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Journal : E-Prodenta Journal of Dentistry

OVERVIEW OF GLOMERULAR HYPERTROPHY AND HYDROPIC DEGENERATION OF DIABETIC RAT KIDNEY MODELS IN GIVING TOMAN FISH Carabelly, Amy Nindia; Sinaga, Udur; Dewi, Nurdiana
E-Prodenta Journal of Dentistry Vol 5, No 1 (2021)
Publisher : Fakultas Kedokteran Gigi UB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.eprodenta.2021.005.01.1

Abstract

Background: Traditional medicine is increasingly favored by the community as an effort to maintain and treat health because it has low side effects and is easy to obtain. Low side effects in administering traditional medicines if the dosage is right, so it is necessary to do an acute toxicity test. One of the consumers of traditional medicine is diabetes mellitus (DM) sufferer. DM can cause delay wound healing. Toman fish is proven to accelerate wound healing. DM sufferers need special attention to their kidneys because in addition to the toxic effects caused by improper doses of traditional medicine, the kidneys can also experience diabetic nephropathy. Objectives: To analyze changes in glomerular hypertrophy and hydropic degeneration in the administration of 16 mL / KgBW Toman fish extract orally for 14 days in diabetic wistar rat kidneys. Methods: This study was a true experimental design with a post test only with control group design. The study was divided into a treatment group of toman fish extract at a dose of 16 mL / Kg BW orally for 14 days in diabetic rat kidney models and a control group in the form of feeding only. Results: The administration of toman fish extract in DM rat showed changes in the glomerular hypertrophy picture of 25-50% and decreased glomerular hypertrophy score which was significantly different from the control group. There was no feature of hydropic degeneration in either group. Conclusions: Giving toman fish extract to DM rat can reduce glomerular hypertrophy and does not cause hydropic degeneration
Co-Authors Ahda Ahda Annisa Ahmad Syaify, Ahmad Akhmad Akhdiannoor Ramadhan Al Supartinah Alfia Fitriani Alfia Fitriani, Alfia Amelia, Aura Amy Nindia Carabelly Ana Azizah Ansari Anita Diana Putri Ardi Siswanto Asnawati Asnawati Asnawati Asnawati Aspriyanto, Didit Aulia Azizah Baehaqi Bambang Setiawan Beta Widya Oktiani Debby Saputera, Debby Devi Puspita Handayani Dewi Puspitasari Diana Wibowo Feryra Putri Ayu Suma Feryra Putri Ayu Suma, Feryra Putri Firdaus, I Wayan Arya Krishnawan Fuady, Ridwan Ichshalul Gusti Wina Ayu Hazarisa Haliza, Ninda Andrea Hamdani, Riky Haryanto Adi Nugroho Hasvina Sofrullah Hatta, Isnur Hilda Ayu Setyawati Hilda Ayu Setyawati, Hilda Ayu Husnul Khatimah I Wayan Arya Krishnawan Firdaus Ichrom Nahzi, Muhammad Yanuar Ika Kustiyah Oktaviyanti Ika Kusuma Wardani Ivan Arie Wahyudi Kelana, Adhytya Suryo Khatimah, Husnul Lena Rosida Lena Rosida Lia Yulia Budiarti Lisda Hayatie, Lisda Maharani Laillyza Apriasari Maulida Rahmaniah Melinda Hairi Melinda Hairi, Melinda Muhammad Yunanda Anhar Naura Ifthinan Luthfiana Nisa Azaria Nita Herlina Nita Herlina, Nita Noryunita Rahmah Noryunita Rahmah, Noryunita Nur Atika Nur Tsaniya, Gusti Erysa Nurrahman, Tri Oktiani, Beta Widya Phradina Fili Septishelya Putra, Fedriko Gamaliel Raharja, Suka Dwi Rahmad Arifin Rahmadella, Afifah Renie Kumala Dewi Renita Renita Rahmad Renita Renita Rahmad, Renita Riska Nisaul Karimah Riski Agustin Riski Agustin, Riski Rosihan Adhani, Rosihan Salma Humaira Sari, Galuh Dwinta Setyawardhana, Raden Harry Dharmawan Sherli Diana Sinaga, Udur Sitepu, Alexander Siti Almira Rahma Siti Bale Sri Rantinah Sonia Dewi Maharani Suka Dwi Raharja Sunjaya Tunggala Sunjaya Tunggala, Sunjaya Syafa Layyina Amalia Tri Putri, Deby Kania Utami, Juliyatin Putri Wahyuni A Wahyuni A, Wahyuni Yasmina Aulia Yusfarani, Mirza Fitria Yusrinie Wasiaturrahmah Zahra, Aisyah Nur Zainatun Nadhira