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Gaucher Disease with Normocytic Normochrome Anemia Manifestation in a 13-Month-Old Baby: A Case Report Nova Linda; Nice Rachmawati Masnadi; Gustina Lubis; Amirah Zatil Izzah
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 9 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i9.578

Background: Gaucher disease is a sphingolipidosis, an inherited disorder of metabolism resulting from glucocerebrosidase deficiency, causing the deposition of glucocerebroside and related compounds. This study aimed to describe Gaucher disease in one year old baby girl. Case presentation: A 13-month-old girl was referred from the district hospital with a diagnosis of hemolytic anemia. The Patient come with major complaints in the form of enlarged abdomen since 6 months ago. The patient looked pale and coughed since 7 days ago, accompanied by a cold. Ultrasound examination of the abdomen shows splenomegaly. Based on supporting examinations, the effect of normocytic normochrome anemia with reticulocytosis was obtained. The bone survey resulted in an Erlenmeyer flask image on both the humerus and femur suitable for Gaucher disease. The results of microscopic evaluation on bone marrow smear found large cells with Gaucher cell characteristics. Laboratory evaluation of glucocerebroside enzymes showed that there was a deficiency deficiency β-glucosidase. Patients get enzyme replacement therapy for 7 times, each therapy is carried out every 2 weeks. Conclusion: Enzyme replacement therapy is the definitive effective therapy in patients with Gaucher disease. Follow-up should, in principle, be individualized, as the heterogeneity of the disease and a number of associated conditions precludes strict protocolized follow-up.

Correlation of Neutrophil to Lymphocyte Ratio (NLR) Values to Ejection Fraction, Fraction Shortening, and E/A Ratio in Children with Rheumatic Heart Disease (RHD) at Dr. M. Djamil General Hospital, Padang, Indonesia Farid I Hussein; Didik Hariyanto; Amirah Zatil Izzah
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 16 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i16.698

Background: Monitoring the performance of the cardiac function is a must in monitoring patients with rheumatic heart disease (RHD). Echocardiography is the main diagnostic tool that plays a role in monitoring heart function, but the existence of this tool is only in tertiary health services and generally requires special expertise. This study aims to determine the correlation between the neutrophil to lymphocyte ratio (NLR) and markers of cardiac function performance on echocardiography, namely ejection fraction, fraction shortening, and E/A ratio in children with rheumatic heart disease at Dr. M. Djamil General Hospital, Padang, Indonesia. Methods: This was an analytical observational study with a cross-sectional approach. A total of 34 subjects were included in this study. Data analysis using SPSS was univariate and bivariate, with p<0.05. Results: There was a correlation between the NLR value and the echocardiographic ejection fraction (EF) parameter (p>0.05) with a very weak correlation strength, while the correlation between the NLR value and the FS echocardiography parameter (p<0.05), the direction of the correlation formed is positive with a strong correlation weak (r=0.388). As for the correlation of NLR values with echocardiographic parameters E/A (p<0.05), the direction of the correlation formed was positive with a weak correlation strength (r=0.353). Conclusion: There is a weak correlation between NLR values with FS and E/A echocardiographic parameters and no correlation between NLR and EF echocardiographic parameters in rheumatic heart disease patients at Dr. M. Djamil General Hospital, Padang, Indonesia.

Correlation of Neutrophil to Lymphocyte Ratio (NLR) Values to Ejection Fraction, Fraction Shortening, and E/A Ratio in Children with Rheumatic Heart Disease (RHD) at Dr. M. Djamil General Hospital, Padang, Indonesia Farid I Hussein; Didik Hariyanto; Amirah Zatil Izzah
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 16 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i16.698

Background: Monitoring the performance of the cardiac function is a must in monitoring patients with rheumatic heart disease (RHD). Echocardiography is the main diagnostic tool that plays a role in monitoring heart function, but the existence of this tool is only in tertiary health services and generally requires special expertise. This study aims to determine the correlation between the neutrophil to lymphocyte ratio (NLR) and markers of cardiac function performance on echocardiography, namely ejection fraction, fraction shortening, and E/A ratio in children with rheumatic heart disease at Dr. M. Djamil General Hospital, Padang, Indonesia. Methods: This was an analytical observational study with a cross-sectional approach. A total of 34 subjects were included in this study. Data analysis using SPSS was univariate and bivariate, with p<0.05. Results: There was a correlation between the NLR value and the echocardiographic ejection fraction (EF) parameter (p>0.05) with a very weak correlation strength, while the correlation between the NLR value and the FS echocardiography parameter (p<0.05), the direction of the correlation formed is positive with a strong correlation weak (r=0.388). As for the correlation of NLR values with echocardiographic parameters E/A (p<0.05), the direction of the correlation formed was positive with a weak correlation strength (r=0.353). Conclusion: There is a weak correlation between NLR values with FS and E/A echocardiographic parameters and no correlation between NLR and EF echocardiographic parameters in rheumatic heart disease patients at Dr. M. Djamil General Hospital, Padang, Indonesia.

Korelasi Antara Rasio Neutrofil Limfosit Dengan Derajat Klinis Anak Terkonfirmasi COVID-19 Raniathia Frieska; Amirah Zatil Izzah; Rizki Rahmadian
Jurnal Ilmu Kesehatan Indonesia Vol 4 No 1 (2023): Maret 2023
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v4i1.913

Latar Belakang: COVID-19 adalah penyakit infeksi yang disebabkan oleh SARS-CoV-2 dan menjadi pandemic sejak kemunculannya pertama pada awal tahun 2020. Di Indonesia, anak di bawah usia 18 tahun merupakan 13% dari kasus konfirmasi dengan 1% kematian. Derajat klinis yang paling banyak ditemukan pada anak tergolong lebih ringan dibandingkan dewasa. Rasio neutrofil limfosit (NLR) adalah biomarker yang digunakan untuk mendeteksi dini beratnya derajat klinis COVID-19. Objektif: Penelitian ini bertujuan untuk mengetahui korelasi antara NLR dengan derajat klinis anak terkonfirmasi COVID-19 di RSUP Dr. M. Djamil Padang. Metode: Penelitian ini merupakan studi analitik retrospektif dengan desain cross-sectional menggunakan data sekunder berupa rekam medis pasien dengan total sampel 41 anak dengan kasus terkonfirmasi COVID-19 periode Maret 2020 – Desember 2021. Korelasi gamma akan digunakan untuk menilai korelasi antara dua variable. Hasil: Penelitian ini menunjukkan kelompok usia terbanyak pada rentang usia 6-15 tahun (48,8%) dan jenis kelamin perempuan (56,1%). Lebih banyak sampel dengan derajat klinis ringan (51,4%) dengan nilai hitung neutrofil dan limfosit pada umumnya normal. Nilai NLR < 3,13 ditemukan pada 85,7% sampel. Ditemukan korelasi positif yang kuat (r=0,748, p=0,018) antara NLR dan derajat klinis. Nilai NLR <3,13 lebih banyak ditunjukkan pada derajat klinis ringan (61,1%) dibandingkan dengan derajat klinis berat (25%). Nilai NLR ≥3.13 lebih banyak ditunjukkan pada derajat klinis berat (60%) dan tidak sama sekali pada derajat klinis ringan. Kesimpulan: Kesimpulan penelitian ini adalah sebagian besar kasus COVID-19 pada anak di RSUP Dr. M. Djamil Padang berumur 6-15 tahun, perempuan, berderajat klinis ringan, nilai hitung neutrofil dan limfosit normal. Lebih dari sebagian pasien ditemukan dengan nilai NLR <3,13 serta terdapat korelasi positif yang kuat antara NLR dengan derajat klinis COVID-19.

Hubungan Faktor Risiko dengan Kejadian Infeksi Saluran Kemih pada Anak di RSUP Dr. M. Djamil Padang Sherly Vanessa Putri Hadiyanto; Amirah Zatil Izzah; Siti Nurhajjah
Jurnal Ilmu Kesehatan Indonesia Vol 4 No 2 (2023): Juni 2023
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v4i2.1059

Latar Belakang: Penyakit infeksi saluran kemih pada anak masih menjadi masalah kesehatan karena tingginya angka kesakitan dan kematian pada anak di negara berkembang, termasuk Indonesia. Penyakit ini menempati urutan kedua penyakit infeksi tersering pada anak setelah infeksi saluran nafas atas. Kejadian ISK dapat dipengaruhi oleh berbagai macam faktor risiko, seperti sirkumsisi, konstipasi kronis, status gizi, dan cara membersihkan genitalia. Objektif: Mengetahui hubungan faktor risiko dengan kejadian ISK pada anak di RSUP Dr. M. Djamil Padang. Metode: Jenis penelitian ini adalah analitik dengan rancangan penelitian case control. Jumlah sampel pada penelitian ini adalah 120 orang, yang terdiri dari 60 orang pasien anak dengan infeksi saluran kemih pada kelompok kasus dan 60 orang pasien anak tanpa infeksi saluran kemih pada kelompok kontrol di RSUP Dr. M. Djamil Padang periode Januari 2018 – Desember 2021. Analisis data dilakukan dengan menggunakan chi square. Hasil: Hasil penelitian didapatkan karakteristik pasien infeksi saluran kemih pada anak yang terbanyak yaitu usia <1 tahun (43,3%), laki-laki (51,7%), belum sirkumsisi (77,4%), tidak ada konstipasi kronis (63,3%), gizi kurang (53,3%), dan cara membersihkan genitalia dari arah depan ke belakang (62,1%). Secara statistik ditemukan hubungan yang bermakna antara konstipasi kronis (p=0,006), status gizi (p=0,005) dengan kejadian infeksi saluran kemih pada anak, sedangkan sirkumsisi (p=0,569), cara membersihkan genitalia (p=0,395) tidak memiliki hubungan yang bermakna dengan kejadian infeksi saluran kemih pada anak. Kesimpulan: Konstipasi kronis dan status gizi merupakan faktor risiko kejadian infeksi saluran kemih pada anak sedangkan sirkumsisi dan cara membersihkan genitalia tidak memiliki hubungan yang bermakna dengan kejadian infeksi saluran kemih pada anak.

Hubungan Kadar Ferritin Serum dengan Fungsi Tiroid pada Anak dengan Thalassemia beta Mayor Melisha Lisman Gaya; Eka Agustia Rini; Amirah Zatil Izzah
Sari Pediatri Vol 25, No 1 (2023)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp25.1.2023.27-31

Latar belakang. Thalassemia beta mayor merupakan penyakit yang ditandai dengan anemia kronik, hipoksia kronik jaringan, dan pemberian transfusi darah seumur hidup. Penumpukan besi akibat pemberian transfusi berulang berefek toksik pada berbagai organ, termasuk kelenjar tiroid.Tujuan. Mengetahui hubungan antara kelebihan beban besi dengan kejadian hipotiroid pada anak yang menderita thalassemia beta mayor.Metode. Penelitian cross-sectional terhadap 43 subjek dengan thalassemia beta mayor dan mendapat transfusi darah rutin pada periode April 2018-Februari 2019. Subjek dipilih secara total sampling dan dikelompokkan berdasarkan kadar ferritin serum <2500 µg/L dan >2500 µg/L. Hasil kadar tiroksin dan thyroid stimulating hormone dikelompokkan menjadi eutiroid dan hipotiroid. Hasil analisis statistik bermakna bila p<0,05.Hasil. Kadar ferritin serum <2500 µg/L dan >2500 µg/L terdapat pada masing-masing 19 (44,2%) dan 24 (55,8%) subjek. Hipotiroid terjadi pada 13 (38,1%) subjek dengan kadar ferritin >2500 ?g/L dan delapan (38,1%) subjek dengan kadar ferritin <2500 µg/L. Tidak ditemukan hubungan bermakna antara ferritin serum dengan fungsi tiroid pada subjek (p=0,432).Kesimpulan. Persentase hipotiroid meningkat seiring peningkatan kadar ferritin serum, tetapi tidak terdapat hubungan bermakna antara kadar ferritin serum dengan fungsi tiroid pada anak dengan thalassemia beta mayor.

Anemia Defisiensi Besi Berat pada Remaja Abdurrahman Arsyad As Siddiqi; Amirah Zatil Izzah
Majalah Kedokteran Andalas Vol 46, No 8 (2024): Online Januari 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i8.p1319-1330.2024

Iron deficiency anemia (IDA) is anemia caused by a reduced body iron reserve to form red blood cells. During periods of rapid growth, such as the first year of life and adolescence, the need for iron increases, leading to an increased incidence of iron deficiency anemia during these periods. Deficiency of iron can lead to concealed intestinal bleeding. This case report discusses a 10-year and 7-month-old male patient with a diagnosis of severe iron deficiency anemia accompanied by occult bleeding. The patient received a blood transfusion due to a very low Hb level of 3.9 g/dl. The transfusion was administered gradually with a target Hb of 6 g/dl and was followed by iron supplementation. The blood transfusion provided was in the form of red cell packs, administered slowly in sufficient amounts to raise the Hb to a safe level.

Enhancing Ante Natal Care (ANC) Quality Through Interprofessional Collaboration (IPC) Among Health Workers Miftahul Fikrah; Laila Isrona; Amirah Zatil Izzah
International Journal of Medicine and Health Vol. 3 No. 4 (2024): Desember : International Journal of Medicine and Health (IJMH)
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/ijmh.v3i4.4353

The increased of Maternal Mortality Rate (MMR) can be lowered through by various efforts, one of them with quality Antenatal Care (ANC). Quality of ANC services can be given by several health workers who work together in giving services to patients through the Interprofessional Collaboration (IPC). IPC or interprofessional collaboration can improve health service quality. The purpose of this study is to find out an overview of the level of perception of health workers about IPC on ANC services in Lubuk Buaya Health Center. This study is descriptive research using crosssectional design. The study sample is 30 health workers who are determined by the total sampling method. Data collection use the Collaborative Practice Assessment Tools (CPAT) questionnaire. The results of the study can be found that all health workers (100%) have a high perception of IPC in ANC services with components of connection among members, coordination and division of roles, and missions, goals, and objectives have the highest percentage (100%) and decision-making and conflict management components have the lowest percentage (10%). All health professions consist of GPs, midwives, nurses, dentists, pharmacists, nutritionists, and ATLM have a high perception (100%) of IPC on ANC services. The dentist professions have a high perception of all eight components, meanwhile other professions have a high perception of the seven components of perception and have a moderate perception in one component of perception, that is the components of decision making and conflict management. In general, health workers have a high perception of IPC in ANC services, but there are still a moderate perception in one components of perception so efforts are needed to improve IPC competence in that component.

Hubungan Karakteristik Pasien terhadap Luaran Pasien COVID-19 dengan Komorbid Kanker di RSUP Dr. M. Djamil Padang Nivolla, Rhona; Izzah, Amirah Zatil; Nurhayati, Nurhayati
Jurnal Ilmu Kesehatan Indonesia Vol. 5 No. 3 (2024): September 2024
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v5i3.1217

Latar Belakang: Coronavirus Disease 2019 (COVID-19) rentan dialami oleh pasien kanker karena memiliki daya tahan tubuh yang rendah. Penelitian mengenai hubungan karakteristik pasien (jenis kelamin, usia, diagnosis kanker, derajat klinis COVID-19, dan komorbid lainnya) terhadap luaran pasien COVID-19 dengan komorbid kanker belum banyak dilakukan di Indonesia. Objektif: Mengetahui hubungan karakteristik pasien terhadap luaran pasien COVID-19 dengan komorbid kanker di RSUP Dr. M. Djamil Padang. Metode: Jenis penelitian ini adalah kohort retrospektif. Subjek penelitian ini adalah pasien rawat inap COVID-19 dengan komorbid kanker di RSUP Dr. M. Djamil Padang periode Maret 2020 – Desember 2022. Jumlah sampel penelitian adalah 43 pasien. Analisis data dilakukan dengan menggunakan chi square. Hasil: Hasil penelitian didapatkan karakteristik pasien COVID-19 dengan komorbid kanker dengan luaran meninggal terbanyak, yaitu perempuan (50,0%), usia di atas 60 tahun (60,0%), memiliki kanker darah (44,4%), memiliki derajat klinis COVID-19 sakit berat (60,0%), dan memiliki komorbid lainnya (72,7%). Uji statistik dengan chi square menunjukkan terdapat hubungan bermakna antara karakteristik komorbid lainnya terhadap luaran pasien COVID-19 dengan komorbid kanker (p=0,038). Tidak terdapat hubungan bermakna antara karakteristik jenis kelamin (p=0,683), usia (p=0,385), diagnosis kanker (p=1,000), dan derajat klinis COVID-19 (0,640) terhadap luaran pasien COVID-19 dengan komorbid kanker. Kesimpulan: Terdapat hubungan bermakna antara karakteristik komorbid lainnya terhadap luaran pasien COVID-19 dengan komorbid kanker.

Gambaran Klinis COVID-19 pada Mahasiswa FK Universitas Andalas Berdasarkan Status Vaksinasi COVID-19 Hanif, Rayhendra; Suharti, Netti; Rasyid, Rosfita; Putra, Andani Eka; Russilawati, Russilawati; Izzah, Amirah Zatil
Jurnal Ilmu Kesehatan Indonesia Vol. 5 No. 4 (2024): Desember 2024
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v5i4.1256

Background: COVID-19 is a disease caused by SARS-CoV-2 that’s highly infectious and has caused a pandemic. Vaccines are one of the most effective measures to control the spread of COVID-19. COVID-19 vaccines work by targeting the viral spike protein which can be varied in each variant of SARS-CoV-2 that threatens vaccines’ performance. This may allow breakthrough infection to occur with varying clinical characteristics. Objectives: This study aims to determine the clinical characteristics of COVID-19 on students at Medical Faculty of Andalas University based on their COVID-19 Vaccination status Methods: This research was observational descriptive. Data were collected using questionnaire with total sampling technique from December 2022 to January 2023 at the Medical Faculty of Andalas University. The questionnaire contained identity of respondent’s history, clinical characteristics of COVID-19 and their COVID-19 vaccination status. Questionnaire data were processed and displayed in frequency distribution tables. Results: The result showed that 100 samples out of 241 populations on this study were mostly women, mean age of 21.2 years old ± 0,7, range of age between 19-23 years old, most were already vaccinated for the third time, most were infected only once, and most infections happened after the second vaccination. The most common symptoms were fever, sore throat and cough. The severity of COVID-19 infections were relatively mild based despite of the vaccination status. No samples were reported of having severe critical illness. Conclusion: The symptoms of COVID-19 were relatively similar regardless of the vaccination status and the severity of COVID-19 infections were relatively mild regardless of the vaccination status on students at Medical Faculty of Andalas University.

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