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Journal : Journal of Applied Nursing and Health

Lactate and SOFA Score as Predictors of Sepsis Mortality: A Retrospective Observational Study Hardianti, Anugerah; Ahsan, Ahsan; Kristianto, Heri; Lande, Hasriadi
Journal of Applied Nursing and Health Vol. 7 No. 2 (2025): Journal of Applied Nursing and Health
Publisher : Chakra Brahmanda Lentera Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55018/janh.v7i2.324

Abstract

Background: Managing sepsis in the emergency room presents a significant challenge, as the condition is often difficult to recognize, leading to a delay in identification and diagnosis, frequently only after the patient has reached a critical state. This study aims to analyze the correlation between lactate levels and Sequential Organ Failure Assessment (SOFA) scores with mortality risk in patients with sepsis: a retrospective study conducted in the emergency room of Dr. Wahidin Sudirohusodo Hospital, Makassar. This study follows the STROBE guidelines for observational research. Methods: This study employs a quantitative, analytical observational design with a retrospective approach. The sample consists of 321 sepsis patients diagnosed with sepsis or presenting comorbidities associated with sepsis in the Emergency Room of Dr. Wahidin Sudirohusodo Hospital, Makassar. The sample size was determined using the Slovin formula. Purposive sampling was employed as the sampling technique, while data analysis included descriptive statistics, chi-square tests, and binary logistic regression. Results: Elevated lactate levels and SOFA scores were significantly associated with increased mortality (p <0.05). Lactate levels demonstrated an odds ratio (OR) of 5.329, indicating that patients with low lactate levels were 5.3 times more likely to survive than those with high lactate levels. The SOFA score produced an OR of 10.058, suggesting that patients with lower SOFA scores had a 10.1 times greater chance of survival compared to those with higher scores. Lactate level was identified as the primary predictor of mortality. Conclusion: The results of this study indicate a significant correlation between blood lactate levels and SOFA scores with sepsis-related mortality in the Emergency Department (ED). Among these two parameters, blood lactate emerged as the most dominant predictor. These results underscore the importance of implementing early detection tools for sepsis, such as lactate testing and simplified SOFA assessments, as part of routine triage workflows, particularly at Dr. Wahidin Sudirohusodo General Hospital in Makassar.
Co-Authors Abdul Qodir Adiantara, Ken Rangga Galang Agwin Fahmi Fahanani Ahmad Fauziansyah Ahmad Fauziansyah Zian Ahmad Hasyim Wibisono Ahsan Ahsan Ahsan Ahsan Ahsan Ahsan Aisyah Dzil Kamalah Aisyah Dzil Kamalah Alfrina Hany Alfrina Hany, Alfrina Anggreni, Ni Kadek Indah Sunar Ardani Galih Prakosa Arinda Nur Yunitasari Artawan, I.K Arum Desi Pratiwi, Arum Desi Bagus Rahmat Santoso Blow, David Bursriansyah, Amanda Putri Cahyani, Dewi Fadlilah Christina, Kezia Devi Nur Cahaya Ningsih Dewi Gayatri Dewi Purnama Sari Dewi, Kadek NP Dian Pitaloka Priasmoro, Dian Pitaloka Didik Saudin Dina Dewi Sartika Lestari Ismail Djanggan Sargowo Dwi Astika Sari Efris Kartika Sari Elly Nurachmah Elvida, Anisya Efa Erik Irham Lutfi Fajar Ari Nugroho Fatma, Endah Panca Lydia Ferdian Utama Fetreo Negeo Putra Fitriono, Eko Nani Fujianti, Mery Eka Yaya Hardianti, Anugerah I Wayan Gede Saraswasta Ilahude , Imran Indah Winarni Indra, Mochamad R Irawan, Paulus Lucky Tirma Ismail, Dina Dewi Sartika Lestari Jaenulloh Jenal Abidin Kadek NP Dewi Ken Rangga Galang Adiantara Laily Yuliatun Laksmi, Ida Ayu Agung Lande, Hasriadi Lenny Nurhandayani Loeki Enggar Fitri M. Fahrul Arifin Maydinah, Anissa Mifetika Lukitasari Mochamad R Indra Muchamad Supriyadi MUHAMMAD YUSUF Nadie Fatimatuzzahro Nanang Bagus Sasmito Ni Made Candra Yundarini Ni Putu Jeny Mardiati Nia Kurnianingsih Nofita Dewi Kok Mesa Noorhamdani Noorhamdani Novi Khila Firani Novita Titis Harbiyanti Nunung Khairun Nissa Oper Oper, Nunung Khairun Nissa Purnama, Avief Destian Putri, Anyelir Viola Fatika Rahma Micho Widyanto Ratih Paramita Suprapto Renny Nova, Renny Retty Ratnawati Rieski, Wenny Arta Rinik Eko Kapti, Rinik Eko Rosikhah Al-Maris Rulli Rosandi Rustiana Tasya Ariningpraja Saifurrohman Saifurrohman Sandra Novita Yunianto Sartika Lestari Ismail, Dina Dewi Setyawati Soeharto Setyoadi Setyoadi Setyoadi Setyoadi Siti Nur Afifah Siti Roudhotul Jannah, Siti Roudhotul Sri Andarini Sri Andarini Sujud Priono Suryanto Suryanto Susetyo, Agus Suwaryo, Putra Agina Widyaswara Titin Andri Wihastuti Titin Andri Wihastuti Tony Suharsono Wibisono, Ahmad Hasyim Yulian Wiji Utami Yuyun Yueniwati