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All Journal Jurnal Kedokteran Brawijaya e-Journal Pustaka Kesehatan Dentika Dental Journal Jurnal Pangan dan Agroindustri STOMATOGNATIC- Jurnal Kedokteran Gigi ODONTO Dental Journal Insisiva Dental Journal : Majalah Kedokteran Gigi Insisiva UNEJ e-Proceeding Dental Journal (Majalah Kedokteran Gigi) Jurnal Kedokteran Gigi Universitas Padjadjaran Padjadjaran Journal of Dentistry Journal of Dentomaxillofacial Science Jurnal Kesehatan Komunitas Warta Pengabdian Padjadjaran Journal of Dental Researchers and Students Jurnal Material Kedokteran Gigi Indonesian Journal of Life Sciences Odonto dental journal Jurnal Penelitian The Indonesian Journal of Health Science
Zahreni Hamzah
Bagian Biomedik, Fakultas Kedokteran Gigi, Universitas Jember, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Health Professions Immunology & microbiology Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Potensi ekstrak daun singkong (Manihot esculenta Crantz.) terhadap profil leukosit darah tepi model tikus disfungsi ovarium dan periodontitisPotential of cassava leaves (Manihot esculenta Crantz.) extract on peripheral blood leukocyte profile in ovary dysfunction and periodontitis rat model Lutfi Meiga Sari; Zahara Meilawaty; Pudji Astuti; Amandia Dewi Permana Shita; Agustin Wulan Suci Dharmayanti; Zahreni Hamzah
Jurnal Kedokteran Gigi Universitas Padjadjaran Vol 33, No 1 (2021): April 2021
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/jkg.v33i1.30751

Abstract

Pendahuluan: Disfungsi ovarium merupakan keadaan ovarium yang mengalami kegagalan dalam sekresi hormon seks steroid. Penurunan sekresi hormon terutama estrogen dapat memicu peningkatan sitokin proinflamasi seperti IL-1, IL-6 dan TNF-α yang berperan dalam resorpsi tulang dan reaksi inflamasi periodontal. Salah satu drug of choice dari periodontitis adalah metronidazole. Penggunaan metronidazole secara sistemik dapat mengakibatkan efek samping, sehingga diperlukan bahan alternatif yang memiliki efek terapi antiinflamasi. Salah satu tanaman yang memiliki efek antiinflamasi adalah daun Singkong. Tujuan penelitian adalah menganalisis potensi ekstrak daun Singkong sebagai antiinflamasi terhadap profil leukosit darah tepi model tikus disfungsi ovarium dan periodontitis. Metode: Jenis penelitian eksperimental laboratoris dengan post-test only control group design. Sampel penelitian sebanyak 18 ekor tikus betina yang dibagi menjadi dua kelompok besar yakni kelompok disfungsi ovarium dan kelompok kecil periodontitis. Pembuatan model tikus disfungsi ovarium dan tikus periodontitis dilakukan selama 28 hari. Setelah masing-masing kelompok dibagi menjadi 3 kelompok yang diberikan perlakuan aquades, metronidazole dan ekstrak daun Singkong selama 7 hari. Setiap tikus diambil darahnya melalui plexus infraorbitalis pada hari ke-1, hari ke-3 dan hari ke-7. Darah yang diambil selanjutnya dilakukan perhitungan jumlah sel leukosit darah tepi menggunakan kamar hitung dan perhitungan jenis dengan cara visual. Hasil: Hasil uji LSD menunjukkan bahwa terdapat perbedaan bermakna jumlah leukosit darah tepi antar hari pada kelompok tikus yang mengalami disfungsi ovarium (p≤0,05). Simpulan: Ekstrak daun Singkong (Manihot esculenta Crantz) dapat menurunkan profil leukosit perifer model tikus disfungsi ovarium dan periodontitis.Kata kunci: Disfungsi ovarium, periodontitis, profil leukosit perifer, ekstrak daun singkong. ABSTRACTIntroduction: Ovarian dysfunction is when the ovaries fail in the secretion of steroid sex hormones. Decreased secretion of hormones, especially estrogen, can trigger an increase in pro-inflammatory cytokines such as IL-1, IL-6 and TNF-α, which play a role in bone resorption and periodontal inflammatory reactions. One drug of choice for periodontitis is metronidazole. Systemic use of metronidazole can cause side effects, so an alternative material with a therapeutic anti-inflammatory effect is needed. One of the plants that have an anti-inflammatory effect is cassava leaves. The research objective was to analyse the potential of cassava leaf extract as an anti-inflammatory against the peripheral blood leukocyte profile in a mouse model of ovarian dysfunction and periodontitis. Methods: This was an experimental laboratory study with a post-test only control group design. The research sample consisted of 18 female rats divided into two large groups: the ovarian dysfunction group and the small periodontitis group. The making of mouse models of ovarian dysfunction and periodontitis rats was carried out for 28 days. After each group was divided into three groups treated with distilled water, metronidazole and cassava leaf extract for seven days. Blood was drawn from each mouse through the infraorbital plexus on day 1, day three, and 7. The blood that was taken was then performed to calculate the number of peripheral blood leukocytes using the counting room and the calculation of the type by visual means. Results: The results of the LSD test showed that there was a significant difference in the number of peripheral blood leukocytes between days in the group of rats with ovarian dysfunction (p≤0.05). Conclusion: Cassava leaf extract (Manihot esculenta Crantz) can reduce the profile of peripheral leukocytes in a mouse model of ovarian dysfunction and periodontitis.Keywords: Ovarian dysfunction, periodontitis, peripheral leukocytes profile, cassava leaf extract.
Pencabutan Gigi yang Irrasional Mempercepat Penurunan Struktur Anatomis dan Fungsi Tulang Alveolar Zahreni Hamzah; Nadia Kartikasari
STOMATOGNATIC - Jurnal Kedokteran Gigi Vol 12 No 2 (2015)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

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Abstract

Tooth extraction is the most common dental treatment procedure in Indonesia. This is happened due to lack of knowledge and awareness of the effect of tooth extraction. Many patients requested dental extraction for some reason such as do not stand the pain anymore, dental treatment is expensive and long, althought the fact that such cases can still be treated. This condition called irrational extraction. Irrational extraction may cause loss of important componets for bone regeneration such as periodontal ligament stem cells/PDLSC, dental pulp stem cells/DPSC, extracellular matrix/ECM and local growth factor. PDLSC has potential differentiation into osteoblast, fibroblast periodontal ligament, and sementoblast. DPSC induces odontontoblast to form reparative dentin. Local growth factors are important component for hard and soft tissue regeneration. Due to loss of important component for bone regeneration, bone became small, thin, and brittle, which allows bone fracture. The purpose of this review is to explain the effect of irrational extraction on mesenchymal stem cell, periodontal ligament, ECM, and local growth factor. This knowledge is expected to reduce irrational tooth extraction.
Hubungan Kadar Insulin Pankreas dan Kadar Glukosa Darah pada Model Tikus Wistar Jantan setelah Diinduksi Bisphenol-A Mala Hayati; Zahreni Hamzah; Ari Tri Wanodyo
STOMATOGNATIC - Jurnal Kedokteran Gigi Vol 17 No 1 (2020)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/stoma.v17i1.23606

Abstract

This study was to determine the relation between pancreas insulin levels and blood glucose levels in male wistar rat models after Bisphenol-A induction. This research was a laboratory experimental study with a randomized separate pretest-post test control group design. The samples consist of 12 rats that divided into 2 groups. Each group consist 6 rats. In the treatment group, bisphenol-a is given peroral at a dose of 20mg/ kg for 28 days. Pancreas insulin levels will be examined by ELISA and blood glucose levels measurement done by glucometer before decapitation procedure. The data were analyzed by Pearson correlation test for blood glucose levels and pancreas insulin levels (p <0.05). The results showed r count (0.802), sig. 2 tailed (0.002), which mean there is a strong correlation and a positive relation between pancreas insulin levels and blood glucose levels. The higher the pancreas insulin levels, the blood glucose levels will also increase. There was a strong correlation and a positive relation between pancreas insulin levels and blood glucose levels, which is when pancreas insulin levels elevated, blood glucose levels will also be increased in BPA-induced rat with dose of 20 mg / kg / day for 28 days.
Pengaruh Bisphenol-A (BPA) terhadap Kadar Insulin Pada Hepar Tikus Wistar Jantan Rizky Purboningtyas; Zahreni Hamzah; Swasthi Prasetyarini
STOMATOGNATIC - Jurnal Kedokteran Gigi Vol 16 No 2 (2019)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/stoma.v16i2.23089

Abstract

Bisphenol-A (BPA) is a synthetic chemical substance in the form of monomers which is commonly used as plastic constituents. BPA is often found in household appliances, food and beverage containers, and in dental sealants and acrylic base dentures. BPA can contaminate or enter the human body mostly through oral route or swallowed along with food consumed. It is known that BPA exposure through the oral route can cause several diseases, and one of them is endocrine and metabolic problems, which is Diabetes Mellitus. This study was to analyze the decrease of insulin levels in the liver of male Wistar rats after being exposed by BPA. 18 adult male Wistar rats were divided into 3 groups. Group I (control 1) was not given any treatment, only acclimatized for 7 days. Group II (control 2) was treated with sterile aquadest orally for 28 days. Group III (treatment group) was given oral BPA treatment with a dose of 20 mg / kg body weight for 28 days. After sacrificed, the hepar was homogenated and the insulin level was determined by ELISA. Data were analyzed with One Way Anova test and LSD test. Bisphenol-A (BPA) with a dose of 20 mg/kgBB exposed for 28 days can reduce on hepar insulin levels in adult male Wistar rats.
Pengaruh BPA (Bisphenol A) terhadap Kadar Insulin dalam Serum Darah Tikus Wistar Jantan Fitria Nurhabiba Agustine; Swasthi Prasetyarini; Zahreni Hamzah
STOMATOGNATIC - Jurnal Kedokteran Gigi Vol 16 No 1 (2019)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/stoma.v16i1.19959

Abstract

BPA is a synthetic material that widely used in basic material of PVC making. PVC is needed in production of household appliances, food container, mineral water bottles, feeding bottles and dental sealant. BPA is known as one of EDCs which have an effect to increase insulin levels on blood. Furthermore, BPA could lead to DMT2. The objective was to determine the effect of BPA on blood insulin levels in adult male wistar rats. 18 male wistar rats were divided into 3 groups. BPA solution was made by dissolve 20 mg/kgBB crystal BPA into corn oil. Group 1 (K1) not given any treatment and dissected in day-0. Group 2 (K2) given aquadest treatment orally for 28 days and dissected in day-29. Group 3 (P) given BPA solution treatment orally for 28 days and dissected in day-29. The treatment given once a day on 09.00 AM. The blood collected after 12 hours fasting. Blood collecting procedure done with the rats were anasthetized first with eter 10% through inhalation and then dissect the rats until the heart is exposed. Blood was collected from the heart for 3 ml and were sentrifugated to get the serum. Insulin examination done by ELISA on serum that has been collected. Data were analyzed by One Way Anova test and Post hoc Test LSD. BPA with 20 mg/kgBB dose increasing blood serum insulin levels on adult male wistar rats by 1,38 mIU/L.
Profil Tekanan Darah Pada Lansia di Kecamatan Arjasa Kabupaten Jember Tantin Ermawati; Suhartini Suhartini; Zahreni Hamzah Hamzah; Zahara Meilawati
Warta Pengabdian Vol 11 No 4 (2017): Warta Pengabdian
Publisher : LP2M Universitas Jember

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Abstract

Pada tahap lanjut usia akan terjadi perubahan-perubahan terutama pada perubahan fisiologis karena dengan semakin bertambahnya usia, fungsi organ tubuh akan semakin menurun. Salah satunya adalah perubahan elastisitas pembuluh darah yang dapat mengakitkan peningkatan tekanan darah. Tujuan dari pengabdian dan penelitian ini adalah untuk mengetahui profil tekanan darah pada lansia di Kecamatan Arjasa Kabupaten Jember. Jenis penelitian ini adalah penelitian diskriptif observasional secara cross sectional. Subyek penelitian diambil dari populasi lansia di Kecamatan Arjasa yang dilakukan pengukuran tekanan darah sistole dan tekanan diastole dengan metode auskultasi. Hasil pengukuran menunjukkan bahwa tekanan sistole khususnya pada kelompok lansia usia 60-74 tahun mengalami peningkatan kurang lebih 20 mmHg dari tekanan darah sistole yang normal. Sedangkan pada tekanan diastole, untuk semua kelompok usia mengalami peningkatan 3-8 mmHg. Adanya perubahan pada tekanan darah ini di pengaruhi oleh banyak faktor. Faktor Usia menjadi alah satu faktor yang menyebabkan peningkatan darah.
The benefits of information system of water pollution at Bedadung river towards oral and dental health of the community Heru Ernanda; Zahreni Hamzah; Dyah I. Setyowati; Ary TW. Handayani; Tecky Indriana
Journal of Dentomaxillofacial Science Vol. 3 No. 2 (2018): (Available online: 1 August 2018)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/jdmfs.v3i2.738

Abstract

Objective: The purpose of creating the river water pollution information systems related to oral and dental health community is to facilitate the analysis of diseases caused by water pollution.Material and Methods: The Environment-based Health Management Information System based on GIS is based on real data of Bedadung River-Jember Regency, East Java, Indonesia includes the location of the dumping points, photo dumping points, the area of garbage accumulation, and tooth and mouth disorders that arise due to contamination of river water, which is associated with community dental and oral health data that taken by survey.Results: Through the Environmental Health Information System information can be displayed about the environment and the dental and oral status of the population around the Bedadung river.Conclusion: The use of the Environment-Based Health Management Information System is very important to help support the government's decision to prevent the spread and severity of community diseases caused by river water pollution, reduce morbidity and mortality, and reduce the burden of government financing to treat diseases and disability integrated in an integrated manner.
Potential number of tooth losses in clicking, popping and crepitation of Temporomandibular Disorders (TMD) in elderly Elfrida M. Agustina; Zahreni Hamzah; Zainul Cholid
Journal of Dentomaxillofacial Science Vol. 5 No. 3 (2020): (Available online: 1 December 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/jdmfs.v5i3.1078

Abstract

Objective: Clicking, popping, and crepitation is the most common symptom of Temporomandibular Disorders (TMD). TMD can be caused by tooth loss, and tooth loss is widespread among the elderly. Material and Methods: This research is using a correlational analysis with a cross-sectional study approach. Tooth loss was divided into six regions (R1, R2, R3, R4, R5, R6) and joint sounds were divided into four categories (clicking, popping, crepitation, normal). Result: Multinomial logistic regression analysis test for overall tooth loss showed a p-value of 0.000 in clicking and crepitation, and for popping, it has a p-value of 0.248. The results of tests on six regions of tooth loss obtained a p-value of 0.017 at R1 for clicking sound and p-value of 0.014 at R2 for crepitation. This showed that clicking and crepitation had a significant correlation with the amount of tooth loss (p<0.05). Conclusion: The amount of tooth loss has a significant relationship with clicking and crepitation of Temporomandibular Joint (TMJ).
Studi pendahuluan silika amorf sekam padi sebagai scaffold sintetis bone graft: efeknya terhadap aktivitas sel osteoblas (In-vitro) Didin Erma Indahyani; Zahreni Hamzah; Pujiana Endah Lestari
Jurnal Material Kedokteran Gigi Vol 1 No 1 (2012): JMKG Vol 1 No 1 Maret 2012
Publisher : Ikatan Peminat Ilmu Material dan Alat Kedokteran Gigi (IPAMAGI)

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Abstract

Synthetic bone graft material was developed as a scaffold that serves to template the formation of bone. The ideal scaffold should be biodegradable, osteoindukctive, and osteoconductive. Silica proven to support and promote bone growth. Rice husk contains silica is quite high. The purpose of this study is to analyze the amorphous silica from rice husk as synthetic bone graft material (scaffold), particularly on osteoblast activity in vitro. The research was conducted by isolating silica from rice husk.The results of isolation would be conditioned on the culture medium of primary osteoblasts. Primary osteoblast cultures derived from rat calvaria wistar age of 2 days, growing in Alpha-Modified Eagle Medium (α-MEM) (as a negative control), α-MEM in conditioning with silica 58s (as a positive control) and α-MEM that conditioned with silica from rice husk (as treatment group). Osteoblast activity was observed by analyzing the expression of alkaline phosphatase, using Alkaline phosphatase Kits at days 7 and 14. The results obtained that the rice husk silica were significantly (p <0.05) has the expression of alkaline phosphatase higher than the control group and potitif group. This may imply that the amorphous silica of rice husk affects the increase in osteoblast activity in vitro. It was concluded that rice husk silica increases osteoblast cell activity that is potentially as scaffold for bone graft synthetic material.
Efektivitas Ekstrak Bawang Putih dan Bawang Hitam dalam Menghambat Pertumbuhan Candida albicans Ni Made Widia Sasmita Indraswari; Dyah Indartin Setyowati; Zahreni Hamzah
Pustaka Kesehatan Vol 10 No 2 (2022): Volume 10 No.2, 2022
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v10i2.14625

Abstract

Antifungal drugs that already exist have several side effects, so it needs to be developed a new drug from natural ingredients. Garlic and black garlic are known to have organosulfur compounds that can be used as an antifungal. This study aimed to determine the effectiveness of garlic (A. sativum) and black garlic extract in inhibiting the growth of Candida albicans. This study used 3 groups, namely control group, the garlic (A. sativum) extract group and the black garlic extract group by using concentration 100%, 75%, 50%, and 25% with 3 times replication. Extraction using maceration method with 96% ethanol solvent, while the antifungal test using disk diffusion method. antifungal effect is determined by calculating the inhibition zone formed on Sabouraud Dextrosa Agar (SDA) media after incubating for 24 hours. The results of Kruskall-Wallis test showed a significance value (p <0.05) which means there were differences in all groups. In the Mann-Whitney test showed a significance value (p >0.05) which means there are no significant differences between treatment groups. In conclusion, garlic extract is more effective compared to black garlic extract but the difference is not significant.
Co-Authors Adji , Novan Krisno Agustin Wulan Suci Dharmayanti Amandia Dewi Permana Shita Amandia Dewi Permana Shita Ari Tri Wanodyo Ari Tri Wanodyo Handayani Ari Tri Wanodyo Handayani Ari Tri Wanodyo Handayani Arina, Yuliana Mahdiyah Daat Ary TW. Handayani Asyifa Af Ida Haffiz Banun Kusumawardani Daat Arin, Yuliana Mahdiyah Debi Suntari Dessy Rachmawati Didin Erma Indahyani Dominica Diana Siswadi Dwi Prijatmoko Dwi Saputro, Agung Erdiyanto Anindito Dwi Warna Aju Fatmawati Dwita Aryadina Rachmawati Dyah I. Setyowati Dyah Indartin Dyah Indartin Setyowati Dyah Indartin Setyowati Dyah Indartin Setyowati Elfrida M. Agustina Elyana Asnar STP Elyda Akhya Afida Misrohmasari Endang Joewarini Erfin Ramadana Pratama Erna Sulistyani Fitria Nurhabiba Agustine Hafizh, Cinantya Handayani, Ari T.W. Happy Harmono Heru Ernanda Hosea Ferdinan Ida Bagus Narmada Izzata Barid Jevina Sicilia Ahliawan kristianningrum dian Kristianningrum Dian Sofiana Kushariyadi Kushariyadi Kusumadewi, Jihan Tahira Lisa Wahyu Zelda Federika Lutfi Meiga Sari Mala Hayati Mei Syafriadi Melok Aris Wahyukundari, Melok Aris Nadia Kartikasari Ni Made Widia Sasmita Indraswari Niken Probosari Paramudibta Lungit Kuncaraningtyas Piramida, Delyta Prasetyo , Aris Pratama, Armando Hayden Maghriza Prihatiningrum, Berlian Pudji Astuti Pujiana Endah Lestari Purwandhono , Azham Rizki Fitriani, Atmim Rizky Purboningtyas Rondhianto Rondhianto Rothschildi, Dhesyarmani Putri Sari Setyaningsih Setyaningsih, Sari Suhartini Suhartini Suhartini Suhartini Suhartini Suhartini Suhartini Suhartono Taat Putra Swasthi Prasetyarini Tantin Ermawati Tecky Indriana Zahara Meilawati Zahara Meilawaty Zainul Cholid