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Adenomyosis- surgical treatment for women’s infertility Laparotomy with Osada technique I Nyoman Hariyasa Sanjaya; Cokorda Istri Mirayani Pemayun; Ni Komang Anik Pirgantari; Made Diah Vendita Sakuntari; Ni Wayan Dewi Purwanti; Ni Putu Nining Gianni; Ni Luh Made Diah Mas Cahyani Putri; Ni Luh Md Dwi Laxmi Satriani; Firsta Sesarina Mintariani; Anak Agung Wahyu Putri Agustini; Ketut Widyani Astuti
Indonesian Journal of Perinatology Vol. 3 No. 2 (2022): (Available online: 1 December 2022)
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/inajperinatol.v3i2.25

Abstract

Introduction: Adenomyosis became challenging in the gynecological field and healthcare economic aspect. The prevalence of adenomyosis is widely ranged in different countries. Infertility is one of the frightening complications. Thus a radical adenomyosis tissue removal method using the triple-flap (the Osada technique) could be done. Using this technique the adenomyosis tissue can be removed as much as possible while maintaining normal uterine function. Thus, in this case, report, we performed a woman diagnosed with adenomyosis underwent the surgery with Osada technique. Case description: A 30-year-old woman went to the medical care of Kasih Medika. She has been married for 4,5 years and did not have any children. She had a history of abdominal pain every menstruation, and it has persisted since 2 months ago even though not on the menstrual schedule. Transvaginal sonographic examination revealed a diffusely enlarged uterus and thickening of the uterine wall. A laparotomy is performed using the Osada technique (triple flap. After that, around 1 month after surgery, the patient will undergo an ultrasound examination and the patient will undergo the GnRH agonist therapy (Tapros) 3 times. Conclusion: Adenomyosis is one of the challenging diseases. Adequate treatment must be done to minimalize the infertile probability Laparotomy with the Osada technique could be done. Infertility examination in both couples also must be done. Undergoing the GnRH agonist therapy also can give a better result for the patient.
Pregnancy with choriangioma: a placental disorder that causes fetal death I Nyoman Hariyasa Sanjaya; Cokorda Istri Mirayani Pemayun; Ni Komang Anik Pirgantari; Made Diah Vendita Sakuntari; Ni Wayan Dewi Purwanti; NI Putu Nining Gianni; Ni Luh Made Diah Mas Cahyani Putri; Ni Luh Md Dwi Laxmi Satriani; Firsta Sesarina Mintariani; Anak Agung Wahyu Putri Agustini
Indonesian Journal of Perinatology Vol. 3 No. 2 (2022): (Available online: 1 December 2022)
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/inajperinatol.v3i2.26

Abstract

Introduction: Chorioangioma is the most common non-trophoblastic vascular tumor of the placenta. It was estimated that the incidence of chorioangioma was 1%. Although the incidence was not widely large, it has high mortality and morbidity. Commonly, chorioangiomas is a small asymptomatic lesion found only after birth after careful excision of the placenta. In making it easier to visualize the food vessels entering the placental mass and peritumoral diffuse vasculature we could use the color doppler. The wide range of outcomes and limited studies related to this case makes it quite difficult to handle. Thus, this study aimed to provide information on chorioangioma from diagnosis to the management. Case description: Mother A is our referral patient who was recommended to do an ultrasound, with a diagnosis of 20 weeks gestation with suspected IUFD and a cyst in the placenta measuring 6.5cm x 4.1cm x 5.4 cm, the mother has not felt fetal movement. Ultrasound examination revealed a hematoma at the time of insertion of the umbilical cord in the placenta. The location of the placenta in the corpus anterior grade 1. No heartbeat was found in the baby, and the baby's weight was 529 grams. Conclusion: The adverse outcome is known to be associated with chorioangioma. It depends on the mass size, and the existence of fetal hydrops. The worst prognosis that we found in this case was no heartbeat when the baby was born.
The inclination of psychological disorder of post sectio caesarean based on characteristic Ni Wayan Dewi Purwanti; Ni Komang Erny Astiti; I G A A Novya Dewi; I Nyoman Hariyasa Sanjaya; I Nyoman Wirata; G. A Eka Utarini
JNKI (Jurnal Ners dan Kebidanan Indonesia) (Indonesian Journal of Nursing and Midwifery) Vol 10, No 3 (2022)
Publisher : Alma Ata University Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21927/jnki.2022.10(3).205-213

Abstract

Background: Psychological problems in postpartum mothers, both vaginal postpartum and post SC, can have a negative impact on the cognitive development of babies and can reduce maternal and infant bonding. Post SC have a risk of postpartum depression four times greater than mothers with vaginal deliveries. However, previous studies looked at postpartum mothers in general, not specifically in post-SC who had a higher risk. Research related to early detection of the risk of post-SC psychological disorders is quite limited.  The prevalence of mothers with postpartum depression symptoms in Denpasar in 2019 was 25.4%. Early detection can be done using the Edinburgh Postpartum Depression Scale (EPDS).Objectives: The aims of this research to identify the psychology of post SC mothers based on characteristics including age, race/ethnicity, last education, income, pregnancy status, parity, living with a nuclear or large family, lactation problems, and type of SC in the Dr.dr. I Nyoman Hariyasa Sanjaya,SpOG(K)-KFM.MARS 2022.Methods: Descriptive research design with a cross-sectional subject approach model. The sample of this research is 34 samples with the Consecutive Sampling technique. Types of primary data taken by EPDS and characteristic questionnaire. This study uses quantitative descriptive univariate analysis.Results: The prevalence of Post SC which indicates a psychological disorder is 44.12%. Post SC which indicates more psychological disorders are mothers with a productive age range of 20-35 years by 26.47%, Asian race 41.18%, higher education level which is 38.24%, very high revenue 38.24%, desired pregnancies status 35.29%, 29.41% multiparas, 23.53% mothers living with large families, 38.24% experiencing lactation problems, and 26,47% elective SC types.Conclusions: This study found that 44.12% of Post SC indicated experiencing psychological disorders, the majority were Post SC at the age of 20-35 years, Asian race, good education, very high revenue, desired pregnancy status, multipara, mothers living with large families, mothers with lactation problems, and elective cesarean section. The environment and health workers can conduct screening as early as possible so that the impact of this psychological disorder can be prevented.
Performance of Rapid Antibody Test and RT-PCR as Frontline Test for COVID-19 Diagnosis in Pregnancy: an Experience in Indonesia Evert S. Pangkahila; Ryan S. Mulyana; Hariyasa Sanjaya; Mulyantari K; Daniel H. Susanto
Journal Research of Social Science, Economics, and Management Vol. 1 No. 7 (2022): Journal Research of Social Science, Economics, and Management
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2051.354 KB) | DOI: 10.59141/jrssem.v1i7.106

Abstract

Ensuring an accurate diagnosis is critical for limiting the spread of SARS-CoV-2 and for the clinical management of COVID-19, especially in pregnant women. For now real-time reverse transcription polymerase chain reaction (RT-qPCR) is the currently recommended laboratory method for the diagnosis of acute SARS-CoV-2 infection. More recently, several easy-to-perform rapid antigen detection tests have been developed and are recommended as first-line screening test in several countries. The purpose of this study was to evaluate the comparative performance of a rapid antibody test and RT-PCR for the detection of SARS-CoV-2 infection, as a front-line test for the diagnosis of COVID-19 in pregnancy. This research method is a descriptive study to describe comparation of sensitivity and specificity between rapid SARS-CoV-2 antibody test to the gold standard nasopharyngeal RT-PCR swab test. Of the 271 samples, only 257 were eligible and fourteen cases were excluded from the study due to a lack of rapid antibody test and RT-PCR results. The results of this study showed that the rapid SARS-CoV-2 antibody test sensitivity was 80.95%, and the specificity was 90.68%, the NPV (negative predictive value) and the PPV (positive prognosis value) were 98.17% and 43.59%, respectively. Based only on the results of IgM and IgG, IgM and IgG sensitivity were 33.33% (7/21) and 71.43% (15/21), respectively, and the specificity was 91.1% (215/236, 21 false positive) and 91.53% (216/236, 20 false positive), respectively. The use of rapid antibody tests during pregnancy is a screening tool and is not currently applicable for diagnostic tool. To minimize false positives and negatives results, the use of rapid antibody tests should be combined with the RT-PCR test results.
The Polymorphism of rs2549782 gene Endoplasmic Reticulum aminopeptidase-2, high Concentration of Free Fetal DNA, and Cystatin C as Risk Factors of Preeclampsia I Nyoman Hariyasa Sanjaya
Journal of Global Pharma Technology Volume 12 Issue 01
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Recently, the mechanism of the preeclampsia (PE) occurrence has not gained widespread agreement. This is related to the variations intreatment, maternal factor, and fetal morbidities as well as mortality. However, the studies of the placenta associated with PE mechanism have derived serious attention. This study aims to determine the role of rs2549782 ERAP 2 gene polymorphism, extracellular fetal DNA content, and high-level C cystatin in maternal serum as a risk factor for PE Methods: A matched case-control study among 62 maternal over 20 weeks of gestation was conducted in the Department of Obstetrics and Gynecology, Faculty of Medicine, Sanglah General Hospital, Biomolecular Laboratory of Medical Faculty, Universitas Udayana, Bali, Indonesia andProdia Laboratory Denpasar.A 12 months-period of the study was enrolled from August 1st 2016-2017. The polymorphism examination of rs2549782 ERAP 2 gene, extracellular fetal DNA content and C cystatin respectively were evaluated among 31 maternal with PE as case and 31 maternal as control (Normal). Data were analyzed using SPSS version 16 for Windowsto determine the association of rs2549782 ERAP2 genepolymorphism, extracellular fetal DNA level, and maternal serum cystatin C level using Chi-square Test and Odds Ratio (OR). Discriminant tests with logistic regression were displayed in table and narrative form.Results: The ERAP2 gene polymorphism in the case was found 7.5 times (OR = 7.50 IK95%: 3.53-15.92; p = 0.002) higher significantly compared to the control. The cell-free fetal (cff) DNAlevel in the case was 6.67 times (OR, 6.67 IK; 95% 2.67-26.33, p; 0.001) higher significantly than the control. In addition, the level of cystatin C in the case was also 6.5 times (OR, 6.5 IK; 95% 3.04-13, 89, p; 0.007) higher significantly when compared to the control. However, there wasno significant difference in the polymorphism of rs2549782 ERAP2 gene, extracellular fetal DNA, and cystatin C between groups (P>0.05).Conclusion: In can be concluded that the polymorphism of rs2549782 ERAP2 gene, extracellular fetal DNA, and high maternal serum C cystatin increase the risk of PE.Keywords:Preeclampsia, Rs2549782 polymorphism, ERAP2, DNA, cystatin C.
PERBANDINGAN EFEKTIVITAS TERAPI ORAL DAN INTRAVENA PADA IBU HAMIL DENGAN ANEMIA DEFISIENSI BESI: SEBUAH SYSTEMATIC REVIEW Eka Setiawan, Putu Pandu; Putra Adnyana, Ida Bagus; Wijaya Surya, I Gede Ngurah Harry; Hariyasa Sanjaya, I Nyoman
E-Jurnal Medika Udayana Vol 12 No 7 (2023): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2023.V12.i07.P03

Abstract

Anemia defisiensi besi (IDA) utamanya lebih banyak terjadi pada wanita salah satu faktornya adalah kehamilan. Pilihan pertama dalam pengobatan anemia defisiensi besi untuk hampir semua pasien adalah terapi besi oral. Tujuan dari systematic review ini untuk mengetahui efektifitas terapi intravena dan terapi oral sebagai pengobatan untuk IDA pada Ibu Hamil. Penulisan systematic review ini dilakukan berdasarkan pedoman PRISMA. Pencarian artikel dilakukan pada database Pubmed dan Sciencedirect dari tahun 2016-2020 dengan kriteria inkulsi wanita hamil dengan IDA dan hasil mean Hb untuk setiap intervensi. Judul dan abstrak ditinjau berdasarkan relevansi penelitian. Penilaian kualitas studi menggunakan Cochrane Systematic Review ROB Tools. Pada tahap akhir didapatkan sebanyak enam artikel. Secara umum kualitas studi cukup baik. Berdasarkann Systematic review yang telah dilakukan menunjukan bahwa terapi besi intravena lebih unggul dalam hal tolerabilitas dan koreksi anemia bila dibandingkan dengan terapi oral. Terapi IV juga menghasilkan peningkatan Hb yang lebih cepat. Kata kunci:Kehamilan., Terapi., Anemia Defisiensi Besi
Relationship between total 25(OH)D and interleukin-2 contents in preterm conversion patients Sanjaya, I Nyoman Hariyasa; Mulyana, Ryan Saktika; Kamajaya, I Gusti Ngurah Agung Trisnu
Indonesian Journal of Perinatology Vol. 5 No. 1 (2024): Available online: 1 June 2024
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/inajperinatol.v5i1.37

Abstract

The most essential nutrient for pregnant women is vitamin D. A lack of vitamin D can cause preterm labor and other issues like low birth weight, preeclampsia, and issues with the baby's bones. According to some research, there is no safe top level and a 75–80 nmol/L range. According to additional studies, an ideal range is between 75 and 110 nmol/L and a daily dosage of 1800 to 4000 IU of vitamin D3. In both early and late pregnancies, women with sufficient vitamin D levels (at least 30 ng/mL) exhibited a significant decrease in the incidence of preeclampsia. It is also known that vitamin D modulates the immune system in several ways. T-cell proliferation can be suppressed, and pro-inflammatory cytokines, including IL-2, IFN-, and IL-17, can be produced less frequently when vitamin D is present. A lack of vitamin D may lead to a rise in cytokines that promote inflammation, such as IL-2. This paper will, therefore, examine the relationship between vitamin D, IL-2 levels, and the risk of premature labor.
The effect of maternal diabetes on the formation of fetal surfactant Sanjaya, I Nyoman Hariyasa; Sutandi, Chatrine
Indonesian Journal of Perinatology Vol. 5 No. 1 (2024): Available online: 1 June 2024
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/inajperinatol.v5i1.42

Abstract

Elevated maternal blood glucose levels in pregnancy correlate with increased risk of pregnancy complications, labor, and pregnancy outcomes. Type II alveolus cells produce a combination of fat and protein called pulmonary surfactant. To assist in preserving lung stability, pulmonary surfactant plays a crucial function in lowering the propensity of the alveolus to recoil and preventing alveolus collapse. The hallmark of maternal diabetes is the malfunctioning of pancreatic β-cells, which results in insufficient insulin production to sustain proper blood glucose levels. Respiratory distress syndrome (RDS) in newborns is caused by surfactant lack of sufficiency, which is caused by fetal hyperglycemia and hyperinsulinism brought on by maternal diabetes. Appropriate treatments are required to improve glycemic management since maternal diabetes raises the risk of RDS in term newborns. These therapies include a deeper comprehension of the molecular mechanisms behind gestational diabetes mellitus that impact the surfactant system. Phosphatidylglycerol levels are either nonexistent or extremely low in infants with RDS. Phosphatidylglycerol synthesis during pregnancy in diabetics is known to be delayed in comparison to the non-diabetic control group. For this reason, proper care is essential to enhancing long-term health and neonatal outcomes. These findings underscore the need for early detection and management of maternal diabetes to mitigate the risk of RDS and improve neonatal health.
The Role of Cytokines, Hormones, and Cellular Regulation in Improving Maternal and Fetal Well-Being Hariyasa Sanjaya, I Nyoman; Sutandi, Chatrine; Syauta, Fetrisya
Indonesian Journal of Perinatology Vol. 5 No. 1 (2024): Available online: 1 June 2024
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/inajperinatol.v5i1.51

Abstract

Maternal and fetal well-being is a complex interplay of various factors. A key factor is that women receiving early and adequate pregnancy care are more likely to achieve positive pregnancy outcomes. Several studies have identified internal maternal factors as significant contributors to the well-being of both mother and fetus. However, scientific research and discussions on the role of cytokines, hormones, and cellular regulation in maternal and fetal well-being outcomes still need to be completed. Progesterone, a vital hormone for pregnancy and humans, influences immune function directly and through mediators by promoting the synthesis of T helper cell-type cytokines. The favorable benefits of dydrogesterone on repeated spontaneous miscarriages and impending miscarriages may be attributed to the regulating effects of these cytokines and the hormone's capacities. T helper cell-produced cytokines are linked to allograft rejection. Lastly, our finding of cellular regulatory mechanisms, including apoptosis, autophagy, and cellular senescence, highlights the multifaceted nature of maintaining maternal and fetal health during pregnancy. This review aims to delve deeper into the role of cytokines, hormones, and cellular regulation in enhancing maternal and fetal well-being.
Ethnopharmacological insights and clinical prospects of ten Indonesian medicinal plants for pregnancy, postpartum, and lactation: a systematic review Sanjaya, I Nyoman Hariyasa; Andonotopo, Wiku; Bachnas, Muhammad Adrianes; Dewantiningrum, Julian; Pramono, Mochammad Besari Adi; Mulyana, Ryan Saktika; Pangkahila, Evert Solomon; Akbar, Muhammad Ilham Aldika; Rahardjo, Theresia Monica; Suryawan, Aloysius; Rahardjo, Bambang; Yeni, Cut Meurah; Aldiansyah, Dudy; Bernolian, Nuswil; Wiradnyana, Anak Agung Gede Putra; Sulistyowati, Sri; Stanojevic, Milan; Kurjak, Asim
Indonesian Journal of Perinatology Vol. 6 No. 1 (2025): (Available online: 1 June 2025)
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/inajperinatol.v6i1.77

Abstract

Background: The perinatal period involves significant physiological and metabolic transitions, particularly concerning hypertensive disorders, preeclampsia, hemorrhage, lactation challenges, and oxidative stress. Although pharmacological therapies are available, their safety and accessibility remain inconsistent, especially in resource-limited settings. Indonesia’s extensive biodiversity and deep-rooted ethnomedicinal traditions offer promising yet underutilized botanical alternatives. This study aimed to review the efficacy of Indonesian medicinal plants used in pregnancy, postpartum, and lactation. Methods: This systematic review investigates ten Indonesian medicinal plants traditionally used during pregnancy, postpartum recovery, and lactation: Sauropus androgynus, Curcuma longa, Moringa oleifera, Nigella sativa, Centella asiatica, Orthosiphon aristatus, Syzygium polyanthum, Andrographis paniculata, Solanum nigrum, and Zingiber officinale. Literature from 2000 to 2025 was reviewed using PRISMA guidelines across global and regional databases. Phytochemical composition, mechanisms of action, therapeutic effects (e.g., antihypertensive, antidiabetic, galactagogue, hemostatic, antioxidant), and clinical relevance were critically evaluated. Results: All ten plants demonstrated pharmacological potential relevant to perinatal health challenges. Notably, Zingiber officinale offers antiemetic and anti-inflammatory benefits during early pregnancy, complementing the lactogenic, antihypertensive, and wound-healing properties of other species. However, gaps persist in human trials, dosage standardization, and regulatory oversight. Conclusion: The review highlights the importance of integrating validated traditional botanicals into perinatal care through interdisciplinary research, targeted clinical trials, and culturally responsive health policies. Bridging ethnopharmacology with maternal health systems offers a scalable, sustainable pathway toward maternal wellness and equity in Indonesia and comparable global settings.
Co-Authors Adhi Pribadi Aldiansyah, Dudy Aldika Akbar, Muhammad Ilham Aloysius Suryawan Anak Agung Ngurah Anantasika Anak Agung Wahyu Putri Agustini Anak Agung Wahyu Putri Agustini Anak Agung Wahyu Putri Agustini Anak Agung Wahyu Putri Agustini Andonotopo, Wiku Bachnas, Muhammad Adrianes Bambang Rahardjo Cokorda Istri Mirayani Pemayun Cokorda Istri Mirayani Pemayun Cokorda Istri Mirayani Pemayun Cokorda Istri Mirayani Pemayun Cut Meurah Yeni Daniel H. Susanto Denni Prasetyo Dyah Pradnyaparmita Duarsa Eka Setiawan, Putu Pandu Endang Sri Widiyanti Evert Solomon Pangkahila Firsta Sesarina Mintariani Firsta Sesarina Mintariani Firsta Sesarina Mintariani Hartanto Hartanto I G A A Novya Dewi I Gede Ngurah Harry Wijaya Surya I Gusti Kamasan Arijana I Ketut Surya Negara I Made Gede Widnyana I Made Mahardika I Nyoman Gede Budiana I Nyoman Wirata I Wayan Murdita Ida Bagus Gde Fajar Manuaba Ida Bagus Putra Adnyana Ida Bagus Putra Adnyana, Ida Bagus IGP Surya, IGP Julian Dewantiningrum Kadek Budi Juliantari Kamajaya, I Gusti Ngurah Agung Trisnu Ketut Widyani Astuti Kurjak, Asim Kusuma, Anak Agung Ngurah Jaya luh sudiarmini Made Adi Kusuma Made Diah Vendita Sakuntari Made Diah Vendita Sakuntari Made Diah Vendita Sakuntari Made Wiryana Marta, Kadek Fajar Murdita, I Wayan Ni Kadek Mulyantari Ni Komang Anik Pirgantari Ni Komang Anik Pirgantari Ni Komang Anik Pirgantari Ni Komang Erny Astiti Ni Luh Made Diah Mas Cahyani Putri Ni Luh Made Diah Mas Cahyani Putri Ni Luh Made Diah Mas Cahyani Putri Ni Luh Md Dwi Laxmi Satriani Ni Luh Md Dwi Laxmi Satriani Ni Luh Md Dwi Laxmi Satriani Ni Luh Putu Yulia Padmawati Ni Nyoman Dewi Purwanti Ni Nyoman Sri Budayanti Ni Putu Nining Gianni Ni Putu Nining Gianni Ni Putu Nining Gianni Ni Wayan Dewi Purwanti Ni Wayan Dewi Purwanti Ni Wayan Dewi Purwanti Ni Wayan Dewi Purwanti Nuswil Bernolian Pramono, Mochammad Besari Adi Putra, Wayan Artana Putu Doster Mahayasa Putu Pandu Eka Setiawan Rey Jauwerissa Ryan S. Mulyana Ryan Saktika Mulyana Sri Sulistyowati Stanojevic, Milan Sutandi, Chatrine Syauta, Fetrisya Tasa Riszkia Theresia Monica Rahardjo Tjokorda Gde Agung Suwardewa Utarini, Gusti Ayu Eka Widi, Made Yudha Ganesa Wikantyas Wijaya Surya, I Gede Ngurah Harry Wiradnyana, Anak Agung Gede Putra Wiradnyana, Anak Agung Putra