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All Journal Jurnal Keperawatan Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Kedokteran Brawijaya Prosiding Seminas Competitive Advantage Wacana, Jurnal Sosial dan Humaniora Indonesian Journal of Disability Studies Research Journal of Life Science MNJ (Malang Neurology Journal) Universa Medicina Majalah Kesehatan FKUB BIMIKI (Berkala Ilmiah Mahasiswa Ilmu Keperawatan Indonesia) JSMARTech : Journal of Smart Bioprospecting and Technology Az-Zahra: Journal of Gender and Family Studies Pharmaceutical Sciences and Research (PSR) Jurnal Ners dan Kebidanan (Journal of Ners and Midwifery)
Retty Ratnawati
Faculty of Medicine, Brawijaya University, Jl. Veteran, Malang
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Journal : Universa Medicina

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Catechins decrease neurological severity score through apoptosis and neurotropic factor pathway in rat traumatic brain injury Ratnawati, Retty; Arofah, Annisa Nurul; Novitasari, Anastasia; Utami, Sartika Dewi; Hariningsih, Made Ayu; Rahayu, Masruroh; Rianawati, Sri Budhi; Purnomo, Hari; Dalhar, Mochammad
Universa Medicina Vol 36, No 2 (2017)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2017.v36.110-122

Abstract

BACKGROUNDCatechins inhibits apoptosis through anti oxidant and anti inflamation pathway. Catechins also increases brain-derived neurotrophic factor (BDNF). There was a few research that explained the role of catechins in traumatic brain injury (TBI). The objective of the study was to evaluate the effect of catechins administration on neurologic severity score (NSS) through apoptosis and neurotropic pathway in traumatic brain injury rat model.METHODSA post test only controlled group design was performed using traumatic brain injury rat (Rattus novergicus) model through weight drop models. It was devided into negative control group, positive control group, TBI+catechins 513 mg/kgBW, TBI+catechins 926 mg/kgBW, TBI+catechins 1113 mg/kgBW. NSS was measured in the first hours, day three, and day seven. The expressions of NFkB, TNFa, Bcl-2, Bax, caspase 3, caspase 8, BDNF, and the numbers of apoptosis cells were evaluated by imunohistochemystry method. One way Anova and Kruskal Wwallis were used to analyse the data.Results TNFa, caspase 8, number of apoptosis cells were significantly decreased on the seventh day administration compared to the third day administration (p<0.05). Catechins increased the expression of Bcl-2/Bax and BDNF significantly (p<0.05). Yet, there were no significant differences between expression of caspase 3, NSS, Bcl-2/Bax ratio, and BDNF toward third days administration of catechins compared with seven days administration (p>0.050).ConclusionsAdministration of catechins decreased NSS through inhibiting inflammation and apoptosis, as well as induced the neurotrophic factors in rat brain injury. Catechins may serve as a potential intervention for TBI.
Co-Authors A.A. Ketut Agung Cahyawan W AA Sudharmawan, AA Almira, Nabila Sella Anak Agung Gede Sugianthara Analis W Wardhana Anastasia Novitasari, Anastasia Annisa Nurul Arofah Annisa' Wigati Rozifa Ardani Galih Prakosa, Ardani Galih Artamevia, Dian Arum Desi Pratiwi, Arum Desi Atma Gunawan Aulanni'am, Aulanni'am Cahayani, Wike Astrid Christian Julio Suhardi, Christian Julio Darwatik, Darwatik Dian Hasanah Dian Susmarini, Dian Diana Lyrawati Dina Dewi SLI Eviana Norahmawati Fahanani, Agwin Fahmi Faridha Khaira H Fauzi Ahmad Muda Ferdina, Cucun Setya Harbiyanti, Novita Titis HARI PURNOMO Heri Kristianto Herin Mawarti Hery Wibowo Hidayat Sujuti Ika Subekti Wulandari, Ika Subekti Ikhda Ulya, Ikhda Inggita Kusumastuty Intan Berlian, Intan Irawan, Dwi Dianita Kenty Wantri Anita, Kenty Wantri Kumboyono Kumboyono Kumboyono, K Kurnianingsih, Nia Lilik Supriyati, Lilik Lilik Wahyuni Lisa Aulia, Lisa Made Ayu Hariningsih, Made Ayu Masruroh Rahayu, Masruroh Mochammad Dalhar Noorma Lukitasari Nur Permatasari Nurdiana Nurdiana Pratista Adi Krisna, Pratista Adi Prayogo, Nabila Putri Purwitasari, Alief Ayu Rahma, Oktivani Adelathifa Rayhanna, Qanitha Ailsya Reza Fitra Kusuma, Reza Fitra Rinik Eko Kapti, Rinik Ririn Handayani Risma Karlina Prabawati Sartika Dewi Utami, Sartika Dewi Sarwono . Sawitri, Lia Siti Nurfitria, Siti Sri Andarini Sri Budhi Rianawati, Sri Budhi Sri Haryuni Sri Rianawati Suprapto, Ratih Paramita Tinny Endang Hernowati Titisari, Nurina Wike Wike, Wike Wiwi Jaya Yudhantara, Dearisa Surya