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All Journal Sari Pediatri Paediatrica Indonesiana AcTion: Aceh Nutrition Journal Amerta Nutrition Journal of Electronics, Electromedical Engineering, and Medical Informatics AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Heart Science Journal journal of Basic Medical Veterinary Narra J Journal of Medical Science; Jurnal Ilmu Medis Rumah Sakit Umum Daerah dr. Zainoel Abidin, Banda Aceh Narra X Trends in Infection and Global Health
Herlina Dimiati, Herlina
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Control & Systems Engineering Dentistry Electrical & Electronics Engineering Engineering Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Veterinary Other

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Journal : Paediatrica Indonesiana

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Diagnostic value of clinical manifestations of Group A and Group B compared with rubella serology results in congenital rubella syndrome Sulasmi, Sulasmi; Dimiati, Herlina; Andid, Rusdi; Darussalam, Dora; Thaib, Teuku Muhammad; Anidar, Anidar
Paediatrica Indonesiana Vol. 64 No. 2 (2024): March 2024
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi64.2.2024.139-44

Abstract

Background Congenital rubella syndrome (CRS) is the triad of defects/abnormalities in the heart, eyes, and ears, resulting from rubella virus infection, especially in the first trimester of pregnancy. Manifestations of CRS are divided into Group A including: hearing loss, congenital heart disease, cataracts or glaucoma, and pigmentary; Group consisted of purpura, splenomegaly, microcephaly, mental retardation, retinopathy and icteric radiolucent bone disoreder that appears within 24 hours after birth. CRS diagnosis is based on serologic rubella test results. Comprehensive management of CRS is needed to achieve optimal child development. However, not all referral center hospitals in Indonesia have serological rubella examination modalities. Objective To evaluate the diagnostic value of group A and group B clinical manifestations compared to rubella serology results in the diagnosis of CRS. Methods This cross-sectional study used secondary data from medical records of pediatric patients with suspected CRS who meet the criteria for groups A and B aged less than 12 months who had been hospitalized at Dr. Zainoel Abidin Regional General Hospital, Banda Aceh, during the three-year study period (2019-2021) which have complete data were included in the study. The IgM serology results were used as diagnostic comparison that performed at the age of less than 12 months. Results A total of 126 patients met the inclusion criteria. Sixty-five (51.6%) subjects were male, 80 (63.5%) subjects had normal birth weight, and 89 (70.6%) subjects were aged <6 months. The diagnostic sensitivity for groups A, B, as well as A and B clinical manifestations were 100%, 75%, and 100%, respectively. This excellent sensitivity value suggests that the clinical manifestations of groups A and B would be suitable as screening tools because they could “catch” many patients with suspected CRS. Conclusion The clinical manifestations of group A and group B have excellent diagnostic value as a screening tool for CRS.
Urinary neutrophil gelatinase-associated lipocalin to predict acute kidney injury in children with critical illness Fajri, Rizky; Sovira, Nora; Haris, Syafruddin; Dimiati, Herlina; Bakhtiar, Bakhtiar; Amna, Eka Yunita
Paediatrica Indonesiana Vol. 65 No. 1 (2025): January 2025
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi65.1.2025.47-53

Abstract

Background Acute kidney injury (AKI) can increase mortality in children with critical illness. Urinary neutrophil gelatinase-associated lipocalin (uNGAL) is a biomarker for early prediction of AKI in children. Objective To determine the diagnostic value of uNGAL as a predictor of AKI in children with critical illness. Methods This observational cross-sectional study was conducted in the Emergency Room, Pediatric Intensive Care Unit, and Pediatric Ward of Zainoel Abidin Public Hospital, Banda Aceh, Indonesia, between August and December 2023. Subjects were 40 children aged 1 month to 18 years with critical illness. uNGAL levels were measured on the first day of admission. Blood urea and creatinine levels were measured on the first and third days of admission. We calculated the diagnostic sensitivity and specificity of uNGAL to predict AKI. The optimal uNGAL cut-off point for this purpose was determined using receiver operating characteristic (ROC) curve analysis. Result In the majority of patients (29/40; 72.5%) critical illness occurred at the ages of 5 to 18 years. The most common primary diseases were central nervous system disorders in 14/40 (35%) patients, gastrointestinal infection in 6/40 (15%) patients, and malignancy in 5/40 (12.5) patients. Median uNGAL levels were significantly elevated in subjects with renal impairment [17.37 (range 6.13-29.70) ng/mL] compared to those with normal renal function [4.87 (range 0.32-29.49) ng/mL] (P=0.0001). The optimal uNGAL cut-off point was >9.99 ng/mL, with an AUC of 0.842, 81% sensitivity, and 78.9% specificity to predict AKI. The OR of AKI in children with uNGAL levels >9.99 ng/mL was 10.66 (95%CI 2.30 to 49.30; P=0.003). Conclusion Urinary neutrophil gelatinase-associated lipocalin (uNGAL) can be used as a predictor of acute kidney injury in children with critical illness.
Co-Authors Adi Purnawarman, Adi Aini, Zahratul Akbar, Zaki Al Bahri Amna, Eka Yunita Andriyani, Dia Anidar Anidar, Anidar Azhari Azhari Bakhtiar Bakhtiar Basir, Nurlida Dewi, Teungku Puspa Dora Darussalam, Dora Edward, Eka D. Edward, Eka Destianti Fajar, Sukmawan Fajri, Fauzan Fajri, Rizky Gunawan, Aris Hamny Sofyan Hasan, Denny I. Hasan, Denny Irmawati Hasibuan, Reina Rizqia Muharrami Haypheng, Te Herdata, Heru N. Heru Noviat Herdata, Heru Noviat Hidayaturrahmi, Hidayaturrahmi Husnah Husnah Ichsan Ichsan Imran Imran Ismy, Jufitriani Jasa, Zafrullah Khany Kartini Hasballah Machya, Farish Maharani, Cut Rika Mahmud , Nissa N. Maimun Syukri, Maimun Mauliza , Mauliza Mauliza, Mauliza Melinda Melinda Mudatsir , Mudatsir Mudatsir Mudatsir Muhammad Yani, Muhammad Muhammad, Insyirah Mulya Safri, Mulya Munirwan, Haris Muslim Akmal Nadia, Nurul Nora Sovira, Nora Nurjannah Nurjannah Raihani, Rifa Ramadhan, Muhammad Fatih Ramadhani, Hanum Aulia Rasaki, Rico Redwood-Campbell, Lynda Rosaria Indah Rusdi Andid, Rusdi Safrizal Safrizal Sakdiah Sakdiah, Sakdiah Salsabila, Nisa Saputra, Irwan Saputra, Jefri Dwi Sentosa, Sukmawan F. Siti Aminah Srikandi, Mira Subkhan, Muhammad Sudung O. Pardede, Sudung O. Sulaiman Yusuf Sulasmi Sulasmi Syafruddin Haris, Syafruddin Syahrizal Syahrizal Teuku Heriansyah, Teuku Thaib, T.M. Thaib, Teuku Muhammad Utami, Niken Asri Wiranda, Ulzi Echa Yunidar