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All Journal Indonesian Journal of Pharmaceutical Science and Technology Jurnal Agroindustri Biology, Medicine, & Natural Product Chemistry Jurnal Fitofarmaka Indonesia Jurnal Penelitian Pendidikan IPA (JPPIPA) Window of Health : Jurnal Kesehatan Media Farmasi Media Kesehatan Politeknik Kesehatan Makassar PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Journal of Pharmaceutical and Medicinal Sciences ad-Dawaa : Journal of Pharmaceutical Sciences Jurnal farmasi UIN Alauddin Makassar Devotion: Journal of Research and Community Service Narra J Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Pengabdian Kefarmasian Media Farmasi Jurnal Tumbuhan Obat Indonesia Media Penelitian dan Pengembangan Kesehatan Indonesian Journal of Jamu
Maulita Indrisari, Maulita
Sekolah Tinggi Ilmu Farmasi Makassar
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Electrical & Electronics Engineering Energy Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health

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Activitas, Formulasi dan Efektivitas Gel Ekstrak Beras Hitam (Oryza sativa L) terhadap Bakteri Staphylococcus aureus dan Escherichia coli Khairi, Nur; Hapiwaty, Saldi; Indrisari, Maulita; Marwati, Marwati
Jurnal Penelitian Pendidikan IPA Vol 9 No 6 (2023): June
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i6.3914

Abstract

Black rice (Oryza sativa L.) contains chemical compounds, namely ferulic acid, -oryzanol, amino acids, tannins, phenolics, and anthocyanins which have potential as antibacterial agents. This study aims to formulate an antibacterial gel preparation from black rice extract with an extract concentration of 10% and to test the antibacterial effectiveness of the gel preparation against Staphylococcus aureus and Escherichia coli bacteria. Black rice extract was obtained by maceration using 70% ethanol solvent: 3% citric acid. The extract obtained was then formulated in a gel dosage form. The results showed that black rice extract could be formulated as an antibacterial gel preparation that met the organoleptic, homogeneity, pH, spreadability, and adhesion requirements. In the results of the antibacterial effectiveness test, there is a clear zone which represents the ability to inhibit the growth of the tested bacteria by the gel. Black rice extract can be formulated in a gel dosage form with an extract concentration of 10% and a physically stable formula is obtained in formula III with a carbopol concentration of 2%. The average diameter of the antibacterial gel FIII preparation of black rice extract in inhibiting Staphylococcus aureus bacteria was classified as strong, namely 11.17 ± 0.34 mm, while inhibition of Escherichia coli bacteria was also relatively strong, namely 12.20 ± 0.46 mm
The Effectiveness of Black Mulberry Bark (Morus Nigra L.) Ethanol Extract in Reducing Blood Glucose Levels in Male Mice (Mus Musculus) Induced by Aloxan Saritani, Ayunda Tamara Barito; Indrisari, Maulita; Sembiring, Thyrister Nina Asarya; Nurkalbi, Nuni Rismayanti; Saputra, Agil
Devotion : Journal of Research and Community Service Vol. 6 No. 12 (2025): Devotion: Journal of Community Research
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/devotion.v6i12.25595

Abstract

Diabetes Mellitus (DM) is a disorder of carbohydrate metabolism characterized by a disruption of the body's ability to produce insulin. The bark of the black mulberry stem has a high chemical content of anthocyanins, phenolics, flavanoids and has been known to have many properties. The purpose of this study was to determine the effectiveness of ethanol extract of black mulberry stem bark (Morus nigra L.) on reducing blood glucose levels in male mice (Mus musculus). This research is included in the laboratory-scale experimental type of research. The simplicia of the black mulberry stem is macerated then produces a dry extract. Antidiabetic testing was carried out by dividing 24 mice into 6 groups, namely a healthy control group, a positive control group (glibenchlamid), a negative control group (Na CMC 0.5%), and a 10% b/v dose extract group, a 15% b/v dose extract group, a 20% b/v dose extract group, which was induced with an allocation of 130 mg/kg BB. Based on the results of research that has been carried out, ethanol extract of black mulberry stem bark at a dose of 20% b/v has the highest effect of reducing blood glucose levels with a percentage decrease of 33.51%, compared to doses of 10% and 15%, showing a percentage decrease of 5.51% and 2.36%.
Effectiveness of breadfruit leaf extract in mouthwash formula to inhibit the bacteria of Streptococcus mutans that causes caries Khairi, Nur; Aisyah, Andi Nur; Indrisari, Maulita; Sukmawati, Sukmawati; Nisa, Michrun
Media Penelitian dan Pengembangan Kesehatan Vol. 36 No. 1 (2026): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v36i1.2722

Abstract

Background: Dental caries is caused by Streptococcus mutans, which forms biofilms and produces acid that damages tooth enamel. Prevention is often achieved through mouthwashes containing antibacterial agents, but commercial products may have side effects due to chemical ingredients. Artocarpus altilis (breadfruit) leaves contain bioactive compounds like flavonoids and tannins, which have potential as natural antibacterial agents. Objective: This study aimed to evaluate the antibacterial activity of Artocarpus altilis leaf extract and formulate an effective mouthwash against Streptococcus mutans. Methods: The study used a true experimental design with a pretest-posttest control group. The extract was obtained by maceration with 96% ethanol. Three mouthwash formulations were prepared with varying glycerin concentrations (15%, 20%, and 25%). Antibacterial activity was assessed using the paper disk method, and data were analyzed using Kruskal-Wallis and Mann-Whitney tests. Results: The 2-4% extract had strong antibacterial activity, with inhibition zones ranging from 20.25–23.81 mm, significantly different from the negative control (p<0.05). The mouthwash formulations were liquid, yellow-green in color, with a characteristic breadfruit and mint scent, pH ranging from 5.5 to 7.9, and viscosity of 1 cPs. The mouthwash exhibited strong antibacterial activity, with inhibition zones between 18.81±1.5 mm and 18.94±0.5 mm, showing no significant differences across formulas (p>0.05). Conclusion: The 2% Artocarpus altilis extract and 15% glycerin formula was stable and effectively inhibited Streptococcus mutans
Development and Evaluation of a Stable Topical Cream Formulated with Annona squamosa Seed Extract as a Natural Pediculosis Agent Khairi, Nur; Muslimin, Lukman; Mubarak, Fhahri; Indrisari, Maulita; Fajriansyah, Fajriansyah
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.1355-1363

Abstract

Head lice infestation (Pediculosis capitis) remains a global public health concern, exacerbated by growing resistance to conventional pediculicides such as permethrin and malathion. This study aimed to evaluate the pediculicidal activity and formulation stability of a topical cream containing Annona squamosa (sugar apple or srikaya) seed extract as a natural alternative for treating pediculosis. The ethanolic extract of A. squamosa seeds was obtained through maceration, producing a 10.005% yield. Pediculicidal assays were conducted using various extract concentrations (5%, 7.5%, and 10%), followed by formulation of oil-in-water creams with extract concentrations of 7.5%, 10%, and 12.5%. Physical stability tests included assessments of viscosity, pH, spreadability, adhesion, and homogeneity. Results showed a dose–response relationship, with lice mortality increasing from 60% at 5% extract to 87% at 10%. Extract. The formulated creams demonstrated high efficacy—86% to 96% mortality—comparable to 1% permethrin. All formulations maintained acceptable physicochemical properties (pH 4.8–5.5, viscosity within 27,000–47,000 cps) and remained stable after accelerated storage. These findings indicate that A. squamosa seed extract is a potent pediculicidal agent that can be effectively incorporated into a stable topical formulation. The study supports the potential of A. squamosa as a safe, sustainable, and plant-based alternative for managing pediculosis while addressing the challenge of chemical resistance.
Gastroprotective Effect of the Aqueous Fraction of Tamarindus indica L. Leaves Against Aspirin-Induced Gastric Injury in Mice Rahimah, Sitti; Indrisari, Maulita; Patabang, Devia Novelia
Jurnal Jamu Indonesia Vol. 11 No. 2 (2026): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i2.462

Abstract

Tamarindus indica L. leaves contain bioactive compounds, particularly tannins and saponins, which may contribute to gastric mucosal protection. This study aimed to evaluate the gastroprotective effect of the aqueous fraction of T. indica leaves in aspirin-induced gastric injury in mice. Twelve mice were randomly divided into four groups (n = 3): normal control, negative control, and two treatment groups receiving the aqueous fraction at doses of 6 mg/30 g and 12 mg/30 g body weight prior to aspirin induction. Gastroprotective activity was assessed through macroscopic observation and histopathological examination of gastric tissues. Aspirin administration caused gastric mucosal injury characterized by erosion, ulceration, and hemorrhage. Treatment with the aqueous fraction reduced gastric damage and improved epithelial integrity. The dose of 12 mg/30 g body weight showed the most pronounced protective effect. These findings suggest that the aqueous fraction of T. indica leaves has potential gastroprotective activity.
Co-Authors Abd Halim Umar Abdul Halim Umar Ade Irma Sari Ade Putri Allyah Agustina Ma'tang Parinding Aisyah, Andi Nur Akbar Awaluddin Aksa, Rahmat Amriani Amriani Amriani Sapra Amriani Sapra Andi Nur Aisyah Andi Nur Aisyah Andi Nur Aisyah, Andi Nur Aisyah Arisah, Arisah Asril Burhan Astuti Amin Awaluddin, Akbar Dewingsky, Lyevy Djamaluddin, Suci F Fadhillah Maryam Fhahri Mubarak Fitriyanti Jumaetri Habibie Habibie Hapiwaty, Saldi Ikbal Ikbal Ikbal Indradewa, Rhian Irwana, Rina Ismah Mahmud Ismail Khairi, Nur Lukman Lukman Madinatul munawwarah Margaretha Margaretha Marliana Pasang Marliana Pasang, Marliana Marwati Marwati Marwati Marwati Maryam, Fadhillah Mar’atun Jannah, Imrawati, Muzakkir Baitz, Megawati - Megawati Megawati Michrun Nisa Mus, Suwahyuni Muslimin, Lukman Noer Fauziah Nur Rahma Rumata Nurhikma Awaluddin Nurkalbi, Nuni Rismayanti Nurkhairi, Nurkhairi Nursamsiar Nursamsiar Nurul Hikma Nurwijayanti paluseri, Andi Patabang, Devia Novelia Riska Rahayu Rosyid, Sujud Z Sami, Fitriyanti Saputra, Agil Saritani, Ayunda Tamara Barito Sembiring, Thyrister Nina Asarya Sitti Rahimah Sitti Rahimah Sitti Rahimah, Sitti Solly Aryza St. Rahimah Sukmawati Sukmawati Sukriani Kursia, Sukriani Surida Surida Surida, Surida Suryani Tawali Suwahyuni Mus Syamsu Nur Syamsu Nur, Syamsu Syamsu Nur, Syamsu Nur Utami, Novi F. Wahyu Hendrarti Wahyu Hendrarti Wahyu Hendrarti Zulham Zulham