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All Journal Medicina Jurnal Ergonomi Indonesia (The Indonesian Journal of Ergonomic) Indonesian Journal of Tropical and Infectious Disease WMJ (Warmadewa Medical Journal) Biology, Medicine, & Natural Product Chemistry Jurnal Ilmiah Kedokteran Wijaya Kusuma Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Jurnal Biomedika dan Kesehatan Community Development Journal ABDI MOESTOPO: Jurnal Pengabdian pada Masyarakat Cermin Dunia Kedokteran Aesculapius Medical Journal Warmadewa Minesterium Medical Journal Abdi Widya: Jurnal Pengabdian Masyarakat Biomedika
Saktivi Harkitasari, Saktivi
Universitas Warmadewa
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Library & Information Science Medicine & Pharmacology Public Health Social Sciences Other

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Mesial Temporal Lobe Epilepsy as a Common but Elusive Case: A Case Report Junior, Darren; Wulandari, Putu Kintan; Harkitasari, Saktivi; Sumardika, I Wayan; Sumadewi, Komang Trisna
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 9 No 01 (2025): Qanun Medika Vol 09 No 01 January 2025
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v9i01.22259

Abstract

Epilepsy is a common neuronal disorder that could include partial or generalized seizures due to abnormal brain electrical activity. A 32-year-old female patient was presented to the emergency room with a chief complaint of seizure. The seizure semiology started with epigastric pain, which then progressed into sudden speech arrest. Afterward, the patient experienced left-sided head movement followed by jerkings on the left hand. The patient then became unconscious and experienced full body rigidity. Physical examinations, vital signs, and laboratory results showed no abnormalities. Diagnostic assessments only showed unspecific signs of diffuse cerebral edema through a CT Scan and an atrophy of the right hippocampus with a slight increase in FLAIR signal intensity and dilatation of the right lateral ventricle pericornu through MRI. The patient was given phenytoin and folic acid twice daily. The presence of right mesial temporal sclerosis served as a possible cause of epilepsy in this patient despite having several obscurities. The patient showed atypical signs of generalized tonic seizure progression, adult-onset seizures, and increased MRI FLAIR signal intensity. More detailed examinations and constant reports of epilepsy cases are highly needed among physicians to provide more specific methods and tools to diagnose, classify, and treat epilepsy in the future.
Genetic Mutations and Polymorphisms Related to Severity, Mortality, and Antibody-Dependent Enhancement of Dengue Virus (DENV) Infection: A Literature Review Purnamasidhi, Cokorda Agung Wahyu; Junior, Darren; Satya Diksha, I Gusti Ngurah Ariestha; Hiranandini Prawista, I Gusti Ayu Maha; Guptha, I Dewa Gede Agung Siwa; Pratyaksa, I Gusti Ngurah Dinda; Indratmo, Novea; Suteja, Richard Christian; Harkitasari, Saktivi
Indonesian Journal of Tropical and Infectious Disease Vol. 13 No. 3 (2025)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v13i3.70457

Abstract

The dengue virus (DENV) is a blood-borne Flavivirus transmitted through vectors and ranks as the fastest-spreading tropical disease globally. Dengue infection could exhibit mild to severe symptoms depending on various factors. Antibody-dependent enhancement (ADE) is a cross-reactive phenomenon between different DENV strains that clinicians should be aware of, as it leads to a higher incidence of dengue with warning signs and severe dengue. On the molecular level, many genes contribute to the severity and pathophysiology of ADE. Mutations and polymorphisms in these genes could alter the course of dengue infection. This article aims to comprehensively review studies that measure the impact of dengue-related genetic mutations and polymorphisms on the severity, mortality, and ADE of DENV infection. We performed a literature review to identify relevant articles on PubMed, Science Direct, Europe PMC, and Google Scholar. The review examines polymorphisms across multiple gene families: Fcγ receptors, cytokines (TNF-α, TGF-β1, IL-10), immune regulatory genes (MICB, PLCE1, RIPK2), antigen-presenting machinery (DC-SIGN, TAP), and host defense mechanisms (VDR, CTLA-4, MBL, HPA). These genetic variations have population-specific effects and may confer both protection in some populations and increased susceptibility to severe outcomes of dengue in others. The effects of these polymorphisms are context-dependent and differ according to the phase of infection, ethnicity, and gene-gene interactions. Overall, it could be concluded that aside from external factors, polymorphisms on human genes regulating mechanisms and components related to dengue infection have been extensively discussed to play a role in the overall clinical outcome.
INNOVATION IN STREPTOCOCCUS SUIS MENINGITIS DIAGNOSTICS: CHALLENGES AND SOLUTIONS Sumadewi, Komang Trisna; Harkitasari, Saktivi; Astini, Dewa Ayu Agung Alit Suka; Evayanti, Luh Gede
Jurnal Biomedika dan Kesehatan Vol 9 No 1 (2026)
Publisher : Fakultas Kedokteran Universitas Trisakti

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Abstract

Streptococcus suis (S. suis) is a significant zoonotic pathogen that can cause severe infections in humans, primarily manifesting as meningitis, septicemia, and endocarditis. This review focuses on the pathophysiology of S. suis meningitis, emphasizing the bacterium's mechanisms for crossing the blood-brain barrier (BBB) and eliciting a robust inflammatory response. The review highlights the virulence factors, including collagenase-like protease and capsular polysaccharides, that facilitate the pathogen's evasion of the immune system and contribute to the severity of the disease. Notably, the prevalence of S. suis infections remains a critical public health concern, particularly in regions with high pig consumption, where occupational exposure increases the risk of human disease. The manuscript also evaluates current diagnostic techniques, comparing traditional methods, such as cerebrospinal fluid culture, with advanced molecular diagnostics, including polymerase chain reaction (PCR) and next-generation sequencing (NGS). These newer methods demonstrate enhanced sensitivity and specificity, crucial for timely and accurate diagnosis. Furthermore, emerging innovations in diagnostic technology, including point-of-care testing and biosensors, hold promise for rapid identification of S. suis, potentially mitigating morbidity associated with the disease. This comprehensive review highlights the urgent need for enhanced diagnostic capabilities and public health strategies to reduce the burden of S. suis meningitis, promoting interdisciplinary collaboration to improve disease prevention and management.
Hypertension: the risk factors of non-hemorrhagic stroke Desyanti Risky Putri; Saktivi Harkitasari; Masyeni, Sri
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol. 15 No. 1 (2026): March 2026
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v15i1.4736

Abstract

Background: Stroke is the leading cause of disability and the third leading cause of death worldwide. This study aims to investigate hypertension as a risk factor for non-hemorrhagic stroke (NHS). Methods: This study was designed as a retrospective, observational, analytic case-control study involving a total of 112 participants. Data analysis utilised the chi-square test, with a significance level set at p < 0.05 and a 95% confidence interval (CI). Results: The findings revealed that NHS patients were predominantly in the 45-60 year age group (44.6%), primarily male (69.6%), and mostly of Balinese ethnicity (94.6%). A significant number of NHS patients were diagnosed with hypertension (53.6%). The most frequently reported clinical symptoms were weakness or paralysis in the extremities (94.6%). An improvement in outcomes was observed in 80.4% of patients, with a median length of hospital stay of 4 days. Laboratory data were normal, and CT scans identified hypodense lesions in 60.7% of cases. The results of the chi-square statistical analysis indicated an odds ratio (OR) of 2.65, with a 95% CI of 1.22–5.74 and p = 0.013. In conclusion, this study suggests that hypertension increases the risk of non-hemorrhagic stroke by 2.65 times compared to individuals without hypertension.
Co-Authors Agus Eka Darwinata Anak Agung Bagus Ngurah Nuartha Anak Agung Ngurah Agung Bayu Sutha Asri Lestarin Astini, Dewa Ayu Agung Alit Suka Audria, Intan Safira Cokorda Agung Wahyu Purnamasidhi Desyanti Risky Putri Dewa Ayu Agung Alit Suka Astini Dewa Ayu Sri Shita Meliani Dewi Manuaba, Ida Ayu Laxmi Ananda Diksha, I Gusti Ngurah Ariestha Satya Evayanti, Luh Gede Giovanca Verentzia Purnama Guptha, I Dewa Gede Agung Siwa Hiranandini Prawista, I Gusti Ayu Maha I Dewa Ayu Inten Dwi Primayanti, I Dewa Ayu Inten Dwi I Gede Purna Weisnawa I Gusti Ngurah Agung Cahyadi Putra I Komang Hotra Adiputra I Made Wandia I Wayan Sumardika Ida Bagus Giri Sena Putra Indratmo, Novea Jerry Junior, Darren Kadek Ayu Astuti Ketut Tuti Parwati Merati Komang Trisna Sumadewi Komang Triyani Kartinawati Made Ilora Hiranandasastri Masyeni, Sri Ni Made Kharisma Praba Yuanika Ni Putu Diah Witari, Ni Putu Ni Putu Sukarini Pratiwi, Cokorda Agung Pratyaksa, I Gusti Ngurah Dinda Primatanti, Putu Asih Putra Parwati, Tjok Istri Putu Asih Primatanti R. A.T. Kuswardhani Richard Christian Suteja Rima Kusuma Ningrum Satya Diksha, I Gusti Ngurah Ariestha Sumadewi, Komang Trisna Suteja, Richard Christian Suyasning Hastiko Indonesia Tanjung Subrata Thomas Eko Purwata Tjok Istri Putra Parwati Toddy Hendrawan Yupardhi, Toddy Hendrawan Utama, I Made Susila Wiranatha, I Gede Wulandari, Putu Kintan