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All Journal Bionatura Farmaka Indonesian Journal of Pharmaceutical Science and Technology Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ JFIOnline Jurnal Ilmu Kefarmasian Indonesia JURNAL FARMASI GALENIKA Majalah Farmasetika Journal of Community Development Indonesian Journal of Biological Pharmacy Pharmaceutical Sciences and Research (PSR) Neraca Manajemen, Akuntansi, dan Ekonomi Jurnal Farmasi Galenika
Ida Musfiroh -, Ida Musfiroh
Fakultas Farmasi Universitas Padjadjaran
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences

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Journal : Bionatura

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Prediksi Aktivitas Antikanker Payudara Senyawa Fevicordin dari Biji Phaleria macrocarpa (Scheff) Boerl. pada ERĄ Melalui Hubungan Kuantitatif Struktur dan Aktivitas metode Multiple Linear Regression Analysis dan Partial Component Analysis Muchtaridi -; A. Mutalib -; Jutti Levita -; A. Diantini -; Ida Musfiroh -
Bionatura Vol 13, No 1 (2011): Bionatura Maret 2011
Publisher : Direktorat Sumber Daya Akademik dan Perpustakaan

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Abstract

In this study fevicordin is proposed to be used for anti breast-cancer. The development of this compound was based on Quantitative Structure Activity Relationship (QSAR) study of 37 estrogen analogues using MLRA (Multiple Linier Regression Analysis) and PCA (Partial Component Analysis). QSAR equations resulted from MLRA and PCA techniques are:Log Ki = -16.5348 + 9.4000 Ovalitas - 0.0472 Molar Volume - 1.3985 Dipole Energy + 0.4891 Dipole Length + 0.0000 Torsion Energy + 0.0113 Total Areaand Log Ki = -16.8273 – 1.4970 Homo – 0.0214 Area Polar + 0.4940 Dipol – 0.0131 Total Area, respectively.The models were used to predict fevicordin’s Ki value, which had been studied using radioligand binding assay by Nakata and his colleagues, and resulted 6.13-15M (in Tris buffer using 3H-estradiol as competitor) and 2.60.10-14M (in Hepes buffer using [125I]estradiol as competitor), respectively.Keywords : Fevicordin, Breast cancer, ERá, Ki, QSAR
Co-Authors A. Diantini - A. Mutalib - ADAM RENALDI Ahmad Muhtadi Ajeng Diantini, Ajeng Aliya Nur Hasanah Almira Agustini Hadirana Ami Tjitraresmi, Ami Anisa D. Aryanti, Anisa D. Anisa Marieta Astiani, Tina Asy Syifa, Khadijah BUNGA DACILIA HARSANTI Dea Gilang Kancanawatie Deden Indra Dinata, Deden Indra Deti Dewantisari Dian Amalia Maharani Dinda Arditta Driyanti Rahayu Eka Rosalianti Emma Emawati, Emma Entris Sutisna, Entris ERLIN ELISABETH HUTAPEA Faizal Alfaridz Farida Fauzia, Farida Farkhani, Meigita Indah Fenadya Rahayu Agustriono Gofarana Wilar Hardhi Suryatno, Hardhi Hasna Nur Syahidah Hidayat, Nafisa Nurfatia Holis Abdul Holik, Holis Abdul Iis Karlida Jutti Levita Kartasasmita, Rahmana E Kartasasmita, Rahmana E Laelasari, Eli Lina Indriati Luthfia Azzahra Maharani, Anisa MEGANTARA, SANDRA Moelyono, M W Moelyono, M W Muchtaridi Muchtaridi MUHAMMAD NAUFAL MU'TASHIM Nadia Ulil Fatiya NADYA INDAH DEWANTI, NADYA INDAH NAZILLA RESHKA FATHURRAHMAN Nia N Susanti, Nia N Nita Sari Nurhaliza, Muthiah Nursyamsiah, Tresna Nursyamsiah, Tresna NURUL KARTIKA HANDAYANI Nyi Mekar Saptarini Oktavia Sabetta Sigalingging Patihul Husni Perwira, Anggun Putri Rahmad Aprianto Rahmad Aprianto, Rahmad RAMADHAN, SAQILA ALIFA Rembulan Kusmawati, Rembulan Resti Azura, Alia Rismiatin - Rizki Desvianto Rizki Desvianto, Rizki Rochjana, Anna Uswatun Hasanah Safira Annissa SALMA ALAINA ATISHA Shafirany, Mareetha Zahra Shelvy E Suherman, Shelvy E Slamet Ibrahim - Sri Adi Sumiwi Sriwidodo B, Sriwidodo Steven A. Pamolango, Steven A. Sulistiyaningsih - Sulistiyaningsih -, Sulistiyaningsih Syafdal Farisi Theresia Ratnadevi ULY AULIA ULFAH Wahyu Ashri Aditya Wiwiek Indriyanti Wiwiek Indriyanti, Wiwiek Wiwiek Indriyati, Wiwiek Yasarah Hisprastin Yasmiwar Susilawati Yola Desnera Putri Yoppi Iskandar Yulia Sukmawardani, Yulia Zahra Siti Hanifah