Article Per Year (5 Year)
p-Index From 2021 - 2026
3.996
P-Index
This Author published in this journals
All Journal Jurnal Pengajaran MIPA Jurnal Pengajaran Matematika dan Ilmu Pengetahuan Alam Formica Online Journal of Mathematical and Fundamental Sciences Jurnal Pendidikan Biologi Indonesia Jurnal Pendidikan Biologi Science and Technology Indonesia Jurnal Biodjati Jurnal IPA Terpadu Syntax Literate: Jurnal Ilmiah Indonesia Jurnal Ilmu Alam dan Lingkungan Diklabio: Jurnal Pendidikan dan Pembelajaran Biologi Assimilation: Indonesian Journal of Biology Education BIOSFER : Jurnal Biologi dan Pendidikan Biologi PERENNIAL Spizaetus: Jurnal Biologi dan Pendidikan Biologi Jurnal Ilmiah Biologi UMA (JIBIOMA) Yumary: Jurnal Pengabdian kepada Masyarakat Jurnal Riset Teknologi Pencegahan Pencemaran Industri Proceeding Biology Education Conference Journal of Natural Sciences BIOMA : Jurnal Biologi dan Pembelajarannya SN-Biosper Makara Journal of Science Quagga: Jurnal Pendidikan dan Biologi Jurnal Esabi (Jurnal Edukasi dan Sains Biologi) Journal of Character and Environment JIPI (Jurnal IPA dan Pembelajaran IPA) Jurnal Teknologi Lingkungan UNMUL Ecotourism and Environment Conservation Journal The Impact : Jurnal Pengabdian Kepada Masyarakat Journal of BioSustainability
Wahyu Surakusumah
Universitas Pendidikan Indonesia
Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

Published : 44 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : Science and Technology Indonesia

 1 
Anticancer Effectivity of Nanocrystals Derived from Mangosteen (Garcinia mangostana) Peel Extract on Leukemia HL-60 Cells Gondokesumo, Marisca Evalina; Novilla, Arina; Prahastuti, Sijani; Kusuma, Hanna Sari Widya; Widowati, Wahyu; Zahiroh, Fadhilah Haifa; Hadiprasetyo, Dhanar Septyawan; Surakusumah, Wahyu
Science and Technology Indonesia Vol. 10 No. 1 (2025): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.1.228-237

Abstract

Leukemia, characterized by abnormal leukocyte proliferation, ranks ninth in Indonesia as the most common cancer. While treatments such as chemotherapy and radiation effectively target cancer cells, they also risk damaging healthy blood cells. This has spurred interest in exploring low-toxicity herbal compounds as potential therapies, with mangosteen peel emerging as a widely researched option. Nanotechnology, which has the potential to enhance the bioavailability of herbal compounds, is also a focus of extensive research. This study objective was to assess the impact of Mangosteen Peel Nanocrystal (MPN) on HL-60 leukemia cells by analyzing various parameters, including cytotoxicity, reactive oxygen species (ROS) levels, senescence, and gene expression changes. MPN was prepared with high-speed milling and characterized using particle size analyzers, microscopy, and stability assessments. HL-60 cells were cultured and subjected to MPN treatment. Cytotoxicity was evaluated using WST-8 assays, ROS levels were assessed using flow cytometry, and senescence analyses using Senescence-Associated b-Galactosidase Staining. AKT and FLT-1 gene expression were determined via qRT-PCR. MPN has been successfully characterized as a nanoparticle based on size, stability, and morphology. MPN has an impact on leukemia cells by increasing cytotoxicity, decreasing ROS levels, inducing senescence, and modulating AKT and FLT-1 gene expressions. The findings suggest potential implications for MPN in targeting leukemia cells. The study sheds light on the promising effects of MPN in leukemia cell models, indicating its potential applications in targeting cancer cells, inducing senescence, decreasing ROS levels, and modulating gene expressions related to cell survival and proliferation.
Co-Authors Abthal, Ok M. Adha, Khoerotul Nur Fadhilah Afifi Mutiarani Afri Irawan Afri Irawan, Afri Agie Syirban Gizawi Agustine, Liana Amelia Qodaryanti Amelia Qodaryanti, Amelia Aulia Khaerunnisa Aulia Khairunnisa Aulia, Hanna Azis, Rizal Aziz, Adika Muhammad Azizah, Hilda Nur Azkiya Annurbaiti Bambang Supriatno Bangun, Adityana Arta Christofan, Vinno Bayu Dewina, Restu Utari Dewina, Utari Didik Priyandoko Dieni Asma Mardiyah Dina Nur Permatasari Dini Indriani, Dini Ekaputri, Rendi Zulni Erma, Nabila Fadhilah, Eksa Adhwa Fadhilah, Fathan Fakhran Rozali Daulay Fatharani, Aulia Fatma Ainul Ilmia Fauziah, Abidah Fauziah, Aisyah Fikria Feldina Gustanti Gumanti, Zarfani Hadiprasetyo, Dhanar Septyawan Hadistia, Nabilla Halisa Halisa, Halisa Hanieyane, Dendu Noutera Pramayuditya Hanna Sari Widya Kusuma, Hanna Sari Widya Hardhaneszha, Azkaifa Syawqie Hendriantika, Ratu Dewi Hernawati Hernawati Hertien K Surtikanti Hertien Koosbandiah Surtikanti Hertien Koosbandiah Surtikanti Hildawati Febiana Irma Kusumastuti Juansah, Rahadian Deden Kamaludin, Syaris Khofifah, Tsani Kocha, Santana Koosbandiah Surtikanti, Hertien Kurniawan, Try Kusdianti Kusdianti Lestari, Emilia Mia Maesaroh, Tika Mardiyah, Dieni Asma Marhamah, Yualinda Durotul Marisca Evalina Gondokesumo, Marisca Evalina Maulana Yusuf Mauseni Wantika Dewi Mrs Sariwulan Diana Naufalia Zahrannanda Nisa Pangsuma Novilla, Arina Nur Ilmiah Sakinah Nurani, Lisna Wahyu Nurhaliza, Salma Setia Nurjamil, Aris Muhammad Nusayba Abdul Wahid Peristiwati Peristiwati, Peristiwati Polando, Chersy Tiffany Polandos, Chersa Steffany Polandos, Chersy Tiffany Prameswari, Alfi Hanifah Putra, Muhammad Naufal Nugraha R. Riandi, R. Rabani, Naila Aulia Ramadhani, Abidah Bunga Regina Pacis Resti*, Novita Riandi Riandi Rini Marwati Rizal Awaludin Malik Rizal Awaludin Malik, Rizal Awaludin Rizka Khairunisa Rizki, Fajri Khoirul Saffanah Nadhirah Salma Salsabila Sholihah, Ika Adhani Sidik, Abdul Faqih Fajar Sijani Prahastuti Silaban, Oky Rizkiana Siti Sofiah Soemarwoto, Rini Sri Anggraeni Suhara, . Surtikanti Hertien Koosbandiah, Surtikanti Syaris Kamaludin Tina Safaria Tina Safaria Nilawati Topik Hidayat WAHYU WIDOWATI Widi Purwianingsih YAYAN SANJAYA Yuliandini, Sinta Yunita Yunita Yusuf Andi Senjaya Zahira, Nurul Zahra Zahiroh, Fadhilah Haifa