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Tsamrotul Ilmi
Program Studi Profesi Apoteker, Fakultas Ilmu Kesehatan, Universitas Kadiri
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Journal : Multicore International Journal of Multidisciplinary (MIJM)

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Prediction of Scabertopin from Tapak Liman (Elephantopus scaber) for Antileukemic Saristiana, Yuneka; Prasetyawan, Fendy; Salmasfattah, Novynanda; Ilmi, Tsamrotul; Fadel, Muhammad Nurul; Besan, Emma Jayanti
Multicore International Journal of Multidisciplinary (MIJM) Vol. 1 No. 1 (2025): May
Publisher : Marasofi International Media and Publishing (MIMP)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64123/mijm.v1.i1.5

Abstract

Leukemia remains a significant global health challenge, necessitating the exploration of novel therapeutic agents with improved efficacy and safety profiles. Elephantopus scaber (commonly known as Tapak Liman) is a medicinal plant traditionally used for various ailments, including cancer. Scabertopin, a sesquiterpene lactone isolated from E. scaber, has attracted scientific interest due to its potential antileukemic properties. This study aims to predict the antileukemic activity of Scabertopin through an in silico approach. The compound's chemical structure was retrieved in SMILES format from the PubChem database and analyzed using the PASS (Prediction of Activity Spectra for Substances) online tool. The prediction results indicated a high probability of antileukemic activity, with a Pa (probability of activity) value of 0.822 and a Pi (probability of inactivity) value of 0.004. These findings suggest a strong likelihood that Scabertopin exhibits antileukemic effects, supporting its potential as a candidate for further pharmacological and clinical investigations. The use of computational prediction tools provides an efficient and cost-effective preliminary screening method for identifying promising bioactive compounds from natural sources. This study contributes valuable insights into the therapeutic potential of Scabertopin and highlights the importance of traditional medicinal plants in drug discovery for leukemia treatment.
Co-Authors Abd Rofiq Achmad Wahdi An Nisa Sukmawati, Datin Anak Agung Indah Krisnadewi Anggeria Nimas Saputri Anies Fuady Anis Akhwan Dhafin Anis Akhwan Dhafin Antika, Ayu Rindi Arifani Sisiwidiasari Arifani Siswidiasari Arifani Siswidiasari Arifani Siswidiasari Arifani Siswidiasari Arlita Wulan Yuniar Ate, Chrispianus Christian Besan, Emma Jayanti Bin Abd Kadir, Mujtahid Bin Abd Khadir, Mujtahid Chandra Arifin Datin An Nisa Sukmawati Desna Talia Saputri Dinda Eviana Eka Hayati Rhomah Elly Megasari Elsa Mahardika Putri Fahma Laili, Nur Fauna Herawati Fendy Prasetyawan Fery Yuniarto, Prayoga Fitrani Khansa Henni Wati Herawati, Fauna Indra Zulfayanto Intan Mawarni, Okky Juwita, Syntia Tanu Khadir, Mujtahid Bin Abd Laili , Nur Fahma Laili, Nur Fahma Leny Witaning Kusumati Lintang Bismantara Lintang Bismantara B.G.PS Mawarni, Okky Intan Muhammad Nurul Fadel Mujtahid Bin Abd Kadir Mujtahid Bin Abd Kadir Mujtahid Bin Abd Khadir Mujtahid Bin Abd. Kadir Mustangin Mustangin Neni Probosiwi Neni Probosiwi Neni Probosiwi Nimas Ayu Rahardini Nur Fahma Laili Nur Fahma Laili Nur Fahma Laili Nur Fama Laili Nurkamah, Siti Okky Intan Mawarni Oktaviarika Dewi H Pertama Sari, Tiara Prayoga Ferry Yuniarto prayoga fery yuniarto Prayoga Fery Yuniarto Probosiwi , Neni Putri , Elsa Mahardika Putri, Elsa Mahardika Putri, Galuh Margareta Restyana, Anggi Rika Yulia Rika Yulia Rochmad Krissanjaya Salmasfattah, Novyananda Salmasfattah, Novynanda Sari, Sania Puspita savitri, Lisa Sinta Lestari Siti Nurul Hasana Sri Haryuni Sri Haryuni Sri Lestari Sugeng, Santoso Sukmawati , Datin An Nisa Sukmawati, Datin An-Nisa Tandela, Tantik Widhi Astutik Winartiana Yayuk Suprihatin Yenny Ardiyanti Yuneka Saristiana Yuniar, Arlita Wulan Yuniarto, Prayoga Fery