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All Journal PROSIDING SEMINAR NASIONAL WARTA Biomedika Pharmacon INDONESIAN JOURNAL OF PHARMACY Jurnal Penelitian Sains Teknologi JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Kreativitas PKM Jurnal Ilmu Kefarmasian Indonesia Jurnal Ners Science Midwifery Abdi Geomedisains Proceeding ISETH (International Summit on Science, Technology, and Humanity) Prosiding University Research Colloquium Prosiding Seminar Nasional Pengabdian Masyarakat Inovasi Jurnal Pengabdian Masyarakat (IJPM) Usadha Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian Pharmacon: Jurnal Farmasi Indonesia
Tanti Azizah Sujono
Universitas Muhammadiyah Surakarta
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Journal : Pharmacon

 1 
Effect Test Stimulant of Curcuma Rhizome Infusion (Curcuma xanthorrhiza Roxb.) On Male Mice Swiss Strain Tary, Neni Lugki Nian; Sujono, Tanti Azizah
Pharmacon: Jurnal Farmasi Indonesia Vol 14, No 1 (2017)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v14i1.540

Abstract

The used of plants efficacious as medicines in the prevention of health problems had been known for along time the Indonesian people. The utilization of plants as medicine was based on the experience passeddown from generation to generation. The used of traditional medicines relatively favored by the people,the underlying factor are traditional medicines have less side effects than the modern medicines if usedappropriately. Curcuma (Curcuma xanthorrhiza Roxb.) used as refreshment which had stimulant effect..Stimulant was a substance that can stimulated the central nervous system which can speed up the processesin the body and minimize fatigue. Need to research the effects of stimulant infusion of curcuma rhizome.The research was conducted experimental methods pre-test and post-test. Twenty-five male mice Swissstrain used as experimental animals, which are divided into five groups, positive control (caffeine 100mg /kg BW), negative control (distilled water 0,5ml /20g BW), infusion of curcuma dose I (2.5 g/ kg BW), doseII (5g / kg BW), and dose III (10g / kg BW) respectively. Animal experiments tested using methods NatatoryExhaustion and treated with oral route. The effects of stimulant tired was calculated the time differencebefore and after treatment. The data obtained were analyzed non-parametric statistical tests, it’s KruskalWallis and Mann Whitney with a 95% confidence level. Infuse curcuma rhizome had the stimulant effect,the effect was obtained by increased the dose. At doses of 2.5 g / kg BW, 5g / kg BW, and 10 g / kg BW wasprovide a stimulant effect respectively by 2.82 minutes, 3.71 minutes and 4.94 minutes. Stimulant effect doseII and III had a greater effect than the positive control (p<0,05), the dose I had similar effect compare withcontrol positive (p>0,05). 
Efek Nefroprotektif Ekstrak Etanol Bawang Putih (Allium sativum L.) pada Tikus yang Diinduksi Gentamisin Sujono, Tanti Azizah; Rizki, Fanny Atika
Pharmacon: Jurnal Farmasi Indonesia Edisi Khusus: RAKERDA, SEMINAR, PID IAI
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v0i0.10510

Abstract

Gentamicin can induce damage to the kidney because of the accumulation of epithelial cells in the cortex. This accumulation can cause an increase in Reactive Oxygen Species (ROS), which in turn can trigger an increase in free radicals which causes a decrease in kidney function, which can be seen with Blood Urea Nitrogen (BUN) and sCr (serum creatinine) parameters. Garlic (Allium sativum L.) contains several bioactive compounds, including alliin, allisin, ajoene, and allil cysteine. The content of allisin has activity as an antioxidant. This study used a nephrotoxic mouse modelling method with 100 mg/kgBW of gentamicin induction intraperitoneally, then BUN and sCr levels were checked 24 hours after the 10th day induction. This study aimed to determine the effect of garlic ethanol extract in preventing the decline of renal function in rats induced by gentamicin with a parameter of BUN and sCr. The animal test were divided into 5 treatment groups, normal control group, negative controls, and three treatment groups at a dose of 50, 120, and 300 mg/kgBW for 10 days of concurrent treatment between extracts with gentamicin. The results of the study showed that garlic ethanol extract with a dose of  50, 120, 300 mg/kgBW was able to prevent a decrease  in kidney function due to the administration of gentamicin significantly when compared with negative controls (p 0,05).
Efek Nefroprotektif Ekstrak Etanol Bawang Putih (Allium sativum L.) pada Tikus yang Diinduksi Gentamisin Tanti Azizah Sujono; Fanny Atika Rizki
Pharmacon: Jurnal Farmasi Indonesia Edisi Khusus: RAKERDA, SEMINAR, PID IAI
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v0i0.10510

Abstract

Gentamicin can induce damage to the kidney because of the accumulation of epithelial cells in the cortex. This accumulation can cause an increase in Reactive Oxygen Species (ROS), which in turn can trigger an increase in free radicals which causes a decrease in kidney function, which can be seen with Blood Urea Nitrogen (BUN) and sCr (serum creatinine) parameters. Garlic (Allium sativum L.) contains several bioactive compounds, including alliin, allisin, ajoene, and allil cysteine. The content of allisin has activity as an antioxidant. This study used a nephrotoxic mouse modelling method with 100 mg/kgBW of gentamicin induction intraperitoneally, then BUN and sCr levels were checked 24 hours after the 10th day induction. This study aimed to determine the effect of garlic ethanol extract in preventing the decline of renal function in rats induced by gentamicin with a parameter of BUN and sCr. The animal test were divided into 5 treatment groups, normal control group, negative controls, and three treatment groups at a dose of 50, 120, and 300 mg/kgBW for 10 days of concurrent treatment between extracts with gentamicin. The results of the study showed that garlic ethanol extract with a dose of  50, 120, 300 mg/kgBW was able to prevent a decrease  in kidney function due to the administration of gentamicin significantly when compared with negative controls (p 0,05).
Effect Test Stimulant of Curcuma Rhizome Infusion (Curcuma xanthorrhiza Roxb.) On Male Mice Swiss Strain Neni Lugki Nian Tary; Tanti Azizah Sujono
Pharmacon: Jurnal Farmasi Indonesia Vol 14, No 1 (2017)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v14i1.540

Abstract

The used of plants efficacious as medicines in the prevention of health problems had been known for along time the Indonesian people. The utilization of plants as medicine was based on the experience passeddown from generation to generation. The used of traditional medicines relatively favored by the people,the underlying factor are traditional medicines have less side effects than the modern medicines if usedappropriately. Curcuma (Curcuma xanthorrhiza Roxb.) used as refreshment which had stimulant effect..Stimulant was a substance that can stimulated the central nervous system which can speed up the processesin the body and minimize fatigue. Need to research the effects of stimulant infusion of curcuma rhizome.The research was conducted experimental methods pre-test and post-test. Twenty-five male mice Swissstrain used as experimental animals, which are divided into five groups, positive control (caffeine 100mg /kg BW), negative control (distilled water 0,5ml /20g BW), infusion of curcuma dose I (2.5 g/ kg BW), doseII (5g / kg BW), and dose III (10g / kg BW) respectively. Animal experiments tested using methods NatatoryExhaustion and treated with oral route. The effects of stimulant tired was calculated the time differencebefore and after treatment. The data obtained were analyzed non-parametric statistical tests, it’s KruskalWallis and Mann Whitney with a 95% confidence level. Infuse curcuma rhizome had the stimulant effect,the effect was obtained by increased the dose. At doses of 2.5 g / kg BW, 5g / kg BW, and 10 g / kg BW wasprovide a stimulant effect respectively by 2.82 minutes, 3.71 minutes and 4.94 minutes. Stimulant effect doseII and III had a greater effect than the positive control (p0,05), the dose I had similar effect compare withcontrol positive (p0,05). 
Uji Aktivitas Antikolesterol Kombinasi Ekstrak Teh Oolong, Buncis Dan Kayu Manis Ahmad Fauzi; Tanti Azizah Sujono; Azis Saifudin; Arifah Sri Wahyuni
Pharmacon: Jurnal Farmasi Indonesia Vol 19, No 1 (2022)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v19i1.18193

Abstract

Hyperlipidemia has an important role in the occurrence of cardiovascular, cerebrovascular, and peripheral vascular diseases. High cholesterol and LDL levels in the blood are at risk of causing various diseases such as atherosclerosis, pancreatic dysfunction and kidney disorders. Meanwhile, high triglyceride levels can cause impaired liver, pancreas and kidney function. Green bean, oolong tea and cinnamon are plants that can lower cholesterol levels. Oolong tea contains catechins, Green Bean contain phytosterols and cinnamon contains cinnamaldehyde. Determination of secondary metabolite levels of extracts was carried out using the Liquid Chromatography – Mass Spectroscopy (LC-MS) method. The activity test was carried out with 30 Wistar white rats which were divided into 6 test groups. The normal control group was treated with CMC-Na without feeding hypercholesterolemia, the positive control group was treated with simvastatin 0.4 mg/KgBW, the negative control group was treated with CMC-Na, the test groups 1, 2 and 3 were treated with cinnamon extract, oolong tea and green bean, respectively (150:50:50 mg/KgBW), (50:150:50 mg/KgBW) and (50:50:150 mg/KgBW). The detected metabolite content was cinnamaldehyde in cinnamon up to 10%, catechins in oolong tea up to 12% and stigmasterol in beans as much as 3.4%.The results obtained by test group 1 and test group 2 can reduce cholesterol and triglyceride levels (p0.05). All test groups had no significant effect on HDL and LDL levels.
Co-Authors . Haryoto . Haryoto, . . MUHTADI . Muhtadi A Anifatussaa'dah Agung Endro Nugroho Ahmad Fauzi Ambarwati Andi Suhendi Anifatussaa'dah, A Anindya, Talitha Ahnaf Anjati, Yasinta Widia Ardalia Rinanda Oktaviani Arief Nurrochmad Arifah Sri Wahyuni Asti Arum Sari Azis Saifudin Azzahra, Annisa Alya Balqis, Moetia Rahman Basusena, Rahardian Surya Burhanudin Ichsan Citra, Tia Mella Dedi Hanwar Desi Rahmawati Dewi, Adinda Putri Sari Dewi, Syochi Jannati Pramudya Dwi Sarbini Dzafira, Laila Eka Prasnaparamita W Em Sutrisna Emsutrisna, E Endang Lukitaningsih Erna Herawati Erna Herawati, Erna Fahriza Mei Trihatmoko Fakhrudin, Muh. Fanny Atika Rizki Faridita khoirun Nisa' Fidhia Nur Rifaini Firdaus, Farhand Ahmad Fitriani, Rizki Ainun Fortuna, Tista Ayu Haliza Arzeti Nurseptiria Hana, Ulya Rosa Handayani, Eka Wuri Harindasari, Amorita Azzah Haryoto - Haryoto Haryoto Haryoto, H Haya Nabilah Utama Hertaliyana, Junita Ayu HI, Marsilia Rosa Sinensis Hidayah Karuniawati Ichsan, Burhanudin Ida Maesaroh Ida Maesaroh, Ida Ika Trisharyanti Dian Kusumowati Ilham Ramadhan Isnaniyah, Dhevi Zahra Latifatul Jeli Marlita Katarina Lulu Widyanti Khusnul Khotimah khusnul khotimah Kusumastuti, Lina Ayu Laila Dzafira LANGKAH SEMBIRING Lina Ayu Kusumastuti Listiana Masyita Dewi Mariska Sri Harlianti Marsilia Rosa Sinensis HI Marsya, Vitania Maryati, M Merlindasari, Aulia Pungky Muhammad Da&#039;i Muhtadi - Muhtadi Muhtadi Muhtadi, M Muslihah, Sayyidah Nurul Neni Lugki Nian Tary Nisa', Faridita khoirun Nurseptiria, Haliza Arzeti Oktaviani, Ardalia Rinanda Peni Indaryudha Peni Indaryudha, Peni Peni Indrayudha Pratama, Wilson Candra Teguh Raafika Studiviani Rachmalia, Fauniza Marwa Rahardian Surya Basusena Rahmadani, Sandika Rahmatullah, Wahyu Ratna Yuliani Ratna Yuliani Raudatul Patimah Raudatul Patimah, Raudatul Retno Sintowati - Rifaini, Fidhia Nur Rima Munawaroh Rizki Ainun Fitriani Rizki, Fanny Atika Roshitasari, Eva Sanjaya, Muhammad Riyanto Sari, Erlinda Novita Sartono Putro Sativa, Wieke Rachma Sayyidah Nurul Muslihah Setyo Nurwaini Shofiah, Mira Sri Wahyuni Studiviani, Raafika Subagus Wahyuono Subekti, Istiara Syahputri, Janies Arly T.N. Saifullah Sulaiman T.N. Saifullah Sulaiman, T.N. Saifullah Tary, Neni Lugki Nian Tia Mella Citra Tista Ayu Fortuna Trihatmoko, Fahriza Mei Ujiantya, Sabrina Dian Parasika Ullya Nur Wahyu Hidayah Ullya Nur Wahyu Hidayah, Ullya Nur Wahyu umi laelatul qomar Utama, Haya Nabilah Vitania Marsya Wahyu Utami Wahyu Utami, Wahyu Wati, Abil Lia Wulan Rahmadhani, Wulan