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All Journal Jurnal Tumbuhan Obat Indonesia Biota Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY Journal of Islamic Pharmacy Science and Technology Indonesia Jurnal Farmasi Sains dan Komunitas Journal of Islamic Medicine Jurnal Biolokus: Jurnal Penelitian Pendidikan Biologi dan Biologi Pharmed: Journal of Pharmaceutical Science and Medical Research Pharmademica: Jurnal Kefarmasian dan Gizi Jurnal Sains dan Kesehatan
Weka Sidha Bhagawan
Universitas PGRI Madiun
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health

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The effect of genitri (Elaeocarpus ganitrus) in leukocytes profile of wistar rats as a prospective immunomodulatory agent Primiani, Cicilia Novi; Pujiati, Pujiati; Bhagawan, Weka Sidha; Waris, Waris; Krisnamurti, Gabriella Chandrakirana
Jurnal Biolokus : Jurnal Penelitian Pendidikan Biologi dan Biologi Vol 8, No 1 (2025): June
Publisher : Universitas Islam Negeri Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30821/biolokus.v8i1.3987

Abstract

Immunomodulator is an agent to activate and modulate the immune response. It is one of the approaches to prevent chronic disease and maintain homeostasis. Recently,  plant phytochemicals have been developed as prospective immunomodulatory agents. Genitri (Elaeocarpus ganitrus), a local plant cultivated in Indonesia, exhibited various biological properties and potential as an immunomodulatory agent. This study aims to identify the potency of genitri as immunomodulatory agent through leukocyte profiling. Genitri leaf (P1), seed (P2), and fruit (P3) were prepared as powder and administered to male wistar rats weighted 250-300 g twith six replications for 28 days. The total leukocytes were  counted and leukocytes were being  profiled following the treatment with genitri powder then  compared with control treatment (P0). The immunomodulatory activity of genitri was shown by the increased leukocytes count following treatment. Based on data from the treatment group (P2), genitri seeds were able to increase leukocytes by 10595.83 cells/µl. The highest total leukocytes were found in treatment P2 with total leukocytes 10595.83 cells/µl. Based on the leukocyte profile, lymphocytes and monocytes were found to be the highest in all treatments. Treatment with genitri was able to stimulate an increase in lymphocytes and monocytes. An increase in total leukocytes given genitri is an indication of an increased immune response.
Co-Authors . Waris Agnis Pondineka Ria Aditama Aissyah Nurfatma Amaranto, Jennifer Anik Listiyana Annisa, Rahmi Arum Suproborini Arum Suproborini Asri Wido Mukti Asti Rahayu Atiqah, Sri Nur Atiza Fajrin Maulidya Bhagawan, Weka Burhan Ma'arif Burhan Ma’arif Cicilia Novi Primiani Cicilia Novi Primiani Devi Safrina Dewi Ratih Tirto Sari Dian Susanti Donato, Percival Faisal Akhmal Muslikh Fidia Rizkiah Inayatilah Firsta Roisatul Islamiyah Hadya, Chorida Muhjatul Heni Pujiastuti Hison, Jade Huwaida, Fadhila Isma Irawati, Santia Izza Nailia Shirvi Jauhar Maknun Septaza Rahmandika Krisnamurti, Gabriella Chandrakirana Kurniawan Hidayat Perdana Putra Lestari, Nia Ayu Lisniawati Lisniawati M Bakti Samsu Adi Ma'arif Z.A, Burhan Ma'arif, Burhan Ma'arif, Burhan Mandalawati, Titin Maritha, Vevi Mochammad Amrun Hidayat Muhammad Evy Prastiyanto Norachuriya, Zedny Nur Rahmawati Wijaya Nurfatma, Aissyah Octavia, Nur Ika Peria, Jo Prasetyo, Yona Primiani, Cicilia Novi Primiani, Cicilia Novi Primiani Pujiati Pujiati Pujiati Putra, Aditya Dwi Permana Rahmawati, Eka Diana Rahmi Annisa Ramadhani D.A., Ria Ramdhani, Alfina Widya Retno Susilowati Ria Ramadhani Dwi Atmaja Rina Nurmaulawati Rivera, Alice Rizal Maarif Rukmana, Rizal Maarif Rizkiah, Fidia Roihatul Mutiah Roihatul Mutiah Safitri, Rusiana Yulia Santos, Gema Silfarohana, Rantika Suproborini, Arum Tanghal, Analiza Taufik, Imam Teguh Pamungkas, Rizki Putra Ubaidillah Abdel Barsyaif Yanuar Ashari Cahyaningrum Yaya Sulthon Aziz Yen Yen Ari Indrawijaya Zatalini, Dioni Zatalini, Dioni Fadia