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Hirowati Ali, Hirowati
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EFEK EKSTRAK DAUN KEMANGI (Ocimum basilicum L.) TERHADAP KADAR HIGH-DENSITY LIPOPROTEIN TIKUS (Rattus norvegicus) MODEL ATEROSKLEROSIS Mazara, Fitria; Mahata, Liganda Endo; Kadri, Husnil; Putri, Biomechy Oktomalio; Ali, Hirowati; Khaira, Fathiyyatul; Rusjdi, Dina Arfiani
Mandala Of Health Vol 17 No 2 (2024): Mandala of Health: a Scientific Journal
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2024.17.2.11432

Abstract

Atherosclerosis is the cardiovascular disease’s main pathological mechanism. Basil leaves are food companion that s widely consumed by Indonesians and contains phenolic and flavonoid bioactive compounds that can increase HDL levels. The purpose of this study was to see the effect of basil leaves extract (Ocimum basilicum L.) on HDL levels in atherosclerosis model rat. This study was conducted using the post test only control group design method on 29 rats. The rats were divided into 5 groups, K-, K+, P1, P2, and P3. K- is group of rats without treatment. K+ was treated with partial carotid ligation (PCL) and high fat diet (HFD), P1 was treated with PCL, HFD and given a dose of 100 mg/kgB basil leaves extract, P2 was treated with PCL, HFD and given a dose of 200 mg/kgBB basil leaves extract, P3 was treated with PCL, HFD and given simvastatin 1.5 mg/rat/day. HFD was given for 7 days, basil leaves extract and simvastatin given for 14 days using oral feeding tube. HDL levels tested with CHOD-PAP method using a microlab 300 spectrophotometer. The result from this study were analyzed by Saphiro-Wilk test, and Kruskal-Wallis test. The mean HDL levels obtained in the K- group were 52,65(49,70‒68.10) mg/dL, K+ 49,67±8,77 mg/dL, P1 52.70±1.58 mg/dL, P2 54.40±9.94 mg/dL, P3 58,05 ±5,34 mg/dL. The results showed there was a non-significant increase in HDL levels (p=0.377) in atherosclerosis model rat by giving basil leaves extract on both dose, and simvastatin.
The Effect of Basil Leaves Extract (Ocimum basilicum) on The Triglyceride Level in Atherosclerosis Rats Atmi, Serly Rahma; Mahata, Liganda Endo; Rahmatini, Rahmatini; Rofinda, Zelly Dia; Ali, Hirowati; Aliska, Gestina; Khaira, Fathiyyatul
Majalah Obat Tradisional Vol 30, No 2 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.94222

Abstract

Atherosclerosis is the main cause of cardiovascular disease (CVD) characterized by fat accumulation and transformation, inflammation, smooth muscle cell proliferation, and necrotic cell remnants in the tunica intima of blood vessels. Basil leaves are known to contain active biochemical compounds that have the potential to reduce lipids. This is an experimental study that investigated the effect of basil leaves on rat triglyceride levels in atherosclerotic models. This research consisted of five groups of rats that were induced atherosclerosis by partial carotid ligation and a high-fat diet for 7 days. The treatment group was given basil leaves extract ethanol with 100 mg/kgBW, 200 mg/kgBW dose, and simvastatin 1,5mg/rat/day. Examination of triglyceride levels by enzymatic calorimetry GPO-PAP method using Micro Lab 300. The data were analyzed using One-way ANOVA and Post Hoc Bonferroni. The results showed that there was an average decrease in triglyceride levels in rats given basil leaves extract with 100 mg/kg BW dose and indicated that the Ocimum basilicum leaves extract affected triglyceride levels in rats induced by atherosclerosis.
Relationship Between Dried Amnion Sheet and Dry Powdered Amnion with Changes in Wound Area in Acute Wounds Ferdinand, Ferdinand; Afriwardi, Afriwardi; Perdanakusuma, David Sontani; Ali, Hirowati
Indonesian Journal of Global Health Research Vol 7 No 5 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i5.6906

Abstract

Dried sheet amnion has long been used as a wound treatment that provides better results than standard general care. In addition to dried amnion sheet, dry powdered amnion preparations have begun to be used for wound care. This study aims to evaluate the effectiveness of dry powdered amnion compared to dried amnion sheets in wound healing, and to compare both treatments with standard acute wound care. Sixty-three healthy Wistar rats were randomly divided into three groups: dried amnion sheet treatment group, dry powdered amnion treatment group, and standard wet wound care control group. The research procedure began with the administration of anesthesia using penthotal at a dose of 10mg/kgBW intramuscularly. The backs of the rats were shaved and a 2x1cm wound was designed using a GOAL razor blade after disinfection with 10% betadine solution and 1:30 savlon. Wounds were made on the backs of the rats, and treatments were given according to the group. The wound area was evaluated at time points 6 hours after treatment, day 2 and day 5. Statistical analysis was performed to compare the effectiveness of the treatments. Both treatments with dry powdered amnion and dried amnion sheets significantly reduced the wound area compared to the control group. However, treatment with dried amnion sheets showed higher efficacy in reducing wound area compared to treatment with dry powdered amnion. Statistical analysis confirmed significant differences in wound area reduction between groups. Dry powdered amnion and dried amnion sheets were effective in reducing wound area compared to standard wet wound care. Treatment with dried amnion sheets showed greater efficacy than treatment with dry powdered amnion.
Exploring the Effects of Bone Marrow Mesenchymal Stem Cells on Amyloid Plaque Reduction in a Rat Model of Alzheimer's Disease Annita, Annita; Revilla, Gusti; Ali, Hirowati; Almurdi, Almurdi
Majalah Kedokteran Andalas Vol. 47 No. 1 (2024): MKA Januari 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v47.i1.p79-86.2024

Abstract

Objective: This study aimed to evaluate the therapeutic potential of Bone Marrow-derived Mesenchymal Stem Cells (BM-MSCs) in mitigating amyloid plaque formation in Alzheimer's disease induced by Aluminum Chloride (AlCl3) in rats. Methods: Rats were divided into three groups: negative control, positive control (AlCl3-induced), and treatment (AlCl3 + BM-MSCs). Cognitive function was assessed five days post-induction, and amyloid plaques were quantified using Congo Red staining in the cortex and hippocampus. Results: A significant reduction in amyloid plaque was observed in rats treated with BM-MSCs. The proportion of stained areas decreased from 1.88 to 1.73 in the cortex and from 1.61 to 1.47 in the hippocampus, compared to AlCl3-only controls. Conclusion: BM-MSCs demonstrated a moderate but statistically significant reduction in amyloid plaque in a rat model of Alzheimer's disease, indicating their therapeutic potential.
Differences in Scube1 and Scube2 Gene Expression in Type II Diabetes Mellitus Patients with Dyslipidemia Saputri, Rahmi Agu; Ali, Hirowati; Tjong, Djong Hon; Anggraini, Debie; Yarni, Sisca Dwi
Jurnal Biologi Tropis Vol. 25 No. 4 (2025): Oktober-Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4.9875

Abstract

The Scube1 gene is expressed in atherosclerosis (plaque buildup in blood vessels), while Scube2 is expressed in DIT (Diffuse Intimal Thickening) which is used to describe diffuse thickening of the intima of blood vessels. This study aims to determine the differences in the expression of the scube1 gene in blood samples of type II DM patients with dyslipidemia and type II DM with non-dyslipidemia and differences in the expression of the scube2 gene in blood samples of type II DM patients with dyslipidemia and type II DM with non-dyslipidemia. With a comparative cross-sectional research method, the sample size of this study was determined based on the Lameshow hypothesis test formula which obtained 18 blood samples of type II DM with dyslipidemia, and 18 blood samples of type II DM with non-dyslipidemia. Blood samples of type II DM patients with dyslipidemia and blood samples of type II DM patients without dyslipidemia showed significantly different expression of the scube1 gene, with a p-value of 0.000. Similarly, blood samples from type II DM patients with dyslipidemia and those from type II DM patients without dyslipidemia showed a significant difference in scube2 gene expression (p = 0.001). Thus, it can be said that the expression of the Scube1 and Scube2 genes is significantly influenced by the complications of diabetes mellitus with dyslipidemia. This happens because it is believed that hyperglycemia in type II DM contributes to endothelial cell dysfunction, which occurs prior to blood vessel damage and results in progressively more severe blood vessel problems. Along with hyperglycemia, type II diabetes also results in dyslipidemia, an alteration in the normal lipid profile. Both dyslipidemia and hyperglycemia contribute to macrovascular and microvascular problems in type II diabetes.
Differential Levels and Biological Roles of eNOS and SCUBE1 in Endothelial Dysfunction: A Systematic Review Siregar, Muhammad Abi Ghoffari; Ali, Hirowati; Rahmadian, Rizki; Rasya, Salsabila Faiha Wiendra
Jurnal Biologi Tropis Vol. 25 No. 4 (2025): Oktober-Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4.10226

Abstract

Endothelial dysfunction (ED) is a systemic disorder marked by impaired nitric oxide (NO) availability, which is essential for maintaining vascular tone and managing oxidative stress. This dysfunction contributes to vascular pathologies such as atherosclerosis and coronary artery disease (CAD) by fostering vasoconstriction, increased permeability, and inflammatory responses, thereby highlighting the urgent need for biomarkers and interventions aimed at mitigating endothelial dysfunction and its associated risks. The relationship between eNOS and SCUBE1 relates to endothelial function and oxidative stress. This study seeks to clarify the benefits and drawbacks of each biomarker in its capacity as a preventive strategy against endothelial dysfunction. This systematic review, adhering to the PRISMA Checklist, examines evidence on the role of endothelial function and oxidative stress in endothelial dysfunction, with emphasis on the biomarkers eNOS and SCUBE1. Literature searches were conducted in PubMed, ScienceDirect, and Google Scholar, and study quality was appraised based on reported biomarker values and relevance. There were 8 articles with increased eNOS and decreased ROS in several treatments, associated with prevention of endothelial dysfunction. There were 6 articles with increased SCUBE1 in several diseases (breast cancer, STEMI, hashimoto's thyroiditis, peripheral ischemic, pulmonary arterial hypertension, atherosclerosis) being markers of endothelial dysfunction. Both biomarkers can work well according to their release pathways, they can be novel biomarkers of endothelial dysfunction in various diseases. Their main role is on endothelial function, SCUBE1 controls BMPR2 signaling (angiogenic, proliferation, apoptosis) and eNOS focuses on endothelial health through NO production (vasodilation, maintaining vascular tone).
Efek Ekstrak Daun Kemangi (Ocimum Basilicum) Terhadap Kadar LDL Tikus (Rattus Norvegicus) Model Aterosklerosis Kencana, Gita; Ali, Hirowati; Noverial, Noverial; Kadri, Husnil; Mahata, Liganda Endo; Pertiwi, Dian
Innovative: Journal Of Social Science Research Vol. 5 No. 3 (2025): Innovative: Journal Of Social Science Research
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/innovative.v5i3.19552

Abstract

Penelitian ini bertujuan untuk mengetahui efek ekstrak daun kemangi (Ocimum basilicum) terhadap kadar LDL pada tikus (Rattus Norvegicus) model aterosklerosis. Desain yang digunakan adalah post-test only control group design dengan 30 ekor tikus jantan yang dibagi menjadi lima kelompok: kontrol negatif (K-), kontrol positif (K+), kontrol statin (KS), perlakuan I (P1; 100 mg/kgBB ekstrak daun kemangi), dan perlakuan II (P2; 200 mg/kgBB). Induksi aterosklerosis dilakukan melalui ligasi parsial arteri karotis dan pemberian diet tinggi lemak selama 7 hari. Pemberian simvastatin dan ekstrak kemangi dilakukan secara oral selama 7 hari. Kadar LDL diukur menggunakan metode CHOD-PAP dengan alat Microlab 300. Hasil analisis statistik menunjukkan perbedaan bermakna kadar LDL antara kelompok K-, KS, dan P2 dibandingkan dengan kelompok K+ (p<0,05). Rerata kadar LDL tertinggi ditemukan pada kelompok K+ (64,56 mg/dL) dan terendah pada kelompok KS (31,62 mg/dL). Dapat disimpulkan bahwa ekstrak daun kemangi, khususnya dosis 200 mg/kgBB, berpotensi menurunkan kadar LDL pada tikus model aterosklerosis.
Determinants and risk factors influencing stunting among toddlers Muthara, Indah; Desmawati, Desmawati; Ali, Hirowati
Malahayati International Journal of Nursing and Health Science Vol. 8 No. 9 (2025): Volume 8 Number 9
Publisher : Program Studi Ilmu Keperawatan-fakultas Ilmu Kesehatan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/minh.v8i9.1548

Abstract

Background: Optimal growth and development in toddlers require appropriate food for growing toddlers. Stunting indicates inadequate nutritional intake in children. Purpose: To determine the risk factors and determinants associated with stunted infant development growth. Method: A descriptive quantitative with analytical survey specially focusing on cross-sectional method. The study took place from September 2024 to July 2025 in Dadok Tunggul Hitam Community Health Center, Padang. The independent variables studied were toddler age, gender, birth weight history, exclusive breastfeeding history, number of siblings, mother's age, mother's education, mother's occupation, family income, and gadget use, while the dependent variable was toddler growth. Using random sampling and the Slovin formula, 86 respondents meeting the inclusion and exclusion criteria were selected and categorized into two groups: suspect and normal. Data analysis began with univariate tests to describe the distribution of respondent characteristics, followed by bivariate analysis using the chi-square test and multivariate analysis with logistic regression. Results: The logistic regression results show that the most influential factor on the occurrence of suspicious developmental events is gadget use, especially in the high use category, with an increased risk of up to 18 times (Exp(B) = 18.125; p = 0.000). Toddler age also plays a significant role, with an approximately 5-fold increase in risk (Exp(B) = 5.406; p = 0.008). The number of siblings and family income also contribute each increasing the likelihood of developmental disorders by approximately 3–4 times (p < 0.05). Conclusion: Gadget use is the factor most strongly linked to growth delays in toddlers.
Co-Authors Afriwardi Afriwardi Aizah, Havina Nurul Almurdi Almurdi Amel Yanis Anggraini, Debie Annita, Annita Ansharina, Hafiznie Atmi, Serly Rahma Basyir, Vaulinne , Beni Indra, Beni Cimi Ilmiawati, Cimi Desmawati Desmawati Desmawati Desmawati Dessy Arisanty Dian Pertiwi Dina Arfiani Rusjdi Djong Hon Tjong Eryati Darwin Fadila, Zurayya Fathiyyatul Khaira, Fathiyyatul Febrina, Widia Ferdinand Ferdinand, Ferdinand Finny Fitry Yani Gestina Aliska Gusti Revilla Hakikah, Tika Hasmiwati Husnil Kadri Julita, Ema Kencana, Gita Lydia Aswati, Lydia Mahata, Liganda Endo Mahendika, Devin Mazara, Fitria Muhammad Arif Muthara, Indah Nora Harminarti Noverial, Noverial Nur'aisyah, Shafira Perdanakusuma, David Sontani Putri, Biomechy Oktomalio Putri, Nabila Priscilla Rahmadian, Rizki Rahmatini . Rasya, Salsabila Faiha Wiendra Restu Susanti Sahputra, Roni Eka Saputri, Rahmi Agu Silviam, Nelmi Siregar, Muhammad Abi Ghoffari Siti Aisyah Sriyanti, Roza Sukri Rahman Tofrizal Wydya, Satya Yarni, Sisca Dwi Yusrawati Yusrawati Yusri, Elfira Zelly Dia Rofinda