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All Journal MEDIA MEDIKA INDONESIANA Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Journal of Mathematical and Fundamental Sciences Jurnal Wiyata : Penelitian Sains dan Kesehatan Jurnal Kimia Terapan Indonesia JPSCR : Journal of Pharmaceutical Science and Clinical Research PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Ilmu Kefarmasian Indonesia Majalah Farmasetika Berkala Ilmiah Kimia Farmasi Borneo Journal of Pharmacy
Bambang Tri Purwanto
Department Of Pharmaceutical Chemistry, Faculty Of Pharmacy, Universitas Airlangga, Surabaya
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health Social Sciences Other

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Synthesis of Methyl 3-(4-hydroxyphenyl) acrylate using Domestic Microwave Irradiation at 200 Watt Power Moch Davit Abdul Majid; Ekowati, Juni; Purwanto, Bambang Tri
Berkala Ilmiah Kimia Farmasi Vol. 10 No. 2 (2023): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikfar.v10i2.38479

Abstract

In this study, a methylation reaction was carried out for the p-coumaric acid compound using potassium carbonate as a base and dimethyl carbonate as a methylation agent with acetone as a solvent. The methylation reaction was carried out using microwave irradiation from microwave domestic with a power of 200 watts. The purity test was carried out on a TLC plate using three different eluents and produced a single stain that was different from the initial compound. The phenol functional group tested with FeCl3 reagent showed a positive purple color. Compound identification was done using an FT-IR spectrophotometer and a 1H-NMR spectrometer. In the synthesized FT-IR spectrum, there was an absorption of the ester group at wave numbers 1671 cm-1 (C=O group) and 1243 cm-1 (C-O group), there was a band at 3378 cm-1 indicating the presence of the phenol group. There were differences in fingerprint results in the FT-IR spectrum of the p-coumaric acid compound and the results of the methylation reaction. The 1H-NMR spectrum confirmed the presence of three methyl ester protons of the carboxylic acid and the phenolic OH. This indicated that the synthesis produced a compound, namely methyl (E)-3-(4-hydroxyphenyl) acrylate. Keywords: methyl (E) 3-(4hydroxyphenyl) acrylate), p-coumaric acid, Potasium Carbonate, Microwave Irradiation, Synthesis
UJI IN SILICO AKTIVITAS ANALGESIK DAN TOKSISITAS SENYAWA TURUNAN N-BENZOIL-N’-4-METOKSIFENILTIOUREA SEBAGAI CALON OBAT ANALGESIK Juwanti, Aulia; Purwanto, Bambang Tri; Poerwono, Hadi
Jurnal Wiyata Penelitian Sains dan Kesehatan Vol 11, No 2 (2024)
Publisher : LP2M IIK (Lembaga Penelitian dan Pengabdian Masyarakat Institut Ilmu Kesehatan) Bhakti Wiy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56710/wiyata.v11i2.863

Abstract

Abstrak Latar belakang : Senyawa N-(Benzoil)-N’-4-metoksifeniltiourea mempunyai gugus farmakofor yang sama dengan asam mefenamat yang mempunyai aktivitas sebagai analgesik, sehingga layak dijadikan senyawa induk untuk dikembangkan lebih lanjut melalui modifikasi struktur. Tujuan : Penelitian ini bertujuan untuk memprediksi aktivitas analgesik dan toksisitas dari duapuluh senyawa turunan N-(Benzoil)-N’-4-metoksifeniltiourea sebagai calon obat analgesik. Salah satu mekanisme kerja turunan N-(Benzoil)-N’-4-metoksifeniltiourea sebagai analgesik adalah menghambat COX2, yang berperan penting dalam mengubah asam arakidonat menjadi prostaglandin. Metode : Aktivitas biologis dapat diprediksi melalui pemodelan molekul yang disebut uji in silico,menggunakan program molecular operating environment (MOE) sedangkan toksisitas dapat diprediksi menggunakan program pkCSM. Uji in silico dilakukan dengan melakukan docking senyawa yang akan diprediksi aktivitasnya dengan target reseptor COX2, PDB 5IKR. Hasil : Hasil docking berupa energi ikatan digambarkan dengan nila Score (S). Senyawa dengan nilai S kecil berarti mempunyai ikatan ligan-reseptor yang stabil dan diprediksi mempunyai aktivitas yang besar. Dari hasil uji in silico disimpulkan bahwa turunan N-(benzoil)-N’-4-metoksifeniltiourea diprediksi menimbulkan toksisitas relative rendah, dan mempunyai aktivitas yang lebih besar dibandingkan asam mefenamat. Simpulan : N-(Etoksibenzoil)-N’-4-metoksifeniltiourea diprediksi mempunyai aktivitas analgesik paling besar sehingga senyawa terpilih untuk disintesis dan dikembangkan lebih lanjut. Abstract Background: The compound N-(benzoyl)-N'-4-methoxyphenylthiourea has the same pharmacophore group as mefenamic acid which has analgesic activity, so it is suitable to be used as a parent compound for further development through structural modification. Objective: This study aims to predict the analgesic activity and toxicity of twenty N-(benzoyl)-N'-4-methoxyphenylthiourea derivative compounds as candidate analgesic drugs. One of the mechanisms of action of the N-(benzoyl)-N'-4-methoxyphenylthiourea derivative as an analgesic is to inhibit COX2, which plays an important role in converting arachidonic acid into prostaglandins. Method: Biological activity can be predicted through molecular modeling called in silico testing, using the molecular operating environment (MOE) program, while toxicity can be predicted using the pkCSM program. The in silico test is carried out by docking the compound whose activity will be predicted with the target receptor COX2, PDB ID 5IKR. Results: The docking results in the form of bond energy are described by the value Score (S). A compound with a small S value means it has a stable ligand-receptor bond and is predicted to have large activity. From the in silico test results, it was concluded that the N-(benzoyl)-N'-4-methoxyphenylthiourea derivative is predicted to cause relatively low toxicity, and has greater activity than mefenamic acid. Conclusion: N-(Ethoxybenzoyl)-N'-4-methoxyphenylthiourea are predicted to have the greatest analgesic activity so the compounds were selected for synthesis and further development.
Inovasi Produk Olahan Tahu dan Pengemasannya serta Pengembangan Pemasaran dalam Upaya Meningkatkan Pendapatan Perajin Tahu di Desa Karanganyar Kecamatan Wates Kabupaten Kediri: Innovation in Processed Tofu Products and Their Packaging and Marketing Development in an Effort to Increase the Income of Tofu Crafters in Karanganyar Village, Wates District, Kediri Regency Purwanto, Bambang Tri; Ekowati, Juni; Widiandani, Tri; Hariyadi, Dewi Melany; Hendradi, Esti; Yusuf, Helmy; Purnomo, Ahmad Toto; Ramadhani, Firmansyah Ardian; Siswandono, Siswandono; Wiyono, Anang Setyo; Yuliati, Ninis; Kristianingsih, Ida; Savitri, Orchidea Meidy Nurintan; Maulia, Arwinda; Rahman, Ave
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 9 No. 11 (2024): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v9i11.8698

Abstract

MSMEs in the food sector are among the main supporters of Indonesia's economic activities. As a food production center in the form of tofu products, Kediri Regency is well known to the public, with white, yellow, silk, and other tofu products. Most of the tofu production carried out to date is only in the form of tofu products in their original form. This is because tofu craftsmen have not utilized other processed tofu products to increase their income. This community service activity aims to introduce innovations in processed tofu products, packaging, marketing, and processing of liquid tofu waste into new products which are expected to increase the income of tofu makers in Karanganyar village, Wates District, Kediri Regency. This community service activity was carried out using the media of presenting several materials and carrying out two-way interactive discussions. Evaluation of this activity was carried out with pre- and post-tests from the participants by answering 10 questions related to the three materials. The results obtained after being analyzed using the SPSS program showed differences between the pre-and post-tests of the participants, whereas the post-test results showed that the participants had understood the material provided during this activity. Thus, it can be concluded that this activity can be proven to be understood by the participants regarding innovation in processed tofu products and processing of tofu liquid waste.
Edukasi dan Pelatihan Pemanfaatan Tanaman Obat Keluarga di Desa Dlingo Bantul sebagai Upaya Pencapaian Tujuan SDGs di Bidang Kesehatan: Education and Training on the Use of Family Medicinal Plants in Dlingo Village, Bantul, as an Initiative to Support the Achievement of Health-Related SDGs Sukardiman, Sukardiman; Kusumawati, Idha; Handayani, Rosita; Sudjarwo, Sudjarwo; Munandar, Tristiana Erawati; Yusuf, Helmy; Diyah, Nuzul Wahyuning; Poerwono, Hadi; Purwanto, Bambang Tri
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 10 No. 7 (2025): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v10i7.10042

Abstract

Global health issues have become increasingly urgent following the COVID-19 pandemic, which resulted in approximately 6.6 million deaths by 2022. This impact has prompted communities to revert to traditional medicines, aligning with the National Development Planning System (RPJPN) 2005-2025, which promotes a health paradigm through traditional remedies. Community service activities were carried out in partnership with the Ngudi Makmur Farmer Group (POKTAN) in Dlingo Village, Bantul Regency. The primary objective of this activity was to enhance residents’ knowledge in Dlingo Village regarding the benefits and processing of Family Medicinal Plants (TOGA). The methods employed included material development, counseling sessions, question-and-answer discussions, and direct practical training in the preparation of aromatherapy candles. Evaluation was undertaken using pretests and posttests, which demonstrated a significant increase in participants’ understanding. The average scores rose from 81.67 (pretest) to 132.5 (posttest), with a statistically significant difference (p <0.001). These findings indicate that the counseling was effective in improving knowledge about TOGA and its utilization in producing aromatherapy candles. Such activities not only enhance awareness but also reinforce community autonomy in managing traditional medicinal resources, in line with the health-related objectives of the Sustainable Development Goals (SDGs).
UJI IN SILICO AKTIVITAS ANALGESIK DAN TOKSISITAS SENYAWA TURUNAN N-BENZOIL-N’-4-METOKSIFENILTIOUREA SEBAGAI CALON OBAT ANALGESIK Juwanti, Aulia; Purwanto, Bambang Tri; Poerwono, Hadi
Jurnal Wiyata Penelitian Sains dan Kesehatan Vol 11 No 2 (2024)
Publisher : LP2M IIK (Lembaga Penelitian dan Pengabdian Masyarakat Institut Ilmu Kesehatan) Bhakti Wiy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56710/wiyata.v11i2.863

Abstract

Abstrak Latar belakang : Senyawa N-(Benzoil)-N’-4-metoksifeniltiourea mempunyai gugus farmakofor yang sama dengan asam mefenamat yang mempunyai aktivitas sebagai analgesik, sehingga layak dijadikan senyawa induk untuk dikembangkan lebih lanjut melalui modifikasi struktur. Tujuan : Penelitian ini bertujuan untuk memprediksi aktivitas analgesik dan toksisitas dari duapuluh senyawa turunan N-(Benzoil)-N’-4-metoksifeniltiourea sebagai calon obat analgesik. Salah satu mekanisme kerja turunan N-(Benzoil)-N’-4-metoksifeniltiourea sebagai analgesik adalah menghambat COX2, yang berperan penting dalam mengubah asam arakidonat menjadi prostaglandin. Metode : Aktivitas biologis dapat diprediksi melalui pemodelan molekul yang disebut uji in silico,menggunakan program molecular operating environment (MOE) sedangkan toksisitas dapat diprediksi menggunakan program pkCSM. Uji in silico dilakukan dengan melakukan docking senyawa yang akan diprediksi aktivitasnya dengan target reseptor COX2, PDB 5IKR. Hasil : Hasil docking berupa energi ikatan digambarkan dengan nila Score (S). Senyawa dengan nilai S kecil berarti mempunyai ikatan ligan-reseptor yang stabil dan diprediksi mempunyai aktivitas yang besar. Dari hasil uji in silico disimpulkan bahwa turunan N-(benzoil)-N’-4-metoksifeniltiourea diprediksi menimbulkan toksisitas relative rendah, dan mempunyai aktivitas yang lebih besar dibandingkan asam mefenamat. Simpulan : N-(Etoksibenzoil)-N’-4-metoksifeniltiourea diprediksi mempunyai aktivitas analgesik paling besar sehingga senyawa terpilih untuk disintesis dan dikembangkan lebih lanjut. Abstract Background: The compound N-(benzoyl)-N'-4-methoxyphenylthiourea has the same pharmacophore group as mefenamic acid which has analgesic activity, so it is suitable to be used as a parent compound for further development through structural modification. Objective: This study aims to predict the analgesic activity and toxicity of twenty N-(benzoyl)-N'-4-methoxyphenylthiourea derivative compounds as candidate analgesic drugs. One of the mechanisms of action of the N-(benzoyl)-N'-4-methoxyphenylthiourea derivative as an analgesic is to inhibit COX2, which plays an important role in converting arachidonic acid into prostaglandins. Method: Biological activity can be predicted through molecular modeling called in silico testing, using the molecular operating environment (MOE) program, while toxicity can be predicted using the pkCSM program. The in silico test is carried out by docking the compound whose activity will be predicted with the target receptor COX2, PDB ID 5IKR. Results: The docking results in the form of bond energy are described by the value Score (S). A compound with a small S value means it has a stable ligand-receptor bond and is predicted to have large activity. From the in silico test results, it was concluded that the N-(benzoyl)-N'-4-methoxyphenylthiourea derivative is predicted to cause relatively low toxicity, and has greater activity than mefenamic acid. Conclusion: N-(Ethoxybenzoyl)-N'-4-methoxyphenylthiourea are predicted to have the greatest analgesic activity so the compounds were selected for synthesis and further development.
PREPARASI 4-ASETAMIDOFENIL BENZOAT DAN UJI AKTIFITAS ANALGESIK PADA MENCIT (Mus musculus) Muchlisin, M Artabah; Purwanto, Bambang Tri; Astuti, Engrid Juni
Media Farmasi: Jurnal Ilmu Farmasi Vol. 10 No. 2: September 2013
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v10i2.1165

Abstract

> Untuk mengembangkan senyawa turunan acetaminophen baru, dilakukan preparasi 4-acetamidofenil benzoat senyawa. Senyawa ini disintesis dengan mereaksikan dari acetamidofenil dengan benzoil klorida dengan metode Schotten Baumann. Kemurnian senyawa dibuktikan dengan kromatografi lapis tipis (KLT) dan titik lebur. Pada hasil KLT, senyawa yang disintesis memiliki 1 spot dengan tiga eluen yang berbeda dan memiliki rentang titik lebur 171,67-172,67ºC. Sehingga dapat disimpulkan senyawa hasil sintesis murni. Karakterisasi struktur senyawa hasil sintesis dianalisis dengan spektrofotometer UV-VIS, spektrofotometer IR, NMR. Hasil analisis struktural menunjukkan bahwa senyawa hasil sintesis adalah 4 - acetamidofenil benzoat. Uji aktivitas analgesik dilakukan pada tikus menggunakan metode penghambatan nyeri dengan asam asetat glasial 0,6 % sebagai agen penginduksi nyeri. Hasil sintesis 4 - acetamidofenil benzoat memiliki ED50 73,48 mg / kg dan acetaminofen memiliki ED50 68,30 mg / kg. Secara statistik, potensi analgesik 4 - acetamidofenil benzoat sebanding dengan acetaminofen .
Upaya Peningkatan Kualitas Produk UMKM Makanan Minuman di Surabaya Melalui Pelatihan Keamanan Aditif dan Kemasan Pangan serta Program Self Declare Halal Menggunakan Aplikasi SEHATI: Efforts to Improve the Quality of Food and Beverage MSME Products in Surabaya Through Additive and Food Packaging Safety Training as well as a Self-declare Halal Program Using the SEHATI Application Nofianti, Kholis Amalia; Ekowati, Juni; Purwanto, Bambang Tri; Prayoga , Adistiar; Yuwono, Mochammad; Prayoga, Adistiar; Rijal, Muhammad Agus Syamsur; Suciati, Suciati; Paramita, Diajeng Putri; Sulistyowaty, Melanny Ika; Hakim, Luqmanul
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 9 No. 8 (2024): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v9i8.7044

Abstract

MSMEs in the food sector are the dominant economic support in Indonesia. Surabaya has more than 60 thousand MSMEs. In food production at the MSME level, food additives and packaging is inevitable. Despite the current regulations, people still encounter dangerous food additives or packaging. This is caused by a lack of knowledge and awareness of food producers and consumers. On the other hand, since the implementation of the halal guarantee system, the use of halal labels on food and beverage products has become very important. For MSMEs, the government makes it easy to get a halal label through the self-declare halal program using the SEHATI. This activity aims to provide training on safe food additives and packaging, halal food, and the self-declare halal program using the SEHATI application in Surabaya. Carrying out activities using presentation and two-way interaction. Evaluate activities through pretest and posttest for each topic. The lowest values for food packaging, it is 52.92 and 79.58. The highest value was shown by the halal topic with an average of 69.58 and 97.92. The significance of the increase in value was demonstrated by the Wilcoxon test using SPSS 22 which showed the Asymp. Sig (2-tailed) value for the three topics less than 0.05. Thus, it can be concluded that this activity has proven to be able to improve participants' abilities regarding safe food additives and packaging, as well as halal food and the introduction of the self-declare halal program.
Peningkatan Pemberdayaan Masyarakat Tuban tentang Keamanan dan Kehalalan Pangan dalam Rangka Mempertahankan Kondisi Good Health and Well Being - SDG’s3: Enhancing Empowerment of Tuban Society Regarding Food Safety and Halalness in Order to Maintain Good Health and Well Being -SDG’s3 Ekowati, Juni; Yuwono, Mochammad; Prayoga, Adistiar; Rosita, Noorma; Purwanto, Bambang Tri; Adrianto, Muhammad Faris; Purwitasari, Neny; Ifadotunnikmah, Farida; Nofianti, Kholis Amalia; Sulistyowaty, Melanny Ika; Suzana, Suzana; Ulvan, Angkasa Megistra; Setiawan, Albertus Aditya; Afandi, Ryan; Wahyuningsih, Etik; Rianti, Dian Ratna; Febrianti, Winanda Rizki
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 9 No. 12 (2024): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v9i12.8410

Abstract

The food industry experiences various serious problems when several food MSMEs (micro/small/medium enterprises), especially micro-scale ones, practice improper food manufacturing methods, such as the use of formalin and borax which are prohibited for food preservation, and the marketing of expired food, even repackaged, and the writing of halal labels that are not followed by the fulfillment of requirements. Efforts to prevent things that are detrimental to the community, as well as food and beverage MSME actors, are not only the responsibility of government agencies but also the entire community, including universities for education and assistance in improving the quality and quantity of products produced, as well as the quality of human resources of business actors. The methods used include counseling and skills training, and the outcome is an increase in knowledge of 31%
Thiourea Derivatives as Estrogen Receptor Alpha Inhibitors for Breast Cancer Therapy: An In Silico Evaluation with ADMET Prediction and Molecular Docking Puspaweni, Hestining; Purwanto, Bambang Tri; Widiandani, Tri; Siswodihardjo, Siswandono; Muchlisin, M. Artabah
Borneo Journal of Pharmacy Vol. 7 No. 3 (2024): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v7i3.7396

Abstract

Breast cancer remains a significant public health concern, necessitating the discovery of novel therapeutic agents. This study investigates the potential of thiourea derivatives, specifically HU, HTMX, and BMPTU compounds, as estrogen receptor alpha (ERα) inhibitors using computational approaches. Drug-likeness assessments using Lipinski's Ro5 confirmed the oral bioavailability of all compounds. Additionally, ADMET analysis indicated favorable pharmacokinetic properties, with minimal metabolic interactions and acceptable safety profiles, except for BMPTU2, which showed potential hepatotoxicity. Molecular docking simulations revealed strong binding affinities between BMPTU derivatives, particularly BMPTU2, BMPTU3, and BMPTU4, and key ERα residues. These interactions suggest their potential as ERα modulators, warranting further in silico and experimental validation. In conclusion, the findings highlight the potential of BMPTU derivatives, especially BMPTU2, BMPTU3, and BMPTU4, as promising lead compounds for developing novel ERα-targeted breast cancer therapies. Further optimization and validation are crucial to fully elucidate their therapeutic potential.
Co-Authors Achmad Toto Poernomo Afandi, Ryan Aguslina Kirtishanti Anang Setyo Wiyono Anindi Lupita Nasyanska Dewi Melani Hariyadi Dian Agung Pangaribowo Dian Triwidiandany Diyah, Nuzul Wahyuning Edy Sulistyowati Engrid Juni Astuti Esti Hendradi Etik Wahyuningsih Farida Ifadotunnikmah Febrianti, Winanda Rizki Gunardi Gunardi Hadi Poerwono Handayani, Rosita Hariyadi, Dewi Melany I NYOMAN WIJAYA Ida Kristianingsih Idha Kusumawati Juni Ekowati Juwanti, Aulia Kholis Amalia Nofianti Lailatul Nuraini Luqmanul Hakim M. Artabah Muchlisin Maulia, Arwinda Melanny Ika Sulistyowaty Moch Davit Abdul Majid Mochammad Yuwono Muchlisin, M. Artabah Muhammad Agus Syamsur Rijal Muhammad Faris Adrianto, Muhammad Faris Munandar, Tristiana Erawati Ninis Yuliati, Ninis Noorma Rosita Nuzul Wahyuning Diyah Paramita, Diajeng Putri Prayoga, Adistiar Purnomo, Ahmad Toto Purwitasari, Neny Puspaweni, Hestining Rahman, Ave Ramadhani, Firmansyah Ardian Ratna Asmah Susidarti Rianti, Dian Ratna Riesta Primaharinastiti Savitri, Orchidea Meidy Nurintan Setiawan, Albertus Aditya Siswandono, Siswandono Siswandono, Siswandono Siti Musinah Siti Rahmah Suciati Suciati Sudjarwo Sudjarwo Sukardiman Suko Hardjono Suzana SUZANA, SUZANA Syahrani, Achmad Tri Widiandani Ulvan, Angkasa Megistra Yusuf, Helmy