusion: There was antibacterial and antifungal efficacy of FDLE. Also, there was no toxic effect of giving FDLE at doses of 1,250, 2,500, and 3,750 mg/kgBW was showed on urea and creatinine normal level.

PHARMACOLOGICAL INVESTIGATION OF THE ORAL WOUND HEALING ACTIVITY OF Stachytarpheta jamaicensis ROOT EXTRACT GEL IN WISTAR RATS Utami, Juliyatin Putri; Wasiaturrahmah, Yusrinie; Carabelly, Amy Nindia; Aspriyanto, Didit; Nahzi, Yanuar Ichrom; Arifin, Rahmad; Ramadhaniyah, Nur; Jatmiko, Habibi Naufal
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 12 No. 1 (2025)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2025.9390

The Stachytarpheta jamaicensis (L) Vahl root contains bioactive compounds like saponins, alkaloids, flavonoids, tannins, phenols, and terpenoids, which have antibacterial and anti-inflammatory properties. This study investigates the wound healing effects of Stachytarpheta jamaicensis (L) Vahl root extract gel in oral mucosa. The experiment involved 28 male Wistar rats, divided into four groups: a positive control treated with povidone iodine 10%, a negative control treated with gel base, and two experimental groups treated with 6% and 10% S. jamaicensis root extract gels. The gel was applied twice daily, and wound healing was assessed by epithelial thickness, inflammation cell and hydroxyproline content. Both concentrations of S. jamaicensis root extract gel significantly enhanced wound healing, as shown by increased epithelial thickness, inflammation cell and hydroxyproline content levels compared to the negative control. These findings suggest that S. jamaicensis root extract gel effectively promotes wound healing in the excision wound model.

GAMBARAN KESEIMBANGAN UKURAN GIGI DENGAN ANALISIS BOLTON PADA PELAJAR SUKU BANJAR (USIA 15-18 TAHUN) Kholish Atikah Azzam; Diana Wibowo; Alexander Sitepu; Rosihan Adhani; Yusrinie Wasiaturrahmah
Dentin Vol 8, No 2 (2024)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentin.v8i2.13110

ABSTRACTBackground: South Kalimantan recorded having a high incidence of dental and oral health problems around 59.6% and malocclusion cases around 12%. The population of Banjar tribe in South Kalimantan is around 90%. Banjar’s genetic factors can influence the development of tooth size therefore influence result of normal occlusion. Bolton analysis is an index needed to determine balance of tooth size of upper and lower jaw. Objective: The aim of this research is to describe the discrepancy sizes using Bolton analysis in Banjar students (aged 15-18 years). Method: This research is an observasional descriptive study with cross-sectional approach. Results: The results showed that the average balance value for the size of the 6 anterior teeth (Anterior Ratio) was 79.51% ± 8.67. It was found that 97.6% of the samples were unbalanced with the highest frequency of jaw discrepancies in the mandible and the average value for balance size of the 12 teeth. overall (Overall Ratio) 91.32 ± 5.17, it was found that 98.8% of the sample numbers were unbalanced with the highest frequency of jaw discrepancy in the maxilla, namely 46 people (56.1%). Conclusion: The balance of tooth size in the Banjar tribe based on the anterior Bolton ratio was found to be predominantly unbalanced with the highest imbalance located in the lower jaw (mandible) and the overall Bolton ratio was found to be predominantly unbalanced with the highest imbalance located in the upper jaw (maxilla).Keywords : Tooth Size Discrepancy; Bolton Analysis; Banjar tribe ABSTRAK Latar Belakang: Kalimantan Selatan tercatat memiliki angka kejadian permasalahan kesehatan gigi dan mulut yang tinggi yaitu sekitar 59,6% dan kasus maloklusi sekitar 12%. Penduduk terbesar di Kalimantan Selatan adalah suku Banjar sekitar 90% dari populasi. Faktor genetik Suku Banjar dapat mempengaruhi perkembangan ukuran gigi sehingga dapat menentukan hasil oklusi normal. Analisis Bolton merupakan indeks yang sering digunakan dan diperlukan untuk menentukan keseimbangan ukuran gigi rahang atas dan bawah. Tujuan: Tujuan penelitian ini untuk mengambarkan keseimbangan ukuran gigi dengan analisis Bolton pada pelajar Suku Banjar (Usia 15-18 Tahun). Metode: Penelitian ini merupakan penelitian observasional deskriptif dengan pendekatan cross-sectional Hasil: Hasil penelitian menunjukan nilai rata-rata keseimbangan ukuran 6 gigi anterior (Anterior Rasio) 79,51% ± 8,67 didapati 97,6% jumlah sampel tidak seimbang dengan frekuensi rahang yang berdeskrepansi terbanyak pada mandibula dan nilai rata-rata keseimbangan ukuran 12 gigi keseluruhan (Overall Rasio) 91,32 ± 5,17 didapati 98,8% jumlah sampel tidak seimbang dengan frekuensi rahang yang berdeskrepansi terbanyak pada maksila yaitu 46 orang (56,1%). Kesimpulan: Keseimbangan ukuran gigi pada Suku Banjar berdasarkan rasio anterior Bolton didapati mayoritas tidak seimbang dengan letak ketidakseimbangan tertinggi pada rahang bawah (mandibula) dan rasio keseluruhan Bolton didapati mayoritas tidak seimbang dengan letak ketidakseimbangan tertinggi pada rahang atas (maksila). Kata kunci : Analisis Bolton, Keseimbangan Ukuran Gigi, Suku Banjar

EFEKTIVITAS ANTIBAKTERI EKSTRAK DAUN KECAPI (Sandoricum koetjape Merr) TERHADAP PERTUMBUHAN BAKTERI Aggregatibacter actinomycetemcomitans (Studi in Vitro) Dini Maulani; Yusrinie Wasiaturrahmah; Bayu Indra Sukmana; I Wayan Arya Krisnawan Firdaus; Irham Taufiqurrahman
Dentin Vol 9, No 1 (2025)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentin.v9i1.16559

Background: Aggressive periodontitis is a disease that rapidly destroys the periodontal tissue caused by the dominance of Aggregatibacter actinomycetemcomitans bacteria by 90%. Aggressive periodontitis treatment can be in the form of antibiotics. One of the antibiotics that can be used is metronidazole gel 25%, but this drug can have side effects if used in the long term. There are herbal plants, namely kecapi leaves (Sandoricum koetjape Merr) which contain compounds that can be used as antibacterials including saponins, alkaloids, flavonoids, and triterpenoids. Objective: To determine the antibacterial effectiveness of kecapi leaves extract (Sandoricum koetjape Merr) concentrations of 10%, 20%, 30%, 40%, 50%, 60%, and 70% on the growth of Aggregatibacter actinomycetemcomitans bacteria. Methods: True experimental design with post test only with control group and there were 9 treatment groups with 3 repetitions. The treatment in this study was kecapi leaves extract concentration of 10%, 20%, 30%, 40%, 50%, 60%, and 70%, the positive control was metronidazole gel 25% and the negative control was aquadest. The antibacterial test used the liquid dilution method to determine the value of Minimum Inhibitory Content (MIC) and solid dilution to determine the value of Minimum Bactericidal Content (MBC). Results: Based on the results and data analysis, it was found that kecapi leaf extract had a Minimum Inhibitory Content (MIC) at a concentration of 10% and a Minimum Inhibitory Content (KBM) at a concentration of 30%. Conclusion: Kecapi leaves extract (Sandoricum koetjape Merr) concentration of 10%, 20%, 30%, 40%, 50%, 60%, and 70% has antibacterial effectiveness against the growth of Aggregatibacter actinomycetemcomitans.Keywords: Aggregatibacter actinomycetemcomitans, Aggressive Periodontitis, Kecapi leaves ABSTRAKLatar belakang: Periodontitis agresif merupakan penyakit yang merusak jaringan periodontal dengan cepat yang disebabkan oleh dominasi bakteri Aggregatibacter actinomycetemcomitans sebesar 90%. Perawatan periodontitis agresif dapat berupa antibiotik. Salah satu antibiotik yang dapat dipakai yaitu metronidazol gel 25%, namun obat ini dapat memberikan efek samping apabila digunakan dalam jangka panjang. Terdapat tumbuhan herbal yaitu daun kecapi (Sandoricum koetjape Merr) yang mengandung senyawa yang dapat digunakan sebagai antibakteri diantaranya saponin, alkaloid, flavonoid, dan triterpenoid. Tujuan: Mengetahui efektivitas antibakteri ekstrak daun kecapi (Sandoricum koetjape Merr) konsentrasi 10%, 20%, 30%, 40%, 50%, 60%, dan 70% terhadap pertumbuhan bakteri Aggregatibacter actinomycetemcomitans. Metode: True experimental dengan desain post test only with control group dan terdapat 9 kelompok perlakuan dengan 3 kali pengulangan. Perlakuan pada penelitian ini yaitu ekstrak daun kecapi konsentrasi 10%, 20%, 30%, 40%, 50%, 60%, dan 70%, kontrol positif berupa metronidazol gel 25% dan kontrol negatif berupa akuades. Uji antibakteri menggunakan metode dilusi cair untuk mengetahui nilai Kadar Hambat Minimum (KHM) dan dilusi padat untuk mengetahui nilai Kadar Bunuh Minimum (KBM). Hasil: Berdasarkan hasil dan analisis data didapatkan bahwa ekstrak daun kecapi memiliki Kadar Hambat Minimum (KHM) pada konsentrasi 10% dan Kadar Bunuh Minimum (KBM) pada konsentrasi 30%. Kesimpulan: Ekstrak daun kecapi (Sandoricum koetjape Merr) konsentrasi 10%, 20%, 30%, 40%, 50%, 60%, dan 70% memiliki efektivitas antibakteri terhadap pertumbuhan bakteri Aggregatibacter actinomycetemcomitans.Kata Kunci : Aggregatibacter actinomycetemcomitans, Daun kecapi, Periodontitis Agresif

UJI EFEKTIVITAS ANTIBAKTERI EKSTRAK DAUN KALANGKALA (Litsea angulata) TERHADAP PERTUMBUHAN BAKTERI Porphyromonas gingivalis (In vitro) Nor Rahman Sugiarto; Yusrinie Wasiaturrahmah; Tri Nurrahman; Muhammad Yanuar Ichrom Nahzi; Juliyatin Putri Utami; Bayu Indra Sukmana
Dentin Vol 9, No 2 (2025)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentin.v9i2.17742

ABSTRACTBackground: Dental and oral health has not been a major focus due to the low level of public awareness regarding the importance of maintaining dental and oral health in Indonesia. Periodontitis is a disease with a prevalence of 74.1% in Indonesia. The main cause of chronic periodontitis is the bacterium Porphyromonas gingivalis. Chlorhexidin 0.2% is gold standard that preventing periodontitis. However Chlorhexidin 0.2% has long-term side effects such as tooth discolouration. Therefore, an alternative mouthwash that has antibacterial properties is needed. Kalangkala leaf (Litsea angulata) is known to have the potential to inhibit the growth of Porphyromonas gingivalis bacteria. Objective: To determine the antibacterial effectiveness of kalangkala (Litsea angulata) leaf extract against Porphyromonas gingivalis bacteria with concentrations of 6.25%, 12.5%, 25%, and 50% based on the minimum inhibitory Concentration (MIC) and minimum bactericidal Concentration(MBC). Methods: True experimental research with posttest-only with control group design. The sample consisted of 6 groups with Chlorhexidin 0.2% as positive control and distilled water as negative control with 4 samples each. Data were analysed using normality, homogeneity, Krusskall wallis, and Mann-whitney tests. Results: From the test results, there was no minimum inhibition 6.25%, 12.5%, 25%, and 50%. The testing was not pursued for MBC. Conclusion: There is no antibacterial effectiveness of kalangkala (Litsea angulata) leaf extract against Porphyromonas gingivalis.Keywords: antibacteria, leaf extract, litsea angulata, porphyromonas gingivalis ABSTRAK Latar Belakang: Kesehatan gigi dan mulut belum menjadi fokus utama karena tingkat kesadaran masyarakat yang rendah terkait pentingnya merawat kesehatan gigi dan mulut di Indonesia Periodontitis merupakan penyakit dengan prevalensi 74,1% di Indonesia. Penyebab utama periodontitis kronis yaitu bakteri Porphyromonas gingivalis. Chlorhexidin 0,2% merupakan gold standard dalam mencegah terjadinya periodontitis, tetapi Chlorhexidin 0,2% memiliki efek samping jangka panjang seperti perubahan warna pada gigi. Untuk mencegah terjadinya efek jangka panjang tersebut perlu obat kumur alternatif yang memiliki sifat antibakteri. Daun kalangkala (Litsea angulata) diketahui memiliki potensi untuk menghambat pertumbuhan bakteri Porphyromonas gingivalis. Tujuan: Mengetahui efektivitas antibakteri ekstrak daun kalangkala (Litsea angulata) terhadap bakteri Porphyromonas gingivalis dengan konsentrasi 6,25%, 12,5%, 25%, dan 50% berdasarkan Kadar hambat minimum (KHM) dan kadar bunuh minimum (KBM) Metode: Penelitian eksperimen murni (True Experimental) dengan rancangan percobaan menggunakan posttest-only with control group design. Sampel terdiri dari 6 kelompok dengan Chlorhexidin 0,2% sebagai kontrol positif dan akuades sebagai kontrol negatif dengan pengulangan masing-masing sebanyak 4 sampel. Data dianalisis dengan uji normalitas, homogenitas, Krusskall wallis, dan uji Mann-whitney. Hasil: Hasil uji tidak terdapat KHM pada semua konsentrasi ekstrak kalangkala yaitu konsentrasi 6,25%, 12,5%, 25%, dan 50%, sehingga tidak dilanjutkan untuk pengujian KBM. Kesimpulan: Tidak terdapat efektifitas antibakteri ekstrak daun kalangkala (Litsea angulata) konsentrasi 6,25%, 12,5%, 25%, dan 50% terhadap bakteri Porphyromonas gingivalis.Kata Kunci: antibakteri, ekstrak daun, litsea angulata porphyromonas gingivalis

PENGARUH PERENDAMAN GIGI DESIDUI PADA LARUTAN KITOSAN SISIK IKAN HARUAN (Channa striata) TERHADAP PELEPASAN ION KALSIUM Noval Ihza Maulana; Didit Aspriyanto; Deby Kania Tri Putri; Yusrinie Wasiaturrahmah; Sherli Diana
Dentin Vol 8, No 2 (2024)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentin.v8i2.13109

ABSTRACTBackground: Haruan fish (Channa striata) scale chitosan solution can maintain tooth structure by reducing the solubility rate of hydroxyapatite which makes up tooth enamel. Haruan fish (Channa striata) scale chitosan solution prevents tooth demineralization in an acidic environment. Objective: To analyze the effect of soaking deciduous teeth in chitosan solution from haruan fish scales (Channa striata) with concentrations of 1.25%, 2.5% and 5% on the release of calcium ions in an acidic environment. Method: Pure experimental research with a post-test only design with control group, consisting of 4 treatment groups. The negative control was immersion of deciduous teeth in lactic acid solution pH 5.2, and treatment groups with concentrations of 1.25%, 2.5% and 5%. All groups soaked deciduous teeth in lactic acid solution with a pH of 5.2 for each group. Measurement of calcium release levels in deciduous teeth using UV-Vis spectrophotometry instruments. Results: The results of this study are hypothesized to be acceptable or that there is an effect of soaking deciduous teeth in haruan fish scale chitosan (Channa striata) concentrations of 1.25%, 2.5% and 5% in inhibiting the release of calcium ions. This study showed that there were no significant differences between the 1.25%, 2.5% and 5% treatment groups, but there were significant differences between the control group and all treatment groups. Conclusion: Haruan fish (Channa striata) scale chitosan with concentrations of 1.25%, 2.5%, and 5% is able to inhibit the release of calcium in deciduous teeth and has potential as a demineralization inhibitor biomaterial.Keywords : Caries, Calcium, Chitosan, Demineralization, Haruan. ABSTRAK Latar Belakang: Larutan kitosan sisik ikan haruan (Channa striata) dapat menjaga struktur gigi melalui proses penurunan laju kelarutan hidroksiapatit penyusun enamel gigi. Larutan kitosan sisik ikan haruan (Channa striata) mencegah demineralisasi gigi dalam lingkungan asam. Tujuan: Menganalisis pengaruh perendaman gigi desidui pada larutan kitosan dari sisik ikan haruan (Channa striata) dengan konsentrasi 1,25%, 2,5%, dan 5% terhadap pelepasan ion kalsium dalam lingkungan asam. Metode: Penelitian eksperimental murni dengan desain post-test only with control group, terdiri dari 4 kelompok perlakuan. Kontrol negatif yaitu perendaman gigi desidui pada larutan asam laktat pH 5,2, dan kelompok perlakuan konsentrasi 1,25%, 2,5%, serta 5%. Semua kelompok perendaman gigi desidui dalam larutan asam laktat dengan pH 5,2 dilakukan pada setiap kelompok. Pengukuran kadar pelepasan kalsium gigi desidui menggunakan instrumen spektrofotometri UV-Vis. Hasil: Hasil penelitian ini hipotesis dapat diterima atau adanya pengaruh perendaman gigi desidui pada kitosan sisik ikan haruan (Channa striata) konsentrasi 1,25%, 2,5%, dan 5% dalam menghambat pelepasan ion kalsium. Pada penelitian ini menunjukkan tidak adanya perbedaan signifikan antar kelompok perlakuan 1,25%, 2,5%, dan 5%, namun terdapat perbedaan bermakna antara kelompok kontrol dengan semua kelompok perlakuan. Kesimpulan: Kitosan sisik ikan haruan (Channa striata) dengan konsentrasi 1,25%, 2,5%, dan 5% mampu menghambat pelepasan kalsium pada gigi desidui dan memiliki potensi sebagai biomaterial agen penghambat demineralisasi. Kata kunci : Demineralisasi, Haruan, Kalsium, Karies, Kitosan

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