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Rangga Saputra
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Journal : INDOGENIUS

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Zinc Oxide and Aloe Vera Gel Therapy Wound Care on Healing Diabetic Ulcers Tarkawi; Saputra, Rangga; Rusmiayunita, Siti; Agustin, Siti Sarah; Diana, Sri; Nurfalyya, Tia
INDOGENIUS Vol 4 No 3 (2025): INDOGENIUS
Publisher : Department of Publication of Inspirasi Elburhani Foundation Desa. Pamokolan, Kecamatan Cihaurbeuti, Kabupaten Ciamis, Provinsi Jawa Barat, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56359/igj.v4i3.842

Abstract

Background & Objective: Diabetic ulcers are a chronic complication of diabetes mellitus that are difficult to heal and carry a high risk of amputation. Wound healing in people with diabetes is often hampered by impaired circulation, neuropathy, and infection. Topical therapies such as zinc oxide cream And Aloe Vera gel They have been used to accelerate healing through different but complementary mechanisms. To determine the effectiveness of topical zinc oxide cream and aloe vera gel on the healing of diabetic ulcers based on recent research results. Method: Using the literature review method by searching for articles in the PubMed, ScienceDirect, Google Scholar databases, Connected Papers, Research Gate and Research Square, with publications spanning 2015–2025. Of the 25 articles found, 7 met the inclusion criteria. Result: Aloe Vera gel has been shown to be effective in accelerating the healing of diabetic ulcers by reducing wound assessment scores (Bates-Jensen, Winner Scale), increasing tissue regeneration, and shortening the inflammatory phase. Zinc Oxide cream has been shown to accelerate the transition from the inflammatory phase to the proliferative phase, protect wound tissue from bacterial colonization, and support collagen synthesis. Several preclinical studies combining Aloe Vera with Zinc Oxide nanoparticles have shown accelerated wound closure compared to single treatments. No serious side effects were found from the use of these two therapies. Conclusion: Zinc oxide cream and aloe vera gel are both effective in accelerating the healing of diabetic ulcers through complementary mechanisms. Both are safe, accessible, and affordable, making them potentially useful adjuvant therapies in healthcare settings. Further research, including controlled clinical trials of a pure combination of the two therapies, is needed to confirm their effectiveness and safety.
Co-Authors Adhisti Kurnia Yulianti Adi Syahputra Purba Agnia Faizafika Agustin, Siti Sarah Ahmad Soleh Aidil Adoha Dly Aisy, Diah Rihhadatul Amelia, Salsabila Ana Mentari Andaresta, Windy Anggara, Norma Arum Yuliya Lestari Asep Purwo Yudi Utomo Askha, Muhammad Riski Baiq Najwa Tiara Safitri Bintang Prima Vidyasari Cahyaseno, Dwi Putri Dian Septinova Dimas Taufiqurahman Diyani, Siti Djoko Hananto Ezra Oktaliansah fahrudin Febliansa, M. Rahman Fitria Zulhaedar Ginting, Apri Chandra Putra Gusmaneli Haeriyah, Siti Hasbi Firmansyah Hendi Kariyanto Ikhwal, Farhan imanuddin, bayu Imlan Dongoran Intan Intan Irawan, M. Ary Irmawati Irmayatul Hikmah Jayanta Lisa Isdiyanto M. Martono Diel Marbun, Abri Andry Saresa Melda Siahaan Muhammad Dimas Muhammad Mona Adha Musthofa Galih Pradana Najwa, Lu`luin Natalia Kartika Saputri Naufal Rifki Abibreza Nidia Yuniarsih Noviasuci, Wulan Novyangga, Purnama Nurfalyya, Tia Nurwahid, Alifh Oliber A. Arde, Bernardo Onsardi, Onsardi Rahmadi Rahmadi Rahmawati, Rista Nova Revaldo Xsanal Hakim Rini Suharti Rino Rino Riski Hidayah Rita Donna Marlina Rizki Amelia Rofaida, Aryani Rohman Rohman Rukhayati Rusmiayunita, Siti Safitri, Aulia Nur Santi, Dwi Ros Saputra, M. Farid Ardiansyah Aris Sartika, Imas Septiany, Virgenia Setiawan, Raehan Putra Sevia Indah Purnama Shadrina, Dhiya Siti Hanipah Sri Diana Sugiartha, I Wayan Sulaeman Sulaeman Sulaiman Tarkawi Tintin Kurtini Titin Sugianti Tumilar, Randy Eka Tumilar, Randyr Eka Uki Hares Yulianti Viona Veliza Winutan, Lintang Yanti Triguna Yuni Susilowati