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All Journal Jurnal Farmasi Udayana Jurnal Mahasiswa Farmasi Fakultas Kedokteran dan Ilmu Kesehatan UNTAN Indonesian Journal of Pharmaceutical Science and Technology Biology, Medicine, & Natural Product Chemistry Majalah Obat Tradisional JURNAL PENGABDIAN KEPADA MASYARAKAT Jurnal Kelautan Tropis JURNAL PENGABDI SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Al-Khidmah BULETIN AL-RIBAATH PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Journal Syifa Sciences and Clinical Research (JSSCR) Media Karya Kesehatan Indonesian Journal of Pharmaceutical Education Sasambo Journal of Pharmacy Pharmaceutical Sciences and Research (PSR) Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan Journal Pharmacy of Tanjungpura Berita Biologi
Siti Nani Nurbaeti
Faculty Of Medicine, Universitas Tanjungpura
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Pengaruh Isolasi Cangkang Telur Ayam Ras Petelur Terhadap Kadar Abu Rico Arianto; Siti Nani Nurbaeti; Fajar Nugraha; Inarah Fajriaty; Hadi Kurniawan; Adnan Pramudio
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.13982

Abstract

Eggshell powder for laying hens contains calcium carbonate CaCO3 (98%) and calcium (28%), efficacious as an antiseptic, antibacterial, and the development of the mineral apatite in the formation of bones and teeth. Eggshell powder is an organic waste that has the potential to be used as a supplement material for calcium sources for humans. However, the content of eggshells consists of inorganic compounds that produce ash. Eggshells as a supplement material must meet quality and safety standards, but this has never been done. Therefore, in this study, an ash content test was carried out with the aim of knowing the inorganic content in the isolation of eggshells of laying hens. Eggshells were isolated by demineralization and deproteination processes. The test results showed that the ash content in the eggshells of laying hens was 95.13%, while in the isolation results the ash content was 96.13%.
Pengaruh Pemberian Lozenges Kombinasi Kulit Pisang dan Kulit Nanas terhadap Tikus Putih (Rattus norvegicus L.) galur Wistar Adelita Ahyanurri; Liza Pratiwi; Hadi Kurniawan; Inarah Fajriaty; Siti Nani Nurbaeti; Nugraha Fajar; Pratiwi Apridamayanti
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.13811

Abstract

Banana peel and pineapple peel have high potassium content. The banana peel and pineapple peel combination can be used as lozenges in potassium supportive therapy. The safety of banana peel and pineapple peel combination lozenges must be ensured by the acute toxicity test. One of the parameters observed during toxicity testing is the organ index. This study aims to determine the relationship between dose and toxicity in acute oral administration of banana peel and pineapple peel combination lozenges on the heart, lungs, liver, spleen, and kidneys organ index in white rats (Rattus norvegicus L.) Wistar strain. Acute toxicity based on OECD 425 guidelines for the Up-and-Down Procedure (UDP) method. Rats were grouped into 2000 mg/kg BW and 5000 mg/kg BW dose groups, consisting of 5 rats. Organ indexes were analyzed using SPSS Independent Sample T-test with 95% confidence level (p0.05). The result showed no significant difference between both doses (P0.05) in heart, lungs, liver, spleen, and kidneys organ index. Based on the results, it can be concluded that banana peel and pineapple peel combination lozenges did not affect white rats’ heart, lungs, liver, spleen, and kidney organ index.
Pengaruh Ekstrak Kulit Pisang dan Kulit Nanas terhadap Aktivitas Motorik dan Perilaku Tikus Wistar Novia Novia; Fajar Nugraha; Siti Nani Nurbaeti; Inarah Fajriaty; Pratiwi Apridamayanti; Hadi Kurniawan; Liza Pratiwi
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.13908

Abstract

Banana peel and pineapple peel are organic wastes that contain potassium, so it can potentially be developed into lozenges form as supportive antihypertensive therapy. Banana peel and pineapple peel as health supplement ingredients must meet safety requirements. The study of subchronic toxicity test was aimed to determine the toxic effect of repeated administration of a combination of banana peel and pineapple peel extract on motor activity and behavior of Wistar rats. The study was conducted by giving the test preparations repeatedly for 28 days in the control group, doses of 100 mg/KgBW, 400 mg/KgBW, 1000 mg/KgBW, control satellite, and satellite at 1000 mg/KgBW dose, as well as additional 14 days of observation in the satellite group to observe the reversibility effect. The test results showed that administering a combination of banana peel and pineapple peel extract showed normal observation on motor activity and behavior of Wistar rats. This study concludes that the combination of banana peel and pineapple peel did not give toxic effect on motor activity and behavior of Wistar rats.
Pengaruh Pemberian Kombinasi Ekstrak Kulit Pisang dan Kulit Nanas terhadap Indeks Organ Tikus Wistar Melania Niken Safira; Pratiwi Apridamayanti; Hadi Kurniawan; Inarah Fajriaty; Fajar Nugraha; Siti Nani Nurbaeti; Liza Pratiwi
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.13910

Abstract

Banana peel and pineapple peel contain potassium which may be developed into health supplements. The development of banana peels and pineapple peels as ingredients for potassium supplements must meet safety aspects that can be proven by subchronic toxicity tests. This subchronic toxicity test aimed to determine the effect of repeated administration of a combination of banana peel and pineapple peel extract for 28 days on the liver, kidney, kidney, lung, heart, and spleen index of Wistar rats. This research used male and female white rats which were divided into six treatment groups, namely the control group, low dose, middle dose, high dose, satellite control, and high dose satellite. The results showed that there was a significant increase in the liver and kidney organ index, and a significant decrease in the adrenal gland organ index after administration of a combination of banana peel and pineapple peel extract. This research concludes that the combination of banana peel and pineapple peel extract has an effect on the liver, kidney, and adrenal gland organ index in Wistar white rats.
Formulasi Sediaan Emulsi Mengandung Astaxanthin dari Ekstrak Minyak Virgin Coconut Oil Cincalok Indah Aprianti; Siti Nani Nurbaeti; Hadi Kurniawan
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.13635

Abstract

Cincalok is a fermented product made from small shrimps and is a traditional food from West Kalimantan, Indonesia. Cincalok fermentation is produced with the composition of sugar and salt and the appropriate fermentation time. Shrimp in general contain several active compounds, one of which is astaxanthin which gives shrimp its red colour. The shrimp fermentation process resulted in an increase in astaxanthin concentrations compared to ordinary shrimp, caused by the breaking of protein bonds in the fermentation process. Virgin coconut oil is used for astaxanthin extraction because of its good solubility in oil. The emulsion formulation was carried out using 2 different non-ionic emulsifiers to see the effect of the emulsifier on the physical dan chemical properties and stability of the emulsion. Emulsifiers used are cremophor RH 40 and tween 80. The evaluation includes organoleptic testing, determination of content, pH, emulsion type, globule size and distribution of globule size, and viscosity. Stability evaluation were also carried out including volume creaming, centrifugation, heating and cooling, and freeze-thaw tests. The results and data showed that the emulsion formula using emulsifier tween 80 was more physically stable than the formula using cremophor RH 40
Evaluasi Tingkat Pengetahuan Masyarakat dalam Swamedikasi dan Penggunaan Obat yang Rasional (POR) Menggunakan Metode Focus Group Discussion (FGD) Siti Nani Nurbaeti; Hafrizal Riza; Hadi Kurniawan; Shoma Rizkifani; Fajar Nugraha
Jurnal Buletin Al-Ribaath Vol 17, No 2 (2020): Buletin Al-Ribaath
Publisher : Universitas Muhammadiyah Pontianak

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29406/br.v17i2.1945

Abstract

Swamedikasi adalah penggunaan obat tanpa resep atau upaya seseorang dalam mengobati gejala penyakit tanpa melakukan konsultasi ke dokter. Kegiatan ini bertujuan meningkatkan pengetahuan masyarakat di Kecamatan Rasau Jaya, Kabupaten Kubu Raya, Kalimantan Barat mengenai swamedikasi dan cara penggunaan obat yang rasional. Metode yang digunakan adalah Focus Group Discussion (FGD). Hasil kegiatan menunjukkan terjadi peningkatan pemahaman peserta dengan indikator nilai rata-rata pretest adalah 45,32 (skala 0-100) dan nilai rata-rata posttest adalah 86,67 (skala 0-100). Metode FGD berhasil meningkatkan pemahaman masyarakat Kecamatan Rasau Jaya mengenai swamedikasi dan penggunaan obat secara rasional. Hasil pengisian kuesioner menunjukkan kegiatan ini dinilai sangat bermanfaat dan mengharapkan adanya keberlanjutan kegiatan.
Penetapan Kadar Astaxanthin Dalam Cincalok Yang Difermentasi Siti Nani Nurbaeti; Aulia Faradilla; Hadi Kurniawan; Inarah Fajriaty; Fajar Nugraha
Jurnal Farmasi Udayana Vol. 11, No. 1, Tahun 2022
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2022.v11.i01.p06

Abstract

Cincalok merupakan makanan tradisional khas Kalimantan Barat yang dibuat dari proses fermentasi dengan bahan dasar udang rebon. Udang rebon memiliki kandungan senyawa karotenoid, yaitu senyawa astaxanthin yang dikenal memiliki manfaat sebagai antioksidan. Pada penelitian ini dilakukan analisis kandungan senyawa astaxanthin dalam udang rebon yang telah difermentasi menjadi cincalok. Udang rebon diambil dari Desa Mendalok, Sungai Kunyit, Kalimantan Barat. Tujuan penelitian ini untuk mengetahui kadar senyawa astaxanthin dalam cincalok yang telah difermentasi selama 1 minggu dan 2 minggu. Ekstraksi cincalok 1 minggu dan 2 minggu masing-masing dibuat sebanyak 3 batch dengan metode maserasi menggunakan pelarut aseton selama 3 hari berturut-turut. Ekstrak yang diperoleh kemudian dilakukan pengukuran kadar senyawa astaxanthin dengan metode spektrofotometri UV-Vis pada panjang gelombang visibel (477 nm). Hasil kadar astaxanthin yang diperoleh tiap 100 g berat basah cincalok yaitu 3,292 mg (cincalok fermentasi 1 minggu) dan 0,920 mg (cincalok fermentasi 2 minggu).
Optimasi Kombinasi Karbopol 940 dan HPMC Terhadap Sifat Fisik Gel Ekstrak dan Fraksi Metanol Daun Kesum (Polygonum minus Huds.) dengan metode Simplex Lattice Design Sari, Rafika; Nurbaeti, Siti Nani; Pratiwi, Liza
Pharmaceutical Sciences and Research Vol. 3, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Indonesia especially Kalimantan Barat well known by its biodiversity, one of the potential resource is Kesum leaves. Kesum leaves are potential by its antibacterial effect, so that it can be formulated into pharmaceutical dosage form, especially gel. This research aims to know the best comparison between Carbopol 940 and Hydroxypropyl methylcellulose (HPMC) gel base affecting the physical stability of methanol extract and fraction of kesum leaves gel by Simplex Lattice Design (SLD) method. Gels were prepared into three variation base such as gel A (100% Carbopol - 0% HPMC); gel B (0% Carbopol - 100% HPMC); and gel C (50% Carbopol – 50% HPMC). According to SLD method, the optimum combination obtained among the basis were 100% Carbopol - 0% HPMC for Kesum leaves methanol extract gel and 10% Carbopol – 90% HPMC for Kesum leaves methanol fraction gel. Then , the gels were tested their physical stability including adhesive ability spreadability and pH. Results were analyzed using One sample t- test and was known there was no difference of the physical stability between Kesum leaves methanol extract gel and Kesum leaves methanol fraction gel.
Uji Toksisitas Fraksi Air Impatiens balsamina Pada Tikus Betina Galur Sprague Dawley Nurqolbiah, Entang; Kusharyanti, Indri; Nurbaeti, Siti Nani
Pharmaceutical Sciences and Research Vol. 1, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The present study was aimed to predict the level of toxicity of aqueous fraction of Impatiens balsamina by acute toxicity study using OECD guideline 425. Female Sprague Dawley 8-12 week and weight between 140-170 gram were used, the amount of experimental rats were 10 rats. Rats were sequentially administered all the fraction in single dosage (limit test) of 2000 mg/kg body weight and 5000 mg/kg of body weight. All the animals were individually studied for mortality, wellness parameters, food consumption,water consumption, body weight. Histopathological examination was done on the liver and kidney. The result of this study showed that no mortality and no significant changes were observed in wellness parameter, body weight, food consumption, and water consumption at 2000 and 5000 mg/kg of body weight for 48 hour and 14 days. Histopathological examination of fraction treated groups showed lesion of hepatic cells. Based on the result of this research, the researcher conclude that LD50 of aqueous fraction of Impatiens balsamina L was greater than 5000 mg/kg of body weight, which is classified as mild toxic.
Characterization and Antioxidant Activity of Banana Peels, Pineapple Peels, and Combination Extracts of both Peels as Raw Materials in the Development of Hard Candy Pratiwi Apridamayanti; Hadi Kurniawan; Fajar Nugraha; Inarah - Fajriaty; Siti Nani Nurbaeti; Liza Pratiwi
Majalah Obat Tradisional Vol 27, No 3 (2022)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.77474

Abstract

Kepok banana and pineapple are horticultural commodities found in West Kalimantan. The two fruits are generally used as processed foods such as fried bananas and pineapple jam. The use of fruit as food often leaves the peel as a by-product, which can produce waste twice the weight of the food consumed. Meanwhile, waste utilization is an innovation in food processing into functional products which are developed into hard candy. Therefore, this research aims to the specific and non-specific characterization of raw materials for making candy, namely the combination of banana and pineapple peel extract (KP-KN). The characterization is organoleptic tests on the content of ethanol-soluble and water-soluble extracts. The Total phenolic content was determined by the Follin ciocalticeu method with UV/Vis spectrophotometry. Furthermore, antioxidant activity tests with DPPH and FRAP methods using UV/Vis spectrophotometry and ELISA to determine antioxidant activity. The mineral content was observed using the molybdate vandalate method with UV/vis spectrophotometry and ICP-MS, Heavy metal contamination using the ICP-MS tool, and microbial contamination using the plate method. Moreover, the infundation process was carried out on banana and pineapple peels, and the results were evaporated using a food dehydrator to obtain a combination extract. The results showed that the organoleptically KP-KN combination extract had a bitter taste, pineapple smells, 15.57% ash content, ethanol soluble extract content of 55.10%, and 47.99% water-soluble extract. Also, the total phenolic of 6.22 g/Kg, as well as the mineral content of Potassium (K), Calcium (Ca), Iron (Fe), Magnesium (Mg), Zinc (Zn), and Phosphorus (P), which were 47.23 g/Kg, 291.43 mg/Kg, <1x10-6 g/Kg, 2.59x10-3 g/Kg, and 2.38 g/Kg, respectively. Meanwhile, the heavy metal and bacterial contamination test showed that Arsenic (As), Sn, Mercury (Hg), and lead (Pb) were <1x10-6 g/Kg and Cadmium (Cd) was 0.0293. In the microbial contamination test with bacterial components including the ALT test, a value of 4.83 x 103 cfu/g was found, and there was no contamination from E.coli, mold, and yeast bacteria, DPPH and FRAP methods showed antioxidant activity combination extract banana peels and pineapple peels with values of 1390.96±2.83 mg/L and 4542.81±1.10 mg/L compare antioxidant activity of ascorbic acid as standard is 2.13 mg/L and 4.83 mg/L. The test with the KP-KN combined extract can be used as a raw material for making hard candy because it contains minerals needed by the body, meets the safety and quality requirements of traditional medicines, and has antioxidant activity in vitro.
Co-Authors Adelita Ahyanurri Adnan Pramudio Agus Fitriangga Agustriangga, Muhammad Rafly Albianus Febri Tarung Andhi Fahrurroji Aprianti, Indah Apridamayanti, Pratiwi Ardianto, Verdi Arif Wicaksono Aulia Faradilla Benny Wijaya Sunggono Benny Wijaya Sunggono, Benny Wijaya Cristin, Bella Deisberanda, Fortunata Saesarria Dhenaya Pradina Dwi I. Prayitno Eka Kartika Untari Elisabeth indah Mulatsih Entang Nurqolbiah Entang Nurqolbiah Entang Nurqolbiah, Entang Faisal Kholid Fahdi Fajar Nugraha Fajar Nugraha Fajar Nugraha Fajriati, Inarah Fajriaty, Inarah Faradilla, Aulia Fauzan, Suhaimi Fitri, Aulia Kemala Goh, Sri Wahyuni Hadi Kurniawan Hadi Kurniawan, Hadi Hadi, Kurniawan Hafrizal Riza Hafrizal Riza, Hafrizal Hariyanto IH Hidayat, Kartika Nur IH, Harianto Indri Kusharyanti Indriyani, Risa Isnindar Isnindar Khalishah, Hana Laksono Trisnantoro Liza Pratiwi Luliana, Sri M Rafly Agustriangga Mauludia Mauludia Melania Niken Safira Muhammad Andre Reynaldi Mulatsih, Elisabeth indah Nia Anzini Nia Risnawati Novia Novia Pratiwi Apridamayanti Prayitno, Dwi Imam Putri, Arsalna Daersa Rafika Sari Rafika Sari Rico Arianto Risa Indriyani Ropiqa, Meri Safrilla Anggraeni Septira Murtiningsih Shoma Rizkifani Sri Wahdaningsih Thamrin Usman Tiara Bella Pratiwi Veronika, Vina Winda Rahmalia Yuswar, Muhammad Akib