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All Journal MEDIA MEDIKA INDONESIANA Journal of Nutrition and Health JURNAL GIZI INDONESIA JURNAL PROMOSI KESEHATAN INDONESIA Journal of Nutrition College Jurnal Keolahragaan Journal of Biomedicine and Translational Research Indonesian Journal of Human Nutrition Sari Pediatri GIZI INDONESIA Wikrama Parahita : Jurnal Pengabdian Masyarakat AcTion: Aceh Nutrition Journal Jurnal Gizi Klinik Indonesia JOURNAL SPORT AREA ENDOGAMI Jurnal Ilmiah Kajian Antropologi Jurnal Aplikasi Teknologi Pangan Journal of Applied Food Technology Amerta Nutrition Indonesian Journal of Global Health research Journal SAGO Gizi dan Kesehatan Poltekita: Jurnal Ilmu Kesehatan Media Penelitian dan Pengembangan Kesehatan Penelitian Gizi dan Makanan (The Journal of Nutrition and Food Research) JSSF : Journal of Sport Science and Fitness Jurnal Info Kesehatan Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Etika Ratna Noer
Department Of Nutrition Science, Faculty Of Medicine, Universitas Diponegoro, Semarang, Indonesia; Center Of Nutrition Research (CENURE), Faculty Of Medicine, Universitas Diponegoro, Semarang, Indonesia
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : Poltekita: Jurnal Ilmu Kesehatan

 1 
Effect of Leunca Fruit (Solanum nigrum L.) on Oxidative Stress in rats fed a High Fat High Sucrose Diet Nurdin, Nurhanifah Muthmainnah; Muis, Siti Fatimah; Anjani, Gemala; Noer, Etika Ratna; Ayustaningwarno, Fitriyono
Poltekita: Jurnal Ilmu Kesehatan Vol. 18 No. 3 (2024)
Publisher : Poltekkes Kemenkes Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33860/jik.v18i3.3818

Abstract

Decreased levels of superoxide dismutase (SOD) and increased levels of malondialdehyde (MDA) are markers of oxidative stress and indicate obesity. Leunca fruit (Solanum Nigrum L) is a plant that contains antioxidants that can reduce the level of oxidative stress in obesity. The purpose of this study was to determine the effect of leunca fruit administration on SOD and MDA levels in obese rats. This type of research is true experimental with a post-test-only research design where 30 male Sprague Dawley rats were divided into five groups consisting of 2 control groups K(-) and K(+) and three treatment groups (P1, P2, P3). Groups K+, P1, P2, and P3 were fed a high-fat and sucrose diet (21% lard, 34% sucrose). The K (-) control group is a group of healthy rats that only receive standard feed without being given leunca fruit. Group K (+) is a group of obese rats without leunca fruit. Leunca fruit was given for six weeks at a dose of 0.8g (P1), 1.6g (P2), and 2.4g (P3). Serum SOD levels were measured by ELISA method and MDA levels were measured by TBARS method. Statistical analysis using One Way Anova test. Administration of leunca fruit with graded doses can significantly increase SOD activity p=0.000 (p<0.05) and can significantly reduce MDA levels in obese rats in each treatment group p=0.000 (p<0.05). Leunca fruit with a dose of 2.4g/BB rat is the most effective dose to increase SOD levels and reduce MDA levels. The limitation of this study that there is no weighing of the remaining rat feed at each meal, so that the percentage of rat intake is was unknown.
Co-Authors ,Adriyan Pramono Adhimah, Ayu Fauziyyah Adriyan Pramono Ahmad Syauqy Akifah, Adzro'ul Ali Rosidi Amalia Nita Widyastuti, Amalia Nita Ameliora Dwi Astani Amirullah, M Fadil Anggia Berlian Buntarlan Anggit Wicaksono Anggriany, Nissa Ani - Margawati Ani Margawati Ani Margawati Anjani, Gemala Apoina Kartini Argan Caesar Budiatmaja Arviyani, Tiffany Nisa Arwinda Nugraheni Aryu Candra Astrine Permata Leoni Ayu Rahadiyanti Befi Sundari Binar Panunggal BR Purba, Martalena Candra, Adiska Rani Ditya Choirun Nissa Choirun Nissa Danarsi, Chorina Swasti Denny Nugroho Sugianto Deny Yudi Fitranti Deny Yudy Fitranti Desi Sofiyana destiana - florencia Destikasari, Widya Dewanti Dewanti Dewi Kurnia Sandi Dewi Marfu’ah Kurniawati Dewi, Luthfia Dian Ratna Sawitri Diana Nur Afifah, Diana Nur Djuara P Lubis Elvizahro Leiyla Endang Mahati Endang Mahati Endrinikapoulos, Ariana Enny Probosari Erin Ratna Kustanti Etisa Adi Murbawani Faizah Fulyani Fajrani, Alifia Mukti Fajrani, alifiaA muktiM Farid Agung Rahmadi, Farid Agung Fatih Az Zahra Febriani, Brilliantika Resy Fidiasari, Intan Sepna Fillah Fithra Dieny Fillah Fitra Dieny Fitriyanti, Addina Rizky Fitriyono Ayustaningwarno Fronthea Swastawati Gunawan, Sekar Ayu Putri Gustiana Mega Anggita Hardhono Susanto Hartanti Sandi Wijayanti Hastuti, Vivilia Niken Henny, Via Anugrah Hersanti Sulistyaningrum Hidayati Hidayati Ihat Hatimah Ilmiati, Fatia Ira Roza Milinda Jamhari Jamhari Jauharany, Firdananda Fikri Khasanah, Dwi Puji Khikmaturrohman, Sya’bani Isnaen KIRANA LAKSMI Kusmiyati Tjahjono Kusuma, Donny Wira Yudha Leo Nacion Santillana Lingga Edytias Pratiwi Lora Sri Nofi Maria Martiani Maria Mexitalia Maria Mexitalia Maria Pangkrasia Kirimunun Marsa, Firdaus Shadiqa Martalena Br Purba MARTHA ARDIARIA Martha Irene Kartasurya Miftahul Adnan Mita Arini Mohammad Arif Ali, Mohammad Arif Mohammad Sulchan Mohammad Zen Rahfiludin Muflihatul Muniroh Muniroh, Muflihatul Nani Maharani Nawai, Fatmayanti Niken Puruhita Ninik Rustanti Novitasari, Anggi Nurahmatika, Prisma Nurdin, Nurhanifah Muthmainnah Nurjanah, Ayu Nurmasari Widyastuti Nuryanto Nuryanto Nyoman Suci Widyastiti Perdanawati, Mia Permatasari, Mayang Januarti Pramita Ariawati Putri Purwita Wijaya Laksmi Rachma Purwanti Rahardiyanti, Ayu Rahma, Devi Elvina Randenia, Nabila Reny Sartika Ria Purnawian Sulistiani Ria Purnawian Sulistiani, Ria Purnawian Robi Andoyo Roni Aruben Rosmalinda, Yusie Said Junaidi Sandi, Dewi Kurnia Siti Baitul Mukarromah Siti Fatimah Muis Siti Fatimah Muis Sophia Rose Sri Achadi Nugraheni Sugiarto Sugiarto Sumardi Widodo Suroto Tiara Rosania Hestuningtyas Tiffany Nisa Arviyani Titis Rakhma Imtihani Tjahjono, Kusmiyati DK Tsani, A. Fahmy Arif Usydatul Falasifah Vanessa Yudha Azizul Ilmi Widya Destikasari Widyastuti, Trioni Winda Amalia Pertiwi Wita Rizki Amelia Yenni, Fitri Yuswo Supatmo Zainab Sholihah Zainudin Amali Zelyn Damayanti Zetta, Adelia Paradya