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All Journal International Journal of Public Health Science (IJPHS) Tropical Medicine Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Jurnal Keperawatan Bina Sehat Jurnal Ilmiah Teknik Elektro Komputer dan Informatika (JITEKI) JURNAL KEPERAWATAN SEHAT Math Didactic: Jurnal Pendidikan Matematika RABIT: Jurnal Teknologi dan Sistem Informasi Univrab Health Notions Jurnal Ilmiah Keperawatan (Scientific Journal of Nursing) JBN (Jurnal Bedah Nasional) Jurnal Ilmu Kedokteran dan Kesehatan INTERNATIONAL JOURNAL OF NURSING AND MIDWIFERY SCIENCE (IJNMS) Jurnal Biomedika dan Kesehatan Bhamada: Jurnal Ilmu dan Teknologi Kesehatan (E-Journal) Buletin Ilmiah Sarjana Teknik Elektro Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jaringan Laboratorium Medis JURNAL ILMIAH OBSGIN : Jurnal Ilmiah Ilmu Kebidanan & Kandungan Jurnal Aisyah : Jurnal Ilmu Kesehatan Science Midwifery Indonesian Journal of Global Health research International Journal of Robotics and Control Systems Prisma Sains: Jurnal Pengkajian Ilmu dan Pembelajaran Matematika dan IPA IKIP Mataram JHeS (Journal of Health Studies) Journal of Scientific Research, Education, and Technology Jurnal Ilmiah Pengabdian Masyarakat Bidang Kesehatan Engagement: Jurnal Pengabdian Kepada Masyarakat Bhamada: Jurnal Ilmu dan Teknologi Kesehatan (E-Journal)
Tri Ratnaningsih
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Religion Arts Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Control & Systems Engineering Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Journal : Tropical Medicine Journal

 1 
The Effect of Bacille Calmette-Guerin (BCG) on the Changes in Number and Functional Activities of Mononuclear Phagocytes in Malaria- infected Mice Model Supargiyono -; Mahardika Agus Wijayanti; Tri Ratnaningsih; Dian Nugraheni
Tropical Medicine Journal Vol 1, No 1 (2011): Tropical Medicine Journal
Publisher : Pusat Kedokteran Tropis

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/tmj.4569

Abstract

Introduction: Recent studies have indicated that Bacille Calmette-Guerin (BCG) vaccination may have benefi cial eff ect on the survival of infant living in malaria endemic area as well as of malaria-infected mice model. However, the impact of injection of BCG vaccine on the changes in number and functional activities of Mononuclear Phagocytes during malaria-infection in animal model is still poorly understood.Objectives: To evaluate the eff ect of BCG on the changes in number and functional activities of Mononuclear Phagocytes (MPs) during Plasmodium berghei infection.Methods: Two groups of 18 Swiss mice were used. The fi rst group was given 0.1 ml of BCG injection subcutaneously and the second was the control non-BCG group. One week after BCG injection, all mice in both groups were inoculated with 107 Plasmodium berghei infected erythrocytes. The parasitaemia were monitored daily and the number and functional activity of splenic and peritoneal macrophages were tested.Results: The parasites were detected in the blood of both groups on the fi rst day after infection. The parasitaemia in the control group grew slowly until day 3, followed by rapid increased up to 38.96% on day 9. Parasitemia of mouse which still alive on day 12 was 59.6%. The parasitaemia of BCG-injected mice were also increased at lower rate after day 3, and the mice still survive until day 15 after infection. The number of peritoneal macrophages from BCG-injected mice increased to a higher degree compared to the non-BCG injected mice. Moreover, the phagocytic activities of peritoneal macrophages in BCG injected group were increased higher up to twice (200%) of normal levels compared to the non-BCG control group which increase only up to 1,5 times (150%) of the normal levels.Conclusion: The injection of BCG on Plasmodium berghei infected Swiss mice resulted in the extension of survival of the mice until day 15, accompanied by higher increased in number of circulating blood, splenic and peritoneal MPs, and the phagocytic activities of peritoneal MPs up to 137% of the increased in non-BCG mice.Keywords: BCG vaccine, malaria, Plasmodium berghei, macrophages, phagocytosis.
Co-Authors ADAM FERDIANSYAH Adnan, Muhammad Luthfi Afiahayati Afiahayati, Afiahayati Aflifia Birruni Sabila AGUS AGUS Agustiawan, Agustiawan Amar Akbar Ambarwati, Tri Juningaju Andini, Yusria Annis Catur Adi Antariksa, Putri Mayang Sari Arijadi, Desi Arta Farmawati Astutik, Widya Asysyifa, Azzahra Ayu Sari Ning Ati Br. Karo, Dina Andriani Budi Mulyono Caibigan, Ritchie Natuan Chatarina Umbul Wahyuni Dian Nugraheni Diannisa Ikarumi Dicky Moch Rizal Dicky Moch Rizal Dimas Chaerul Ekty Saputra Donytra Arby Wardhana Dwi Aris Agung Nugrahaningsih Dwi Cahyani Ratna Sari Dyah Aruming Tyas E. Elsa Herdiana Murhandarwati Ellsyana Erdyan Romadeni putri Elna, Nandara Priyanti Eti Nurwening Sholikhah Faisal Ibnu Fardhiasih Dwi Astuti Fatimah, Bunga Futri, Irianna Hadi Prayitno, Hadi Hanggoro Tri Rinonce Harahap, Nur Imma Hari Basuki Notobroto Harmaniati, Harmaniati Heriyanto Putri, Rona Hafida Heriyanto, Moch Junaidy Hilmia Fahma Ibnu, Faizal Ifa Roifah Ima Rahmawati Imam Zainuri Indah Lestari, Indah Indra Lesmana Indra Yulianti Iwan Dwiprahasto Jaya, Sudi Indra La Tabari, Muhammad Fadhlan Lutfi Wahyuni Mahardika Agus Wijayanti Mariadi, M. Meilinawati, Elies Miftahurrahmi, Rofifah Muhammad Sajidin Muliasih, Mulat Mulyadi Mulyadi Mulyati Mulyati Muryadi, Elvaro Islami Niken Satuti Nur Handayani Nilam Purwa Seven, Nilam Nina Widyaningrum Nisa, Afifah Khairu Nurrahma, Bira Arumndari Pagan, Muasir Phann, Raksmey Prajna Paramita, Prajna Putri, Rona Hafida Heriyanto Retnowati, Jajuk Rina Nur Hidayati Rina Susilowati Ristya Widi Endah Yani Riza Anama, Riza Rizki A. Gumilang Rodhi Hartono Rodhi Hartono Rosalia, Sabella Rahmawati, Rhea Santoso, Griselda Elisse Sasangka, Bambang Sismindari . Sitawati, Andini Dyah Siti Indatul Laili siti indatul laili, siti indatul Siti Mas Miranda Soewono Soewono Soewono, Soewono Sunat, Khamron Supargiyono - Supatmini, Erna Suryono Yudha Patria Sutaryo Sutaryo Syarifa, Cut Alima Teguh Triyono Titik Nuryastuti Titis Murti Utami, Titis Tri Peni Tri Peni, Tri Tria Wahyu Ningrum Tristifany, Annisa Tun, Su Sandi Hla Usi Sukorini Usman, Muhammad Alvin Ramadhan Widiyanti, Ayu Tri Widodo, Irianiwati Widya Asmara Widyasari, Vita Wijayanti, Lumastari Ajeng Win, Thinzar Aung Windarwati, Windarwati Windu Santoso, Windu Yanasta Yudo Pratama Yusnaini Yusnaini Zakiyah, Nurul Zakiyah, Nurul Zamroni, Asroful Hulam