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All Journal Jurnal Ilmiah Farmasi Jurnal Kesehatan Reproduksi AL KAUNIYAH Jurnal Kesehatan Andalas Folia Medica Indonesiana BIO-SITE |BIOLOGI Sains Terapan Majalah Kedokteran Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Jurnal Pengabdian Pada Masyarakat SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Riau Journal of Empowerment Jurnal Ilmiah Kesehatan PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Medika Kartika : Jurnal Kedokteran dan Kesehatan Jurnal Ners Jurnal Ilmiah Kesehatan Masyarakat : Media Komunikasi Komunitas Kesehatan Masyarakat BERNAS: Jurnal Pengabdian Kepada Masyarakat JK Unila (Jurnal Kedokteran Universitas Lampung) Jurnal Kedokteran Universitas Palangka Raya Epidemiology and Society Health Review (ESHR) Respiratory Science Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Pharmacy Reports Jurnal Pengabdian Mandiri Dharma Pengabdian Perguruan Tinggi (DEPATI) Madani : Jurnal Pengabdian Kepada Masyarakat Journal of Research in Pharmacy and Pharmaceutical Sciences
Erna Harfiani
Universitas Pembangunan Nasional Veteran Jakarta
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Journal : Jurnal Ilmiah Farmasi

 1 
PERBANDINGAN EFEKTIVITAS BIAYA TERAPI KOMBINASI OBAT ANTIDIABETIK METFORMIN-GLIMEPIRIDE DAN ACARBOSE-GLIMEPIRIDE Tresnawati, Nden Ajeng; Hany Yusmaini; Mila Citrawati; Erna Harfiani
Jurnal Ilmiah Farmasi Vol. 20 No. 1 (2024): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol20.iss1.art9

Abstract

Background: Type 2 diabetes mellitus (DM) is one of the cardiometabolic diseases with the highest prevalence worldwide, including Indonesia. The increasing number of type 2 DMs is known to have become an economic burden on Indonesia's health sector. There are several options for treating type 2 DM, either with monotherapy or in combination. At present, metformin, sulfonylurea, and acarbose have become common drugs in the treatment of type 2 DM. Variations in antidiabetic drugs will cause differences in therapy cost and effectiveness.Objective: The purpose of this study is to analyze the cost-effectiveness of the combination therapy of metformin-glimepiride and acarbose-glimepiride antidiabetic drugs in patients with type 2 DM at RSUD Sumedang in 2021 based on the hospital's perspective.Method: This study collected data by documenting medical records and patient costs from January to December 2021 using a cross-sectional design on 60 samples.Results: Findings from the statistical analysis showed that the combination of metformin and glimepiride did not make a difference in GDS (mean difference 10.70 mg/dL-1; p-value = 0.457). The average total direct medical costs of the acarbose-glimepiride group were higher than that of the metformin-glimepiride group, and there was a significant difference between the average costs of the antidiabetic drugs (p-value = 0.000).Conclusion: The combination of metformin-glimepiride therapy is more cost-effective than acarbose-glimepiride, with an ACER value of metformin-glimepiride Rp. 3,037.48.Keywords: Acarbose, cost effectiveness analysis, glimepiride, metformin, type 2 DM Intisari Latar belakang: Diabetes Melitus (DM) tipe 2 merupakan salah satu penyakit kardiometabolik dengan prevalensi tertinggi di seluruh dunia termasuk Indonesia. Peningkatan jumlah DM tipe 2 diketahui telah menjadi beban ekonomi bagi sektor kesehatan di Indonesia. Terdapat beberapa pilihan terapi dalam pengobatan DM tipe 2 baik secara monoterapi maupun kombinasi beberapa obat. Saat ini obat metformin, sulfonilurea, dan acarbose telah menjadi obat umum dalam pengobatan DM tipe 2 di Indonesia. Variasi terapi obat antidiabetik akan menyebabkan adanya perbedaan biaya dan efektivitas terapi. Tujuan: Tujuan penelitian ini untuk menentukan efektivitas biaya terapi kombinasi obat antidiabetik metformin-glimepirid dan acarbose-glimepirid pada pasien DM tipe 2 Instalasi Rawat Jalan di RSUD Sumedang Tahun 2021 berdasarkan perspektif rumah sakit.Metode: Penelitian ini menggunakan desain studi potong-lintang pada 60 sampel dengan pengambilan data dilakukan secara dokumentasi terhadap data rekam medis dan biaya pasien periode Januari-Desember 2021. Hasil: Hasil analisis statistik menunjukkan tidak terdapat perbedaan bermakna selisih GDS pada kombinasi metformin-glimepirid dan acarbose-glimepirid (rata-rata perbedaan 10,70 mg/dL-1; nilai-p=0.457). Rata-rata total biaya langsung medis kelompok acarbose-glimepirid lebih tinggi dibandingkan metformin-glimepirid serta terdapat perbedaan bermakna rata-rata biaya obat antidiabetik (nilai-p=0.000).Kesimpulan: Kombinasi terapi metformin-glimepirid lebih cost-effective dibandingkan acarbose-glimepirid dengan nilai ACER metformin-glimepirid Rp. 3.037,48.Kata Kunci: Acarbose, analisis efektivitas biaya, DM tipe 2, glimepirid, metfotmin
Co-Authors ., Mashoedojo Abd. Rasyid Syamsuri Abdul Kolib Adi Sukrisno Agneta Irmarahayu Agus Aulung Aisyah, Ammara Almerveldy Azaria Dohongi Almerveldy Azaria Dohongi Angga Hardiansyah Anisah Anisah Anisah Anisah Aprilia, Citra Ayu Ashfia Desi Rahmalina Aulia Chaerani Aulia Chairani Az Zahra, Fatima Boenga Nurcita Citra Ayu Aprilia Dicky Budiman Dinda Nuraini Hanifah Wahab Dwi Arwandi Yogi Saputra Fachri Razi Fajriati Zulfa Hany Yusmaini Ilmi, Ibnu Malkan Bakhrul Ima Maria Isniani Ramadhani Isniani Ramadhani Sekar Prabarini Kartika Putri Amalia Makkiyah, Feda Anisah Manpan Drajat Maria Selvester Thadeus Md Ikhsan Mokoagow Meiskha Bahar Mila Citrawati Muhammad Reiza Muttia Amalia Nabilah, Ayi Nely Jumaliah Nugraha, Yudhi Nugrahayu Widyawardani Nurfitri Bustamam Nurhakim, Althaf Dhaifullah Pasiak, Taufiq Fredrik Primayanti Nurul Ilmi Pritasari, Ilham Arzy Diana Pritha Maya Savitri Putra Sang Fajar El Harry Putra Sang Fajar El Harry Ratna Puspita Ratna Puspita Reiza, Muhammad Retno Yulianti Ria Maria Theresa Ria Maria Theresa Ryan Herardi Sarmoko Sarmoko Serli Marlina Siska Maydianah Sitinjak, Sahat Anugerah Immanuel Sri Rahayu Sri Wahyuningsih Susanti, Febriyolla Sutarto, Riyadi Taufiq Fredrik Pasiak Taufiq Fredrik Pasiak Taufiq Fredrik Pasiak Taufiq Fredrik Pasiak Taufiq Pasiak Taupan Ichsan Tuarita Theodora Putri Simanjaya Tresnawati, Nden Ajeng Ufi Dewintera Uswatun Hasanah Uswatun Hasanah Uswatun Hasanah Utami Wahyuningsih Wahab, Dinda Nuraini Hanifah Wibowo, Muhammad Rizky Wibowo, Putri Larasati Widianingsih Widianingsih Yanti Harjono Hadiwiardjo Yanto Sandy Tjang Yudivaniel Zihono