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Journal : Berkala Ilmu Kesehatan Kulit dan Kelamin

Eosinophil and Eosinophil Cationic Protein Level Raising in Dermatitis Due to Food Patients Umborowati, Menul Ayu; Sawitri, Sawitri; Hoetomo, Marsoedi
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 27, No 2 (2015): BIKKK AGUSTUS 2015
Publisher : Faculty Of Medicine Airlangga University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (115.225 KB) | DOI: 10.20473/bikkk.V27.2.2015.90-96

Abstract

Background: Food allergy prevalence worldwide has been increase. Skin is secondary most often target organ in food allergy reaction. Food allergy affects 35% atopic dermatitis (AD) patients. Diagnosis of food allergy  is still challenge because signs are not specific. Previous researches showed eosinophil and eosinophil cationic protein (ECP) role in food allergy reaction on gastrointestinal tract, but none on dermatitis due to food. Purpose: To evaluate eosinophil and serum ECP in dermatitis due to food. Method: This is a descriptive observational cross sectional study, with dermatitis due to food patients in Dermatovenereology Outpatient Clinic Dr. Soetomo General Hospital Surabaya as subjects. Subjects has been collected trough consecutive sampling during 3 months, then data were analysized descriptively Results: Serum ECP level of dermatitis due to food patients were above normal range in all subjects, with mean level 108.5 µg/L, lowest level 33.011 µg/L and higher level 284.849 µg/L. Mean eosinophil of dermatitis due to food patients just arise above normal limit (0.413µg/L). AD patients were 48.4% among all subjects. Mean serum ECP level of AD patients was higher (121.703 µg/L) than non-AD (96.123 µg/L). Conclusions: Eosinophil and ECP seems have role in dermatitis due to food pathogenesis. Serum ECP examination can be benefits to monitor dermatitis due to food severity.Key words: dermatitis due to food, eosinophil, serum eosinophil cationic protein.
The Profile of Erysipelas and Cellulitis Patients Novarina, Ryski Meilia; Sawitri, Sawitri
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 27, No 1 (2015): BIKKK APRIL 2015
Publisher : Faculty Of Medicine Airlangga University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (149.74 KB) | DOI: 10.20473/bikkk.V27.1.2015.32-40

Abstract

Background: Erysipelas and cellulitis are acute infectious serious skin diseases, due to the entry of bacteria through the unintact skin barrier and can be fatal. Purpose: To determine the clinical manifestation and management of hospitalized erysipelas and cellulitis patients at the dermatolovenerology inpatient Dr. Soetomo General Hospital in period of 2008-2011. Methods: The study was conducted retrospectively based on the medical records of the hospitalized patients include case number, gender, age, main complaint and duration, trigger factors, concomitant factors that can be as the underlying disease, lesion site, laboratory examinations, treatments, length of treatment associated with Erythrocyte Sedimentation Rate (ESR) and the prognosis. Results: The erysipelas and cellulitis cases were 65 cases (1.9%) of the total hospitalized cases of skin diseases, with the number of men and women were 36 and 29 patient, respectively. The highest age group were 45-65 years (35.4%). Main complaint was swelling, redness and pain (66,2%) and the duration of complaints 1-7 days (81.5%), Most triggering factors due to scratching (34%). Anemia (30,8%) is the most underlying disease. The majority of lesion sites are in the lower extremities in 56 patients (86.1%). Laboratory tests showed anemic (30.8%), leukocytosis (44.6%) and (76.9%) ESR > 20mm/h (76.9%). The specimen of the lesion of 18 cases were cultured, there were found majority bacterial were Staphylococcus aureus (37.5%). The managements of treatment of 25 cases (38.5%) were consisted: immobilization, intravenous injection of Ampicillin and wet dressing with normal saline, 15 cases with ESR>50mm/h were treated for 8 -14days. The complications (gangrenosum cellulitis) were found in 1 case (1,5%), and 40 patients (61.5%) discharge from hospital in a recovery state. Conclusion: The management of patients with erysipelas and cellulitis had been appropriate based on the diagnosis and treatment guidelines. Staphylococcus aureus is the most frequent bacteria found in culture.Key words: erysipelas, cellulitis, Staphylococcus aureus.
Profile of Scabies in Children Paramita, Kartika; Sawitri, Sawitri
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 27, No 1 (2015): BIKKK APRIL 2015
Publisher : Faculty Of Medicine Airlangga University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (122.621 KB) | DOI: 10.20473/bikkk.V27.1.2015.41-47

Abstract

Background: Scabies is a common parasitic infestation of the skin caused by Sarcoptes scabiei. Scabies is a common public health problem that occurs throughout the world with an estimated prevalence of 300 million individuals. Factors that lead to the high prevalence of scabies include high humidity, lack of sanitation, overcrowding, malnutrition, poor personal hygiene, knowledge, attitude, and behaviour of less supportive healthy lifestyle. Although scabies is not fatal or life-threatening, but the disease can be severe and persistent, which may lead to weakness and secondary skin infections. Purpose: To evaluate the clinical presentation, diagnosis, and treatment of scabies in children at Dermatovenereology outpatient clinic of Dr. Soetomo General Hospital Surabaya. Methods: A retrospective study within 2009 to 2011 using medical record of new patients, aged < 14 years old. Results: The total patients of scabies were 282 patients (5,9% of all pediatric patients in outpatient clinic). Most common group of age was 5-14 years old with the total 180 patients (63,8%), the majority of complaint was itching at night (90,1%), the most frequent location of the lesions was in the web of the fingers and the most common source of transmission is the patients family  (51,4%). The most given topical scabisid was Permethrin cream 5% (97,3%). Conclusions: The diagnosis of scabies could be established by anamnesis and physical examination. Patients education is needed to reduce the reinfection and cut the source of transmission.Key words: scabies, children, Sarcoptes scabiei, retrospective study.
Oral Corticosteroid Therapy in Leprosys new patients with Type 2 Reaction Listiyawati, Irma Tarida; Sawitri, Sawitri; Agusni, Indropo; Prakoeswa, Cita Rosita Sigit
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 27, No 1 (2015): BIKKK APRIL 2015
Publisher : Faculty Of Medicine Airlangga University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (134.721 KB) | DOI: 10.20473/bikkk.V27.1.2015.48-54

Abstract

Background: Leprosy type 2 reactions is an acute inflammatory episode in lepromatous leprosy patient that ascociated with deposition of immune complexes. Standard regiment for severe reaction is corticosteroid. Almost Leprosy type 2 reactions patients become chronic and recurrent so it implicates to more complications if it was not managed well. Purpose: To determine the distribution of type 2 reactions patients which treated with oral corticosteroid in leprosy division of dermatovenereology outpatient clinic of Dr. Soetomo General Hospital. Methods: Retrospective study using new patients medical record during the period of January 1 2009 until December 31 2013 and the observation continued until December 31 2013. Results: The total type 2 reactions patients with oral corticosteroid was 112 patients, mostly were male aged between 25-64 years and has the Lepromatous Leprosy (LL) type (33%), the reactions happened after RFT  (43.8%), 65.2% had metil prednisolon medication, the initial equivalent dose was 30 mg in 32.1% patient. 21.4% patient had more than one cycle  of corticosteroid therapy and 8.9% patient had the steroid side effect. Conclusion: Leprosys type 2 reactions tend to be chronic and recurrent and the impact were patients got longterm continuously corticosteroid medication, so the patients need to be monitored including side effects.Key words: leprosys type 2 reaction, oral corticosteroid, side effects.
Perbedaan Dermatitis Seboroik dan Psoriasis Vulgaris Berdasarkan Manifestasi Klinis dan Histopatologi Astindari, Astindari; Sawitri, Sawitri; Sandhika, Willy
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 26, No 1 (2014): BIKKK APRIL 2014
Publisher : Faculty Of Medicine Airlangga University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (501.04 KB) | DOI: 10.20473/bikkk.V26.1.2014.1-7

Abstract

Latar belakang: Dermatitis seboroik (DS) dan psoriasis sering sulit dibedakan baik secara klinis maupun secara histopatologi. Anamnesis yang tepat dengan memperhatikan usia, riwayat keluarga, dan pemeriksaan klinis yang teliti serta ditunjang dengan pemeriksaan histopatologi, dapat menentukan diagnosis yang tepat. Tujuan: Mengevaluasi perbedaan DS dan psoriasis supaya klinisi dan patolog bisa membuat diagnosis yang benar.Telaah kepustakaan: Secara epidemiologi, terdapat berbagai perbedaan antara DS dan psoriasis. Hal itu bisa dilihat dari usia saat timbulnya lesi, jenis kelamin, ras, maupun genetik. Lokasi lesi dan manifestasi klinis juga mempunyai ciri yang berbeda. Biopsi kulit dibutuhkan untuk membantu menegakkan diagnosis yang tepat.Gambaran histopatologi DS bervariasi sesuai dengan perjalanan penyakitnya: akut, sub-akut, dan kronis, sedangkan psoriasis mempunyai ciri khas berupa pemanjangan rete ridges, abses Munro atau adanya abses Kojog. Simpulan: Terdapat beberapa perbedaan antara DS dan psoriasis dari usia pertama kali muncul lesi, lokasi lesi, manifestasi klinis dan gambaran histopatologi.Kata kunci: dermatitis seboroik, psoriasis, manifestasi klinis, gambaran histopatologi.
The Efficacy of Topical Vitamin C and Microneedling for Photoaging Pratiwi, Karina Dyahtantri; Listiawan, Muhammad Yulianto; Ervianti, Evy; Damayanti, Damayanti; Hendradi, Esti; Prakoeswa, Cita Rosita Sigit; Sawitri, Sawitri
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 33 No. 1 (2021): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V33.1.2021.55-62

Abstract

Background: Photoaging is premature skin aging caused by exposure to ultraviolet (UV) radiation. Vitamin C is an antioxidant that inhibits the tyrosinase enzyme that can reduce pigmentation. Microneedling procedure can improve the penetration of topical vitamin C, and it has skin rejuvenating effects to reduce wrinkles and minimize pore size. Purpose: The main purpose of this study was to evaluate the efficacy of topical vitamin C application after microneedling intervention for the clinical improvement of photoaging. Methods: Twenty-four women with photoaged skin participated in this randomization study, and they were divided into control and intervention groups. Solution of 0.9% NaCl and microneedling were performed to control group, and topical vitamin C and microneedling were performed to intervention group. Three intervention sessions were repeated at a 2 week interval. Signs of photoaging such as pigmentation, wrinkles, and pores were evaluated using Metis DBQ3-1, and the data were obtained numerically. Result: The data analysis revealed a significant improvement in pigmentation in the intervention group compared to control group (p<0.05). Wrinkles and pores evaluation revealed no significant difference between the control and intervention groups. Conclusion: Topical vitamin C after microneedling procedure has provided a significant improvement in pigmentation compared to NaCl 0.9% after microneedling.
In Vitro Comparison of Antifungal Activity between Epigallocatechin Gallate EGCG) and Nystatin on Candida Sp. Stored Isolates in HIV/AIDS Patients with Oral Candidiasis Wibisono, Yusuf; Hidayati, Afif Nurul; Sawitri, Sawitri; Prakoeswa, Cita Rosita Sigit; Zulkarnain, Iskandar; Ervianti, Evy; Rahmadewi, Rahmadewi; Hendradi, Esti; Endraswari, Pepy Dwi; Murtiastutik, Dwi
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 33 No. 2 (2021): AUGUST
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V33.2.2021.103-109

Abstract

Background: Oral candidiasis is an oral infection caused by Candida albicans. It is one of the most common opportunistic infections found in patients with Human Immunodeficiency Virus (HIV)/Acquired Immune Deficiency Syndrome (AIDS). Due to growing resistance and side effects to common antifungal drugs in recent years, there have been many studies on naturalsubstances as antifungal agents. In this study, Epigallocatechin gallate (EGCG) were examined for in vitro antifungal activity against Candida strains. Purpose: To compare the in vitro antifungal activity of EGCG and nystatin towards Candida sp. isolate in HIV/AIDS patients with oral candidiasis. Methods: This research was an experimental laboratory study conducted at the Dr. Soetomo General Academic Hospital, Surabaya. Forty isolates of Candida albicans and Candida non-albicans were included. The isolates were tested for antifungal activity using the well diffusion and microdilution method for nystatin 1000 IU and EGCG 1.25%. Result: Diffusion test results showed a greater inhibition zone for nystatin against all analyzed Candida strains with an average diameter for Candida albicans formed by EGCG of 2.15 mm and 7.4 mm for Candida non-albicans. Meanwhile, based on the microdilution test, EGCG was better than nystatin towards all analyzed Candida strains. This study showed EGCG Minimum Fungicidal Concentration (MFC) as high as 50% (p < 0.05). Conclusion: Nystatin antifungal activity was better than EGCG supported by a greater inhibition zone in the well diffusion method. However, the antifungal activity of EGCG was better than nystatin based on microdilution methods.
Excellent Response of Infantile Hemangioma with Oral Propranolol: A Case Report Denissafitri, Armyta; Pramitha, Riezky Januar; Yuri Widia; Zulkarnain, Iskandar; Irmadita Citrashanty; Sawitri, Sawitri
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 34 No. 3 (2022): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V34.3.2022.217-222

Abstract

Background: Infantile hemangioma (IH) is the most common benign tumor in infancy. Most IHs resolve spontaneously and do not require treatment. Therapeutic intervention is necessary for life-threatening IH, tumors posing functional risks, ulceration, and severe anatomic distortion, especially on the face. Beta-blockers, most specifically propranolol, have been shown to induce involution of IH, which should be administered as early as possible to avoid potential complications. Purpose: To report a case of IH with visual impairment treated successfully using oral propranolol. Case: A 4-month-old girl weighing, 6.3 kg, with redness plaques on the right face since 3 weeks after birth. The lesions rapidly increased in size within 2 months, and the lesions on her right eyelid made it difficult to open her right eye. Dermatological examination showed erythematous plaques, compressible and varying in size and ptosis. The patient was diagnosed with periocular infantile hemangioma and was given oral propranolol therapy with an initiated dose 3x1 mg. The dose was increased gradually. The lesions were significantly decreased and she could open her right eye normally after 5 months of propranolol therapy. Discussion: Some cases of IH require early treatment. Early treatment is indicated for IH causing functional impairment. The use of propranolol in the management of IH is very effective in the reduction of the lesions and Has minimal side effects. Conclusion: Early diagnosis and intervention with propranolol for IH play an important role in determining the optimal outcomes.
Profile of Disability in Leprosy Patients: A Retrospective Study Geani, Silvani; Rahmadewi, Rahmadewi; Astindari, Astindari; Sawitri, Sawitri; Ervianti, Evy; Utomo, Budi; Cita Rosita Sigit Prakoeswa; Listiawan, Muhammad Yulianto
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 34 No. 2 (2022): AUGUST
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V34.2.2022.109-113

Abstract

Background: Leprosy is a chronic granulomatous infectious disease caused by Mycobacterium leprae that affects peripheral nerves and skin. The interaction between M. leprae and Schwann cells causes irreversible damage to peripheral nervous tissue afterward disability occurs. Involvement of the major nervous trunks of the extremities can produce sensory-motor deficits. The risk factors are delay in diagnosis, gender, age, type of leprosy, duration of disease, number of affected nerves, leprosy reaction, type of treatment, socioeconomic factors, education, ethnicity, and occupation. Purpose: The aim was to study the profile of leprosy patients with disability who seek treatment in Leprosy Division Dermatovenerology Outpatient Clinic RSUD Dr. Soetomo Surabaya. Methods: This was a descriptive retrospective study of leprosy patients with disability from January 2017 to December 2019. Result: The results of this study obtained a total of 275 leprosy patients with disabilities, which consisted of 76 patients (27.6%) with grade-1 disability and 199 patients (72.4%) with grade-2 disability. The majority were male (73.4%) and aged 25-44 years old (42.2%). Other dominant risk factors were MB type leprosy (92%), duration of disease more than 12 months (52.3%), no leprosy reaction (68%), and had received multidrug therapy (45.5%). Conclusion: Knowledge of disability risk factors can assist in improving management and education to prevent disability in leprosy patients.
A Retrospective Study of Verruca Fadila, Arisia; Zulkarnain, Iskandar; Listiawan, M. Yulianto; Hidayati, Afif Nurul; Sawitri, Sawitri; Indramaya, Diah; Utomo, Budi
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 34 No. 2 (2022): AUGUST
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V34.2.2022.77-80

Abstract

Background: Verruca (non genital warts) is a quite common public health problem caused by viral infection of low risk Human Papilloma Virus (HPV) types, risking patients of all backgrounds. There is still no ideal treatment for verruca with little knowledge regarding the effectiveness of the available therapies, which results in the lack of therapeutic standard for patients. Purpose: To evaluate the incidence, management, and effectiveness of verruca treatment. Methods: This was a descriptive, retrospective study with a cross-sectional design.  All patients diagnosed with verruca in Tumor and Skin Surgery Division of the Dermatology and Venereology Outpatient Unit at Dr. Soetomo General Academic Hospital Surabaya between January 2016 and December 2020 were included in the study. Result: The results of this study obtained a total of 113 verruca patients, consisting of 61 (53.98%) male patients and 52 (46.01%) female patients, mostly aged 20-60 years old (45 patients [39.82%]). The upper extremity was the most common location where the lesion was found (39 patients [34.5%]). Electrosurgery was the most performed method (38 patients [33.6%]). Thirty-one patients who were treated and returned to the clinic at least once during the month were evaluated for the resolution of the lesion after undergoing therapy. Among 31 patients, resolution was reported in 35.5% of cases. Conclusion: Verruca is a common condition in general practice with many treatment options available yet often neglected. Knowing the available evidence for efficacy of those treatments is critical for dermatologist when considering treatment and educate patients.
Co-Authors AA Sudharmawan, AA Abdullah, Wakid Afif Nurul Hidayati, Afif Nurul Agung, Jeffrey Agus Budi Wahyudi Akbar, Syaiful Amelia, Rizky Putri Anggraeni, Lussy Ardian, Metah Aprilia Aryani, Ni Asmoro, Rico Suji Astindari Astindari, Astindari Bambang Ikwanto Bani Sudardi Bengat, Bengat Budi Utomo Cita Rosita Sigit Prakoeswa Damayanti Damayanti Denissafitri, Armyta Deswijaya, Adi Deswijaya, R. Adi Dwi Murtiastutik Eerste, Eerste Eko Purnomo Esti Hendradi Evawati Alisah Evy Ervianti Evy Ervianty, Evy Fadila, Arisia Fajar Tegar Ardiansyah Farida Nurhasanah Geani, Silvani Ghufron, Wildan Gozeka Putra, Okky Hamli, Haji Hapsari, Pradnya Paramita Harsono Harsono Hidayah, Maulana Hidayat, Roch Ikhwanto, Bambang Indramaya, Diah Indriani, Farihah INDROPO AGUSNI Irma Tarida Listiyawati, Irma Tarida Irmadita Citrashanty Jana, Ninis Ayu Kibtiah, Mariatul M. Yulianto Listiawan Marsoedi Hoetomo Medisika, Dhea Menul Ayu Umborowati, Menul Ayu Moh. Imron Rosidi Muhammad Ridwan Muhlis Fajar Wicaksana Nurpeni Priyatiningsih Nursugiharti, Titih Nyoman Chaya, Nyoman Palobo, Kezia Arung Pardede, Akim Manaor Hara Pepy Dwi Endraswari, Pepy Dwi Prakoeswa, Cita Rosita Pramitha, Riezky Januar Pratiwi, Karina Dyahtantri Priyatiningsih, Nurpeni Pujiyana , Pujiyana Pujiyana Pujiyana Rahmadewi Rahmadewi Rahmadewi Rahmatika, Amira Suryani Ratnaningrum, Yeni Widyana Nurchahyani Resmi, Dewi Candra Rinasari, Umi Rini Elvira Ryski Meilia Novarina, Ryski Meilia Saefuddin Saefuddin Santoso, Rachmat Sariyanti, Sariyanti Seti, Mutiara Yusi Nanda SHINZO IZUMI Simanjuntak, Magdalena Siti Fadjryana Fitroh Sri Marmoah Sunarsih Sunarsih Sundari, Sri Tengku Riza Zarzani N Trisniartami Setyaningrum Tyarini, Indrawati Aris Umiastuti, Pirlina Veithzal Rivai Zainal Wahyu Widayati, Wahyu Wakit Abdullah Rais Widia, Widia Willy Sandhika Winastuti Dwi Atmanto Yuri Widia, Yuri Yusuf Wibisono Yuwono, Evita Putri