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All Journal Preventif Journal Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Respirologi Indonesia Jurnal Respirasi (JR) Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Jurnal Aisyah : Jurnal Ilmu Kesehatan Respiratory Science The Avicenna Medical Journal Cermin Dunia Kedokteran Jurnal Kesehatan
Faisal Yunus
Universitas Indonesia
Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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The Proportion of Lung Hyperinflation In Patients With Persistent Asthma In Persahabatan Hospital Jakarta Using Multiple Breath N2-Washout Marisa Afifudin; Faisal Yunus; Triya Damayanti
Respiratory Science Vol. 1 No. 2 (2021): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v1i2.20

Abstract

Background: In asthma, small airway dysfunction and inflammation may induce significant lung hyperinflation. The aim of the study is to discover the proportion of lung hyperinflation in patient with persistent asthma in Persahabatan Hospital Jakarta. Method: A cross sectional study with descriptive analysis was done in Asthma clinic Persahabatan Hospital from September-November 2016. Forty-five subjects were recruited consecutively. Interview, physical examination, chest x-ray (CXR), spirometry and multiple breath N2-washout (MBW) were performed. Lung hyperinflation was defined as a residual volume /total lung capacity (RV/TLC%) above the upper limit of normal. Results: The proportion of lung hyperinflation in patients with persistent asthma was 17,8% (8 of 45 subjects). Median RV in milliliter was 1230 (570-2860). Median functional residual capacity (FRC) in milliliter was 1730 (970-3990). Median TLC in milliliter was 3310 (2490-6350). Mean RV/TLC ratio was 36,39% (SD±8,86). Mean FRC/TLC ratio was 52,86% (SD ±6,85). There was a significant correlation between forced expiratory volume in 1 second (FEV1%) value with lung hyperinflation with the decline of FEV1 <60% increased the risk of lung hyperinflation by 8,46 (95%CI=1,155-61,98; p=0,036). There were no significant correlation between age, gender, smoking habit, body mass index (BMI), ACT score, the severity of persistent asthma, duration of asthma, duration of steroid inhalation use, exacerbation history in the last 12-months and emphysematous in CXR with lung hyperinflation (p>0,05). Conclusions: The proportion of lung hyperinflation in patient with persistent asthma in Persahabatan Hospital Jakarta is 17,8%. Lung hyperinflation in persistent asthma is associated with the degree of airway obstruction.
Neutrophyl – Lymphocyte Ratio (NLR) and C-Reactive Protein (CRP) Levels in Stable and Exacerbated Chronic Obstructive Pulmonary Disease (COPD) Patients in Persahabatan Hospital Jakarta Astari Pranindya Sari; Ratnawati Ratnawati; Wahju Aniwidyaningsih; Sita Laksmi Andarini; Faisal Yunus
Respiratory Science Vol. 2 No. 2 (2022): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v2i2.38

Abstract

Background: Although COPD has been believed to be characterized by respiratory disease, there are currently limited study conducted to evaluate inflammation markers and exacerbation rate in COPD by noninvasive methods. We did a prospective cohort study to observe the alteration of Neutrophyl-Lymphocyte Ratio (NLR) and C-reactive protein (CRP) in COPD patients to find any possible correlation with COPD exacerbation status. Method: From July to December 2018, a prospective cohort study was performed with blood and spirometry test on 31 COPD patients during exacerbation (AE-COPD) and stable. The mean of NLR and CRP were compared and analyzed. Results: Both NLR and CRP decreased during stable condition (from 7.95±6.8 to 4.6±5.5 and 43.4±71 to 12.2±18.5) with P<0.01 respectively. We also found a significant inverse correlation between NLR and FEV1/FVC in AE-COPD and CRP showed an inverse correlation only with FEV1 in AE-COPD. Another interesting finding was a subject with very high CRP whose value remained above the nomal limit during stable, and died within 2 months after exacerbation. Conclusion: NLR and CRP levels in COPD patients increased during exacerbation, which may reflect lung function and exacerbation status.
Proportions of Hypertension in Stable COPD Patients at the National Respiratory Center Persahabatan Hospital Dewantoro, Luhur; Wiyono, Wiwien Heru; Yunus, Faisal; Agustin, Heidy; Damayanti, Triya; Antariksa, Budhi; Fachrucha, Fanny; Samoedro, Erlang; Elhidsi, Mia
Jurnal Respirologi Indonesia Vol 44, No 3 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i3.774

Abstract

Background: Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. Most of these deaths are related to cardiovascular disease. This is due to systemic inflammation that causes increased vascular stiffness and hypertension. These comorbidities lead to poor quality of life, low exercise tolerance, and an increased risk of hospitalization. This study aims to report the proportion of hypertension among stable COPD patients in the Indonesian population.Methods: This cross-sectional study was conducted at the National Respiratory Center Persahabatan Hospital between February and March 2023. Stable COPD patients admitted to the Asthma and COPD Polyclinic who met the criteria were enrolled. Clinical information, vital signs, spirometry results, and DLCO measurements were collected.Results: There were 84 subjects participating in this study. The result of this study shows a 60.7% proportion of hypertension in stable COPD patients. Hypertension has a significant correlation with pulmonary functional values (P=0.021), severity degree of clinical COPD (P=0.004), Brinkman index (P=0.008), and age (P=0.0001). However, hypertension association with COPD duration (P=0.505) and DLCO (P=0.122) were not significant.Conclusion: The hypertension proportion in stable COPD Indonesian patients is 60.7%. Hypertension shows a significant association with pulmonary function values, severity degree of clinical COPD, Brinkman index, and age. 
Late-Onset Asthma: A Review Moelamsyah, Yandi Noer; Yunus, Faisal; Nurwidya, Fariz; Amien, Bagus Radityo
Jurnal Respirasi Vol. 10 No. 3 (2024): September 2024
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v10-I.3.2024.272-279

Abstract

Asthma is a chronic respiratory condition with a growing global prevalence, affecting millions of individuals annually. While asthma can develop at any age, late-onset asthma is a specific phenotype that begins in adulthood, as recognized by the Global Initiative for Asthma (GINA) in its 2024 guidelines. This form of asthma is often associated with several predisposing factors, including gender, obesity, occupational exposure, rhinitis, respiratory infections, smoking, stress, and diminished lung function. Unlike early-onset asthma, which frequently involves a history of allergies, late-onset asthma tends to lack allergic triggers, making it a distinct and challenging form of the disease. Managing late-onset asthma is often more complex, as it typically requires higher doses of corticosteroids and demonstrates a reduced responsiveness to standard steroid treatments. The exact mechanisms and pathophysiological processes contributing to the increased severity and poorer clinical outcomes in late-onset asthma remain largely unclear. This uncertainty often leads to underdiagnosis and inadequate management, further complicating patient care. Phenotypic analysis is recommended to improve treatment outcomes. This includes assessing clinical features and utilizing biomarkers, such as inflammatory markers and immunoglobulin E (IgE) levels, to guide targeted therapy when conventional steroid treatments are insufficient. However, there is a significant need for further research to elucidate the underlying mechanisms of late-onset asthma. This literature review is essential to develop more effective, personalized treatment strategies that can address the unique challenges posed by this asthma phenotype, ultimately leading to better management and improved patient outcomes.
The Impact of Klotho Gene Polymorphisms on Chronic Obstructive Pulmonary Disease (COPD): A Systematic Review Lindra, Derallah A; Purwaningsih, Endang; Utomo, Ahmad Rusdan H; Yunus, Faisal; Harahap, Makrup E
Respiratory Science Vol. 5 No. 2 (2025): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v5i2.165

Abstract

Background: Chronic Obstructive Pulmonary Disease (COPD) is linked to persistent inflammation, repetitive strain, and the accelerated aging of the lungs. The Klotho gene is an anti-aging protein that protects cells from inflammation and alveolar damage in COPD patients. At least 10 mutations in the Klotho gene and single nucleotide polymorphisms (SNPs) have been identified in humans. However, the influence of these polymorphisms is not fully understood in COPD patients. This article aims to determine the influence of Klotho gene polymorphisms on COPD patients. Method: This study employs a systematic review by analyzing secondary data from scientific research articles. Data search using the Google Scholar database. Done using the terms: Polymorphism, COPD, and Alpha Klotho gene. Results: Four studies were selected for systematic review. Three studies indicate that Klotho gene polymorphisms can cause alveolar destruction, accelerating emphysema occurrence. There is a relationship between Klotho gene polymorphisms and BMI but not with disease severity parameters. Conclusion: This review indicates that Klotho gene polymorphisms may accelerate emphysema development in COPD patients. There is a relationship between klotho gene polymorphisms and BMI but not with disease severity parameters.
Prevalence and Affecting Factors of Arrhythmias in Stable Chronic Obstructive Pulmonary Disease at a Tertiary Hospital in Indonesia Gozali, Achmad; Wicaksono, Muhammad Bimo Adi; Yunus, Faisal; Ratnawati, Ratnawati; Basalamah, Muhammad Abbas; Amien, Bagus Radityo
Jurnal Respirasi Vol. 11 No. 2 (2025): May 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.2.2025.131-139

Abstract

Introduction: Chronic obstructive pulmonary disease (COPD) represents an increasing global health burden. Among its significant comorbidities, cardiovascular complications, particularly arrhythmias, are of significant concern. Chronic obstructive pulmonary disease and arrhythmias share common risk factors, including advanced age and smoking. This study investigated the prevalence and contributing factors of arrhythmias in stable COPD patients. Methods: This cross-sectional study was conducted among stable COPD patients attending the Asthma-COPD Clinic at Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia, from January to April 2018. The inclusion criteria encompassed a clinical diagnosis of COPD and voluntary participation with written informed consent. Each participant underwent laboratory evaluation, electrocardiography (ECG), blood pressure measurement, and a structured interview. Patients were excluded if they had experienced acute COPD exacerbations during the assessment, had a history of other chronic lung diseases, suffered a recent myocardial infarction, had structural heart disease, were diagnosed with fibrillation, or declined to participate. Results: The prevalence of arrhythmias in stable COPD patients was 24.1%. The types included sinus bradycardia (2.41%), premature atrial contractions/PACs (3.61%), premature ventricular contractions/PVCs (8.43%), and sinus tachycardia (9.64%). The majority of arrhythmic patients were males, with an average age of 68 years old. These patients also had a history of heart disease, exhibited severe COPD symptoms, and demonstrated significant airflow obstruction (average pCO₂ of 36 mmHg). Conclusion: Decreased chloride levels were associated with an increased incidence of arrhythmias. However, no significant associations were observed with airflow limitation, sex, age, bronchodilator use, or arterial blood gas parameters.
Hubungan Kadar Bromotyrosine Urin Dengan Terapi Montelukast, Beclometasone/Formoterol, Dan Kombinasi Selama 3 Bulan Pada Pasien Asma Di Klinik Harum Melati Pringsewu Pinaka Baladika, Dimas Trend; Soeprihatini Soemarwoto, Retno Ariza; Mustofa, Syazili; Yunus, Faisal; Ekawati, Diyan; Wibowo, Adityo
Jurnal Ilmu Kedokteran dan Kesehatan Vol 12, No 7 (2025): Volume 12 Nomor 7
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v12i7.20239

Abstract

Bromotyrosine urin memiliki banyak keuntungan sebagai biomarker potensial penyakit asma mengingat stabilitasnya dan pengumpulan sampel urin yang bersifat non-invasif. Dalam manajemen tatalaksana asma leukotriene receptor antagonist (LTRA) merupakan obat alternatif lini pertama setelah kortikosteroid inhalasi. Penelitian ini bertujuan untuk mengetahui hubungan kadar bromotyrosine urin dengan terapi montelukast selama 3 bulan. Penelitian ini melibatkan 82 pasien berusia antara 6-65 tahun dari Klinik Harum Melati, Pringsewu dari bulan Mei – Desember 2023. Dilakukan uji spirometri, urin, differential count sebelum dan setelah terapi 3 bulan, diklasifikasikan derajat obstruksi ringan (n= 66) dan sedang-berat (n=6) serta pasien non-asma untuk kontrol (n= 10). Hanya 28 pasien yang datang untuk evaluasi setelah 3 bulan terapi. Pasien dibagi menjadi 3 kelompok, yaitu kelompok terapi montelukast (n=14), beclometason/formoterol (n=5), dan kombinasi montelukast dan beclometason/formoterol (n=9). Kadar bromotyrosine urin penderita asma secara bermakna lebih tinggi dibandingkan dengan kontrol (154.11 ng/ml vs 11,87 ng/ml, p= 0,000). Tidak terdapat perbedaan bermakna kadar bromotyrosine urin setelah terapi montelukast (104.24 ng/ml vs 40.79 ng/ml, p=0,433) dan setelah terapi beclometason/formoterol (136,25 ng/ml vs 33,20 ng/ml, p= 0,345. Terjadi penurunan kadar bromotyrosine urin yang bermakna pada kelompok setelah terapi kombinasi montelukast dan beclometasone/formoterol (39.63 ng/ml vs 11.13 ng/ml) (95% CI 3.90-42.43, p= 0.028). Hasil penelitian menunjukkan pasien asma memiliki kadar bromotyrosine urin jauh lebih tinggi dibandingkan dengan non-asma. Kadar bromotyrosine urin menurun secara bermakna setelah terapi kombinasi (montelukast dan beclometason/formoterol) selama 3 bulan.
SERUM METALLOPRETEINASE 3 (MMP-3) LEVELS IN LUNG CANCER AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) PATIENTS Soemarwoto, Retno Ariza; Mustofa, Syazili; Suwarno, Sukarti San; Yunus, Faisal; Listiandoko, Raden Dicky Wirawan; Sinaga, Fransisca TY; Febrihartati, Isura
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 10, No 1 (2025): March
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30604/jika.v10i1.3077

Abstract

Chronic Obstructive Pulmonary Disease (COPD) and Lung Cancer are among the diseases with high mortality rates and a similar genetic disposition. COPD is known to be a significant risk factor for lung cancer. Matrix metalloproteinase-3 (MMP-3) is a protein that plays a role in the growth stage of cancer that has the potential to develop COPD into lung cancer. This descriptive observational study aimed to compare plasma MMP-3 levels among four groups: healthy individuals, lung cancer patients, COPD patients, and patients with both lung cancer and COPD. The findings revealed that plasma MMP-3 levels were lowest in the healthy group and higher in the other groups. The increase in plasma MMP-3 levels among pathological subjects suggests a potential association between serum MMP-3 levels and the development of lung cancer in COPD patients. However, further research is needed to clarify this relationship.
EFFECTIVENESS OF TRIPLE THERAPY WITH SINGLE AND MULTIPLE INHALERS IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE Soemarwoto, Retno Ariza; Putri, Maharani; Meirissa, Tria; Yunus, Faisal; Aryana, Wayan Ferly; Wibowo, Adityo; Oktobiannobel, Jordy
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 10, No 1 (2025): March
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30604/jika.v10i1.3050

Abstract

Introduction: Exacerbations of chronic obstructive pulmonary disease (COPD) contribute to 3 million annual deaths worldwide. Triple therapy (ICS + LABA + LAMA) helps reduce symptoms and exacerbation risk.Objective: To assess the effectiveness and clinical response of single versus multiple inhaler therapy in managing COPD.Methods: A pre-post study was conducted on two groups of COPD patients over 8 weeks. Group 1 (n=47) used a single inhaler, while Group 2 (n=45) used multiple inhalers. Outcomes were measured using the mMRC scale, blood eosinophil levels, and spirometry at weeks 2 and 8.Results: The single-inhaler group significantly reduced mMRC scores, with a median decrease from 4.00 to 2.00 (p0.05). Eosinophil levels also decreased significantly in both groups, with a larger reduction in the single-inhaler group (p0.05). Lung function improved in both groups, but no significant differences were found (p0.05) in terms of time or between-group comparisons.Conclusion: Single-inhaler therapy reduced dyspnea and eosinophil levels more effectively than multiple inhalers. The effectiveness of single inhalers may be attributed to higher adherence due to ease of use. 
E-Cigarette or Vaping Use-Associated Lung Injury (EVALI): A Literature Review Brahmantyo, Adhimas; Esha, Indi; Yunus, Faisal
Jurnal Respirasi Vol. 11 No. 3 (2025): September 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.3.2025.285-297

Abstract

Electronic cigarettes (e-cigarettes) are electronic tools designed to produce an inhalable aerosol from a liquid solution. Electronic cigarette or vaping use-associated lung injury (EVALI) describes any lung damage linked to the consumption of e-cigarettes or vaping products. The liquids and aerosols from e-cigarettes can include tobacco-related nitrosamines, aldehydes, metals, volatile organic compounds, phenolic compounds, polycyclic aromatic hydrocarbons, tobacco alkaloids from tobacco, flavor additives, and various medicinal compounds. Substantial evidence indicates that substances like propylene glycol, vitamin E acetate (VEA), and heavy metals such as lead and arsenic are significant constituents of e-cigarettes, contributing to lung harm. Patients with EVALI may present with sudden or gradually developing respiratory disease, presenting with non-specific signs, including breathlessness, coughing, chest discomfort, and sometimes coughing up blood. Radiological findings in EVALI are often non-specific. The most commonly observed pattern in EVALI is parenchymal organizing pneumonia (OP), identified in 56% of cases, whereby bilateral dominant ground-glass opacity (GGO) was identified, located in the inferior sections of the lungs or diffusely distributed with varying degrees of consolidation.
Co-Authors . Suradi Adang Bachtiar Adityo Wibowo, Adityo Adrianison Adrianison Adrianison, Adrianison Afrizal Agus D. Susanto Agus Dwi Susanto Agustin, Heidy Allen Widysanto Amien, Bagus Radityo Amira P Tarigan, Amira P Angela BM Tulaar Anita Ratnawati Antalia K.M. Katili Antono, Wahyu Anwar Jusuf Aria Kekalih Arifin Nawas Arifin, Arief Riadi Aryana, Wayan Ferly Astari Pranindya Sari Azizman Saad B Setyanto, Darmawan Barmawi Hisyam Basalamah, Muhammad Abbas Brahmantyo, Adhimas Budhi Antariksa Bulkis Natsir Cut Yulia Indah Sari Damayanti, Triya Dewantoro, Luhur Dilangga, Pad Dwi Handoko Eddy Surjanto Ekawati, Diyan Elhidsi, Mia Elisna Sjahruddin Endang Purwaningsih Esha, Indi Fachrucha, Fanny Faisal, Hana Khairina Putri Fariz, Nurwidya Febrihartati, Isura Flora Ekasari Gatot Sudiro Hendarto, Gatot Sudiro Gozali, Achmad Gurning, Andi Sarikawan Hadiarto Mangunnegoro Hana Khairina Putri Faisal Harahap, Makrup E Helena Turnip Herdarto, Muhammad Junus Didiek Idrus Alwi Indi Esha INDRA YOVI Indriani, Sri Indah Isbaniah, Fathiyah Isep Supriyana Joko Riyadi Jordy Oktobiannobel Kirana, Widya Tria Kitagawa, Hiroki Kolewora, Yusuf Musafir Lientje S. Maurits, Lientje S. Lindra, Derallah A Listiandoko, Raden Dicky Wirawan Marisa Afifudin Mariska Pangaribuan Meirissa, Tria Menaldi Rasmin Messah, Anse Diana V Moelamsyah, Yandi Noer Mohammad Farid Neni Sawitri Nury Nusdwinuringtyas Patrama, Satria Permana, Roni Pinaka Baladika, Dimas Trend Putra, Muhammad Ryan Adi Putri Suci Ramadhany Putri, Maharani Ratnawati Antaria Ratnawati Ratnawati Ratnawati Ratnawati Ridha Restilla Ririn Astuty Ningsih Risa Febriana Rochsismandoko Rochsismandoko Rochsismandoko Rochsismandoko Roxanne, Olivia Geraldine Rusmini, Hetti Sabarina Prasetyo Samoedro, Erlang Saroyo, Yudianto Budi Setiawan, Gigih Sinaga, Fransisca TY Sita Laksmi Andarini Soehardiman, Dicky Soemarwoto, Retno Ariza Soemarwoto, Retno Ariza S Soeprihatini Soemarwoto, Retno Ariza Soerjanto Soerjanto Sri Melati Munir Suradi Suradi Surya Hajar Fitria Dana Suwarno, Sukarti San Syafruddin A.R. Lelosutan Syah Putra Yahya, Wiendo Syazili Mustofa Tamsil Syafiuddin, Tamsil Triya Damayanti Utomo, Ahmad Rusdan H Wahju Aniwidyaningsih Wicaksono, Muhammad Bimo Adi Widjajalaksmi Widjajalaksmi Wiwien H. Wiyono Wiwien Heru Wiyono Yulino Amrie Zaini, Jamal Zarfiardy Aksa Fauzi Zulhadji, Harry Agustio Zulkarnain Barasila