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All Journal Journal of Mathematical and Fundamental Sciences Panrita Abdi - Jurnal Pengabdian pada Masyarakat ALCHEMY Jurnal Penelitian Kimia JSFK (Jurnal Sains Farmasi & Klinis) PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Journal of halal product and research (JHPR) Jurnal Pengabdian Masyarakat Asia Berkala Ilmiah Kimia Farmasi Jurnal Kreativitas dan Inovasi (Jurnal Kreanova) Camellia
Kholis Amalia Nofianti
Departemen Ilmu Kefarmasian Fakultas Farmasi Universitas Airlangga, Surabaya
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health Social Sciences Veterinary Other

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Prediction of the Potential of Benzoxazinone, 2-phenyl-4H-benzo[1,3]oxazin-4-one, and 2-[2-(4-methoxyphenyl)vinyl]-3,1-benzoxazin-4-one as New Anti-Tuberculosis Nofianti, Kholis Amalia; Hakim, Luqmanul; Suzana; Ifadotunikamah, Farida
Berkala Ilmiah Kimia Farmasi Vol. 11 No. 1 (2024): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikfar.v11i1.56056

Abstract

Even though it had been almost five decades, the decline in the prevalence of tuberculosis had still been low due to the rise of drug resistance. Recently, benzoxazinone compounds had begun to gain potential as anti-tuberculosis agents because of their interesting structure and similarity to isoniazid, the most widely used TB drug, which had reportedly experienced many cases of resistance. This research tested the ability of the core compound benzoxazinone and its two derivatives to bind to the enoyl ACP-CoA receptor, which was responsible for the formation of mycobacterial walls. In silico tests were carried out using pkcsm to determine the pharmacokinetic profile, and molecular docking tests using Molegro Virtual Docker were conducted to determine the pharmacodynamic profile through binding to the enoyl ACP-CoA receptor. The selected receptors were downloaded from the protein data bank with the code 2IDZ. The research results showed that the three test compounds had good intestinal and skin absorption profiles, indicating that they could be administered orally or transdermally. The docking results, expressed by moldock score and rerank score, showed that the three test compounds had better potential compared to isoniazid. Thus, the test compounds could be developed as new anti-tuberculosis agents. Keywords:  Tubercolosis, Benzoxazinone, Mycobacterium Tuberculosis, Pkcsm, Molegro Virtual Docker
Pemanfaatan Suplemen Makanan Secara Tepat Guna untuk Menjaga dan Meningkatkan Daya Tahan Tubuh Diyah, Nuzul Wahyuning; Poerwono, Hadi; Nofianti, Kholis Amalia; Poernomo, Achmad Toto; Hidayati, Shabrina Wahyu; Isnaeni, Isnaeni
Camellia : Clinical, Pharmaceutical, Analytical and Pharmacy Community Journal Vol 3 No 2 (2024): Camellia (Clinical, Pharmaceutical, Analytical, and Pharmacy Community Journal)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/cam.v3i2.24882

Abstract

Komponen makanan telah dikenal memberikan fungsi perlindungan terhadap benda asing yang mengakibatkan masalah kesehatan bagi masyarakat. Mikronutrien seperti vitamin dan mineral sangat penting bagi tubuh manusia dan kebutuhan hariannya harus dipenuhi melalui sumber makanan. Jika kebutuhan harian tidak terpenuhi karena beberapa kondisi, maka diperlukan tambahan suplemen makanan. Beberapa vitamin dan mineral berfungsi sebagai imunomodulator dan melindungi respons imun inang, sehingga mencegah penurunan daya tahan tubuh akibat serangan patogen. Berdasarkan acuan berbagai penelitian, artikel ini membahas fungsi suplemen vitamin dan mineral sebagai imunomodulator dalam meningkatkan daya tahan tubuh melalui sistem imun dan mekanisme kerja yang memperantarai fungsi ini. Kekurangan vitamin dan mineral dapat menyebabkan penurunan kinerja sistem imun, yang menjadi penyebab utama keadaan patologis dan imunologis yang tidak menguntungkan. Dari berbagai hasil penelitian secara in vitro dan in vivo dapat disimpulkan bahwa mikronutrien utama yang berperan dalam respons imun, yaitu: vitamin A, C, D, E, B6, B12, folat, dan mineral seng, zat besi, tembaga, dan selenium, dapat meningkatkan daya tahan tubuh terhadap infeksi.  Kekurangan asupan harian mikronutrien dari makanan dapat diatasi dengan memanfaatkan suplemen makanan.
Pemanfaatan Iradiasi Gelombang Mikro pada Sintesis Metil orto-metoksisinamat Yaqin, Istna Nur’ainul; Ekowati, Juni; Nofianti, Kholis Amalia; Suzana, Suzana
JSFK (Jurnal Sains Farmasi & Klinis) Vol 8 No 2 (2021): J Sains Farm Klin 8(2), Agustus 2021
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.8.2.157-163.2021

Abstract

Tujuan penelitian ini adalah mensintesis senyawa metil orto-metoksisinamat (MOMS) yang terbukti berdasarkan uji in silico dapat digunakan mengobati penyakit kardiovaskular, yaitu sebagai antiplatelet. Sintesis MOMS dilakukan dari material awal asam orto-hidroksisinamat (AOHS) dengan metode iradiasi gelombang mikro dan membandingkan profil KLT selama proses reaksi sintesis pada tiga daya iradiasi gelombang mikro tersebut (120, 280 dan 400Watt). Reaksi yang digunakan adalah reaksi metilasi pada gugus OH asam karboksilat dan gugus fenolik dari senyawa AOHS dengan dimetil sulfat sebagai agen pemetilasi. Kondisi reaksinya diatur dalam suasana basa K2CO3 menggunakan pelarut aseton. Pengambilan sampel pada proses reaksi sintesis dilakukan setiap 30 detik pada masing-masing daya microwave dan dievaluasi noda yang terbentuk pada plat kromatografi lapisan tipis (KLT), dan dilanjutkan sampai reaksi sempurna. Hasil penelitian menunjukkan bahwa kesempurnaan reaksi semakin cepat dengan bertambahnya daya microwave. Prosentase hasil yang diperoleh 72%. Berdasarkan analisis senyawa menggunakan spektrofotometer FT-IR, spektrometer 1H-NMR dan 13C-NMR, disimpulkan bahwa reaksi sintesis senyawa MOMS dapat dilakukan dengan memanfaatkan iradiasi gelombang mikro, hal ini disebabkan adanya gugus polar pada AOHS yang dapat menyerap iradiasi gelombang mikro. Semakin tinggi daya yang digunakan pada reaksi metilasi AOHS, maka semakin cepat waktu yang dibutuhkan untuk kesempurnaan reaksi
Upaya Peningkatan Kualitas Produk UMKM Makanan Minuman di Surabaya Melalui Pelatihan Keamanan Aditif dan Kemasan Pangan serta Program Self Declare Halal Menggunakan Aplikasi SEHATI: Efforts to Improve the Quality of Food and Beverage MSME Products in Surabaya Through Additive and Food Packaging Safety Training as well as a Self-declare Halal Program Using the SEHATI Application Nofianti, Kholis Amalia; Ekowati, Juni; Purwanto, Bambang Tri; Prayoga , Adistiar; Yuwono, Mochammad; Prayoga, Adistiar; Rijal, Muhammad Agus Syamsur; Suciati, Suciati; Paramita, Diajeng Putri; Sulistyowaty, Melanny Ika; Hakim, Luqmanul
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 9 No. 8 (2024): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v9i8.7044

Abstract

MSMEs in the food sector are the dominant economic support in Indonesia. Surabaya has more than 60 thousand MSMEs. In food production at the MSME level, food additives and packaging is inevitable. Despite the current regulations, people still encounter dangerous food additives or packaging. This is caused by a lack of knowledge and awareness of food producers and consumers. On the other hand, since the implementation of the halal guarantee system, the use of halal labels on food and beverage products has become very important. For MSMEs, the government makes it easy to get a halal label through the self-declare halal program using the SEHATI. This activity aims to provide training on safe food additives and packaging, halal food, and the self-declare halal program using the SEHATI application in Surabaya. Carrying out activities using presentation and two-way interaction. Evaluate activities through pretest and posttest for each topic. The lowest values for food packaging, it is 52.92 and 79.58. The highest value was shown by the halal topic with an average of 69.58 and 97.92. The significance of the increase in value was demonstrated by the Wilcoxon test using SPSS 22 which showed the Asymp. Sig (2-tailed) value for the three topics less than 0.05. Thus, it can be concluded that this activity has proven to be able to improve participants' abilities regarding safe food additives and packaging, as well as halal food and the introduction of the self-declare halal program.
Peningkatan Pemberdayaan Masyarakat Tuban tentang Keamanan dan Kehalalan Pangan dalam Rangka Mempertahankan Kondisi Good Health and Well Being - SDG’s3: Enhancing Empowerment of Tuban Society Regarding Food Safety and Halalness in Order to Maintain Good Health and Well Being -SDG’s3 Ekowati, Juni; Yuwono, Mochammad; Prayoga, Adistiar; Rosita, Noorma; Purwanto, Bambang Tri; Adrianto, Muhammad Faris; Purwitasari, Neny; Ifadotunnikmah, Farida; Nofianti, Kholis Amalia; Sulistyowaty, Melanny Ika; Suzana, Suzana; Ulvan, Angkasa Megistra; Setiawan, Albertus Aditya; Afandi, Ryan; Wahyuningsih, Etik; Rianti, Dian Ratna; Febrianti, Winanda Rizki
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 9 No. 12 (2024): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v9i12.8410

Abstract

The food industry experiences various serious problems when several food MSMEs (micro/small/medium enterprises), especially micro-scale ones, practice improper food manufacturing methods, such as the use of formalin and borax which are prohibited for food preservation, and the marketing of expired food, even repackaged, and the writing of halal labels that are not followed by the fulfillment of requirements. Efforts to prevent things that are detrimental to the community, as well as food and beverage MSME actors, are not only the responsibility of government agencies but also the entire community, including universities for education and assistance in improving the quality and quantity of products produced, as well as the quality of human resources of business actors. The methods used include counseling and skills training, and the outcome is an increase in knowledge of 31%
Pemanfaatan Suplemen Makanan Secara Tepat Guna untuk Menjaga dan Meningkatkan Daya Tahan Tubuh Diyah, Nuzul Wahyuning; Poerwono, Hadi; Nofianti, Kholis Amalia; Poernomo, Achmad Toto; Hidayati, Shabrina Wahyu; Isnaeni, Isnaeni
Camellia : Clinical, Pharmaceutical, Analytical and Pharmacy Community Journal Vol 3 No 2 (2024): Camellia (Clinical, Pharmaceutical, Analytical, and Pharmacy Community Journal)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/cam.v3i2.24882

Abstract

Komponen makanan telah dikenal memberikan fungsi perlindungan terhadap benda asing yang mengakibatkan masalah kesehatan bagi masyarakat. Mikronutrien seperti vitamin dan mineral sangat penting bagi tubuh manusia dan kebutuhan hariannya harus dipenuhi melalui sumber makanan. Jika kebutuhan harian tidak terpenuhi karena beberapa kondisi, maka diperlukan tambahan suplemen makanan. Beberapa vitamin dan mineral berfungsi sebagai imunomodulator dan melindungi respons imun inang, sehingga mencegah penurunan daya tahan tubuh akibat serangan patogen. Berdasarkan acuan berbagai penelitian, artikel ini membahas fungsi suplemen vitamin dan mineral sebagai imunomodulator dalam meningkatkan daya tahan tubuh melalui sistem imun dan mekanisme kerja yang memperantarai fungsi ini. Kekurangan vitamin dan mineral dapat menyebabkan penurunan kinerja sistem imun, yang menjadi penyebab utama keadaan patologis dan imunologis yang tidak menguntungkan. Dari berbagai hasil penelitian secara in vitro dan in vivo dapat disimpulkan bahwa mikronutrien utama yang berperan dalam respons imun, yaitu: vitamin A, C, D, E, B6, B12, folat, dan mineral seng, zat besi, tembaga, dan selenium, dapat meningkatkan daya tahan tubuh terhadap infeksi.  Kekurangan asupan harian mikronutrien dari makanan dapat diatasi dengan memanfaatkan suplemen makanan.
Co-Authors Achmad Toto Poernomo Achmad Toto Purnomo Adinda Adelia Wulandari Afandi, Ryan Alief Putriana Rahman Andang Miatmoko Ardhayanti, Erlina Aty Widyawaruyanti Bambang Tri Purwanto Diyah, Nuzul Wahyuning Diyah, Nuzul Wahyuning Etik Wahyuningsih Farida Ifadotunnikmah Fatin Fadhilah Hasib Febrianti, Winanda Rizki Ghinalya Chalbi Ananda Ghinalya Chalbi Ananda Gusti Rizaldi Hadi Poerwono Hanifah Ridha Rabbani Hidayati, Shabrina Wahyu Ifadotunikamah, Farida Isnaeni Isnaeni Isnaeni Istna Nur’ainul Yaqin Itsna Nur ‘Ainul Yaqin Iwan Sahrial Hamid Juni Ekowati Kholidah Febriani Lidya Tumewu Luqmanul Hakim Marcellino Rudyanto Melanny Ika Sulistyowati Melanny Ika Sulistyowaty Mochammad Yuwono Muhammad Agus Syamsur Rijal Muhammad Faris Adrianto, Muhammad Faris Noor Erma Nasution Noor Erma Nasution Noorma Rosita Norhayati Norhayati Paramita, Diajeng Putri Prayoga, Adistiar Purwitasari, Neny Retno Widyowati Rian Putra Pratama Rianti, Dian Ratna Setiawan, Albertus Aditya Siswandono, Siswandono Siti Nur Indah Rofiqoh Suciati Suciati Suciati Suciati Sugijanto Sugijanto Kartosentono Sukardiman Suzana Suzana SUZANA, SUZANA Syahrani, Achmad Tiara Puspa Asriningrum Tri Widiandani Tutik Sri Wahyuni Tutuk Budiati Ulvan, Angkasa Megistra Wiwied Ekasari Yanu Andhiarto Yaqin, Istna Nur’ainul