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All Journal Jurnal Pengajaran MIPA Jurnal Pengajaran Matematika dan Ilmu Pengetahuan Alam Formica Online Jurnal Pendidikan Biologi Indonesia Jurnal Pendidikan Biologi Science and Technology Indonesia Jurnal Biodjati Jurnal IPA Terpadu Syntax Literate: Jurnal Ilmiah Indonesia Jurnal Ilmu Alam dan Lingkungan Diklabio: Jurnal Pendidikan dan Pembelajaran Biologi Assimilation: Indonesian Journal of Biology Education BIOSFER : Jurnal Biologi dan Pendidikan Biologi PERENNIAL Spizaetus: Jurnal Biologi dan Pendidikan Biologi Jurnal Ilmiah Biologi UMA (JIBIOMA) Yumary: Jurnal Pengabdian kepada Masyarakat Jurnal Riset Teknologi Pencegahan Pencemaran Industri Proceeding Biology Education Conference Journal of Natural Sciences BIOMA : Jurnal Biologi dan Pembelajarannya SN-Biosper Makara Journal of Science Quagga: Jurnal Pendidikan dan Biologi Jurnal Esabi (Jurnal Edukasi dan Sains Biologi) Journal of Character and Environment JIPI (Jurnal IPA dan Pembelajaran IPA) Jurnal Teknologi Lingkungan UNMUL Ecotourism and Environment Conservation Journal The Impact : Jurnal Pengabdian Kepada Masyarakat
Wahyu Surakusumah
Universitas Pendidikan Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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Journal : Makara Journal of Science

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Phytochemical Analysis, Antioxidant Activity, and Cytotoxic Effects of Physalis angulata and Moringa oleifera Leaf Extracts on Cancer and Normal Cells In Vitro Priyandoko, Didik; Widowati, Wahyu; Sholihah, Ika Adhani; Zahira, Nurul Zahra; Bangun, Adityana Arta; Kusdianti, Kusdianti; Hernawati, Hernawati; Surakusumah, Wahyu; Juansah, Rahadian Deden
Makara Journal of Science Vol. 29, No. 1
Publisher : UI Scholars Hub

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Abstract

Physalis angulata and Moringa oleifera have long been the key ingredients of traditional medicine. This study aimed to obtain the metabolite profiles of the ethanolic leaf extracts of P. angulata (ELP) and M. oleifera (ELM), evaluate their antioxidant activity, and assess their toxicity against normal and cancer cells. The leaves were sourced from Balittro, West Java. The extraction used 70% ethanol and continued for 3 days. The metabolites were identified using Gas Chromatography-Mass Spectrometry (GC-MS), antioxidant activity was ascertained via the DPPH assay, and cytotoxicity was evaluated employing the PrestoBlue assay. GC-MS identified 23 compounds in ELP and 15 in ELM. The DPPH assay showed that ELM, ELP, or their combination exhibited marked antioxidant activity, with inhibition ranging from 50% to 90%. The toxicity assay against MCF-7 cancer cells demonstrated that ELP at 1,500 µg/mL and ELM at 1,200 µg/mL induced cytotoxicity. The ELP + ELM formulation exhibited stronger cytotoxic effects than the positive control. In contrast, ELM or ELP did not induce toxicity in normal CV-1 cells and, stimulated viability com-pared to the control. Thus, the phytochemical contents of ELM and ELP exhibited enhanced antioxidant activity, in-duced toxicity in cancer cells, and were safe for normal cells.
Co-Authors Afifi Mutiarani Afri Irawan Afri Irawan, Afri Agie Syirban Gizawi Amelia Qodaryanti Amelia Qodaryanti, Amelia Aulia Khaerunnisa Aulia Khairunnisa Aulia, Hanna Aziz, Adika Muhammad Azkiya Annurbaiti Bambang Supriatno Bangun, Adityana Arta Dewina, Utari Didik Priyandoko Dieni Asma Mardiyah Dina Nur Permatasari Ekaputri, Rendi Zulni Erma, Nabila Fadhilah, Eksa Adhwa Fakhran Rozali Daulay Fatharani, Aulia Fatma Ainul Ilmia Feldina Gustanti Gumanti, Zarfani Hadiprasetyo, Dhanar Septyawan Hadistia, Nabilla Halisa Hanna Sari Widya Kusuma, Hanna Sari Widya Hernawati Hernawati Hertien K Surtikanti Hertien Koosbandiah Surtikanti Hertien Koosbandiah Surtikanti Hildawati Febiana Irma Kusumastuti Juansah, Rahadian Deden Kamaludin, Syaris Koosbandiah Surtikanti, Hertien Kurniawan, Try Kusdianti Kusdianti Maesaroh, Tika Mardiyah, Dieni Asma Marhamah, Yualinda Durotul Marisca Evalina Gondokesumo, Marisca Evalina Maulana Yusuf Mauseni Wantika Dewi Mrs Sariwulan Diana Naufalia Zahrannanda Nisa Pangsuma Novilla, Arina Nur Ilmiah Sakinah Nusayba Abdul Wahid Peristiwati Peristiwati, Peristiwati Polandos, Chersa Steffany Putra, Muhammad Naufal Nugraha R. Riandi, R. Regina Pacis Resti*, Novita Riandi Riandi Rini Marwati Rizal Awaludin Malik Rizal Awaludin Malik, Rizal Awaludin Rizka Khairunisa Saffanah Nadhirah Salma Salsabila Sholihah, Ika Adhani Sidik, Abdul Faqih Fajar Sijani Prahastuti Silaban, Oky Rizkiana Soemarwoto, Rini Sri Anggraeni Suhara, . Surtikanti Hertien Koosbandiah, Surtikanti Syaris Kamaludin Tina Safaria Tina Safaria Nilawati Topik Hidayat WAHYU WIDOWATI Widi Purwianingsih YAYAN SANJAYA Yuliandini, Sinta Yunita Yunita Yusuf Andi Senjaya Zahira, Nurul Zahra Zahiroh, Fadhilah Haifa