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Heri Kristianto
Department Of Medical Surgical Nursing, Faculty Of Health Sciences, Universitas Brawijaya, Indonesia
Religion Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Decision Sciences, Operations Research & Management Dentistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Journal : MEDISAINS

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In vivo study of celery (Apium graveolens L) extract for regenerating pancreatic β-cell Ismail, Dina Dewi Sartika Lestari; Kristianto, Heri; Setyoadi, Setyoadi; Maydinah, Anissa
MEDISAINS Vol 22, No 1 (2024)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v22i1.20079

Abstract

Background: The celery plant (Apium graveolens L.) is a widely distributed herbal plant globally known for being a significant source of natural active products, including phenolic compounds and antioxidants demonstrating antidiabetic activity. Previous research findings have indicated the impact of celery leaf extract on reducing blood glucose levels. However, up to now, there is a dearth of research investigating the potential effect of celery leaf extract on the regeneration of pancreatic beta cells in mice with diabetes models.Objective: This study aims to determine the effect of the ethanol extract of celery leaves on the number of pancreatic cells in Streptozotocin (STZ)-induced mice.Method: This research method uses a randomized controlled group posttest only design. Experimental animals were divided into five groups, including a group of experimental animals in a healthy condition, the group with hyperglycemia, hyperglycemia group with celery extract at 200 mg/kg BW, hyperglycemia group with celery extract at 400 mg/kg, and hyperglycemia group with extract celery is 800 mg/kg BW. Termination was performed on day 60 after therapy and pancreas hematoxylin and eosin staining. They are counting the number of cells with a photo slide with 400x magnification in 5 fields of view—statistical analysis using One-Way ANOVA.Results: The study revealed that celery extract could increase the number of pancreatic cells compared to the control group (P<0.002). Notably, the highest increase in pancreatic cell count was observed in the group administered with 400 mg/BW of celery extract.Conclusion: Celery leaf extract effectively increased the number of beta cells in vivo.
Co-Authors Abdul Qodir Adiantara, Ken Rangga Galang Agwin Fahmi Fahanani Ahmad Fauziansyah Ahmad Fauziansyah Zian Ahmad Hasyim Wibisono Ahsan Ahsan Ahsan Ahsan Ahsan Ahsan Aisyah Dzil Kamalah Aisyah Dzil Kamalah Alfrina Hany Alfrina Hany, Alfrina Ardani Galih Prakosa Arinda Nur Yunitasari Artawan, I.K Arum Desi Pratiwi, Arum Desi Bagus Rahmat Santoso Blow, David Bursriansyah, Amanda Putri Cahyani, Dewi Fadlilah Christina, Kezia Devi Nur Cahaya Ningsih Dewi Gayatri Dewi Purnama Sari Dewi, Kadek NP Dian Pitaloka Priasmoro, Dian Pitaloka Didik Saudin Dina Dewi Sartika Lestari Ismail Dina Dewi SLI Djanggan Sargowo Dwi Astika Sari Efris Kartika Sari Elly Nurachmah Elvida, Anisya Efa Erik Irham Lutfi Fajar Ari Nugroho Fatma, Endah Panca Lydia Ferdian Utama Fetreo Negeo Putra Fitriono, Eko Nani Fujianti, Mery Eka Yaya Hardianti, Anugerah I Wayan Gede Saraswasta Ilahude , Imran Indah Winarni Indra, Mochamad R Irawan, Paulus Lucky Tirma Ismail, Dina Dewi Sartika Lestari Jaenulloh Jenal Abidin Kadek NP Dewi Ken Rangga Galang Adiantara Laily Yuliatun Laksmi, Ida Ayu Agung Lande, Hasriadi Lenny Nurhandayani Loeki Enggar Fitri M. Fahrul Arifin Maydinah, Anissa Mifetika Lukitasari Mochamad R Indra Muchamad Supriyadi MUHAMMAD YUSUF Nadie Fatimatuzzahro Nanang Bagus Sasmito Ni Kadek Indah Sunar A Ni Made Candra Yundarini Ni Putu Jeny Mardiati Nia Kurnianingsih Nofita Dewi Kok Mesa Noorhamdani Noorhamdani Novi Khila Firani Novita Titis Harbiyanti Nunung Khairun Nissa Oper Oper, Nunung Khairun Nissa Purnama, Avief Destian Putri, Anyelir Viola Fatika Rahma Micho Widyanto Ratih Paramita Suprapto Renny Nova, Renny Retty Ratnawati Rieski, Wenny Arta Rinik Eko Kapti, Rinik Eko Rosikhah Al-Maris Rulli Rosandi Rustiana Tasya Ariningpraja Saifurrohman Saifurrohman Sandra Novita Yunianto Sartika Lestari Ismail, Dina Dewi Setyawati Soeharto Setyoadi Setyoadi Setyoadi Setyoadi Siti Nur Afifah Siti Roudhotul Jannah, Siti Roudhotul Sri Andarini Sri Andarini Sujud Priono Suryanto Suryanto Susetyo, Agus Suwaryo, Putra Agina Widyaswara Titin Andri Wihastuti Titin Andri Wihastuti Tony Suharsono Wibisono, Ahmad Hasyim Yulian Wiji Utami Yuyun Yueniwati