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Stabilitas Fisik dan Efektivitas Sediaan Tabir Surya Kombinasi Oksibenson dan Oktil Metoksisinamat dalam Basis Gel Carbomer 940 dengan Penambahan Asam Glikolat Rosita, Noorma; Purwanti, Tutiek; Agustin, Agustin
Majalah Ilmu Kefarmasian Vol. 7, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

To fulfill the consumer expectation, cosmetic industries mostly add glycolic acid as whitening agent to the sunscreen preparation. The aim of this research was to know the effect of glycolic acid addition with the concentration of 8, 10, and 12% w/w on physical stability and effectiveness of sunscreen product containing oxybenzone and octyl methoxycinnamate (2: 7% w/w) in carbomer 940 gel. The physical stability test was done by observing physical appearance, pH, and spreading ability during 60 day storages on zone IV condition (temperature 30±0.5° and RH 70±2%). The efficacy was determinated base on SPF (Sun Protection Factor) value by spectrophotometer. The result of the physical stability test showed that glycolic acid addition affects the physical appearance (consistency) of sunscreen product, but pH and spreading ability are relatively stable. The efficacy test result showed that the addition of glycolic acid has an effect on SPF value of sunscreen product. Product which combined with glycolic acid showed a significant increase of SPF value, compared to control formula. The addition of glycolic acid increased SPF value and alter the effectiveness category from extra protection to maximal protection.
Effect of Sodium Alginate Concentration on Characteristics, Stability and Drug Release of Inhalation Quercetin Microspheres Tekla Kalalo; Andang Miatmoko; Hanafi Tanojo; Tristiana Erawati; Dewi Melani Hariyadi; Noorma Rosita
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 9 No. 2 (2022): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v9i22022.107-114

Abstract

Background: Quercetin is a flavonoid compound that has anti-inflammation activity. However, poor stability presents significant problems for the formulation into dosage forms. Microspheres are one of the potential lung delivery systems because of their ability to encapsulate various types of drugs, protect drugs from environmental effects and can release drugs in a sustained release. Objective: In the present study, the microsphere inhalation system of the anti-inflammation drug, quercetin was developed and evaluated to achieving the targeted delivery of these drugs to the lung. Method: The drug-loaded ca-alginate microspheres were prepared by aerosolization ionic gelation technique followed by freeze-drying. Result: The result of this study showed that particle size was less than 2 µm, the yield ranged from 41.33-76.14%, drug loading was less than 6%, entrapment efficiency ranged from 74.153% - 93.805% and flow properties showed that all formula had an excellent flow. Spherical microspheres were demonstrated by formulations containing 1 and 1.5% sodium alginate. A drug release study showed that the highest drug release of 30.649% was from the formulation with 2.5% sodium alginate, and the lowest drug release of 26.625% was from the formulation with 2% sodium alginate. , A stability study at temperatures of 25áµ’C and 40áµ’C for 28 days showed a decrease in drug loading and entrapment efficiency but an increase in particle size. The formulation containing 1.5% sodium alginate showed the optimal formula. Conclusion: These findings indicated that quercetin ca-alginate microspheres are the potential for inhalation to be delivered to the lung.
The Effect of Decyl Glucoside on Stability and Irritability of Nanostructured Lipid Carriers-Green Tea Extract as Topical Preparations Rufaidah Azzahrah; Noorma Rosita; Djoko Agus Purwanto; Widji Soeratri
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 9 No. 3 (2022): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v9i32022.220-228

Abstract

Background: Green Tea Extract (GTE) is a natural antioxidant compound that can protect the skin from photocarcinogenesis (DNA damage due to ultraviolet exposure). GTE has low stability, which needs a delivery system such as Nanostructured Lipid Carriers (NLC) with decyl glucoside (DG) as a natural surfactant that at the right concentration can produce a significantly small particle size which can improve the stability of the NLC. Objective: To determine the effect of DG usage on the characteristics, physical stability, and irritability of NLC-GTE preparation. Methods: NLC-GTE preparation used the High Shear Homogenization (HSH) method with three formulas, which contained DG 2%, 2.5%, and 3% consecutively. Afterwards, the characteristic and physical stability tests were conducted using the thermal cycling method for three cycles with two different temperatures (48 hours/cycle, 2 - 8°C and 40°C). The irritability test used Hen's Egg Test on the Chorioallantoic Membrane (HET-CAM) method. Results: Characteristic test of organoleptic showed that all formulas were white, odorless, and had a semi-solid consistency. However, the pH, particle size, and polydispersity index values from all formulas were within the normal range of values. The physical stability test result showed that 3% DG was the most stable formula. This formula was within the non-irritating range of values in HET-CAM. Conclusion: NLC-GTE with an increased concentration of DG as a surfactant can improve the characteristics and physical stability of the preparation. F3 (3% DG) is the best formula compared to other formulas and indicates non-irritating in the HET-CAM test.
WEBINAR UPAYA HILIRISASI PRODUK KOSMETIKA PADA SISWA SMK FARMASI DI SURABAYA Dewi Isadiartuti; Widji Soeratri; Noorma Rosita; I Gusti Ayu Adhi Aryapatni; Suko Hardjono; Tristiana Erawati; Herra Studiawan; Maria Lucia Ardhani Dwi Lestari; Virnanda Syafira Hartatiningrum
Panrita Abdi - Jurnal Pengabdian pada Masyarakat Vol. 7 No. 1 (2023): Jurnal Panrita Abdi - Januari 2023
Publisher : LP2M Universitas Hasanuddin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/pa.v7i1.18675

Abstract

Pharmacy Vocational High School (SMK) students are prepared to work immediately after finishing school. Students receive lessons on the basics of pharmaceutical preparation and entrepreneurship. Cosmetics are a pharmaceutical dosage form widely used by the broader community for personal hygiene, appearance improvement, and health functions. The Minister of Health of the Republic of Indonesia No. 1175/Menkes/Per/VIII/2010 concerning cosmetic production permits provides an opportunity for cosmetic products to be produced with simple technology. During the COVID-19 pandemic, which results in a heavy economic burden for the government and society, there are business opportunities for Pharmacy Vocational School students. Community service aims to increase students' knowledge and insight and encourage students in class XI and XII of the Sekesal Pharmacy Vocational School in Surabaya and Kapasari Pharmacy Vocational School in Surabaya to become entrepreneurs in the cosmetics sector. The implementation method is through a webinar that provides material covering products, formulations, stability, and licensing of cosmetic products. Participants had the opportunity to discuss the material provided, fill out evaluations in the form of pre/post-test and make E-posters about cosmetic products. The evaluation results show an increase in participants' knowledge and insight, and participants are interested in producing cosmetic preparations, which are expected to become new business fields that can improve their welfare. --- Siswa Sekolah Menengah Kejuruan (SMK) Farmasi dipersiapkan untuk segera bekerja setelah menamatkan sekolah. Siswa memperoleh pelajaran tentang dasar-dasar pembuatan sediaan farmasi dan kewirausahaan. Kosmetika merupakan salah satu bentuk sediaan farmasi yang banyak digunakan oleh masyarakat luas untuk tujuan kebersihan diri, peningkatan penampilan, dan memiliki fungsi kesehatan. Permenkes RI No 1175/Menkes/Per/VIII/2010 tentang izin produksi kosmetika memberikan peluang produk kosmetika diproduksi dengan teknologi sederhana.  Dalam  masa pandemi covid 19, yang mengakibatkan beban ekonomi berat bagi pemerintah dan masyarakat, terdapat peluang usaha bagi siswa SMK Farmasi. Pengabdian masyarakat bertujuan untuk meningkatkan pengetahuan dan wawasan siswa serta mendorong siswa  kelas XI dan XII SMK Farmasi Sekesal Surabaya dan SMK Farmasi Kapasari Surabaya untuk berwirausaha di bidang kosmetika. Metode pelaksanaan melalui webinar dengan  pemberian materi meliputi produk, formulasi, stabilitas dan perizinan produk kosmetika. Peserta mendapatkan kesempatan berdiskusi tentang materi yang diberikan,  mengerjakan pre/post test, mengisi evaluasi, dan membuat E-poster tentang produk kosmetika. Dari hasil evaluasi diketahui terdapat peningkatan pengetahuan dan wawasan peserta dan peserta tertarik untuk memproduksi sediaan kosmetika yang diharapkan dapat menjadi lahan usaha baru yang dapat meningkatkan kesejahteraannya.
Quercetin Solid Lipid Microparticle Stability and Deposition in Rat Lungs: A Study of Surfactant Effect Hariyadi, Dewi Melani; Sairiyah, Siti Nasikatus; Rahman, Fakhrinnisa Wildani; Rijal, Muhammad Agus Syamsur; Rosita, Noorma; Rahmadi, Mahardian
Science and Technology Indonesia Vol. 9 No. 3 (2024): July
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2024.9.3.682-696

Abstract

This study aims to determine the effect of surfactant concentration on Quercetin SLM as a potential carrier of respiratory diseases, especially ones resulting from oxidative stress injury. Quercetin is a natural antioxidant with high activity. SLM was formed with 5% compritol 888 ATO as a lipid and different concentrations of poloxamer 188 as a surfactant. SLM was produced by a combination of emulsification and sonication involving freeze drying. SLM is characterized by organolepsis, morphology, yield, particle size, drug loading, and entrapment efficiency. The antioxidant activity of quercetin SLMs was tested using the ABTS method. SLMs are characterized as having round and smooth morphology, high yield (F1 88.53%; F2 91.44%; F3 92.87%); particle size (F1 1.81 um; F2 1.90 um; F3 1.94 um); high drug loading (F1 15.96%; F2 13.74%; F3 13.19%); and high entrapment efficiency (F1 96.53%; F2 87.94%; F3 87.48%). Increasing surfactant concentration did not produce a significant difference between formulas. Quercetin SLM showed high antioxidant activity (Quercetin 94.43%; F1 94.35%; F2 94.36%; F3 94.37%). SLM was stable at storage temperatures between 25°C and 40°C. The effect of surfactant can be seen on particle size, drug loading, and entrapment efficiency at 40°C. Results of in vivo deposition study indicated that all SLM formulas were able to deliver quercetin to the lungs. Increasing the concentration of surfactant in Quercetin SLMs made no difference to the lung deposition as confirmed by observations conducted at 1 hour and 4 hours. Quercetin SLM has the potential for lung delivery by inhalation.
Assessment of Antioxidant Activity, Total Phenolic and Flavonoid Contents of Albizia saponaria L. Bark Extract Lukman, Lukman; Rosita, Noorma; Widyowati, Retno
Science and Technology Indonesia Vol. 9 No. 2 (2024): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2024.9.2.494-501

Abstract

Langir (Albizia saponaria L.), belonging to the family of the Fabaceae, is a medicinal endemic plant of South Sulawesi, Indonesia. The Albizia genus shows antioxidant, antibacterial, anthelmintic, antidandruff, and anti-inflammatory properties. In this study, total phenolic (TP) and total flavonoid (TF) extracts from the bark of A. saponaria were screened for robust antioxidant activity in order to identify potential sources of new compounds for use in pharmaceutical formulations in the future. TP and TF of the 96% ethanol extract and fractions (hexane, ethyl acetate, butanol, and water) were calculated by the Folin–Ciocalteu and aluminum chloride procedures, respectively. Furthermore, the antioxidant activity was determined by DPPH free radical scavenging method and ABTS assay. Generally, both extract and fractions showed significant radical scavenging activities. Ethyl acetate fraction exhibited more potent radical scavenging activity in the DPPH method (IC50 35.27 ± 2.85 µg/mL) and ABTS assay (IC50 60.04 ± 0.98 µg/mL), followed by 96% ethanol extract, and hexane, butanol, and water fractions. Furthermore, the highest TP (4.50 ± 0.01 mg/g GAE) and TF (3.55 ± 0.04 mg/g QE) were obtained from ethyl acetate fraction. There was a strong correlation between antioxidant activity with TP (DPPH, R2 = 0.6436; ABTS, R2 = 0.7676) and TF content (DPPH, R2 = 0.5533; ABTS, R2 = 0.5961). The extract’s antioxidant properties may be attributable to its higher phenolic and flavonoid content. In summary, the phenolic and flavonoid content of the ethyl acetate fraction indicates its potential utility as a source of antioxidants.
Stability and Antiaging Effectiveness Studies of Astaxanthin-Loaded Nanostructured Lipid Carriers Using a Combination of Cetyl Palmitate and Soybean Oil Zhihrotulwida, Dzakiya; Soeratri, Widji; Erawati, Tristiana; Rosita, Noorma
Science and Technology Indonesia Vol. 10 No. 2 (2025): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.2.473-481

Abstract

Astaxanthin is a potent antioxidant belonging to carotenoid compounds that is mainly produced from green microalgae Haematococcus pluvialis. Astaxanthin is beneficial for skin health as antiaging agent, but has limitations in its delivery through the skin. Astaxanthin could be formulated in nanostructured lipid carriers to improve its efficacy. The purpose of this study was to evaluate the stability and antiaging effectiveness of astaxanthin-loaded nanostructured lipid carriers (ASX-NLCs) with cetyl palmitate and soybean oil as lipid combinations at several ratios of 100:0, 90:10, 80:20, and 70:30. ASX-NLCs were synthesized using a high-shear homogenization technique. ASX-NLCs were characterized and stability evaluated after storage for 90 days. The antiaging effectiveness of ASX-NLCs was evaluated by in vitro release test using dialysis bag for 8 hours, as well as collagen density and fibroblast count evaluation on UV-induced skin aging mice for 28 days. After storage, all ASX-NLCs did not change significantly in organoleptic, pH, and particle size. However, other parameters including polydispersity index, viscosity, and entrapment efficiency experienced significant changes in some formulas. The release test showed that F4 (70:30) gave the highest cumulative release and was significantly different from F1 (100:0). The collagen density of the groups treated with ASX-NLC F3 (80:20) and F4 (70:30) increased significantly compared to the UVB control group, while the fibroblast count did not differ significantly in all groups. Overall, ASX-NLCs containing cetyl palmitate and soybean oil at ratios of 80:20 and 70:30 could improve the antiaging effect of astaxanthin which might be influenced by its better stability and release.
Pengaruh Asam Hialuronat Terhadap Stabilitas Fisik Coenzym Q10 Dalam Sistem Nanostructure Lipid Carrier (NLC) Sebagai Antiaging Sarifuddin, Nurhidayah; Soerarti, Widji; Rosita, Noorma
Archives Pharmacia Vol 7, No 2 (2025): ARCHIVES PHARMACIA
Publisher : Lembaga Penerbitan Universitas Esa Unggul

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47007/ap.v7i2.9933

Abstract

Koenzim Q10 berfungsi sebagai antioksidan yang dapat melindungi tubuh dari kerusakan yang disebabkan oleh radikal bebas. Asam hialuronat dikenal sebagai polimer hidrofilik yang berasal dari polisakarida yang memiliki kemampuan untuk meningkatkan penetrasi perkutan dengan mengubah komposisi sel stratum korneum yang tersusun rapat sehingga meningkatkan permeabilitas kulit. Asam hialuronat juga berfungsi sebagai pelembab. Nanostructured Lipid Carrier merupakan modifikasi dari sistem SLN, yang terdiri dari campuran lipid padat dan cair (minyak), distabilkan dengan larutan surfaktan berair, merupakan salah satu metode untuk meningkatkan penetrasi obat melalui stratum korneum karena memiliki beberapa keunggulan. Tujuan dari penelitian ini adalah untuk melihat pengaruh penambahan asam hialuronat terhadap stabilitas fisik  Nanostructure Lipid Carrier (NLC) sebagai anti penuaan. Pemeriksaan stabilitas fisik meliputi pH, ukuran partikel, indeks polidispersitas dan viskositas. Uji stabilitas fisik (pH, ukuran partikel dan indeks polidispersitas dan viskositas) dilakukan dengan penyimpanan selama 30 hari pada suhu kamar. Hasil pengukuran menunjukkan bahwa pH, ukuran partikel, indeks polidispersitas dan viskositas stabil selama penyimpanan.
DESIGN AND OPTIMIZATION OF VCO AND OLEIC ACID FOR NLC QUERCETIN USING SIMPLE LATTICE DESIGN Cahyono, Definta Anisa Tamara; Rosita, Noorma; Erawati, Tristiana
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 3 (2025)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i3.1747

Abstract

Quercetin is a flavonoid compound that exhibits skin-brightening activity by inhibiting tyrosinase. However, its topical application is limited because of its low solubility. A Nanostructured Lipid Carrier (NLC) was selected as the delivery system to enhance the stability and topical efficacy of quercetin. This study aimed to optimize the combination ratio of oleic acid and Virgin Coconut Oil (VCO) as the liquid lipid phase in the NLC Blank Formulation using the Simplex Lattice Design (SLD) method. Eight blank NLC formulations were prepared using the high-shear homogenization method and were evaluated based on organoleptic properties, particle size, polydispersity index (PDI), pH, and real-time stability over 30 days. Eight blank NLC Blank Formulations showed that a balanced VCO to oleic acid ratio (5.5:4.5) produced small particle sizes (<160 nm), low polydispersity index (PDI <0.25), and good physical stability. Blank Formulations dominated by either VCO or oleic acid tended to have larger particles and lower stability, indicating that the liquid lipid ratio influenced the NLC characteristics. Optimization using the Simplex Lattice Design (SLD) method identified three optimal lipid ratios: B1 (4.86:5.31), B2 (2:8), and B3 (9:1), each with desirability values near 1. The model was validated by comparing the predicted (dry lab) and experimental (wet lab) data, which showed no significant differences in key parameters (p > 0.05), confirming the reliability of the SLD model. This approach effectively optimized quercetin-loaded NLC Blank Formulations, and the three selected Blank Formulas serve as a strong basis for developing topical quercetin NLC products.
Peningkatan Pemberdayaan Masyarakat Tuban tentang Keamanan dan Kehalalan Pangan dalam Rangka Mempertahankan Kondisi Good Health and Well Being - SDG’s3: Enhancing Empowerment of Tuban Society Regarding Food Safety and Halalness in Order to Maintain Good Health and Well Being -SDG’s3 Ekowati, Juni; Yuwono, Mochammad; Prayoga, Adistiar; Rosita, Noorma; Purwanto, Bambang Tri; Adrianto, Muhammad Faris; Purwitasari, Neny; Ifadotunnikmah, Farida; Nofianti, Kholis Amalia; Sulistyowaty, Melanny Ika; Suzana, Suzana; Ulvan, Angkasa Megistra; Setiawan, Albertus Aditya; Afandi, Ryan; Wahyuningsih, Etik; Rianti, Dian Ratna; Febrianti, Winanda Rizki
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 9 No. 12 (2024): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v9i12.8410

Abstract

The food industry experiences various serious problems when several food MSMEs (micro/small/medium enterprises), especially micro-scale ones, practice improper food manufacturing methods, such as the use of formalin and borax which are prohibited for food preservation, and the marketing of expired food, even repackaged, and the writing of halal labels that are not followed by the fulfillment of requirements. Efforts to prevent things that are detrimental to the community, as well as food and beverage MSME actors, are not only the responsibility of government agencies but also the entire community, including universities for education and assistance in improving the quality and quantity of products produced, as well as the quality of human resources of business actors. The methods used include counseling and skills training, and the outcome is an increase in knowledge of 31%
Co-Authors Adam Pratama Afandi, Ryan Agustin Agustin Agustin Agustin Alya Nur Amilia Amilia, Alya Nur Andang Miatmoko Annuryanti, Febri Ardhani Dwi Lestari1 Arie Sulistyorini Bambang Tri Purwanto Cahyono, Definta Anisa Tamara Dewi Isadiartuti Dewi Melani Hariyadi Dicky Pratama Dini Retnowati Dini Retnowati Dita Savitri Djoko Agus Purwanto Dwi Setiawan Dwi Setyawan Dyah Rahmasari Esti Hendradi Etik Wahyuningsih Farida Ifadotunnikmah Febrianti, Winanda Rizki Firdausiah Fania Dwi Putri Putri Firmansyah Ardian Ramadhani Fransisca Dita Mayangsari Frida Magdalena Hadi Poerwono Hanafi Tanojo Herra Studiawan Hidayah, Rohmawati I Gusti Ayu Adhi Aryapatni I Nyoman Wijaya I NYOMAN WIJAYA Idha Kusumawati Juni Ekowati Kholis Amalia Nofianti M. Agus Syamsur Rijal Mahardian Rahmadi Marcellino Rudyanto Maria Lucia Ardhani Dwi Lestari Melanny Ika Sulistyowaty Mochammad Yuwono Mohammad Agus Sjamsur Rijal Muh. Agus Syamsur Rijal Muhammad Agus Syamsur Rijal Muhammad Faris Adrianto, Muhammad Faris Nurhidayah Sarifuddin Paramanandana, Abhimata Paramita, Diajeng Putri Praditapuspa, Ersanda Nurma Prayoga, Adistiar Purwitasari, Neny Qurrotu A'yunin Rahmadhanniar, Erwinda Rahman, Fakhrinnisa Wildani Retno Sari Retno Sari Retno Widyowati Rianti, Dian Ratna Rohmawati Hidayah Rufaidah Azzahrah Sairiyah, Siti Nasikatus Sarifuddin, Nurhidayah Sayyidati Aqilah Setiawan, Albertus Aditya Soerarti, Widji Sugiyartono1 Suko Hardjono Suzana SUZANA, SUZANA Tekla Kalalo Tiara Jeni Rosadi Tristiana Erawati Munandar Tutiek Purwanti Tutiek Purwati Tutik Sri Wahyuni Ulvan, Angkasa Megistra Virnanda Syafira Hartatiningrum Widji Soerarti Widji Soeratri Widji Soeratri Winanda Rizki Febrianti Wiwik Handayani Yusuf, Helmy Yusuf, Helmy Zhihrotulwida, Dzakiya