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All Journal Indonesian Journal of Pharmaceutical Science and Technology Jurnal Agroindustri Jurnal Fitofarmaka Indonesia Jurnal Penelitian Pendidikan IPA (JPPIPA) Window of Health : Jurnal Kesehatan Media Farmasi Media Kesehatan Politeknik Kesehatan Makassar PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Journal of Pharmaceutical and Medicinal Sciences ad-Dawaa : Journal of Pharmaceutical Sciences Jurnal farmasi UIN Alauddin Makassar Devotion: Journal of Research and Community Service Narra J Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Pengabdian Kefarmasian Media Farmasi Jurnal Tumbuhan Obat Indonesia Media Penelitian dan Pengembangan Kesehatan
Maulita Indrisari, Maulita
Sekolah Tinggi Ilmu Farmasi Makassar
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Electrical & Electronics Engineering Energy Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health

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The Effectiveness of Black Mulberry Bark (Morus Nigra L.) Ethanol Extract in Reducing Blood Glucose Levels in Male Mice (Mus Musculus) Induced by Aloxan Saritani, Ayunda Tamara Barito; Indrisari, Maulita; Sembiring, Thyrister Nina Asarya; Nurkalbi, Nuni Rismayanti; Saputra, Agil
Devotion : Journal of Research and Community Service Vol. 6 No. 12 (2025): Devotion: Journal of Community Research
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/devotion.v6i12.25595

Abstract

Diabetes Mellitus (DM) is a disorder of carbohydrate metabolism characterized by a disruption of the body's ability to produce insulin. The bark of the black mulberry stem has a high chemical content of anthocyanins, phenolics, flavanoids and has been known to have many properties. The purpose of this study was to determine the effectiveness of ethanol extract of black mulberry stem bark (Morus nigra L.) on reducing blood glucose levels in male mice (Mus musculus). This research is included in the laboratory-scale experimental type of research. The simplicia of the black mulberry stem is macerated then produces a dry extract. Antidiabetic testing was carried out by dividing 24 mice into 6 groups, namely a healthy control group, a positive control group (glibenchlamid), a negative control group (Na CMC 0.5%), and a 10% b/v dose extract group, a 15% b/v dose extract group, a 20% b/v dose extract group, which was induced with an allocation of 130 mg/kg BB. Based on the results of research that has been carried out, ethanol extract of black mulberry stem bark at a dose of 20% b/v has the highest effect of reducing blood glucose levels with a percentage decrease of 33.51%, compared to doses of 10% and 15%, showing a percentage decrease of 5.51% and 2.36%.
Effectiveness of breadfruit leaf extract in mouthwash formula to inhibit the bacteria of Streptococcus mutans that causes caries Khairi, Nur; Aisyah, Andi Nur; Indrisari, Maulita; Sukmawati, Sukmawati; Nisa, Michrun
Media Penelitian dan Pengembangan Kesehatan Vol. 36 No. 1 (2026): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v36i1.2722

Abstract

Background: Dental caries is caused by Streptococcus mutans, which forms biofilms and produces acid that damages tooth enamel. Prevention is often achieved through mouthwashes containing antibacterial agents, but commercial products may have side effects due to chemical ingredients. Artocarpus altilis (breadfruit) leaves contain bioactive compounds like flavonoids and tannins, which have potential as natural antibacterial agents. Objective: This study aimed to evaluate the antibacterial activity of Artocarpus altilis leaf extract and formulate an effective mouthwash against Streptococcus mutans. Methods: The study used a true experimental design with a pretest-posttest control group. The extract was obtained by maceration with 96% ethanol. Three mouthwash formulations were prepared with varying glycerin concentrations (15%, 20%, and 25%). Antibacterial activity was assessed using the paper disk method, and data were analyzed using Kruskal-Wallis and Mann-Whitney tests. Results: The 2-4% extract had strong antibacterial activity, with inhibition zones ranging from 20.25–23.81 mm, significantly different from the negative control (p<0.05). The mouthwash formulations were liquid, yellow-green in color, with a characteristic breadfruit and mint scent, pH ranging from 5.5 to 7.9, and viscosity of 1 cPs. The mouthwash exhibited strong antibacterial activity, with inhibition zones between 18.81±1.5 mm and 18.94±0.5 mm, showing no significant differences across formulas (p>0.05). Conclusion: The 2% Artocarpus altilis extract and 15% glycerin formula was stable and effectively inhibited Streptococcus mutans
Phytochemical profiling and enzyme inhibitory activity of Sterculia populifolia DC stem bark extract and fractions against elastase and tyrosinase Khairi, Nur; Nursamsiar, Nursamsiar; Utami, Novi F.; Marwati, Marwati; Nur, Syamsu; Indrisari, Maulita; Kursia, Sukriani
Narra J Vol. 5 No. 3 (2025): December 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i3.1778

Abstract

The demand for natural ingredients in cosmetic and medical applications is steadily increasing, particularly for anti-aging and skin-lightening products. Sterculia populifolia DC, a member of the Sterculia genus, is known to contain diverse bioactive compounds such as flavonoids, phenolics, and terpenoids, which may offer pharmacological benefits. The aim of this study was to evaluate the anti-aging potential of S. populifolia stem bark extract and its solvent-partitioned fractions through enzyme inhibition assays coupled with phytochemical profiling. The stem bark was extracted using 96% ethanol via maceration, followed by sequential liquid-liquid partitioning with n-hexane, ethyl acetate, n-butanol, and water. Phytochemical constituents were characterized using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The inhibitory activities of the extract and fractions against tyrosinase and elastase enzymes were evaluated using spectrophotometric assays, with kojic acid and quercetin as positive controls, respectively. IC₅₀ values were calculated to quantify enzyme inhibition potency. LC-MS/MS analysis revealed key bioactive compounds, including 4-[(E)-(3,5-diamino-1H-pyrazol-4-yl)diazenyl]phenol, isofraxidin, and (22E)-ergosta-4,6,8(14),22-tetraen-3-one. Among the tested samples, the ethanol extract exhibited the most potent activity, with an IC₅₀ of 93.35 µg/mL for elastase inhibition and 133.15 µg/mL for tyrosinase inhibition—classified as strong and moderate activity, respectively. Collectively, these findings demonstrate that S. populifolia stem bark extract possesses promising anti-aging and depigmenting properties, supporting its potential development as a natural bioactive ingredient in cosmetic and skincare formulations.
Formulasi Sampo Antiketombe Liofilisat Buah Mengkudu (Morinda citrifolia): Aktivitas Antijamur, Uji Stabilitas Dan Keamanan Melalui HET-CAM Khairi, Nur; Yasir, Budiman; Indrisari, Maulita
Media Farmasi Vol 22 No 1 (2026): Media Farmasi Edisi April 2026
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v22i1.1898

Abstract

Dandruff is a common issue caused by the overgrowth of Malassezia furfur on the scalp. This study aims to develop a safe antidandruff shampoo formulation based on lyophilized noni fruit (Morinda citrifolia L.) and evaluate its effectiveness in combating dandruff. The lyophilized noni fruit was tested for its antifungal activity at five concentrations: 2%, 4%, 6%, 8%, and 10%, and then formulated into shampoo in three concentrations: F1 (6%), F2 (8%), and F3 (10%). The effectiveness of the shampoo formulations was tested against Malassezia furfur using the agar diffusion method. The safety of the formulations was also evaluated using the HET-CAM method to ensure their non-irritating properties. The results indicated that lyophilized noni fruit exhibited significant antifungal activity, with the largest inhibition zone observed at 10% concentration (23.16 ± 5.36 mm), which was not significantly different from the positive control (ketoconazole). Additionally, the HET-CAM test showed no irritation for all formulations, with an irritation score of 0. This study concludes that lyophilized noni fruit shampoo can serve as an effective and safe natural alternative for dandruff treatment.
Activitas, Formulasi dan Efektivitas Gel Ekstrak Beras Hitam (Oryza sativa L) terhadap Bakteri Staphylococcus aureus dan Escherichia coli Nur Khairi; Saldi Hapiwaty; Maulita Indrisari; Marwati Marwati
Jurnal Penelitian Pendidikan IPA Vol 9 No 6 (2023): June
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i6.3914

Abstract

Black rice (Oryza sativa L.) contains chemical compounds, namely ferulic acid, -oryzanol, amino acids, tannins, phenolics, and anthocyanins which have potential as antibacterial agents. This study aims to formulate an antibacterial gel preparation from black rice extract with an extract concentration of 10% and to test the antibacterial effectiveness of the gel preparation against Staphylococcus aureus and Escherichia coli bacteria. Black rice extract was obtained by maceration using 70% ethanol solvent: 3% citric acid. The extract obtained was then formulated in a gel dosage form. The results showed that black rice extract could be formulated as an antibacterial gel preparation that met the organoleptic, homogeneity, pH, spreadability, and adhesion requirements. In the results of the antibacterial effectiveness test, there is a clear zone which represents the ability to inhibit the growth of the tested bacteria by the gel. Black rice extract can be formulated in a gel dosage form with an extract concentration of 10% and a physically stable formula is obtained in formula III with a carbopol concentration of 2%. The average diameter of the antibacterial gel FIII preparation of black rice extract in inhibiting Staphylococcus aureus bacteria was classified as strong, namely 11.17 ± 0.34 mm, while inhibition of Escherichia coli bacteria was also relatively strong, namely 12.20 ± 0.46 mm
Co-Authors Abd Halim Umar Abdul Halim Umar Ade Irma Sari Ade Putri Allyah Agustina Ma'tang Parinding Aisyah, Andi Nur Akbar Awaluddin Aksa, Rahmat Amriani Amriani Amriani Sapra Amriani Sapra Andi Nur Aisyah Andi Nur Aisyah Andi Nur Aisyah, Andi Nur Aisyah Arisah, Arisah Asril Burhan Astuti Amin Awaluddin, Akbar Dewingsky, Lyevy Djamaluddin, Suci F Fadhillah Maryam Fitriyanti Jumaetri Habibie Habibie Hapiwaty, Saldi Ikbal Ikbal Ikbal Indradewa, Rhian Irwana, Rina Ismah Mahmud Ismail Khairi, Nur Lukman Lukman Madinatul munawwarah Margaretha Margaretha Marliana Pasang Marliana Pasang, Marliana Marwati Marwati Marwati Marwati Marwati Marwati Marwati Marwati Maryam, Fadhillah Mar’atun Jannah, Imrawati, Muzakkir Baitz, Megawati - Megawati Megawati Michrun Nisa Mus, Suwahyuni Muslimin, Lukman Noer Fauziah Nur Rahma Rumata Nurhikma Awaluddin Nurkalbi, Nuni Rismayanti Nurkhairi, Nurkhairi Nursamsiar Nursamsiar Nurul Hikma Nurwijayanti paluseri, Andi Riska Rahayu Rosyid, Sujud Z Sami, Fitriyanti Saputra, Agil Saritani, Ayunda Tamara Barito Sembiring, Thyrister Nina Asarya Sitti Rahimah Sitti Rahimah Sitti Rahimah Solly Aryza St. Rahimah Sukmawati Sukmawati Sukriani Kursia, Sukriani Surida Surida Surida, Surida Suryani Tawali Suwahyuni Mus Syamsu Nur Syamsu Nur, Syamsu Syamsu Nur, Syamsu Nur Utami, Novi F. Wahyu Hendrarti Wahyu Hendrarti Yasir, Budiman Zulham Zulham