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All Journal Jurnal Kedokteran Indonesia Preventif Journal Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Respirologi Indonesia Jurnal Respirasi (JR) Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Jurnal Aisyah : Jurnal Ilmu Kesehatan Respiratory Science The Avicenna Medical Journal Cermin Dunia Kedokteran
Faisal Yunus
Universitas Indonesia
Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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SERUM METALLOPRETEINASE 3 (MMP-3) LEVELS IN LUNG CANCER AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) PATIENTS Soemarwoto, Retno Ariza; Mustofa, Syazili; Suwarno, Sukarti San; Yunus, Faisal; Listiandoko, Raden Dicky Wirawan; Sinaga, Fransisca TY; Febrihartati, Isura
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 10, No 1 (2025): March
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30604/jika.v10i1.3077

Abstract

Chronic Obstructive Pulmonary Disease (COPD) and Lung Cancer are among the diseases with high mortality rates and a similar genetic disposition. COPD is known to be a significant risk factor for lung cancer. Matrix metalloproteinase-3 (MMP-3) is a protein that plays a role in the growth stage of cancer that has the potential to develop COPD into lung cancer. This descriptive observational study aimed to compare plasma MMP-3 levels among four groups: healthy individuals, lung cancer patients, COPD patients, and patients with both lung cancer and COPD. The findings revealed that plasma MMP-3 levels were lowest in the healthy group and higher in the other groups. The increase in plasma MMP-3 levels among pathological subjects suggests a potential association between serum MMP-3 levels and the development of lung cancer in COPD patients. However, further research is needed to clarify this relationship.
EFFECTIVENESS OF TRIPLE THERAPY WITH SINGLE AND MULTIPLE INHALERS IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE Soemarwoto, Retno Ariza; Putri, Maharani; Meirissa, Tria; Yunus, Faisal; Aryana, Wayan Ferly; Wibowo, Adityo; Oktobiannobel, Jordy
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 10, No 1 (2025): March
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30604/jika.v10i1.3050

Abstract

Introduction: Exacerbations of chronic obstructive pulmonary disease (COPD) contribute to 3 million annual deaths worldwide. Triple therapy (ICS + LABA + LAMA) helps reduce symptoms and exacerbation risk.Objective: To assess the effectiveness and clinical response of single versus multiple inhaler therapy in managing COPD.Methods: A pre-post study was conducted on two groups of COPD patients over 8 weeks. Group 1 (n=47) used a single inhaler, while Group 2 (n=45) used multiple inhalers. Outcomes were measured using the mMRC scale, blood eosinophil levels, and spirometry at weeks 2 and 8.Results: The single-inhaler group significantly reduced mMRC scores, with a median decrease from 4.00 to 2.00 (p0.05). Eosinophil levels also decreased significantly in both groups, with a larger reduction in the single-inhaler group (p0.05). Lung function improved in both groups, but no significant differences were found (p0.05) in terms of time or between-group comparisons.Conclusion: Single-inhaler therapy reduced dyspnea and eosinophil levels more effectively than multiple inhalers. The effectiveness of single inhalers may be attributed to higher adherence due to ease of use. 
E-Cigarette or Vaping Use-Associated Lung Injury (EVALI): A Literature Review Brahmantyo, Adhimas; Esha, Indi; Yunus, Faisal
Jurnal Respirasi Vol. 11 No. 3 (2025): September 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.3.2025.285-297

Abstract

Electronic cigarettes (e-cigarettes) are electronic tools designed to produce an inhalable aerosol from a liquid solution. Electronic cigarette or vaping use-associated lung injury (EVALI) describes any lung damage linked to the consumption of e-cigarettes or vaping products. The liquids and aerosols from e-cigarettes can include tobacco-related nitrosamines, aldehydes, metals, volatile organic compounds, phenolic compounds, polycyclic aromatic hydrocarbons, tobacco alkaloids from tobacco, flavor additives, and various medicinal compounds. Substantial evidence indicates that substances like propylene glycol, vitamin E acetate (VEA), and heavy metals such as lead and arsenic are significant constituents of e-cigarettes, contributing to lung harm. Patients with EVALI may present with sudden or gradually developing respiratory disease, presenting with non-specific signs, including breathlessness, coughing, chest discomfort, and sometimes coughing up blood. Radiological findings in EVALI are often non-specific. The most commonly observed pattern in EVALI is parenchymal organizing pneumonia (OP), identified in 56% of cases, whereby bilateral dominant ground-glass opacity (GGO) was identified, located in the inferior sections of the lungs or diffusely distributed with varying degrees of consolidation.
Treatment Outcome of Remdesivir Compared to Favipiravir on Moderate Symptoms COVID-19 Arifin, Arief Riadi; Yunus, Faisal; Patrama, Satria; Putra, Muhammad Ryan Adi; Roxanne, Olivia Geraldine
The Avicenna Medical Journal Vol. 4 No. 1 (2023): The Avicenna Medical Journal
Publisher : Faculty of Medicine, UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/avicenna.v4i1.31132

Abstract

Remdesivir and Favipiravir have been widely used as antiviral agents in treating COVID-19. However, studies providing head on comparison of treatment outcomes between the two antiviruses are rare. The aim of this study is to compare the treatment outcome of Remdesivir and Favipiravir in moderate symptoms COVID-19. Subjects were divided into two groups based on received antivirus during COVID-19 treatment in the hospital, Remdesivir group and Favipiravir group. Post-treatment outcome was measured with three indicators: symptom improvement, negative conversion of RT-PCR, and radiological improvement. Outcomes of both groups were compared with chi square test with Remdesivir serves as a risk factor and Favipiravir as control. Out of a total of 130 subjects, 65 received Remdesivir, and 65 received Favipiravir. Post-treatment RT-PCR and radiologic examination were performed on a median of Day-10 hospitalization. RT-PCR conversion to negative was significantly more likely in Remdesivir group (RR: 1,917, 95% Cl 1,044 – 3,518, p = 0.047, chi square test). There was no significant difference between Remdesivir group and Favipiravir group in symptom improvement on Day-5 (RR 0.941, 95% Cl 0.776 – 1,141), nor Day-7 (RR 1.020, 95% Cl 0.855 – 1.216). There was also no significant difference in radiological improvement (RR 0.855, 95% Cl 0.712 – 1.026). Administering remdesivir to COVID-19 patients significantly increased the occurrence of negative RT-PCR conversion after therapy compared to standard favipiravir therapy.
Pulmonary Aspergilloma Co-Existing with Pulmonary Tuberculosis: A Case Report in Type 1 Diabetes Mellitus (T1DM) Patient Kirana, Widya Tria; Faisal, Hana Khairina Putri; Kitagawa, Hiroki; Setiawan, Gigih; Yunus, Faisal
Jurnal Respirasi Vol. 9 No. 3 (2023): September 2023
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v9-I.3.2023.213-219

Abstract

Introduction: Pulmonary aspergilloma is a disease frequently found in immunocompromised patients. In Indonesia, around 18% of diabetes mellitus (DM) patients suffer from chronic pulmonary aspergilloma. However, data on type 1 DM (T1DM) are still limited. Case: We presented the case of a 22-year-old male admitted to the emergency room due to hemoptysis of approximately 200 ml within six hours before admission, nonspecific chest pain during cough, fever, night sweats, and weight loss of 3 kg over the last months. The patient had a history of T1DM and no prior history of respiratory diseases. Physical examination showed tachycardia, tachypnoea, subfebrile, normal body mass index, and rhonchi on the left thorax. Routine laboratory tests revealed increased blood sugar level (503 mg/dL) and HbA1c 16.4%. Chest X-ray and high-resolution computed tomography (HRCT) showed a cavity with an opaque lesion, crescent sign, consolidation, and reticulonodular infiltrate on the left lung. Rapid molecular tests, tuberculosis (TB), and serum galactomannan (GM) were negative. The patient was diagnosed with pulmonary aspergilloma, T1DM, and clinical TB. He was treated with fluconazole, insulin, and a fixed-dose combination of anti-TB. The patient refused the surgery procedure. Immediately, the hemoptysis stopped, blood glucose level was normal, and concomitant with weight gain. Conclusion: Due to innate and acquired immunity impairment, T1DM is a risk factor for pulmonary infections, including TB and pulmonary aspergilloma. Chest HRCT may help diagnose fungal balls. Though the patient refused to undergo surgery, administering antifungal, anti-TB drugs, and glucose control as initial treatment presented a good prognosis in the patient.
Pregnancy-Related Disorders and Intrauterine Impaired Lung Development Zulhadji, Harry Agustio; Yunus, Faisal; Rasmin, Menaldi; Saroyo, Yudianto Budi; Amien, Bagus Radityo
Jurnal Respirasi Vol. 10 No. 2 (2024): May 2024
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v10-I.2.2024.178-185

Abstract

Various pregnancy-related disorders are known to affect fetal lung development negatively. During pregnancy, chronic nutrition and/or oxygen limitation is known to impede lung maturation and induce airway and lung abnormalities. Structural abnormalities and reduced lung function may be evident immediately after birth, persist, or develop with age. The expansion of the fetal lung, fetal breath movements, fetal lung growth, alveolarization, blood-air barrier, extracellular matrix (ECM), airways, surfactant system, and lung immune function are all affected by nutritional limitations during pregnancy. Gestational hypoxia disrupts fetal lung development, which manifests as morphological and functional pulmonary abnormalities. Additionally, intrauterine growth restriction (IUGR), preeclampsia (PE), exposure to air pollution, and smoking are known to interfere with embryonic lung development. Birth defects, such as bronchopulmonary dysplasia, as well as chronic obstructive pulmonary disease (COPD), can be caused by abnormalities in pregnancy. Adequate nutrition, avoidance of smoking, and watchful monitoring and intervention during pregnancy should be promoted to prevent chronic lung disease of the newborn, child, and adult.
The Correlation Between Type and Stage of Lung Cancer with The Chronic Obstructive Pulmonary Disease Group at Arifin Achmad Hospital, Pekanbaru Gurning, Andi Sarikawan; Munir, Sri Melati; Yunus, Faisal; Fauzi, Zarfiardy Aksa; Adrianison, Adrianison; Yovi, Indra; Indriani, Sri Indah
Jurnal Respirologi Indonesia Vol 45 No 2 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i2.512

Abstract

Background: The relationship between lung cancer (LC) and chronic obstructive pulmonary disease (COPD) has been extensively studied but is still up for debate. COPD is a molecularly based illness and one of the independent risk factors for lung cancer, particularly squamous cell carcinoma. This study uses spirometry to assess the relationship between the type and stage of LC and COPD in a group of LC patients at Arifin Achmad Hospital. Methods: This cross-sectional study was conducted on lung cancer patients in Arifin Achmad Hospital, Pekanbaru, from June 2022 to December 2022. Based on spirometry examination, patients were grouped according to the degree of COPD. Then, the relationship between the COPD group and the type and degree of cancer was determined. Results: The study involved 52 patients predominantly male (71.2%), aged over 40 years (92.3%), Smokers and former smokers with Severe Brinkman index (69.2%), restrictive lung function (34.6%), COPD group D (40.4%), adenocarcinoma (61.5%), stage IV lung cancer (92,3%) and WHO Performance Status Scale 2 (61.5%). The FEV1/FVC rate in this study was 66.67%. There is a link between the stage of lung cancer and the group of COPD (P=0.001). Conclusion: There is a relation between the stage of LC in the COPD group, which is predominantly with stage IV lung cancer, and group D of COPD.
Proportions of Hypertension in Stable COPD Patients at the National Respiratory Center Persahabatan Hospital Dewantoro, Luhur; Wiyono, Wiwien Heru; Yunus, Faisal; Agustin, Heidy; Damayanti, Triya; Antariksa, Budhi; Fachrucha, Fanny; Samoedro, Erlang; Elhidsi, Mia
Jurnal Respirologi Indonesia Vol 44 No 3 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i3.774

Abstract

Background: Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. Most of these deaths are related to cardiovascular disease. This is due to systemic inflammation that causes increased vascular stiffness and hypertension. These comorbidities lead to poor quality of life, low exercise tolerance, and an increased risk of hospitalization. This study aims to report the proportion of hypertension among stable COPD patients in the Indonesian population.Methods: This cross-sectional study was conducted at the National Respiratory Center Persahabatan Hospital between February and March 2023. Stable COPD patients admitted to the Asthma and COPD Polyclinic who met the criteria were enrolled. Clinical information, vital signs, spirometry results, and DLCO measurements were collected.Results: There were 84 subjects participating in this study. The result of this study shows a 60.7% proportion of hypertension in stable COPD patients. Hypertension has a significant correlation with pulmonary functional values (P=0.021), severity degree of clinical COPD (P=0.004), Brinkman index (P=0.008), and age (P=0.0001). However, hypertension association with COPD duration (P=0.505) and DLCO (P=0.122) were not significant.Conclusion: The hypertension proportion in stable COPD Indonesian patients is 60.7%. Hypertension shows a significant association with pulmonary function values, severity degree of clinical COPD, Brinkman index, and age. 
Prevalensi Penyakit Paru Obstruktif Kronik Pada Penyapu Jalan Raya di Jakarta Susanto, Agus Dwi; Antono, Wahyu; Yunus, Faisal
Majalah Kedokteran Indonesia Vol 70 No 6 (2020): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.70.6-2020-262

Abstract

Background: Chronic obstructive pulmonary disease (COPD) is an important disease worldwide in both high-income and low-income countries. Dust has been known to increase COPD risk. During sweeping activity, sweepers are exposed to dust. The street sweepers are exposed to dust particles, bioaerosols, and various harmful gases. In this study we evaluates the prevalence of COPD among street sweepers in Jakarta Method: This is a cross-sectional study among 153 street sweepers in Jakarta, Indonesia with age more than 40 years old with working period more than 2 years. Subjects were collected by cluster sampling method based on working location correlated with Jakarta regional district area. COPD was diagnosed by using questionnaires of COPD Assessment Test (CAT), The Modified British Medical Research Council (mMRC), spirometry examination based on Pneumobile Project Indonesia, and bronchodilator test if there was obstructive results. Results: A total of 153 subjects was selected for spirometry examination. The prevalence of COPD among street sweepers in Jakarta, Indonesia was 10 of 153 subject (6.5%). Six of them were males (60%), do not use face mask (80%), working years greater than 10 years (70%), smokers (60%), and BMI ≤25 kg/m2 (80%). There was a statistically significant relationship between age and COPD (p less than 0,05). Conclusion: Prevalence of COPD among street sweepers in Jakarta is 6.5%. Factor related to the occurrence of COPD is age.
Co-Authors . Suradi Adang Bachtiar Adityo Wibowo, Adityo Adrianison Adrianison Adrianison, Adrianison Agus D. Susanto Agus Dwi Susanto Agustin, Heidy Allen Widysanto Amien, Bagus Radityo Amira P Tarigan, Amira P Angela BM Tulaar Anita Ratnawati Antalia K.M. Katili Antono, Wahyu Anwar Jusuf Aria Kekalih Arifin Nawas Arifin, Arief Riadi Aryana, Wayan Ferly Astari Pranindya Sari Azizman Saad B Setyanto, Darmawan Barmawi Hisyam Basalamah, Muhammad Abbas Brahmantyo, Adhimas Budhi Antariksa Bulkis Natsir Cut Yulia Indah Sari Damayanti, Triya Dewantoro, Luhur Dwi Handoko Eddy Surjanto Ekawati, Diyan Elhidsi, Mia Elisna Sjahruddin Endang Purwaningsih Esha, Indi Fachrucha, Fanny Faisal, Hana Khairina Putri Fariz, Nurwidya Febrihartati, Isura Flora Ekasari Gozali, Achmad Gurning, Andi Sarikawan Hadiarto Mangunnegoro Hana Khairina Putri Faisal Harahap, Makrup E Helena Turnip Idrus Alwi Indi Esha INDRA YOVI Indriani, Sri Indah Isbaniah, Fathiyah Isep Supriyana Joko Riyadi Jordy Oktobiannobel Kirana, Widya Tria Kitagawa, Hiroki Kolewora, Yusuf Musafir Laras, Sekar Lientje S. Maurits, Lientje S. Lindra, Derallah A Listiandoko, Raden Dicky Wirawan Marisa Afifudin Mariska Pangaribuan Meirissa, Tria Menaldi Rasmin Moelamsyah, Yandi Noer Mohammad Farid Neni Sawitri Nury Nusdwinuringtyas Patrama, Satria Pinaka Baladika, Dimas Trend Putra, Muhammad Ryan Adi Putri Suci Ramadhany Putri, Maharani Ratnawati Antaria Ratnawati Ratnawati Ratnawati Ratnawati Ridha Restilla Ririn Astuty Ningsih Risa Febriana Rochsismandoko Rochsismandoko Rochsismandoko Rochsismandoko Roxanne, Olivia Geraldine Sabarina Prasetyo Samoedro, Erlang Saroyo, Yudianto Budi Setiawan, Gigih Sinaga, Fransisca TY Sita Laksmi Andarini Soehardiman, Dicky Soemarwoto, Retno Ariza Soeprihatini Soemarwoto, Retno Ariza Soerjanto Soerjanto Sri Melati Munir Suradi Suradi Surya Hajar Fitria Dana Suwarno, Sukarti San Syafruddin A.R. Lelosutan Syah Putra Yahya, Wiendo Syazili Mustofa Tamsil Syafiuddin, Tamsil Triya Damayanti Utomo, Ahmad Rusdan H Wahju Aniwidyaningsih Wicaksono, Muhammad Bimo Adi Widjajalaksmi Widjajalaksmi Widjanantie, Siti Chandra Wiwien H. Wiyono Wiwien Heru Wiyono Yulino Amrie Zaini, Jamal Zarfiardy Aksa Fauzi Zulhadji, Harry Agustio Zulkarnain Barasila