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Wahyu Surakusumah
Universitas Pendidikan Indonesia
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Journal : Science and Technology Indonesia

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Anticancer Effectivity of Nanocrystals Derived from Mangosteen (Garcinia mangostana) Peel Extract on Leukemia HL-60 Cells Gondokesumo, Marisca Evalina; Novilla, Arina; Prahastuti, Sijani; Kusuma, Hanna Sari Widya; Widowati, Wahyu; Zahiroh, Fadhilah Haifa; Hadiprasetyo, Dhanar Septyawan; Surakusumah, Wahyu
Science and Technology Indonesia Vol. 10 No. 1 (2025): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.1.228-237

Abstract

Leukemia, characterized by abnormal leukocyte proliferation, ranks ninth in Indonesia as the most common cancer. While treatments such as chemotherapy and radiation effectively target cancer cells, they also risk damaging healthy blood cells. This has spurred interest in exploring low-toxicity herbal compounds as potential therapies, with mangosteen peel emerging as a widely researched option. Nanotechnology, which has the potential to enhance the bioavailability of herbal compounds, is also a focus of extensive research. This study objective was to assess the impact of Mangosteen Peel Nanocrystal (MPN) on HL-60 leukemia cells by analyzing various parameters, including cytotoxicity, reactive oxygen species (ROS) levels, senescence, and gene expression changes. MPN was prepared with high-speed milling and characterized using particle size analyzers, microscopy, and stability assessments. HL-60 cells were cultured and subjected to MPN treatment. Cytotoxicity was evaluated using WST-8 assays, ROS levels were assessed using flow cytometry, and senescence analyses using Senescence-Associated b-Galactosidase Staining. AKT and FLT-1 gene expression were determined via qRT-PCR. MPN has been successfully characterized as a nanoparticle based on size, stability, and morphology. MPN has an impact on leukemia cells by increasing cytotoxicity, decreasing ROS levels, inducing senescence, and modulating AKT and FLT-1 gene expressions. The findings suggest potential implications for MPN in targeting leukemia cells. The study sheds light on the promising effects of MPN in leukemia cell models, indicating its potential applications in targeting cancer cells, inducing senescence, decreasing ROS levels, and modulating gene expressions related to cell survival and proliferation.
Co-Authors Afifi Mutiarani Afri Irawan Afri Irawan, Afri Agie Syirban Gizawi Amelia Qodaryanti Amelia Qodaryanti, Amelia Aulia Khaerunnisa Aulia Khairunnisa Aulia, Hanna Aziz, Adika Muhammad Azkiya Annurbaiti Bambang Supriatno Bangun, Adityana Arta Dewina, Utari Didik Priyandoko Dieni Asma Mardiyah Dina Nur Permatasari Ekaputri, Rendi Zulni Erma, Nabila Fadhilah, Eksa Adhwa Fakhran Rozali Daulay Fatharani, Aulia Fatma Ainul Ilmia Feldina Gustanti Gumanti, Zarfani Hadiprasetyo, Dhanar Septyawan Hadistia, Nabilla Hanna Sari Widya Kusuma, Hanna Sari Widya Hernawati Hernawati Hertien K Surtikanti Hertien Koosbandiah Surtikanti Hertien Koosbandiah Surtikanti Hildawati Febiana Irma Kusumastuti Juansah, Rahadian Deden Kamaludin, Syaris Koosbandiah Surtikanti, Hertien Kurniawan, Try Kusdianti Kusdianti Maesaroh, Tika Mardiyah, Dieni Asma Marhamah, Yualinda Durotul Marisca Evalina Gondokesumo, Marisca Evalina Maulana Yusuf Mauseni Wantika Dewi Mrs Sariwulan Diana Naufalia Zahrannanda Nisa Pangsuma Novilla, Arina Nur Ilmiah Sakinah Nusayba Abdul Wahid Peristiwati Peristiwati, Peristiwati Putra, Muhammad Naufal Nugraha R. Riandi, R. Regina Pacis Resti*, Novita Riandi Riandi Rini Marwati Rizal Awaludin Malik Rizal Awaludin Malik, Rizal Awaludin Rizka Khairunisa Saffanah Nadhirah Salma Salsabila Sholihah, Ika Adhani Sijani Prahastuti Silaban, Oky Rizkiana Soemarwoto, Rini Sri Anggraeni Suhara, . Surtikanti Hertien Koosbandiah, Surtikanti Syaris Kamaludin Tina Safaria Tina Safaria Nilawati Topik Hidayat WAHYU WIDOWATI Widi Purwianingsih YAYAN SANJAYA Yuliandini, Sinta Yunita Yunita Yusuf Andi Senjaya Zahira, Nurul Zahra Zahiroh, Fadhilah Haifa