Article Per Year (5 Year)
p-Index From 2021 - 2026
1.383
P-Index
This Author published in this journals
All Journal Jurnal Natur Indonesia Media Penelitian dan Pengembangan Kesehatan Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Alchemy Jurnal Penelitian Kimia PROSIDING SEMINAR KIMIA Biopropal Industri Medika Tadulako INDONESIAN JOURNAL OF PHARMACY BERITA BIOLOGI Jurnal Bioteknologi & Biosains Indonesia (JBBI) Jurnal Fitofarmaka Indonesia Chimica et Natura Acta Farmasains : Jurnal Ilmiah Ilmu Kefarmasian ANNALES BOGORIENSES JURNAL ATOMIK Biosaintifika: Journal of Biology & Biology Education JSFK (Jurnal Sains Farmasi & Klinis) FITOFARMAKA: Jurnal Ilmiah Farmasi Pharmaceutical And Biomedical Sciences Journal (PBSJ) Journal of Social Research Jurnal Kefarmasian Indonesia Kimia Padjadjaran Annales Bogorienses
Partomuan Simanjuntak
Pusat Penelitian Bioteknologi Lembaga Ilmu Pengetahuan Indonesia Cibinong, Jawa Barat
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences

Published : 35 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : Journal of Social Research

 1 
Study Of The Anti-Obesity Potential Of Chlorogenic Acid Through Molecular Docking Faridah, Faridah; Mumpuni, Esti; Purnomo, Hari; Laksmitawati, Dian Ratih; Simanjuntak, Partomuan
Journal of Social Research Vol. 3 No. 2 (2024): Journal of Social Research
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/josr.v3i2.1910

Abstract

Chlorogenic acid, the primary constituent found in green coffee, is believed to possess anti-obesity properties. Numerous studies have indicated that the etiology of obesity is predominantly influenced by genetic factors. This study employs molecular docking techniques to estimate the effectiveness and toxicity of chlorogenic acid as an anti-obesity agent, focusing on its interaction with PLANTS. Initially, the validation process involved confirming the target cell or receptor (PDB code) which included PPAR-? (3NOA, 2ATH), pancreatic lipase (5ZUN), ghrelin (6ZYF), leptin (3V6O), and melanocortin (6W25, 7F58) through the utilization of YASARA software. In addition, the process of docking chlorogenic acid compounds and a positive control (for comparative purposes) was conducted on target cells utilizing the PLANTS program. The toxicity test and prediction of lethal dose (LD 50) were conducted on active substances and positive controls using the ProTox-II program. Chlorogenic acid exhibits anti-obesity properties by acting as an inhibitor of the ghrelin hormone, as seen by its activity at PDB code 6ZYF with a docking score of -19.7099 higher than the positive controls bupropion -18.5269 and naltrexone -18.5871. Furthermore, it has been determined to possess a generally safe profile, with an LD50 value of 5000 mg/kg body weight. The docking studies indicate that chlorogenic acid exhibits anti-obesity activity specifically at PDB code 6ZYF, where it functions as an inhibitor of the ghrelin hormone. Chlorogenic acid typically exhibits modest efficacy as an anti-obesity agent, hence presenting potential avenues for enhancing its effectiveness by structural modifications
Co-Authors A.A. Ketut Agung Cahyawan W Amalia . ANDRIA AGUSTA Arif Soeksmanto Arini Khaerunnisa Batan, Alfrida Bina Lohita Sari Bustanussalam ., Bustanussalam Bustanussalam Bustanussalam, Bustanussalam Daniel Daniel Dian Malini Otovina, Dian Malini Dian Ratih Laksmitawati Djamil, Ratna Djoko, Wahyuni Dyna Grace Romatua Aruan E.G. Said, E.G. Edward J Dompeipen, Edward J Efendy, Oscar Enny Sudarmonowati ERIS SEPTIANA Esti Mumpuni, Esti Farida Farida Farida, Yunahara Faridah Faridah Fauzy Rachman Gianny, Demitra Hardiyati, Iin HARI PURNOMO Harmastini Sukiman, Harmastini Haro, Gindo Koraag, Alfa Michael Gabriel Kusharyoto, Wien Lamek Marpaung, Lamek Lekatompessy, Sylvia J.R. Lilik Sulastri M. Rahayuningsih Mastura, Mastura Mawadah, Nursifa Muhammad Ahkam Subroto Murniaty Simorangkir Nasution, Pandapotan Ngadiman Ngadiman NISA RACHMANIA MUBARIK Purwoko, Marcus Yudhi Putra, Ari Permana Reubun, Yonathan Tri Atmodjo Ribu Surbakti, Ribu Rudi Kartika, Rudi Rumella Simarmata, Rumella Rurianti, Wandesta Rutdianti, Rutdianti Saifur Rohman SARONOM SILABAN Setyningrum, Eka Damayanti Shirly Kumala Siswa Setyahadi Sri Hartati Sukiman, Harmastini I. Suwarno, Tisno Suwarno, Tisno Syamsudin Syamsudin Tarigan, Elsera Br. Tarso Rudiana, Tarso Taurhesia, Shelly Titi Parwati, Titi Tiwit Widowati, Tiwit Tonel Barus, Tonel Wiwi Winarti Yadi, Yadi Yatri Hapsari, Yatri Yudhi Purwoko, Marcus Laurentius