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All Journal Jurnal Medik Veteriner Jurnal Layanan Masyarakat (Journal of Public Service) Journal of Applied Veterinary Science and Technology LOSARI: Jurnal Pengabdian Kepada Masyarakat journal of Basic Medical Veterinary Jurnal Agro Veteriner
Hidayatik, Nanik
Divisi Kedokteran Dasar Veteriner Fakultas Kedokteran Hewan, Universitas Airlangga
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Medicine & Pharmacology Public Health Social Sciences Transportation Veterinary Other

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Journal : journal of Basic Medical Veterinary

 1 
The Effect of Giving Gel Combination of Binahong Leaf Extract and Turmeric Rhizome Extract on Histopathological Epithelial Thickness in II B Degree Burn of Rattus norvegicus Indriyanti, Astrid; Rachmawati, Kadek; Maslachah, Lilik; Damayanti, Ratna; Hidayatik, Nanik; Setiawan, Boedi
Journal of Basic Medical Veterinary Vol. 12 No. 2 (2023): Journal of Basic Medical Veterinary, December 2023
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbmv.v12i2.45753

Abstract

This aim of this research was to study the effect of giving a combination gel of binahong (Anredera cordifolia) leaf and turmeric (Curcuma longa Linn) rhizome extract on histopathology of epithelial thickness which has II B degree burns. Twenty five male white rats (Rattus norvegicus) were divided into five groups. K(-) group was normal skin, K(+) group was skin burns treated with 1% silver sulfadiazine, P1, P2, and P3 was skin burns treated with gel combination of binahong leaf extract and turmeric rhizome extract with increase concentration of binahong leaf extract i.e. 1.25%, 2.5%, and 5%, while the concentration of turmeric rhizome extract i.e. 2% for each treatment. The combination gel of binahong leaf extrac 1.25% and turmeric rhizome extract 2% has potential to be an effective treatment for II B burns as indicated by increased of epithelial thickness. Therefore, this study concluded that 1.25% combination gel of binahong leaf extract and turmeric rhizome extract 2% is the effective dosage to increase epithelial thickness on II B healing degree burns wound healing.
Effect of Excessive Carrot Juice (Daucus carota) Administration on Uric Acid and Blood Glucose Levels in Rats (Rattus norvegicus) An, Chau Yu; Kumar, Bhagya Laxmi Ramesh; Gunalan, Jheevanesh; Rajendaran, Harvina; Al Thalhah, Muhammad Rafsa; Hidayatik, Nanik; Novianti, Arindita Niatazya
Journal of Basic Medical Veterinary Vol. 14 No. 1 (2025): Journal of Basic Medical Veterinary, June 2025
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbmv.v14i1.66784

Abstract

The consumption of carrot juice (Daucus carota) has been associated with various health benefits, yet its effects on metabolic parameters such as uric acid and blood glucose levels remain inadequately explored. Understanding these effects is crucial for developing dietary recommendations, particularly for conditions related to elevated uric acid and blood glucose. This research aimed to investigate the impact of excessive carrot juice administration on uric acid and blood glucose levels in rats (Rattus norvegicus). The study sought to determine whether carrot juice could serve as a beneficial dietary intervention or if it posed risks for metabolic dysregulation. A true experimental design was employed, utilizing a post-test only control group approach. Four healthy rats were divided into two groups: a control group receiving standard rat feed and a treatment group receiving carrot juice alongside their feed for seven days. Blood samples were collected after a 12-hour fasting period, and uric acid and blood glucose levels were measured using an Easy Touch GCU glucometer. Statistical analysis included descriptive statistics and T-tests to assess significant differences between groups. The results indicated that excessive administration of carrot juice significantly decreased uric acid levels in the treatment group compared to the control group (p < 0.05). Conversely, blood glucose levels were found to be significantly higher in the treatment group (p < 0.05), suggesting a complex interaction between carrot juice consumption and metabolic regulation. The study concludes that while excessive carrot juice can effectively lower uric acid levels in rats, it may also lead to increased blood glucose levels. These findings highlight the need for cautious dietary recommendations regarding carrot juice intake, particularly for individuals at risk of hyperglycemia. Future research should focus on larger sample sizes and explore the effects of carrot juice on various physiological systems and stress-related impacts on metabolic parameters.
Nephroprotective Activity of Ethanolic Extract of Papaya (Carica papaya) Seeds on Blood Urea Nitrogen and Creatinine Levels in Albino Rats Induced by Paracetamol Mubarok, Muhammad Syahrul; Yuliani, Gandul Atik; Sunarso, Agus; Hidayatik, Nanik; Kurnijasanti, Rochmah; Hisyam, Mirza Atikah Madarina
Journal of Basic Medical Veterinary Vol. 14 No. 2 (2025): Journal of Basic Medical Veterinary, December 2025
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbmv.v14i2.78386

Abstract

Kidney damage caused by high-dose paracetamol leads to elevated Blood Urea Nitrogen (BUN) and creatinine levels as indicators of impaired renal function. This study aimed to evaluate the dose-dependent nephroprotective effects of ethanolic Carica papaya seed extract on BUN and creatinine levels in paracetamol-induced albino rats. A posttest-only control group design was applied using 25 male Wistar rats divided into five groups: negative control (1% CMC-Na), positive control (paracetamol 1000 mg/kgBW), and three treatment groups receiving Carica papaya seed extract at doses of 100, 200, and 400 mg/kgBW. The extract was administered orally for seven consecutive days before paracetamol induction on day 8 and continued until day 11. Blood samples were collected on day 11, and serum was stored at -20 °C before BUN and creatinine concentrations were analyzed spectrophotometrically. Data were statistically analyzed using one-way ANOVA followed by Duncan’s Multiple Range Test (DMRT) at a significance level of p < 0.05. The results showed a significant and dose-dependent reduction in both parameters in all treated groups compared to the positive control, with the 400 mg/kgBW dose showing the strongest effect and restoring values close to physiological levels. The nephroprotective activity was associated with the antioxidant and anti-inflammatory mechanisms of the bioactive compounds that counteract oxidative stress and preserve renal cellular integrity. In conclusion, the ethanolic extract of Carica papaya seeds demonstrates significant dose-dependent nephroprotection against paracetamol-induced kidney injury in rats.
Co-Authors Ahmad Thoriqul Firdaus Aksono HP., Eduardus Bimo Al arif, Mohammad Anam Al Thalhah, Muhammad Rafsa Al-Arif , M. Anam An, Chau Yu Annise Proboningrat Boedi Setiawan Eka Pramyrtha Hestianah, Eka Pramyrtha Erma Safitri Gandul Atik Yuliani Gradia, Resti Gunalan, Jheevanesh Hani Plumeriastuti Herry Agoes Hermadi Hidajati, Nove Hidanah, Sri Hisyam, Mirza Atikah Madarina Indriyanti, Astrid Irham Zaki Johansyah, Fadilla Anita Kinksky Kadek Rachmawati Khairullah, Aswin Rafif Kumar, Bhagya Laxmi Ramesh Kuncorojakti, Suryo Lilik Maslachah Majid, Rully Abiyoga Mirino, Mario Navyseal Mirni Lamid Mirni Lamid Mubarok, Muhammad Syahrul Novianti, Arindita Niatazya Nusdianto Triakoso Pratomo, Andrika Indra Putri, Mirtanti Kiswandi Rajendaran, Harvina Ratna Damayanti Ratna Damayanti Retno Sri Wahjuni Rimayanti Rimayanti Rochmah Kurnijasanti Rosdianto, Aziiz Mardanarian Rosyada, Zulfi Nur Amrina Sabdoningrum, Emy Koestanti Santoso, Kuncoro Puguh Septiyani Septiyani, Septiyani Sukmanadi, Mohammad Sunarso, Agus Tacharina, Martia Rani Tri Wahyu Suprayogi Warsito, Sunaryo Hadi Widiyatno, Thomas Valentinus Widya Paramita Lokapirnasari Widya Paramita Lokapirnasari Yuliani, Gandul Atik