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All Journal The Indonesian Biomedical Journal Sari Pediatri Paediatrica Indonesiana Molecular and Cellular Biomedical Sciences (MCBS) Majalah Kedokteran Nusantara The Journal Of Medical School Jurnal Review Pendidikan dan Pengajaran (JRPP) Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia El-Mujtama: Jurnal Pengabdian Masyarakat Gudang Jurnal Multidisiplin Ilmu Jurnal Pengabdian Bidang Kesehatan El-Mujtama: Jurnal Pengabdian Masyarakat

Syahril Pasaribu

Departemen Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Sumatera Utara / RSUP H. Adam Malik Medan

Author-ID : 3453510

Religion Aerospace Engineering Arts Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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The effect of treatment for soil-transmitted helminthiasis on cognitive function in children Dewi Sari; Muhammad Ali; Syahril Pasaribu
Paediatrica Indonesiana Vol 52 No 2 (2012): March 2012
Publisher : Indonesian Pediatric Society

Background Soil-transmitted helminth (STH) infections affectone-third of the world's population. School-aged children arereported to have the highest prevalence and intensity of disease,resulting in impaired cognitive function, malnutrition andmorbidity.Objective To examine differences in cognitive function in STHinfectedchildren before and after treatment.Methods We conducted a randomized, open-label, controlled trialfrom November 2 008 - March 2009 in Aek Na bar a, Lab uh an BatuDistrict, North Sumatera Province. Subjects were primary schoolagedchildren with STH infection. Before intervention, data onage, sex, nutritional status, STH infection status and cognitivefunction were collected. Subjects were divided into two groupsby simple randomization. Group I received 400 mg albendazoleand group II received a placebo. Three months after intervention,cognitive function of subjects in both groups was reassessed. Datawas analysed by Student's t test, with P value of less than 0.05considered to be statistically significant.Results Cognitive tests with the Wechsler Intelligence Scale forChildren (WISC) were performed in 120 children infected withSTH. Sixty children received 400 mg albendazole and 60 childrenreceived placebo. Seven children were excluded and one droppedout from this study. Three months after the intervention, wereevaluated cognitive function and found significant differencesin the categories of digit span (P=0.024) and total IQ score(P=0.027) between the two groups.Conclusions Treatment of STH infection with albendazoleimproved cognitive function of children in comprehension, codingand digit span testing. Performance and full IQ scores were alsoimproved after treatment. [Paediatr lndones. 2012;52:99-105].

Parental knowledge, attitude and practice on malaria in Mandailing Natal district Syafruddin Haris; Sri Sofyani; Bidasari Lubis; Munar Lubis; Syahril Pasaribu; Iskandar Z. Lubis
Paediatrica Indonesiana Vol 47 No 4 (2007): July 2007
Publisher : Indonesian Pediatric Society

Background Malaria is still considered to be an important healthproblem in Indonesia. Malaria has been found in islands withdifferent degree of endemicity. Behavior of the community isone of the factors affecting the incidence of malaria in MandailingNatal district.Objective To know the parental knowledge, attitude, and practiceamong parents whose children suffered from malaria or not.Methods A cross sectional study was conducted in six primaryschools and one health centre in October 2004. Subjects wereparents whose children were malaria positive and malaria negativebased on laboratory examination. Sample size was 85 parents foreach group. Selected respondents were interviewed usingstructured questionnaire. Degree of knowledge, attitude, andpractice on malaria were established using scoring system withinthree categories: good, less, and poor. Data were collected andpresented using chi-square and P<0.05 was considered as a levelof significant.Results The mean age of 85 parents whose children were positivemalaria, was 38.47 years (SD 6.67) and the mean age of thosewhose children were negative malaria was 40.41 years (SD 8.05).Parentâ€™s education level was 62.9% primary school and 90% oftheir children were school-aged. There were significant differenceson parental knowledge, attitude and practice in each group(P<0.05). There was also a significant correlation betweenoccupation and knowledge, but not between parental educationlevel and parental age. Parental knowledge and attitude on theincidence of malaria in Mandailing Natal district were good,though their practice were poor.Conclusion There are significant differences on parentalknowledge, attitude and practice, between parents whose childrenwere positive and negative for malaria.

Treatment of intestinal helminthiasis: mebendazole only or mebendazole-pyrantel pamoate? Wisman Dalimunthe; Charles Siregar; Munar Lubis; Syahril Pasaribu; Chairuddin P. Lubis
Paediatrica Indonesiana Vol 47 No 5 (2007): September 2007
Publisher : Indonesian Pediatric Society

Background Although intestinal helminthiasis causes highmorbidity and has a negative impact on childrenâ€™s growth anddevelopment, the efficacy of antihelmintics for multiplehelminthiasis in mass treatment is still doubtful.Objective To compare the efficacy of single dose mebendazoleand a combination of pyrantel pamoate and mebendazole for thetreatment of multiple infections due to Ascaris lumbricoides,hookworm, and Trichuris trichiura.Methods Subjects were elementary school students in Suka Village,Tiga Panah subdistrict, North Sumatera. They were randomizedto either receive mebendazole (M Group) or mebendazole-pyrantel pamoate group (MP Group). Stool examinations wereperfomed on each subjects on day 7, 14, 21, and 28 after treatment.Analyses were perfomed by using chi-squared and Mann-WhitneyU tests.Results The prevalence of intestinal helminthiasis was 95.4%. T.trichiura (88.7%) was the most common cause of infection followedby A. lumbricoides (79.5%), and hookworm (3.1%). Two hundredthirty nine (76.8%) children had multiple infections. Althoughthe egg reduction rate of intestinal helminthiasis in thecombination group was faster than that of the mebendazole group,there was no significant difference in the cure rate of both groups.Conclusion A single dose of mebendazole is preferred for masstreatment of multiple intestinal helminthiasis infections.

Effect of iron and zinc supplementation in the treatment of malaria in children Danny Dasraf; Bugis Mardina Lubis; Bidasari Lubis; Nelly Rosdiana; Munar Lubis; Syahril Pasaribu
Paediatrica Indonesiana Vol 47 No 6 (2007): November 2007
Publisher : Indonesian Pediatric Society

Background Iron and zinc administration for children withmalaria in endemic area were known to decrease parasitemia butdata on their effectiveness when given together to increasereticulocytes as erythropoiesis parameter and hemoglobin isinsufficient.Objective To determine the effect of zinc to increase ironabsorption in the treatment of Plasmodium falciparum malaria inchildren.Methods Children with positive Plasmodium falciparum on theirblood smear (n=86) examination were randomly assigned to dailysupplementation of iron 6 mg per kg body weight per day plusplacebo or iron plus zinc 10 mg per day for 30 days. Venous bloodspecimens were collected at the start and at the end of the study.Results Sixty-nine children completed the supplementations andhad both baseline and follow-up blood specimen study. After 30-day supplementation, the iron plus placebo and iron plus zincgroups showed significant difference on hemoglobin concentration(0.58 and 0.09 g/dl; P<0.05). There was no significant differencein reticulocyte production index and reticulocyte count beforeand after intervention in both groups. There was only significantdifference in red blood cells concentration after supplementationof iron plus placebo and iron plus zinc (4.7 in 4.5 million/Î¼l;P<0.05).Conclusions Iron supplementation with or without zinc showssignificant increase of hemoglobin concentration. It is slightlyhigher in iron plus placebo group.

Efficacy of artemether-lumefantrine and artesunate-amodiaquine for treating uncomplicated falciparum malaria in children Tri Faranita; Ayodhia Pitaloka Pasaribu; Muhammad Ali; Munar Lubis; Syahril Pasaribu
Paediatrica Indonesiana Vol 52 No 5 (2012): September 2012
Publisher : Indonesian Pediatric Society

Background Artesunate-amodiaquine (ASAQ) has been usedas a firsdine treatment for uncomplicated faldparum malariain Indonesia since 2004. Its efficacy depends on amodiaquineresistance of the infecting parasites. Artemether-lumefantrine(AL) has been shown to be highly efficacious in treatinguncomplicated faldparum malaria in several countries. However,there have been few studies on these anti-malarial medicationsin Indonesia.Objective To compare the efficacy of AL to ASAQ for treatinguncomplicated faldparum malaria in children.Methods An open, randomized, controlled trial wasconducted in school-aged children in the Mandailing NatalRegency, North Sumatera Province, Indonesia, from Octoberto December 2010. A total of 280 pediatric, uncomplicatedfalciparum malaria patients were randomly assigned to receiveeither AL or ASAQ for 3 days. Participants were followed-up ondays 1,2,3,7, 14, 28 and 42 following the first medication dose.The outcomes noted were adequate clinical and parasitologicalresponse (ACPR), parasite reduction, parasite clearance time,fever clearance time and adverse events. Analysis was basedon intention-to-treat.Results In this study, ACPRs on day 42 were 86.4% and 90.7%for the ASAQ and AL groups, respectively (p=0.260). On days 7and 14, the AL group had higher cure rates than that of the ASAQgroup (P<0.05). Early treatment failure, late treatment failure andparasitological failure for both groups were similar. We also foundfaster parasite clearance time and higher parasite reduction in theAL group than in the ASAQ group. However, fever clearancetime was shorter in the ASAQ group. The incidence of adverseevents such as nausea, vomiting, malaise, and pruritus were similarbetween the two groups (P=0.441).Conclusion AL had higher efficacy than ASAQ for the treatment of uncomplicated falciparum malaria in children.[Paediatr rndones. 2012;52:260-6].

Comparison of the efficacy of artesunate-amodiaquine with quinine-clindamycin for treatment of uncomplicated falciparum malaria in children Purnama Fitri; Armila Armila; Munar Lubis; Syahril Pasaribu; Chairuddin P. Lubis
Paediatrica Indonesiana Vol 49 No 2 (2009): March 2009
Publisher : Indonesian Pediatric Society

Background Drug-resistant Plasmodium falciparum malaria is amajor contributor to increasing malaria-related morbidity andmortality. Artesunate-amodiaquine is a potential combinationtherapy that shows improved treatment efficacy. Clindamycin incombination with quinine is also a safe and effective treatmentfor multidrug-resistant P. falciparum malaria.Objectives To compare the efficacy of artesunate-amodiaquine andquinine-clindamycin combination therapies for the treatment ofuncomplicated falciparum malaria.Methods This randomized open label trial in 23 2 children agedbetween one month and 18 years old took place in MandailingNatal, North Sumatra, from August to September 2006. The AAgroup received a 3-day oral course of artesunate (4 mg/kg BWonce a day) plus amodiaquine (10 mg/kg BW once a day). TheQC group received a 3-day course of clindamycin (5 mg of base/kgBW twice a day) plus a 7-day course of quinine (10 mg of salt/kgBW orally for the first four days, then 5 mg of quinine salt/kg BWfor the next three days). We performed thin and thick peripheralblood smears on days 0, 2, 7, and 28.Results A total of 232 eligible children were enrolled but only22 7 completed the study (114 in group AA, 113 in group QC).The cure rates were lOOo/o in both groups by the second day, andthere was no recrudescence in either group. We found more sideeffects in AA group compared with in QC group, i.e., headacheand vomiting.Conclusion Artesunate-amodiaquine and quinine-clindamycincombinations showed similar efficacy for the treatment of uncomplicatedP. falciparum.

Parascreen as an alternative diagnostic tool for falciparum malaria Jenny Ginting; Siska Mayasari; Munar Lubis; Syahril Pasaribu; Chairuddin P. Lubis
Paediatrica Indonesiana Vol 48 No 4 (2008): July 2008
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi48.4.2008.220-3

Background Malaria is a parasitic disease with high morbidityand mortality. Rapid immunochromatographic are emerging todetect specific antigens of human plasmodia.Objective To determine the sensitivity and specificity ofParascreenfor the detection of Plasmodium falciparum in children.Methods A diagnostic test study was performed in MandailingNatal District, Penyabungan, North Sumatera. Subjects werepublic health center and hospital patients with symptoms of fever,pallor, headache, and diarrhea. Blood specimens were obtained forParascreen testing. Microscopy of Giemsa-stained blood samplesserved as the gold standard.Results One hundred and four subjects were studied. The sensitiv-ity and specificity ofParascreen were 76% and 100%, respectively.Positive and negative predictive values of the test were 100% and49%, respectively. Likelihood ratio was infinite for a positive testand 0.23% for a negative test.Conclusion Parascreen is a useful and highly specific di-agnostic tool for P. falciparum malaria

The effectiveness of chloroquine compared to Fansidar in treating falciparum malaria Emil Azlin; Ichwan HH Batubara; Wisman Dalimunte; Charles Siregar; Bidasari Lubis; Munar Lubis; Syahril Pasaribu
Paediatrica Indonesiana Vol 44 No 1 (2004): January 2004
Publisher : Indonesian Pediatric Society

Background The most difficult problem in eradicating malaria isthe resistance of P. falciparum to drugs. Mandailing Natal has thehighest malaria incidence in North Sumatera.Objective This study aimed to investigate the efficacy of chloro-quine and Fansidar in treating falciparum malaria.Methods A randomized double-blind study was done from April toMay 2001. Eighty-three patients with acute uncomplicated P.falciparum malaria infection were randomized into two groups.Group I (35 patients) received chloroquine and group II (48 pa-tients) received Fansidar. Blood examinations were performed onthe 1 st , 2 nd , 7 th , and 28 th days.Results The resistance of P. falciparum to drugs in the chloro-quine group were found in 10 patients with R II and 1 patients withR III, while in the Fansidar group, there were 14 patients with R II.Conclusion The efficacy of chloroquine and Fansidar in treatingfalciparum malaria was not significantly different

Hemolytic anemia in falciparum and vivax malarial patients based on serum bilirubin examination Yoyoh Yusroh; Bidasari Lubis; Syahril Pasaribu; Munar Lubis; Tiangsa Sembiring; Adillida Adillida
Paediatrica Indonesiana Vol 44 No 3 (2004): May 2004
Publisher : Indonesian Pediatric Society

Objective To examine hemolysis in falciparum and vivax malarialpatients based on serum bilirubin examination.Methods A cross sectional study was conducted on childrenyounger than 15 years of age who visited public health center inthe district of Mandailing Natal with complaints of fever, shivering,pale, jaundice, diarrhea, or headache between April 9 th and April19 th 2001. Variables recorded were age, gender, body weight, bodyheight, symptoms and signs, anti malarial drugs, and laboratorytest results. Thin and thick blood smears were done as diagnostictools of malaria. Thin blood smear was also performed to deter-mine the level of malaria parasites in blood (parasitemia) and toexamine the morphology of red blood cells. Hemolysis was deter-mined by bilirubin examination.Results In P. falciparum malaria, there was a moderate correlation(r=0.68, p<0.0001) between parasitemia and indirect bilirubin con-centration. While in P. vivax malaria, there was only a weak corre-lation (r=0.46, p=0.007) between parasitemia and indirect bilirubinconcentration. It was also found that in falciparum malaria, para-sitemia, total and indirect bilirubin concentrations were significantlyhigher than that in vivax malaria, with p values of 0.009, 0.015 and0.003, respectively.Conclusion Hemolysis in falciparum malaria is more severe thanthat in P. vivax malaria, with marked elevation of indirect bilirubin.The elevation of serum bilirubin correlated with parasitemia

Association between socioeconomic status and the prevalence of intestinal worm infection in primary school children Sri Alemina Ginting; Isra Firmansyah; Dedi Satria Putra; Dachrul Aldy; Syahril Pasaribu; Chairuddin P Lubis
Paediatrica Indonesiana Vol 44 No 3 (2004): May 2004
Publisher : Indonesian Pediatric Society

Background In Indonesia, medical problems are indicated bydiseases associated with low socioeconomic status. The preva-lence of intestinal worm is still high in Indonesia.Objective The purpose of this study was to find the associationbetween socioeconomic status and the prevalence of intestinalworm infection.Methods A cross sectional study was done on 120 primary schoolchildren in Suka Village, Karo District, North Sumatra Province.Subjects were selected by means of random sampling. Kato Katzmethod was used in stool examination. Socioeconomic status wasreferred from the Survey Keluarga Sejahtera (Wealth Family Sur-vey) 1998 by the BKKBN (the National Coordination Board onFamily Planning). Data of socioeconomic status were collected byinterview using a questionnaire and analyzed by chi square test; pvalue of <0.05 was considered to be statistically significant.Results Eighty-four subjects (70%) suffered from intestinal worminfection. There was no significant association between either age(p=0.811) or nutritional status (p=0.792) and intestinal worm infec-tion, but there was significant association between sex and intes-tinal worm infection (p=0.028). There was also association betweenintestinal worm infection and fatherâ€™s education (p=0.044). Motherâ€™soccupation had a significant association with intestinal worm in-fection (p=0.001), but fatherâ€™s occupation (p=0.474) did not. Nei-ther parentsâ€™ income (p=0.429) nor socioeconomic status (p=0.098)was associated with intestinal worm infection.Conclusion There was significant association between intestinalworm infection and sex, fatherâ€™s education or motherâ€™s occupation

Co-Authors Abdurrozaq Hasibuan Adillida Adillida Amelia, Fereza Andaresta, Novi Araafi, Alif Ardila, Maisyah Aridamuriany D Lubis Ariyansyah, Fauzy Armila Armila Ayodhia P. Pasaribu Ayodhia P. Pasaribu Ayodhia Pitaloka Pasaribu Ayodhia Pitaloka Pasaribu Ayodhia Pitaloka Pasaribu Ayodhia Pitaloka Pasaribu Ayu, Delfriana Aznan Lelo Azwan H. Lubis Berlian Hasibuan Bidasari Lubis Bidasari Lubis Bugis Mardina Lubis Chairuddin P. Lubis Chairuddin P. Lubis Chairuddin P. Lubis Chairuddin P. Lubis Chairuddin P. Lubis Chairul Yoel Chairul Yoel Charles Siregar Charles Siregar Dachrul Aldy Danny Dasraf Dedi Satria Putra Dewi Sari Dina Evalina Gultom Dini Lailani Ditho Athos P. Daulay Dwika Ardelya Pratiwi Emil Azlin Erika S. Panjaitan Erniwaty P Panggabean Evi Kamelia Fauzi Rizal Fitri Arianty Lubis Fitri Asymida Hasibuan, Arini Salsabila HENDRI WIJAYA Ichwan HH Batubara Ifo Faujiah Sihite Inke Nadia Diniyanti Lubis Iskandar Z Lubis Iskandar Z. Lubis Isra Firmansyah Jenny Ginting Latifah Mutiah Nurhidayah Lily Irsa Lubis, Ade Irma Seftyani Mahadi Mahadi Mahruzzaman Naim Maisyah Ardila Muhammad Ali Muhammad Ali Muhammad Ali Muhammad Ali Muhammad Ali Muhammad Ali Muhammad Ali Muhammad Ali Muhammad Ali Muharani, Anisa Munar Lubis Nasution, Ummi Kalsum Nelly Rosdiana Nisrina Nisrina Novianty, Sri Novianty, Sri Nurhandayani dr Oktapiani, Friska Dela Pasaribu, Ayodhia Pitaloka Pasaribu, Ayodhia Pitaloka Pratiwi, Dwika Ardelya Purnama Fitri Raspiyahni, Raspiyahni Regita Cahyani Rita Angraini RIZKA AULIA Rizka Tiara ROSIHAN ANWAR Rusdidjas Rusdidjas Salianto Salianto, Salianto Seftyani, Ade Irma Siska Mayasari Siska Mayasari Lubis Sri Alemina Ginting Sri Rezky Gantina Sri Sofyani Suryani Ginting Susilawati Syafruddin Haris Syamsidah Lubis T. Ernalisna T. Murad El-Fuad T. Razif Tiangsa Sembiring Tiangsa Sembiring Tjut Dharmawati Tri Faranita Wahyudi Wahyudi Windya Sari Nasution Wisman Dalimunte Wisman Dalimunthe Wulan Andika Y Dimyati Yahya G. Lubis Yazid Dimyati Yoyoh Yusroh Yunnie Trisnawati

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