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All Journal Jurnal Natur Indonesia BIOTROPIA - The Southeast Asian Journal of Tropical Biology e-Journal Pustaka Kesehatan BERKALA SAINSTEK Alchemy : Journal of Chemistry Pharmaciana: Jurnal Kefarmasian Biogenesis: Jurnal Ilmiah Biologi Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Pharmaceutical Science and Technology INDONESIAN JOURNAL OF PHARMACY The Indonesian Biomedical Journal JSFK (Jurnal Sains Farmasi & Klinis) JPSCR : Journal of Pharmaceutical Science and Clinical Research PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Ilmu Kefarmasian Indonesia Nusantara Science and Technology Proceedings Makara Journal of Science Jurnal Katalisator Jurnal Pengabdian Masyarakat dan Riset Pendidikan IJSS Borneo Journal of Pharmacy Jurnal Kefarmasian Indonesia Journal of Pharmascience
Ari Satia Nugraha
Drug Utilisation And Discovery Research Group, Faculty Of Pharmacy, University Of Jember, Jember, Indonesia 68121
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health Social Sciences Veterinary Other

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Journal : Makara Journal of Science

 1 
Liparis condylobulbon Reichb. f. from Gumitir, Indonesia: Morphology, Molecular, and Phytochemical Profile Ulum, Fuad Bahrul; Arum, Asyifa Yasmin; Sa’adah, Kurnia; Setyati, Dwi; Dwinianti, Edia Fitria; Rajamani, Ranjithkumar; Nugraha, Ari Satia; Su’udi, Mukhamad
Makara Journal of Science Vol. 30, No. 1
Publisher : UI Scholars Hub

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Abstract

Liparis condylobulbon Rchb.f. is an epiphytic orchid across South and Southeast Asia, which holds notable ethnomedicinal and pharmacological significance. This study aims to characterize Indonesian Liparis condylobulbon using integrated morphological, molecular (matK, rbcL, ITS2), and phytochemical (LC-MS, DPPH) analyses of specimens from Mount Gumitir, providing the first comprehensive taxonomic and pharmacological profile to support species authentication and future bioprospecting. The L. condylobulbon specimen displays diagnostic epiphytic morpho-logy, including fusiform pseudobulbs, two elongate leaves, and an erect inflorescence bearing ~123 flowers. Molecular barcoding using matK, rbcL, and ITS2 confirmed its identity, with phylogenetic analyses consistently clustering it with L. condylobulbon, supporting taxonomic placement despite minor ITS2-based variation. Metabolomic analysis revealed 58 distinct secondary metabolites, including 30 flavonoids, 22 terpenoids, and 6 phenolic compounds, with key bioactives such as diosmin, picrasinoside B, and 6-gingerol exhibiting known anti-inflammatory, antioxidant, and anticancer properties. Although the crude extract showed relatively low antioxidant capacity (IC₅₀ = 650 µg/mL), the chemical diversity and presence of pharmacologically active constituents underscore the species' potential for future phytotherapeutic applications.
Co-Authors Adinda Kusuma Pertiwi Afrian Rosyadi Aissa Dinar Yanuariski Alfarisyi, Muhammad Iqbal Amrina Rosyada Fajriyanti Andhika Puspito Nugroho Arthur Hariyanto Prakoso Arthur Hariyanto Prakoso Arthur Hariyanto Prakoso Arthur Hariyanto Prakoso Arum, Asyifa Yasmin Asia Asia Asia Asia Asia Asia Asia, Asia Ayik Rosita Puspaningtyas1 Azhari, Nuri Putri Azis, Deri Abdul Bambang Kuswandi Bambang Kuswandi Banun Kusumawardani Bawon Triatmoko Billy Harnaldo Putra, Dini Fatmi, Dewi, Itut Septiana Dian Agung Pangaribowo Dinar Mutia Rani Dinarwati, Sri Dwi Koko Pratoko Dwi Setyati Dwinianti, Edia Fitria Eko Cahyo Mayndarto Endah Puspitasari Fathunnisa, Fathunnisa Fawwas Batio Putra Pamungkas Febi, Qonita Nafilah Fuad Bahrul Ulum Gani Asri Muharam Gani Asri Muharam Gusriyani, Sri Harry Ade Saputra Ifan Arif Maulana Ilma, Laila Nurul Indah Purnama Sary, Indah Purnama Indah Purnamasary Ita Husnul Chotimah Iyan Setiawan Kartika Senjarini Kintoko Kintoko Larissa Tania Lestyo Wulandari Lestyo Wulandari Luh Putu Ratna Sundari Mardani Eka Ningrum Mariatul Kibthiyyah Muhammad Habiburrohman Muhammad Habiburrohman Muhammad Habiburrohman Muhammad Zainul Arifin Muhammad Zainul Arifin Muhammad Zainul Arifin Muhammad Zainul Arifin Muharam, Gani Asri Nafa Rosyida Zanuba Naura Bathari Winarto Nimas Ayu Amanda Putri Ninisita Sri Hadi Nita Laila Asyifa Nugroho, Irfan Agus Nuri Nuri Nuri Putri Azhari Pairah, Pairah Prakoso, Arthur Hariyanto Putri Dwi Apriliani Putri Handayani, Maulina Surindri Rajamani, Ranjithkumar Ramadhan Bagus Cahyono Rike Oktarianti Rofiko Nuning Rahayu Rohmatillah, Wilda Nur Romadhona, Ananda Briliana Rosidah, Malihatul S. Sudarko Saeful Akhmad Tauladani Savitri, Ganevi Resta Sa’adah, Kurnia Septianingtyas, Christabel Reviana Silvya Fitri Nur Azizah Sri Untari Siwi Su’udi, Mukhamad Tauladani, Saeful Akhmad Untari, Ludmilla Fitri Waluy Wathon, Syubbanul Wilda Nur Rohmatilah Wilda Nur Rohmatillah Wilda Nur Rohmatillah Wilda Nur Rohmatillah Yandy Noviandri Yashinta Nirmala Siswanti Yoshinta Debby Yulia Yesti, Yulia Ziyan Nihlatul Millah