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All Journal Jurnal Medik Veteriner Jurnal Layanan Masyarakat (Journal of Public Service) Journal of Applied Veterinary Science and Technology LOSARI: Jurnal Pengabdian Kepada Masyarakat journal of Basic Medical Veterinary Jurnal Agro Veteriner
Hidayatik, Nanik
Divisi Kedokteran Dasar Veteriner Fakultas Kedokteran Hewan, Universitas Airlangga
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Medicine & Pharmacology Public Health Social Sciences Transportation Veterinary Other

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Journal : Journal of Applied Veterinary Science and Technology

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The Influence of Oral Administration of Red Dragon Fruit Peels Extract (Hylocereus polyrhizus) on Increasing High Density Lipoprotein in Male White Rats (Rattus norvegicus) Hypercholesterolemia Ahmad Thoriqul Firdaus; Gandul Atik Yuliani; Tri Wahyu Suprayogi; Nusdianto Triakoso; Eduardus Bimo Aksono Herupradoto; Nanik Hidayatik
Journal of Applied Veterinary Science And Technology Vol. 4 No. 1 (2023): April 2023
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/javest.V4.I1.2023.1-4

Abstract

Background: Hypercholesterolemia is one of the most common diseases in the world, with cholesterol levels exceeding normal levels. Hypercholesterolemia can cause various systemic disorders in the body. One of the signs is by decreasing HDL (High-Density Lipoprotein) cholesterol levels. Dragon fruit peel contains many ingredients, such as vitamin B3 (niacin), vitamin C, flavonoids, anthocyanins, and other minerals that can affect the increase in HDL production and reduce total cholesterol levels. Purpose: To know the effect of red dragon fruit peel extract (Hylocereus polyrhizus)on increasing levels of High-Density Lipoprotein (HDL) in male rats (Rattus norvegicus) hypercholesterolemia. Methods: Male rats were made hypercholesterolemic using a mixture of lard (3 ml) and egg yolk (1 g) for 14 days orally. 20 hypercholesterolemic male rats were further divided into 5 treatment groups and given dragon fruit peel extract therapy with different treatments, namely T0 negative control (CMC-Na 1% + aquadest), T1 positive control (Simvastatin 0.0013 mg/200 g BW), T2, T3 and T4 (each 100, 150, 200 mg/kg BW red dragon fruit peel extract) for 14 days orally.  Blood serum was taken on day 36 and tested in the laboratory using a chemical analyzer machine; then the data were analyzed using the univariant multiple way one-way ANOVA statistical test with a significant difference (p>0.05). Results: The P4 treatment group has an effective dose (200 mg/kg BW) to increase high-density lipoprotein (HDL) levels, while the P3 treatment group (dose 150 mg/kg BW) is less effective but can still have an effect. Conclusion: This research showed that red dragon fruit peel extract could increase HDL (High-Density Lipoprotein) cholesterol levels with an effective 200 mg/kg BW dose.
A Comparative Study Between E-Cigarette Vapor and Cigarette Smoke Exposure on the Lungs of Mice (Mus musculus) Putri, Mirtanti Kiswandi; Hestianah, Eka Pramyrtha; Kuncorojakti, Suryo; Widiyatno, Thomas Valentinus; Sukmanadi, Mohammad; Santoso, Kuncoro Puguh; Plumeriastuti, Hani; Hidayatik, Nanik; Khairullah, Aswin Rafif
Journal of Applied Veterinary Science And Technology Vol. 6 No. 2 (2025): October 2025
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/javest.V6.I2.2025.102-108

Abstract

Background: Cigarettes are tobacco products processed with or without additives and are known to contain addictive substances that pose serious health risks to individuals and the public. Inhaled cigarette smoke directly stimulates the activation of macrophage cells in the respiratory tract. Among the affected cells, type II alveolar cells which produce pulmonary surfactant to reduce alveolar surface tension are particularly vulnerable to smoke-induced damage. Purpose:  This study aimed to compare the effects of conventional cigarette smoke and e-cigarette vapor exposure on the number of alveolar macrophages and type II alveolar cells in male mice (Mus musculus). Method: A total of 28 male mice were randomly divided into seven groups. The control group (C) was exposed to ambient air only. Groups A1, A2, and A3 were exposed to 1, 2, and 3 conventional cigarettes per day, respectively, while groups B1, B2, and B3 were exposed to 0.7 mL, 1.3 mL, and 2 mL of e-liquid vapor per day, respectively. All exposures were conducted for 36 consecutive days. Results: A significant difference (p<0.05) was observed in the number of alveolar macrophages among groups C, A1, A2 , A3 , B2 , and B3 , whereas no significant difference was found between A1 and B1. The number of type II alveolar cells significantly differed (p < 0.05) across all groups: C, A1, A2, A3, B1, B2, and B3. Conclusion: Both conventional cigarette smoke and e-cigarette vapor increase alveolar macrophage counts and reduce type II alveolar cell numbers compared to controls. Although both exposures pose health risks, e-cigarette vapor appears to cause milder pulmonary effects than conventional cigarette smoke.
Co-Authors Ahmad Thoriqul Firdaus Aksono HP., Eduardus Bimo Al arif, Mohammad Anam Al Thalhah, Muhammad Rafsa Al-Arif , M. Anam An, Chau Yu Annise Proboningrat Boedi Setiawan Eka Pramyrtha Hestianah, Eka Pramyrtha Erma Safitri Gandul Atik Yuliani Gradia, Resti Gunalan, Jheevanesh Hani Plumeriastuti Herry Agoes Hermadi Hidajati, Nove Hidanah, Sri Hisyam, Mirza Atikah Madarina Indriyanti, Astrid Irham Zaki Johansyah, Fadilla Anita Kinksky Kadek Rachmawati Khairullah, Aswin Rafif Kumar, Bhagya Laxmi Ramesh Kuncorojakti, Suryo Lilik Maslachah Majid, Rully Abiyoga Mirino, Mario Navyseal Mirni Lamid Mirni Lamid Mubarok, Muhammad Syahrul Novianti, Arindita Niatazya Nusdianto Triakoso Pratomo, Andrika Indra Putri, Mirtanti Kiswandi Rajendaran, Harvina Ratna Damayanti Ratna Damayanti Retno Sri Wahjuni Rimayanti Rimayanti Rochmah Kurnijasanti Rosdianto, Aziiz Mardanarian Rosyada, Zulfi Nur Amrina Sabdoningrum, Emy Koestanti Santoso, Kuncoro Puguh Septiyani Septiyani, Septiyani Sukmanadi, Mohammad Sunarso, Agus Tacharina, Martia Rani Tri Wahyu Suprayogi Warsito, Sunaryo Hadi Widiyatno, Thomas Valentinus Widya Paramita Lokapirnasari Widya Paramita Lokapirnasari Yuliani, Gandul Atik