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Journal : Journal of Applied Pharmaceutical Research

Combined effect of bromelain and turmeric against acetic acid induced ulcerative colitis in wistar rats reddi, Padmavathi; Keerthana, K. B; Lalitha Devi, A.; Sree Hari, Y.; Samad, Abdul
Journal of Applied Pharmaceutical Research Vol. 9 No. 2 (2021)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2021.15.24

Abstract

Objective: The present study planned to study the combined effect of Bromelain and Turmeric in acetic acid induced ulcerative colitis in Wistar rats. Methodology: Wistar rats of either sex (n = 30) were divided into 5 groups. Group – I, Sham control, administered single dose of vehicle rectally; Group –II, colitis control, colitis was induced by rectal administration of single dose of 2 ml of 3%, v/v of acetic acid in 0.9% saline; Group–III, treated with Turmeric (50 mg/kg/p.o); Group–IV, treated with Bromelain (100 mg/kg/p.o) and Group –V, treated with both Turmeric (50 mg/kg/p.o) and Bromelain (100 mg /kg/p.o). Colitis was induced in all the treatment groups on first day and drug treatment was continued for 7 days. During the treatment period, Disease Activity Index (DAI) was assessed daily and on 8th day White Blood Cell (WBC) Count and Differential Leucocyte Count (DLC) was performed and on 9th day all the rats were sacrificed for the assessment of intestinal inflammation, colon myeloperoxidase (MPO) levels and Histopathology. Results obtained were analysed by one-way analysis of variance followed by Tukey’s multiple comparison test. Results: Overall changes in DAI, Inflammatory scores, WBC, DLC and MPO has shown significant improvement with Turmeric and Bromelain compared to Colitis control. However, the combined therapy has shown to be more effective in alleviating ulcerative colitis compared to individual therapies. Conclusion: The present study recommends that the combination of Turmeric and Bromelain has synergistic effect in treating ulcerative colitis.
Co-Authors A.A. Ketut Agung Cahyawan W Abda Abda Abdelslam Masoud Abobakr Amhabj Achmad Wicaksono Agus Muchsin Ahmad Ahmad Ahmad, Israr Alamsah, Andi Nour Ali, Javaid Amal A. R, Chaerul Andi Velahyati Baharuddin Andi Vita Sukmarini, Andi Vita Anggriani, Nining Anwar, Bushra Apriandi, Doni Areeb Ahmer ARIS ARIS, ARIS Arshi Saeed, Hafiza Atique, Rameen Ayen, Rosalina Yuliana Ayesha Muazzam Baharuddin, Andi Fathussalam Basri, Utari Nur Azizah Biradar, Ghufran Budiman Budiman Dendi Pratama Ernawan Setyono Erwin Rommel Febriana, Dina Febriansyah Febriansyah Fernanda, Muhammad Galuh Nashrulloh Kartika Mayangsari Rofam Hafiz, Abdul Hamdani Hamdani Hamid, Siti Hardiyanti Mustaina Handayani, Fransisca Heny Harnen Sulistyo Harnen Sulistyo, Harnen Hertati, Hertati Hossain, Md. Jakir Idris, Jabbar Karim, Ham Keerthana, K. B Kurniawati Kurniawati Kuswari, Zeta Lalitha Devi, A. Ludfi Djakfar Mishal Fatima Muanah, Muanah Muazzam, Ayesha Muh. Ikhsan, Muh. Muhammad Chaerul Muhammad Hamza Muhammad Khoiruddin Harahap Muhammad Ridwan Arif Muhammad Zain Kaleem Mujahid Mujahid, Mujahid Muliyadi Hamid Murni Murni Nadeem, Ayesha Nasta'in, Andi Firni Naveed, Areesha Naz, Irum Nurmadhani Fitri Suyuthi Nurnaningsih, Ratna Nurul Alam, AMM Pacitra, Silda Patel , Hrishitva Pradana, Syafa’at Anugrah Pusvitasari, Dwi Putra, Purniadi Rana, Tehreem reddi, Padmavathi Rezwan Shihab, Sk Rini Pebri Utari Ronia, Ronia Rosnaini Daga Saeed, Hafiza Arshi Sahbudin, Muhammad Samad, Mohammad Azwar Sania Tariq Shah, Rabbya Rayan Shehroz Ahmad Sohail, Muhammd Soomro, Hafeezullah Sree Hari, Y. Sri Adrianti Muin St. Rukaiyah Suci, Ida Ayu Sudirman L, Sudirman Sujatmiko Sujatmiko Sultana, Nahida Sunastri, Sunastri Sung Vioary, Anddy SURIANI, LILIS Suryady, Dedy Sutrawati Syirril Ihromi, Syirril Talib, Ambreen Tariq, Imadullah Thomas, Ronald Wahidin, Ikhsan Waseem Akram Wicaksono, Achmad Yasmi, Yasmi Yunus, Mujahid Yusmanizar Yusmanizar Zahra, Maryam Zulkifli Zulkifli