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All Journal Jurnal Ilmiah Farmasi Jurnal Farmasi Udayana MEDISAINS AJIE (Asian Journal of Innovation and Entrepreneurship) JURNAL PHARMASCIENCE Majalah Obat Tradisional MPI (Media Pharmaceutica Indonesiana) INDONESIAN JOURNAL OF PHARMACY Pharmascience Journal of Islamic Pharmacy Jurnal Farmasi Sains dan Komunitas Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) CHEESA: Chemical Engineering Research Articles JSFK (Jurnal Sains Farmasi & Klinis) AMALIAH: JURNAL PENGABDIAN KEPADA MASYARAKAT Jurnal Abdimas Madani dan Lestari (JAMALI) Jurnal Ners Medfarm: Jurnal Farmasi dan Kesehatan Journal of Pharmaceutical and Health Research Hydrogen: Jurnal Kependidikan Kimia Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Medical Sains : Jurnal Ilmiah Kefarmasian Khazanah: Jurnal Mahasiswa Eduvest - Journal of Universal Studies Parapemikir Jurnal Ilmiah Farmasi Borneo Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian
Lutfi Chabib, Lutfi
Department Of Pharmacy, Islamic University Of Indonesia
Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Journal : INDONESIAN JOURNAL OF PHARMACY

 1 
FORMULATION OF NANOCURCUMIN USING LOW VISCOSITY CHITOSAN POLYMER AND ITS CELLULAR UPTAKE STUDY INTO T47D CELLS Chabib, Lutfi; Martien, Ronny; Ismail, Hilda
Indonesian Journal of Pharmacy Vol 23 No 1, 2012
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (818.121 KB) | DOI: 10.14499/indonesianjpharm23iss1pp27-35

Abstract

Using  of  curcumin  as  anti  cancer  agent  is  restricted  by  its low  solubility,  therefore  it  has  low  bioavability.  This  obstacle  can be  solved  by  the  development  of  curcumin  nanoparticle. Nanoparticle  technology  has  been  started  to  be  developed  as  an alternative  solution to  improve drug  delivery pofile, especially  for the less bio-available chemical. This study was aimed to develope nanocurcumin  formulation  with  low  viscosity  chitosan  as  the matrix  and  to  study  its  ability  to  be  taken  into  the cells in  vitro. Method  used  in  the  formulation  of  nanocurcumin  in  this  study  is by ionic gelation followed by freeze drying. Entrapment  Efficiency then  assayed,  and  its  stability  was  tested  by  incubating  the formula  into  artificial  intestinal  fluid  (AIF).  Furthermore,  its toxicity  was  evaluated,  also  its  cellular  uptake  ability  into  T47D cell  line.  It  was  found  that  the  Entrapment  Efficiency  in  acetate buffer  at  pH  4  is  higher  than  at  pH  5.  This  formula  also  has  a good  stability  in  AIF.  For  the  cellular  uptake  study  through fluorescence  microscope,  it  was  found  that  the  complex  has  an ability  to  penetrate  cellular  membrane  into  the  cytosol.  The cytotoxicity  study  tell  us  that  the  nanocurcumin  is  non-toxic  to normal  cell line. For  the characterization of the nanoparticles, the average  size  of  this  particle  is  269.8  nm,  its  zeta-potential  is +18.63 mV, with spherical particle morphology. From the result ofthis study, it is concluded that formulation of nanocurcumin using low viscosity chitosan polymer as the matrix has a great potential as an alternative for anticancer therapy.Key words: nanoparticle, curcumin, low viscosity chitosan, T47D cell line. 
Nanocurcumin Preparation for Reducing Vcam-1 and IL-6 in High Fat Diet-Induced Hyperlipidemic Rats Dimas Adhi Pradana; Maulana Ardhi; Arifa Caryn Dea Utami Hasyono; Dzihni Meytasari; Farah Deastasa Nabilah; Rochmy Istikharah; Lutfi Chabib
Indonesian Journal of Pharmacy Vol 30 No 1, 2019
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1047.714 KB) | DOI: 10.14499/indonesianjpharm30iss1pp58

Abstract

Hyperlipidemia is a pathological condition due to lipid metabolism abnormalities. Increased and oxidized LDL in hyperlipidemia will trigger an inflammatory response and produce proinflammatory cytokines, such as vascular cell adhesion molecule-1 (VCAM-1) and Interleukin-6 (IL-6). Curcumin can be used as antioxidants, anti-inflammatory and antihyperlipidemia, but as it is practically insoluble in water, formulation of curcumin nanosuspension is made to improve the effects of curcumin therapy. This study was conducted to determine the activities of nanocurcumin preparation as preventive measures for rats induced with hyperlipidemia. The test animals used were 49 male Wistar rats divided into 7 test groups: normal control group, negative control group, 80mg/kg BW/day curcumin control group, and nanosuspension curcumin dose of 80mg/kg BW/day, nanoemulsion curcumin dose of 80mg/kg BW/day, SNEDDS curcumin dose of 80mg/kg BW/day and solid lipid nanoparticles dose of 80mg/kg BW/day. Provision of preventive measure was performed on days 1-67. On day 11-67, the induction of lard and egg yolk (1:1) was administered with a volume of 2mL/200g of rat BW. On the 68th day, blood samples were taken for the determination of VCAM-1 and IL-6 parameters using Biotin-Streptavidin-Amplified Enzyme-Linked Immuno-sorbent Assay method. Data analysis of VCAM-1 and IL-6 levels between test groups were conducted by means of normality test and One-way ANOVA (p<0.05). Based on the data of VCAM-1 and IL-6 levels, nanocurcumin dose of 80mg/kg BW preparation was able to significantly improve the preventive activity of curcumin compared to curcumin suspension dose of 80mg/kg BW by reducing VCAM-1 levels in SNEDDS (53.260%), nanoemulsion (52.737%), nanosuspension (52.325%) and solid lipid nanoparticles (51.444%) and decreasing IL-6 levels in SNEDDS (33.030%), nanoemulsion (31.568%), nanosuspension (29.898%), and solid lipid nanoparticles (28.875%).
Co-Authors Achmad Fachrodji Agenilia Permatasari Aghna Mafruha Zahrah, Aghna Mafruha Agus Santosa Agustina Setiawati Aji Winanta Akhmad Fauzy Akhmad Nabil Akhmad Nabil, Akhmad Ali Djamhuri Anggara Setyabawana Putra Aprianto . Aprianto Aprianto Arba Pramundita Ramadani Arifa Caryn Dea Utami Hasyono Arismunandar, Arif Asih Triastuti Baharuddin Yusuf Baharudin Yusuf Baruna, Renno Ramadhani Ika Cynthia Astiti Putri Dewi, Melynia Sintha Dimas Adhi Pradana Dzihni Meytasari Farah Deastasa Nabilah Ferdy Firmansyah Gandhi Barajana Vedha Gani, Michael Raharja Gelu, Maria Andriani Guanse, Yovi Hamzah, Hasyrul Hanida Destriana Fatmawati Hani’atul Kharimah Hannie Fitriani Hasnaeni hasnaeni, Hasnaeni Hastri Kholifah Hayati, Farida Herman Felani Hilda Ismail, Hilda Ipaenin, Jahiria Jenita Gandi, Brigita Tuelvin Kamarulzaman, Ezatul Ezleen Kholidah, Ziyyatul Kinanti, Valentina Putri Embun M. Pandoman febrian Maemonah, Maemonah Martien, Ronny Maulana Ardhi Mimiek Murrukmihadi Mufrod Mufrod Muh Iqbal Pangestu Muhammad Faisal Muhammad Ikhwan Rizki Muhammad Iqbal Pangestu Muhammad Safarullah Muhtadi, Wildan Khairi Muslim, M. Rifqi Fadillah Mutiara Herawati, Mutiara Muzakir, Mellisa Nurul Afifi Lobubun Oktavia Indrati, Oktavia Pramundita, Arba Putra, Prima Aulia Reihan Khairiati Renno Ramadhani Ika Baruna Ria Cahya Andriana Rini Dwiastuti Ririn Wulandari Rischi Dwi Irianti Rischi Dwi Irianti, Rischi Dwi Rizki Awaluddin Rizqi, Syifa Maulidia Rochmy Istikharah Ronny Martien Ronny Martien Samsul Hadi Siti Zahliyatul Munawiroh Suryani, Arman Syarif Hidayatullah Tamhid, Hady Anshory Taufikurrahmi Taufikurrahmi Trianloka, A. M. Bagas Tunny, Risman Uzulul Hikmah Wahyu, Imron Yandi Syukri Yosi Febrianti, Yosi Ziyyatul Kholidah