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All Journal INDONESIAN JOURNAL OF PHARMACY UNEJ e-Proceeding JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Science and Technology Indonesia Panrita Abdi - Jurnal Pengabdian pada Masyarakat Health Notions Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat Indonesian Journal of Chemistry JSFK (Jurnal Sains Farmasi & Klinis) PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang Jurnal Abdi: Media Pengabdian Kepada Masyarakat Jurnal Layanan Masyarakat (Journal of Public Service) Archives Pharmacia Pharmaceutical Sciences and Research (PSR) Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Sains dan Kesehatan Folia Medica Indonesiana
Noorma Rosita
Departemen Ilmu Kefarmasian, Fakultas Farmasi, Universitas Airlangga, Surabaya
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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DESIGN AND OPTIMIZATION OF VCO AND OLEIC ACID FOR NLC QUERCETIN USING SIMPLE LATTICE DESIGN Cahyono, Definta Anisa Tamara; Rosita, Noorma; Erawati, Tristiana
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 3 (2025)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i3.1747

Abstract

Quercetin is a flavonoid compound that exhibits skin-brightening activity by inhibiting tyrosinase. However, its topical application is limited because of its low solubility. A Nanostructured Lipid Carrier (NLC) was selected as the delivery system to enhance the stability and topical efficacy of quercetin. This study aimed to optimize the combination ratio of oleic acid and Virgin Coconut Oil (VCO) as the liquid lipid phase in the NLC Blank Formulation using the Simplex Lattice Design (SLD) method. Eight blank NLC formulations were prepared using the high-shear homogenization method and were evaluated based on organoleptic properties, particle size, polydispersity index (PDI), pH, and real-time stability over 30 days. Eight blank NLC Blank Formulations showed that a balanced VCO to oleic acid ratio (5.5:4.5) produced small particle sizes (<160 nm), low polydispersity index (PDI <0.25), and good physical stability. Blank Formulations dominated by either VCO or oleic acid tended to have larger particles and lower stability, indicating that the liquid lipid ratio influenced the NLC characteristics. Optimization using the Simplex Lattice Design (SLD) method identified three optimal lipid ratios: B1 (4.86:5.31), B2 (2:8), and B3 (9:1), each with desirability values near 1. The model was validated by comparing the predicted (dry lab) and experimental (wet lab) data, which showed no significant differences in key parameters (p > 0.05), confirming the reliability of the SLD model. This approach effectively optimized quercetin-loaded NLC Blank Formulations, and the three selected Blank Formulas serve as a strong basis for developing topical quercetin NLC products.
Peningkatan Pemberdayaan Masyarakat Tuban tentang Keamanan dan Kehalalan Pangan dalam Rangka Mempertahankan Kondisi Good Health and Well Being - SDG’s3: Enhancing Empowerment of Tuban Society Regarding Food Safety and Halalness in Order to Maintain Good Health and Well Being -SDG’s3 Ekowati, Juni; Yuwono, Mochammad; Prayoga, Adistiar; Rosita, Noorma; Purwanto, Bambang Tri; Adrianto, Muhammad Faris; Purwitasari, Neny; Ifadotunnikmah, Farida; Nofianti, Kholis Amalia; Sulistyowaty, Melanny Ika; Suzana, Suzana; Ulvan, Angkasa Megistra; Setiawan, Albertus Aditya; Afandi, Ryan; Wahyuningsih, Etik; Rianti, Dian Ratna; Febrianti, Winanda Rizki
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 9 No. 12 (2024): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v9i12.8410

Abstract

The food industry experiences various serious problems when several food MSMEs (micro/small/medium enterprises), especially micro-scale ones, practice improper food manufacturing methods, such as the use of formalin and borax which are prohibited for food preservation, and the marketing of expired food, even repackaged, and the writing of halal labels that are not followed by the fulfillment of requirements. Efforts to prevent things that are detrimental to the community, as well as food and beverage MSME actors, are not only the responsibility of government agencies but also the entire community, including universities for education and assistance in improving the quality and quantity of products produced, as well as the quality of human resources of business actors. The methods used include counseling and skills training, and the outcome is an increase in knowledge of 31%
PENDIDIKAN KOGNITIF DAN AFEKTIF DAGUSIBU UNTUK PENCEGAHAN RESISTENSI ANTIBIOTIK DI SMA SURABAYA Abhimata Paramanandana; Dini Retnowati; Andang Miatmoko; Dewi Isadiartuti; Sugiyartono1; Mohammad Agus Sjamsur Rijal; Dwi Setiawan; Esti Hendradi; Tutiek Purwanti; Noorma Rosita; Dewi Melani Hariyadi; Tristiana Erawati; Ardhani Dwi Lestari1; Helmy Yusuf; Retno Sari
ABDIMAS TALENTA: Jurnal Pengabdian Kepada Masyarakat Vol. 4 No. 1 (2019): ABDIMAS TALENTA: Jurnal Pengabdian Kepada Masyarakat
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (620.49 KB) | DOI: 10.32734/abdimastalenta.v4i1.2395

Abstract

Antibiotics are not only used for humans, but also often used for cattle and livestock which are then been consumed by humans. This over prescribed and missed used of antibiotic is a major factor in antibiotic resistance. Antibiotic resistance is a condition where bacteria are unable to be treated with antibiotics. In fact, the use of antibiotics is the first response in curing infectious diseases (by bacteria) and preventing infectious diseases spreading. With antibiotic resistance, preventing infectious diseases by bacteria became harder. This community service activity came up with a slogan "Antibiotic Resistence Awareness Movement" was carried out in Surabaya 10 Public High Schools and Surabaya 17 Public High Schools with 60 students per school using several methods, namely: (a) giving lecture material using LCD projectors ) the implementation of poster making competitions, and (c) poster presentations that have been made that are accompanied by question and answer, and (d) evaluation activities in the form of written tests covering pre-test and post-test. Concerning the results of posters results, poster presentations and improving the results of this posttest can be concluded as a result of an increase in understanding and or knowledge of students of SMA 10 and SMA 17 Surabaya
Efek Penambahan Kolesterol dan Tween 80 terhadap Karakteristik dan Stabilitas Fisik Liposom Hydrolyzed Collagen: The Effect of Adding Cholesterol and Tween 80 on the Physical Characteristics and Stability of Hydrolyzed Collagen Liposomes Amilia, Alya Nur; Rosita, Noorma; Yusuf, Helmy
Jurnal Sains dan Kesehatan Vol. 6 No. 1 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i1.2291

Abstract

Hydrolyzed collagen (HC) exhibits excellent anti-aging activity, but when applied topically, it faces limitations related to its physicochemical properties and low permeability to penetrate the skin. A system like liposomes is required. With the addition of cholesterol and Tween 80 surfactant to the liposome formulation, it is anticipated to enhance the characteristics and stability of the system in various combination ratios of Soy phosphatidylcholine: cholesterol: Tween 80, namely (F1= 4: 2: 1), (F2= 4: 1: 1), and (F3= 4: 1: 2). Characterization test results indicate that formula F3 exhibits the best characteristics, with respective values for particle size, PDI, zeta potential, and %EE being 63.26nm ± 0.73; 0.182 ± 0.011; 2.5mV ± 0.1; and 85.54% ± 0.20. Real-time stability test results, analyzed statistically using a Paired T-test, yield p-values for all three formulas (Sig 2-tailed) < 0.05, signifying a significant difference. Formula F2 demonstrates the smallest differences in particle size reduction and %EE. Hence, it can be observed that F2 stands out as the formula with the best characteristics and stability compared to F1 and F3. Keywords:          Characteristics; hydrolyzed collagen; liposomes; cholesterol; Tween 80   Abstrak Hydrolized Collagen (HC) memiliki aktivitas anti-aging yang sangat baik, namum secara topikal memiliki keterbatasan terkait sifat fisika kimia dan permeabilitasnya yang rendah untuk menembus kulit. Dibutuhkan suatu sistem seperti liposom. Dengan penambahan kolesterol dan surfaktan Tween 80 ke dalam formulasi liposom diharapkan akan meningkatkan karakteristik dan stabilitas sistem dalam beberapa perbandingan kombinasi formula Soy phospatidylcholine:  kolesterol: Tween 80 yaitu (F1= 4: 2: 1), (F2= 4: 1: 1), dan (F3= 4: 1: 2). Hasil uji karakteristik menunjukkan formula F3 memiliki karakteristik terbaik dengan nilai ukuran partikel, PDI, zeta potensial, dan %EE secara berturut-turut 63,26nm ± 0,73; 0,182 ± 0,011; 2,5mV ± 0,1; dan 85,54% ± 0,20. Hasil uji stabilitas real-time menunjukkan hasil analisis statistik menggunakan Paired T-test diperoleh p-value ketiga formula yaitu Sig (2- tailed) < 0,05, yang berarti terdapat perbedaan yang signifikan dan formula F2 yang memiliki selisih penurunan ukuran partikel dan %EE terkecil. Sehingga, dapat dilihat bahwa F2 merupakan formula yang memiliki karakteristik dan stabilitas paling baik dibandingkan dengan F1 dan F3. Kata Kunci:         Karakteristik; hydrolized collagen; liposom; kolesterol; tween 80
Effect of Combination Soy Bean Oil and Oleic Acid to Characteristic, Penetration, Physical Stability of Nanostructure Lipid Carrier Resveratrol Soeratri, Widji; Hidayah, Rohmawati; Rosita, Noorma
Folia Medica Indonesiana Vol. 55, No. 3
Publisher : Folia Medica Indonesiana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Resveratrol is an antioxidant that can be used as anti-aging. Topical use has several problems because solubility in water is low and unstable to light. This study aimed to evaluate the effect of the combination of soy bean oil and oleic acid liquid lipids on the characteristics, penetration, and stability of resveratrol nanostructured lipid carriers (NLC). Nanostructured lipid carriers (NLC) were made with high shear homogeneous technique. To determine the characterization of NLC, diffraction scanning calorimetry, X-ray diffraction, and Fourier transforms infrared spectrophotometry were used. Examination of the morphological form was carried out with a transmission electron microscope. The particle size and polydispersity index examination were measured by the Delsa Nanoâ„¢ particle size analyzer, while the efficiency of trapping resveratrol in the NLC system was measured by the dialysis membrane method. Furthermore, the penetration depth test on the skin of mice was done by fluorescence microscope method using rhodamine B markers. Physical stability test was performed by examination of particle size and index polydispersity for 30 days. The formula with liquid soy bean oil and oleic acid liquid lipids improved the characteristics including the effectiveness of entrapment and colloidal stability. However, the formula with soy bean oil and oleic acid combination liquid lipids did not provide better penetration into the skin than the use of single liquid lipids. While the formula with soy bean oil and oleic acid liquid lipids proved to improve the physical stability for 30 days.
Feasibility Prediction of Quercetin and Ascorbic Acid Combination for Skin Lightening through Tyrosinase Inhibition Mechanism by Molecular Docking Nugroho, Nadia Paramitha; Rosita, Noorma; Widji Soeratri
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 3 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i32025.364-371

Abstract

Background: Hyperpigmentation is an aesthetic problem that can affect people psychologically and emotionally. Quercetin and ascorbic acid are topical ingredients commonly used as skin lightening active ingredients by their role as tyrosinase inhibitors. Objective: This research is to determine quercetin’s feasibility to be combined with ascorbic acid or one of its more stable and commercially most used derivatives in cosmetics, 3-O-ethyl ascorbic acid in inhibiting tyrosinase. Methods: The research was conducted in an in silico manner by molecular docking, supplemented by literature research on in vitro experiments. The ligands and receptor preparation were undertaken prior to performing molecular docking with AutoDockTools 1.5.6. Molecular docking was carried out after the validation step with the RMSD value of 0.91 Å. Results: Quercetin has greater binding affinity to tyrosinase (ΔG = -5.01 kcal/mol) than ascorbic acid (ΔG = -4.20 kcal/mol), as well as owning the most similar type of interaction and comparable affinity to L-tyrosine (ΔG = -5.87 kcal/mol) as the native ligand. Quercetin shares several same amino acid residues with ascorbic acid which indicates similar mechanisms of inhibition. Meanwhile, ascorbic acid possesses virtually equal binding affinity to 3-O-ethyl ascorbic acid (ΔG = -4.63 kcal/mol), though has considerably more potent tyrosinase inhibition activity in in vitro studies. Conclusion: Ascorbic acid is postulated to be feasible to combine with quercetin for inhibiting tyrosinase activity to eventually yield more optimized depigmenting effect.
Drug and cosmetic safety training for cadres of family welfare program Tristiana Erawati; Dewi Melani Hariyadi; Noorma Rosita; Widji Soeratri; Tutiek Purwanti; Hadi Poerwono; Marcellino Rudyanto; Helmy Yusuf; Djoko Agus Purwanto; I Nyoman Wijaya
Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang Vol. 9 No. 2 (2024): May 2024
Publisher : University of Merdeka Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26905/abdimas.v9i2.11161

Abstract

In order to increase public understanding and awareness regarding the safety use of drugs and cosmetics, the Community Service Team of the Faculty of Pharmacy, Airlangga University has held community service in Jonggrangan Village, Klaten, Central Java. The community service was carried out on July 31, 2023, with approximately 60 family welfare programs or PKK cadres and health cadres participating through training, presentations, and discussions. The activity began with a pre-test, continued with training, a presentation of the material by three experts, and a discussion, then ended with giving a post-test to the participants. The results of the pre and post-test analysis showed that participants' understanding increased. The results of the analysis of the answers to the 15 questions given showed that the increase in participants' understanding ranged from  2.13-46.02 percent. The impact of these activities on society. The increase in participants' understanding of each topic is not the same depending on the initial understanding. However, the problem is that the level of public understanding after receiving training is still below 50 percent namely on topics about the stages of using cosmetic products and about drug classification. So it is necessary to deepen the material using other strategies (appropriate methods and media).
Pemberdayaan Perempuan dalam Upaya Meningkatkan Kualitas Kesehatan Masyarakat melalui Pemahaman Bentuk Sediaan, Kemasan, Keamanan dan Stabilitas Obat di Kabupaten Magetan untuk Mendukung SDG’s 3 Sari, Retno; M. Agus Syamsur Rijal; Andang Miatmoko; Dini Retnowati; Dewi Isadiartuti; , Idha Kusumawati; Noorma Rosita; Tutik Sri Wahyuni
Jurnal ABDI: Media Pengabdian Kepada Masyarakat Vol. 11 No. 2 (2026): JURNAL ABDI : Media Pengabdian Kepada masyarakat
Publisher : Universitas Negeri Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26740/abdi.v11i2.44377

Abstract

Abstract Health is a condition of physical, mental, spiritual, and social prosperity that allows a person to live a productive life (Law No. 36/2009). Knowledge of drugs is important for the public to avoid the use of counterfeit and illegal drugs, which according to the WHO includes drugs without active ingredients, different ingredients, or with strength that does not match the label. The Community Service Program has been carried out to increase public knowledge, primarily through the role of women, about the dosage form, packaging, safety, and stability of drugs. The activity was carried out using a lecture and discussion method and involved 45 participants from 17 women's organizations in the Magetan area. The results showed that this program succeeded in increasing participants' understanding of drug dosage form, packaging, safety, and stability. This activity also received a positive response from the participants and was reported by local media. The community service program successfully increased the community's knowledge and understanding of drugs and drug stability, thus strengthening SDGs 3. Keywords: Health, medicine, safety, stability, SDGs 3
Co-Authors , Idha Kusumawati Abhimata Paramanandana Afandi, Ryan Agustin Agustin Agustin Agustin Alya Nur Amilia Amilia, Alya Nur Andang Miatmoko Ardhani Dwi Lestari1 Athiyyah, Wafa'ul Bambang Tri Purwanto Cahyono, Definta Anisa Tamara Dewi Isadiartuti Dewi Melani Hariyadi Dicky Pratama Dini Retnowati Dini Retnowati Djoko Agus Purwanto Dwi Setiawan Dwi Setyawan Dyah Rahmasari Esti Hendradi Etik Wahyuningsih Farida Ifadotunnikmah Febrianti, Winanda Rizki Firdausiah Fania Dwi Putri Putri Fransisca Dita Mayangsari Frida Magdalena Hadi Poerwono Hamdan, Siti Hartini Hanafi Tanojo Herra Studiawan Hidayah, Rohmawati I Gusti Ayu Adhi Aryapatni I Nyoman Wijaya Juni Ekowati Kholis Amalia Nofianti M. Agus Syamsur Rijal Mahardian Rahmadi Marcellino Rudyanto Maria Lucia Ardhani Dwi Lestari Melanny Ika Sulistyowaty Mochammad Yuwono Mohammad Agus Sjamsur Rijal Muhammad Agus Syamsur Rijal Muhammad Faris Adrianto, Muhammad Faris Nugroho, Nadia Paramitha Nurhidayah Sarifuddin Paramita, Diajeng Putri Pradita Fiqlyanur Isna Primadana Prayoga, Adistiar Purwitasari, Neny Qurrotu A'yunin Rahmadhanniar, Erwinda Rahman, Fakhrinnisa Wildani Retno Sari Retno Sari Retno Widyowati Rianti, Dian Ratna Rohmawati Hidayah Rufaidah Azzahrah Sairiyah, Siti Nasikatus Sarifuddin, Nurhidayah Sayyidati Aqilah Setiawan, Albertus Aditya Siti Hartini Hamdan Soerarti, Widji Sugiyartono1 Suko Hardjono SUZANA, SUZANA Tekla Kalalo Tiara Jeni Rosadi Tristiana Erawati Tristiana Erawati Tutiek Purwanti Tutiek Purwati Tutik Sri Wahyuni Ulvan, Angkasa Megistra Virnanda Syafira Hartatiningrum Widji Soerarti Widji Soeratri Widji Soeratri Wiwik Handayani Yusuf, Helmy Yusuf, Helmy Zhihrotulwida, Dzakiya