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All Journal HAYATI Journal of Biosciences Jurnal Kedokteran Brawijaya Majalah Kedokteran Bandung Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Cancer Chemoprevention Global Medical and Health Communication Majalah Obat Tradisional Science and Technology Indonesia Journal of Medicine and Health Berkala Ilmiah Kedokteran Duta Wacana Celebes Abdimas: Jurnal Pengabdian Kepada Masyarakat Medika Kartika : Jurnal Kedokteran dan Kesehatan Jurnal Abdimas Ilmiah Citra Bakti (JAICB) Pharmaceutical Sciences and Research (PSR) Journal of Medicine and Health JuTISI (Jurnal Teknik Informatika dan Sistem Informasi) Folia Medica Indonesiana
Teresa Liliana Wargasetia
Faculty Of Medicine, Maranatha Christian University, Bandung, West Java
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Journal : HAYATI Journal of Biosciences

 1 
Apoptotic Potential of Secretome from Interleukin-Induced Natural Killer Cells toward Breast Cancer Cell Line by Transwell Assay Wahyu Widowati; Diana Krisanti Jasaputra; Teresa Liliana Wargasetia; The Fransiska Eltania; Alya Mardhotillah Azizah; Mawar Subangkit; I Nyoman Ehrich Lister; Chrismis Novalinda Ginting; Ermi Girsang; Ahmad Faried
HAYATI Journal of Biosciences Vol. 27 No. 3 (2020): July 2020
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.27.3.186

Abstract

Breast cancer (BC) is the number one cause of deaths from cancer in women. Metastasis in BC is caused by immunosurveillance deficiency, including impairment of Natural Killer (NK) cell maturation, low NK activity, and decreasing cytotoxicity. This study was performed to improve activating receptors and cytotoxicity of NK cells using interleukin 15 (IL15) against BC cells. Human recombinant IL15 was used to induce NK cells. To evaluate the potential of IL15 in inducing NK cells, we measured the activating and inhibiting receptors (NKG2D, NKG2A), apoptotic potency of NK cells on BC cells (MCF7) using transwell assay. The IL15 inducer on the NK cell were measured NKG2D, NKG2A gene expression with quantitative polymerase chain reaction (qPCR), (GzmB) secretion using ELISA, apoptotic gene expression of MCF7 using qPCR. IL15 increased NKG2D expression 4.01-9.13%, but IL15 could not affect toward NKG2A expression on NK cells. IL15-activated NK cells, inhibited BC cells proliferation, induced apoptotic BC cells 25.89-32.19%, induced apoptotic genes of BC cells bax, p53. IL15 increase NK activating receptor (NKG2D), inhibit BC cells proliferation, induce apoptotic percentage and induce apoptotic gene expression.
The Antiaging Potential of Serum Formulations from Centella asiatica, Curcuma longa, Aloe vera, Rosa centifolia, and Salmon DNA on Injured Human Fibroblast Cells Girsang, Ermi; Wargasetia, Teresa Liliana; Rahmat, Deni; Gondokesumo, Marisca Evalina; Harjanti, Mathelda Weni; Widowati, Wahyu; Zahiroh, Fadhilah Haifa; Saufa, Zahra Qisthi; Takasenserang, Oktaviana; Hadiprasetyo, Dhanar Septyawan
HAYATI Journal of Biosciences Vol. 32 No. 3 (2025): May 2025
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.32.3.623-631

Abstract

External aging factors such as UV exposure, pollution, and lifestyle choices contribute to skin aging, resulting in deep wrinkles, fine lines, and rough skin, which can lower self-confidence. Plant extracts have been widely studied for their antiaging potential, while Salmon DNA has shown promise in stimulating collagen production. This study explores the formulation of a serum combining Centella asiatica, Curcuma longa, Aloe vera, Rosa centifolia, and Salmon DNA for its antiaging effects on injured human fibroblast cells. The serum was formulated using extracts from C. asiatica, C. longa, A. vera, R. centifolia, and Salmon DNA. Antioxidant activity was evaluated with the DPPH method, cytotoxicity using the WST-8 assay, and gene expression through qRT-PCR for COL1A1, TGF-β1, HYAL-1, and FGF-2. The serum exhibited weak antioxidant activity (IC50 = 373.33 µg/ml) and reduced cell viability at high concentrations. Gene expression analysis revealed increased expression of COL1A1, TGF-β1, and FGF-2, along with reduced HYAL-1 expression in injured BJ cells. The formulated serum shows potential as an antiaging agent, promoting collagen production and reducing hyaluronidase activity.
Co-Authors , Rizal Abdullah Rasyad Ziyad Achmad R. Permadi Achmad R. Permadi, Achmad R. Ade Kurnia Surawijaya Ahmad Faried Alya Mardhotillah Azizah Andi Wahju Rahardjo Emanuel Andi Wahju Rahardjo Emanuel Anis Syabani Muthmainnah Azis, Rizal Chandra Risdian Chandra Risdian Dani Dani Diana Krisanti Jasaputra Didik Priyandoko Elisabeth, Mariska Elizabeth Yohanes Ermi Girsang Fanny Rahardja Fauziyah, Nida Firyal Ginting, Chrismis Novalinda Girsang, Ermi Gunadi, Michael Sebastian Hadiprasetyo, Dhanar Septyawan Halim, Nathanael Hana Ratnawati HANA RATNAWATI Hanna Sari Widya Kusuma, Hanna Sari Widya Harjanti, Mathelda Weni Harry Murti Haryanti, Mathelda Weni Heddy Herdiman I Nyoman Ehrich Lister Ida AKT Bulan Ida AKT Bulan, Ida AKT Jeffrey ., Jeffrey Khie Khiong Khie Khiong Maranatha, Timothy Imanuel Maria Christine Marisca Evalina Gondokesumo, Marisca Evalina Meganita Marthania Meganita Marthania Meganita Marthania Michael Sebastian Gunadi Michael Sebastian Gunadi Michael Sebastian Gunadi Mohamad I Sapta Mohamad I Sapta, Mohamad I Muthmainnah, Anis Syabani Nainggolan, Ita Margaretha Nathanael Halim Nathanael Halim Nindia Salsabila Mia Dewi Nindya, Faradhina Salfa Ningrum, Siti Ratu Rahayu Putri, Fanny Karuna Qlintang, Sandy RAHMAT, DENI Ratnadewi . Regina Putri Ria Aprilia Tri Puteri Permata Akbar Rizal Rosida Tiurma Manurung Sabrina, Adilah Hafizha Nur Santiadi, Sherly Sarwono, Sylvie Saufa, Zahra Qisthi Sherly Santiadi Sherly Santiadi Sherly Santiadi Sijani Prahastuti Subangkit, Mawar Surawijaya, Ade Kurnia Susy Tjahjani Takasenserang, Oktaviana Teddy Marcus Zakaria Teddy Marcus Zakaria Teddy Marcus Zakaria Teddy Markus Zakaria The Fransiska Eltania Tjandrawati Mozef Tjandrawati Mozef Triharsiwi, Dwi Nur Vinna Kurniawati Sugiaman, Vinna Kurniawati Wahyu Widowati WAHYU WIDOWATI Wahyu Widowati Wahyu Widowati Wahyu Widowati Zahiroh, Fadhilah Haifa