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All Journal Preventif Journal Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Respirologi Indonesia Jurnal Respirasi (JR) Jurnal Aisyah : Jurnal Ilmu Kesehatan Respiratory Science The Avicenna Medical Journal Cermin Dunia Kedokteran Jurnal Kesehatan
Faisal Yunus
Universitas Indonesia
Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Treatment Outcome of Remdesivir Compared to Favipiravir on Moderate Symptoms COVID-19 Arifin, Arief Riadi; Yunus, Faisal; Patrama, Satria; Putra, Muhammad Ryan Adi; Roxanne, Olivia Geraldine
The Avicenna Medical Journal Vol. 4 No. 1 (2023): The Avicenna Medical Journal
Publisher : Faculty of Medicine, UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/avicenna.v4i1.31132

Abstract

Remdesivir and Favipiravir have been widely used as antiviral agents in treating COVID-19. However, studies providing head on comparison of treatment outcomes between the two antiviruses are rare. The aim of this study is to compare the treatment outcome of Remdesivir and Favipiravir in moderate symptoms COVID-19. Subjects were divided into two groups based on received antivirus during COVID-19 treatment in the hospital, Remdesivir group and Favipiravir group. Post-treatment outcome was measured with three indicators: symptom improvement, negative conversion of RT-PCR, and radiological improvement. Outcomes of both groups were compared with chi square test with Remdesivir serves as a risk factor and Favipiravir as control. Out of a total of 130 subjects, 65 received Remdesivir, and 65 received Favipiravir. Post-treatment RT-PCR and radiologic examination were performed on a median of Day-10 hospitalization. RT-PCR conversion to negative was significantly more likely in Remdesivir group (RR: 1,917, 95% Cl 1,044 – 3,518, p = 0.047, chi square test). There was no significant difference between Remdesivir group and Favipiravir group in symptom improvement on Day-5 (RR 0.941, 95% Cl 0.776 – 1,141), nor Day-7 (RR 1.020, 95% Cl 0.855 – 1.216). There was also no significant difference in radiological improvement (RR 0.855, 95% Cl 0.712 – 1.026). Administering remdesivir to COVID-19 patients significantly increased the occurrence of negative RT-PCR conversion after therapy compared to standard favipiravir therapy.
Pulmonary Aspergilloma Co-Existing with Pulmonary Tuberculosis: A Case Report in Type 1 Diabetes Mellitus (T1DM) Patient Kirana, Widya Tria; Faisal, Hana Khairina Putri; Kitagawa, Hiroki; Setiawan, Gigih; Yunus, Faisal
Jurnal Respirasi Vol. 9 No. 3 (2023): September 2023
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v9-I.3.2023.213-219

Abstract

Introduction: Pulmonary aspergilloma is a disease frequently found in immunocompromised patients. In Indonesia, around 18% of diabetes mellitus (DM) patients suffer from chronic pulmonary aspergilloma. However, data on type 1 DM (T1DM) are still limited. Case: We presented the case of a 22-year-old male admitted to the emergency room due to hemoptysis of approximately 200 ml within six hours before admission, nonspecific chest pain during cough, fever, night sweats, and weight loss of 3 kg over the last months. The patient had a history of T1DM and no prior history of respiratory diseases. Physical examination showed tachycardia, tachypnoea, subfebrile, normal body mass index, and rhonchi on the left thorax. Routine laboratory tests revealed increased blood sugar level (503 mg/dL) and HbA1c 16.4%. Chest X-ray and high-resolution computed tomography (HRCT) showed a cavity with an opaque lesion, crescent sign, consolidation, and reticulonodular infiltrate on the left lung. Rapid molecular tests, tuberculosis (TB), and serum galactomannan (GM) were negative. The patient was diagnosed with pulmonary aspergilloma, T1DM, and clinical TB. He was treated with fluconazole, insulin, and a fixed-dose combination of anti-TB. The patient refused the surgery procedure. Immediately, the hemoptysis stopped, blood glucose level was normal, and concomitant with weight gain. Conclusion: Due to innate and acquired immunity impairment, T1DM is a risk factor for pulmonary infections, including TB and pulmonary aspergilloma. Chest HRCT may help diagnose fungal balls. Though the patient refused to undergo surgery, administering antifungal, anti-TB drugs, and glucose control as initial treatment presented a good prognosis in the patient.
Pregnancy-Related Disorders and Intrauterine Impaired Lung Development Zulhadji, Harry Agustio; Yunus, Faisal; Rasmin, Menaldi; Saroyo, Yudianto Budi; Amien, Bagus Radityo
Jurnal Respirasi Vol. 10 No. 2 (2024): May 2024
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v10-I.2.2024.178-185

Abstract

Various pregnancy-related disorders are known to affect fetal lung development negatively. During pregnancy, chronic nutrition and/or oxygen limitation is known to impede lung maturation and induce airway and lung abnormalities. Structural abnormalities and reduced lung function may be evident immediately after birth, persist, or develop with age. The expansion of the fetal lung, fetal breath movements, fetal lung growth, alveolarization, blood-air barrier, extracellular matrix (ECM), airways, surfactant system, and lung immune function are all affected by nutritional limitations during pregnancy. Gestational hypoxia disrupts fetal lung development, which manifests as morphological and functional pulmonary abnormalities. Additionally, intrauterine growth restriction (IUGR), preeclampsia (PE), exposure to air pollution, and smoking are known to interfere with embryonic lung development. Birth defects, such as bronchopulmonary dysplasia, as well as chronic obstructive pulmonary disease (COPD), can be caused by abnormalities in pregnancy. Adequate nutrition, avoidance of smoking, and watchful monitoring and intervention during pregnancy should be promoted to prevent chronic lung disease of the newborn, child, and adult.
The Correlation Between Type and Stage of Lung Cancer with The Chronic Obstructive Pulmonary Disease Group at Arifin Achmad Hospital, Pekanbaru Gurning, Andi Sarikawan; Munir, Sri Melati; Yunus, Faisal; Fauzi, Zarfiardy Aksa; Adrianison, Adrianison; Yovi, Indra; Indriani, Sri Indah
Jurnal Respirologi Indonesia Vol 45 No 2 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i2.512

Abstract

Background: The relationship between lung cancer (LC) and chronic obstructive pulmonary disease (COPD) has been extensively studied but is still up for debate. COPD is a molecularly based illness and one of the independent risk factors for lung cancer, particularly squamous cell carcinoma. This study uses spirometry to assess the relationship between the type and stage of LC and COPD in a group of LC patients at Arifin Achmad Hospital. Methods: This cross-sectional study was conducted on lung cancer patients in Arifin Achmad Hospital, Pekanbaru, from June 2022 to December 2022. Based on spirometry examination, patients were grouped according to the degree of COPD. Then, the relationship between the COPD group and the type and degree of cancer was determined. Results: The study involved 52 patients predominantly male (71.2%), aged over 40 years (92.3%), Smokers and former smokers with Severe Brinkman index (69.2%), restrictive lung function (34.6%), COPD group D (40.4%), adenocarcinoma (61.5%), stage IV lung cancer (92,3%) and WHO Performance Status Scale 2 (61.5%). The FEV1/FVC rate in this study was 66.67%. There is a link between the stage of lung cancer and the group of COPD (P=0.001). Conclusion: There is a relation between the stage of LC in the COPD group, which is predominantly with stage IV lung cancer, and group D of COPD.
Proportions of Hypertension in Stable COPD Patients at the National Respiratory Center Persahabatan Hospital Dewantoro, Luhur; Wiyono, Wiwien Heru; Yunus, Faisal; Agustin, Heidy; Damayanti, Triya; Antariksa, Budhi; Fachrucha, Fanny; Samoedro, Erlang; Elhidsi, Mia
Jurnal Respirologi Indonesia Vol 44 No 3 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i3.774

Abstract

Background: Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. Most of these deaths are related to cardiovascular disease. This is due to systemic inflammation that causes increased vascular stiffness and hypertension. These comorbidities lead to poor quality of life, low exercise tolerance, and an increased risk of hospitalization. This study aims to report the proportion of hypertension among stable COPD patients in the Indonesian population.Methods: This cross-sectional study was conducted at the National Respiratory Center Persahabatan Hospital between February and March 2023. Stable COPD patients admitted to the Asthma and COPD Polyclinic who met the criteria were enrolled. Clinical information, vital signs, spirometry results, and DLCO measurements were collected.Results: There were 84 subjects participating in this study. The result of this study shows a 60.7% proportion of hypertension in stable COPD patients. Hypertension has a significant correlation with pulmonary functional values (P=0.021), severity degree of clinical COPD (P=0.004), Brinkman index (P=0.008), and age (P=0.0001). However, hypertension association with COPD duration (P=0.505) and DLCO (P=0.122) were not significant.Conclusion: The hypertension proportion in stable COPD Indonesian patients is 60.7%. Hypertension shows a significant association with pulmonary function values, severity degree of clinical COPD, Brinkman index, and age. 
The Effectiveness of the Roni App in Enhancing the Resilience of Tuberculosis Patients Permana, Roni; Afrizal; Yunus, Faisal; Bachtiar, Adang
Jurnal Kesehatan - STIKes Prima Nusantara Vol 15 No 3 (2024): Jurnal Kesehatan Volume 15 Nomor 3 Tahun 2024
Publisher : LPPM Universitas Prima Nusantara Bukittinggi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35730/jk.v15i3.1208

Abstract

Tuberculosis (TB) remains a significant global health burden, requiring not only adherence to treatment regimens but also robust psychological resilience for successful recovery. This study evaluated the efficacy of the Roni application, a novel technology-based intervention designed to enhance resilience among TB patients. Employing a quasi-experimental design, 60 TB patients were randomized into an intervention group (n=30) and a control group (n=30). The intervention group utilized the Roni application for one month, while Patients in the control group received standard care. Resilience was assessed at baseline and post-intervention using the Brief Resilience Coping Scale (BRCS). Results demonstrated a statistically significant improvement in resilience scores among participants in the intervention group compared to the control group (p < 0.05). By providing tailored educational resources, motivational support, and opportunities for emotional processing, the Roni application appears to enhance resilience in TB patients effectively. These findings align with theoretical frameworks of stress adaptation and self-efficacy. This study contributes to the growing body of evidence supporting the potential of technology-based interventions to address the psychosocial needs of TB patients and improve treatment outcomes. Future research should investigate the long-term sustainability of these effects and explore the generalizability of this intervention across diverse populations.
Co-Authors . Suradi Adang Bachtiar Adityo Wibowo, Adityo Adrianison Adrianison Adrianison, Adrianison Afrizal Agus D. Susanto Agus Dwi Susanto Agustin, Heidy Allen Widysanto Amien, Bagus Radityo Amira P Tarigan, Amira P Angela BM Tulaar Anita Ratnawati Antalia K.M. Katili Anwar Jusuf Aria Kekalih Arifin Nawas Arifin, Arief Riadi Aryana, Wayan Ferly Astari Pranindya Sari Azizman Saad B Setyanto, Darmawan Barmawi Hisyam Basalamah, Muhammad Abbas Brahmantyo, Adhimas Budhi Antariksa Bulkis Natsir Cut Yulia Indah Sari Damayanti, Triya Dewantoro, Luhur Dwi Handoko Eddy Surjanto Ekawati, Diyan Elhidsi, Mia Elisna Sjahruddin Endang Purwaningsih Esha, Indi Fachrucha, Fanny Faisal, Hana Khairina Putri Fariz, Nurwidya Febrihartati, Isura Flora Ekasari Gozali, Achmad Gurning, Andi Sarikawan Hadiarto Mangunnegoro Hana Khairina Putri Faisal Harahap, Makrup E Helena Turnip Idrus Alwi Indi Esha INDRA YOVI Indriani, Sri Indah Isbaniah, Fathiyah Isep Supriyana Joko Riyadi Jordy Oktobiannobel Kirana, Widya Tria Kitagawa, Hiroki Kolewora, Yusuf Musafir Lientje S. Maurits, Lientje S. Lindra, Derallah A Listiandoko, Raden Dicky Wirawan Marisa Afifudin Mariska Pangaribuan Meirissa, Tria Menaldi Rasmin Moelamsyah, Yandi Noer Mohammad Farid Neni Sawitri Nury Nusdwinuringtyas Patrama, Satria Permana, Roni Pinaka Baladika, Dimas Trend Putra, Muhammad Ryan Adi Putri Suci Ramadhany Putri, Maharani Ratnawati Antaria Ratnawati Ratnawati Ratnawati Ratnawati Ridha Restilla Ririn Astuty Ningsih Risa Febriana Rochsismandoko Rochsismandoko Rochsismandoko Rochsismandoko Roxanne, Olivia Geraldine Sabarina Prasetyo Samoedro, Erlang Saroyo, Yudianto Budi Setiawan, Gigih Sinaga, Fransisca TY Sita Laksmi Andarini Soehardiman, Dicky Soemarwoto, Retno Ariza Soeprihatini Soemarwoto, Retno Ariza Soerjanto Soerjanto Sri Melati Munir Suradi Suradi Surya Hajar Fitria Dana Suwarno, Sukarti San Syafruddin A.R. Lelosutan Syah Putra Yahya, Wiendo Syazili Mustofa Tamsil Syafiuddin, Tamsil Triya Damayanti Utomo, Ahmad Rusdan H Wahju Aniwidyaningsih Wicaksono, Muhammad Bimo Adi Widjajalaksmi Widjajalaksmi Wiwien H. Wiyono Wiwien Heru Wiyono Yulino Amrie Zaini, Jamal Zarfiardy Aksa Fauzi Zulhadji, Harry Agustio Zulkarnain Barasila